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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 0-10 Glycan_Motif denotes Hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T2 30-40 Glycan_Motif denotes hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T3 88-98 Glycan_Motif denotes hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO
T4 178-188 Glycan_Motif denotes hyaluronan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 0-10 https://glytoucan.org/Structures/Glycans/G00017MO denotes Hyaluronan
T2 30-40 https://glytoucan.org/Structures/Glycans/G00017MO denotes hyaluronan
T3 88-98 https://glytoucan.org/Structures/Glycans/G00017MO denotes hyaluronan
T4 178-188 https://glytoucan.org/Structures/Glycans/G00017MO denotes hyaluronan

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-169 Sentence denotes Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end.
TextSentencer_T2 170-286 Sentence denotes Class I hyaluronan synthases (HAS) assemble [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP at the reducing end and also make chitin.
TextSentencer_T3 287-415 Sentence denotes Streptococcus equisimilis HAS (SeHAS) also synthesizes chitin-UDP oligosaccharides, (GlcNAc-β1,4)n-GlcNAc(α1→)UDP (Weigel et al.
TextSentencer_T4 416-422 Sentence denotes 2015).
TextSentencer_T5 423-557 Sentence denotes Here we determined if HAS uses chitin-UDPs as primers to initiate HA synthesis, leaving the non-HA primer at the nonreducing (NR) end.
TextSentencer_T6 558-728 Sentence denotes HA made by SeHAS membranes was purified, digested with streptomyces lyase, and hydrophobic oligomers were enriched by solid phase extraction and analyzed by MALDI-TOF MS.
TextSentencer_T7 729-937 Sentence denotes Jack bean hexosaminidase (JBH) and MS/MS were used to analyze 19 m/z species of possible GnHn ions with clustered GlcNAc (G) residues attached to disaccharide units (H): (GlcNAcβ1,4)2-5[GlcUA(β1,3)GlcNAc]2-6.
TextSentencer_T8 938-1068 Sentence denotes JBH digestion sequentially removed GlcNAc from the NR-end of GnHn oligomers, producing successively smaller GnH2-3 series members.
TextSentencer_T9 1069-1167 Sentence denotes Since lyase releases dehydro-oligos (dHn; M-18), only the unique NR-end oligo lacks dehydro-GlcUA.
TextSentencer_T10 1168-1307 Sentence denotes Hn oligomers were undetectable in lyase digests, whereas JBH treatment created new H2-6m/z peaks (i.e. HA tetra- through dodeca-oligomers).
TextSentencer_T11 1308-1436 Sentence denotes MS/MS of larger GnHn species produced chitin (2-5 GlcNAcs), HA oligomers and multiple smaller series members with fewer GlcNAcs.
TextSentencer_T12 1437-1603 Sentence denotes All NR-ends (97%) started with GlcNAc, as a chitin trimer (three GlcNAcs), indicating that GlcNAc(β1,4)2GlcNAc(α1→)-UDP may be optimal for initiation of HA synthesis.
TextSentencer_T13 1604-1674 Sentence denotes Also, HA made by live S. pyogenes cells had G4Hn chitin-oligo NR-ends.
TextSentencer_T14 1675-1887 Sentence denotes We conclude that chitin-UDP functions in vitro and in live cells as a primer to initiate synthesis of all HA chains and these primers remain at the NR-ends of HA chains as residual chitin caps [(GlcNAc-β1,4)3-4].
T1 0-169 Sentence denotes Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end.
T2 170-286 Sentence denotes Class I hyaluronan synthases (HAS) assemble [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP at the reducing end and also make chitin.
T3 287-415 Sentence denotes Streptococcus equisimilis HAS (SeHAS) also synthesizes chitin-UDP oligosaccharides, (GlcNAc-β1,4)n-GlcNAc(α1→)UDP (Weigel et al.
T4 416-422 Sentence denotes 2015).
T5 423-557 Sentence denotes Here we determined if HAS uses chitin-UDPs as primers to initiate HA synthesis, leaving the non-HA primer at the nonreducing (NR) end.
T6 558-728 Sentence denotes HA made by SeHAS membranes was purified, digested with streptomyces lyase, and hydrophobic oligomers were enriched by solid phase extraction and analyzed by MALDI-TOF MS.
T7 729-937 Sentence denotes Jack bean hexosaminidase (JBH) and MS/MS were used to analyze 19 m/z species of possible GnHn ions with clustered GlcNAc (G) residues attached to disaccharide units (H): (GlcNAcβ1,4)2-5[GlcUA(β1,3)GlcNAc]2-6.
T8 938-1068 Sentence denotes JBH digestion sequentially removed GlcNAc from the NR-end of GnHn oligomers, producing successively smaller GnH2-3 series members.
T9 1069-1167 Sentence denotes Since lyase releases dehydro-oligos (dHn; M-18), only the unique NR-end oligo lacks dehydro-GlcUA.
T10 1168-1307 Sentence denotes Hn oligomers were undetectable in lyase digests, whereas JBH treatment created new H2-6m/z peaks (i.e. HA tetra- through dodeca-oligomers).
T11 1308-1436 Sentence denotes MS/MS of larger GnHn species produced chitin (2-5 GlcNAcs), HA oligomers and multiple smaller series members with fewer GlcNAcs.
T12 1437-1603 Sentence denotes All NR-ends (97%) started with GlcNAc, as a chitin trimer (three GlcNAcs), indicating that GlcNAc(β1,4)2GlcNAc(α1→)-UDP may be optimal for initiation of HA synthesis.
T13 1604-1674 Sentence denotes Also, HA made by live S. pyogenes cells had G4Hn chitin-oligo NR-ends.
T14 1675-1887 Sentence denotes We conclude that chitin-UDP functions in vitro and in live cells as a primer to initiate synthesis of all HA chains and these primers remain at the NR-ends of HA chains as residual chitin caps [(GlcNAc-β1,4)3-4].

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 47-53 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 62-68 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 215-221 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T4 372-378 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T5 386-392 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T6 843-849 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T7 926-932 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T8 973-979 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T9 1358-1365 chem:24139 denotes GlcNAcs
PD-NGLY1-deficiency-B_T10 1428-1435 chem:24139 denotes GlcNAcs
PD-NGLY1-deficiency-B_T11 1468-1474 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T12 1502-1509 chem:24139 denotes GlcNAcs
PD-NGLY1-deficiency-B_T13 1528-1534 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T14 1870-1876 chem:24139 denotes GlcNAc

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 200-203 Disease denotes HAS http://purl.obolibrary.org/obo/MONDO_0019395
T2 313-316 Disease denotes HAS http://purl.obolibrary.org/obo/MONDO_0019395
T3 445-448 Disease denotes HAS http://purl.obolibrary.org/obo/MONDO_0019395

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 121-127 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2 279-285 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T3 342-348 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T4 454-460 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T5 1346-1352 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T6 1481-1487 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T7 1653-1659 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T8 1692-1698 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T9 1856-1862 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 200-203 Disease denotes HAS http://purl.obolibrary.org/obo/MONDO_0019395
T2 313-316 Disease denotes HAS http://purl.obolibrary.org/obo/MONDO_0019395
T3 445-448 Disease denotes HAS http://purl.obolibrary.org/obo/MONDO_0019395

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 287-312 OrganismTaxon denotes Streptococcus equisimilis 119602
T2 613-625 OrganismTaxon denotes streptomyces 1883

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 140-145 Cell denotes a cap http://purl.obolibrary.org/obo/CL:4028003

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 575-584 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-169 Sentence denotes Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end.
TextSentencer_T2 170-286 Sentence denotes Class I hyaluronan synthases (HAS) assemble [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP at the reducing end and also make chitin.
TextSentencer_T3 287-415 Sentence denotes Streptococcus equisimilis HAS (SeHAS) also synthesizes chitin-UDP oligosaccharides, (GlcNAc-β1,4)n-GlcNAc(α1→)UDP (Weigel et al.
TextSentencer_T4 416-422 Sentence denotes 2015).
TextSentencer_T5 423-557 Sentence denotes Here we determined if HAS uses chitin-UDPs as primers to initiate HA synthesis, leaving the non-HA primer at the nonreducing (NR) end.
TextSentencer_T6 558-728 Sentence denotes HA made by SeHAS membranes was purified, digested with streptomyces lyase, and hydrophobic oligomers were enriched by solid phase extraction and analyzed by MALDI-TOF MS.
TextSentencer_T7 729-937 Sentence denotes Jack bean hexosaminidase (JBH) and MS/MS were used to analyze 19 m/z species of possible GnHn ions with clustered GlcNAc (G) residues attached to disaccharide units (H): (GlcNAcβ1,4)2-5[GlcUA(β1,3)GlcNAc]2-6.
TextSentencer_T8 938-1068 Sentence denotes JBH digestion sequentially removed GlcNAc from the NR-end of GnHn oligomers, producing successively smaller GnH2-3 series members.
TextSentencer_T9 1069-1167 Sentence denotes Since lyase releases dehydro-oligos (dHn; M-18), only the unique NR-end oligo lacks dehydro-GlcUA.
TextSentencer_T10 1168-1307 Sentence denotes Hn oligomers were undetectable in lyase digests, whereas JBH treatment created new H2-6m/z peaks (i.e. HA tetra- through dodeca-oligomers).
TextSentencer_T11 1308-1436 Sentence denotes MS/MS of larger GnHn species produced chitin (2-5 GlcNAcs), HA oligomers and multiple smaller series members with fewer GlcNAcs.
TextSentencer_T12 1437-1603 Sentence denotes All NR-ends (97%) started with GlcNAc, as a chitin trimer (three GlcNAcs), indicating that GlcNAc(β1,4)2GlcNAc(α1→)-UDP may be optimal for initiation of HA synthesis.
TextSentencer_T13 1604-1674 Sentence denotes Also, HA made by live S. pyogenes cells had G4Hn chitin-oligo NR-ends.
TextSentencer_T14 1675-1887 Sentence denotes We conclude that chitin-UDP functions in vitro and in live cells as a primer to initiate synthesis of all HA chains and these primers remain at the NR-ends of HA chains as residual chitin caps [(GlcNAc-β1,4)3-4].
T1 0-169 Sentence denotes Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end.
T2 170-286 Sentence denotes Class I hyaluronan synthases (HAS) assemble [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP at the reducing end and also make chitin.
T3 287-415 Sentence denotes Streptococcus equisimilis HAS (SeHAS) also synthesizes chitin-UDP oligosaccharides, (GlcNAc-β1,4)n-GlcNAc(α1→)UDP (Weigel et al.
T4 416-422 Sentence denotes 2015).
T5 423-557 Sentence denotes Here we determined if HAS uses chitin-UDPs as primers to initiate HA synthesis, leaving the non-HA primer at the nonreducing (NR) end.
T6 558-728 Sentence denotes HA made by SeHAS membranes was purified, digested with streptomyces lyase, and hydrophobic oligomers were enriched by solid phase extraction and analyzed by MALDI-TOF MS.
T7 729-937 Sentence denotes Jack bean hexosaminidase (JBH) and MS/MS were used to analyze 19 m/z species of possible GnHn ions with clustered GlcNAc (G) residues attached to disaccharide units (H): (GlcNAcβ1,4)2-5[GlcUA(β1,3)GlcNAc]2-6.
T8 938-1068 Sentence denotes JBH digestion sequentially removed GlcNAc from the NR-end of GnHn oligomers, producing successively smaller GnH2-3 series members.
T9 1069-1167 Sentence denotes Since lyase releases dehydro-oligos (dHn; M-18), only the unique NR-end oligo lacks dehydro-GlcUA.
T10 1168-1307 Sentence denotes Hn oligomers were undetectable in lyase digests, whereas JBH treatment created new H2-6m/z peaks (i.e. HA tetra- through dodeca-oligomers).
T11 1308-1436 Sentence denotes MS/MS of larger GnHn species produced chitin (2-5 GlcNAcs), HA oligomers and multiple smaller series members with fewer GlcNAcs.
T12 1437-1603 Sentence denotes All NR-ends (97%) started with GlcNAc, as a chitin trimer (three GlcNAcs), indicating that GlcNAc(β1,4)2GlcNAc(α1→)-UDP may be optimal for initiation of HA synthesis.
T13 1604-1674 Sentence denotes Also, HA made by live S. pyogenes cells had G4Hn chitin-oligo NR-ends.
T14 1675-1887 Sentence denotes We conclude that chitin-UDP functions in vitro and in live cells as a primer to initiate synthesis of all HA chains and these primers remain at the NR-ends of HA chains as residual chitin caps [(GlcNAc-β1,4)3-4].

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-169 Sentence denotes Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end.
T2 170-286 Sentence denotes Class I hyaluronan synthases (HAS) assemble [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP at the reducing end and also make chitin.
T3 287-415 Sentence denotes Streptococcus equisimilis HAS (SeHAS) also synthesizes chitin-UDP oligosaccharides, (GlcNAc-β1,4)n-GlcNAc(α1→)UDP (Weigel et al.
T4 416-422 Sentence denotes 2015).
T5 423-557 Sentence denotes Here we determined if HAS uses chitin-UDPs as primers to initiate HA synthesis, leaving the non-HA primer at the nonreducing (NR) end.
T6 558-728 Sentence denotes HA made by SeHAS membranes was purified, digested with streptomyces lyase, and hydrophobic oligomers were enriched by solid phase extraction and analyzed by MALDI-TOF MS.
T7 729-937 Sentence denotes Jack bean hexosaminidase (JBH) and MS/MS were used to analyze 19 m/z species of possible GnHn ions with clustered GlcNAc (G) residues attached to disaccharide units (H): (GlcNAcβ1,4)2-5[GlcUA(β1,3)GlcNAc]2-6.
T8 938-1068 Sentence denotes JBH digestion sequentially removed GlcNAc from the NR-end of GnHn oligomers, producing successively smaller GnH2-3 series members.
T9 1069-1167 Sentence denotes Since lyase releases dehydro-oligos (dHn; M-18), only the unique NR-end oligo lacks dehydro-GlcUA.
T10 1168-1307 Sentence denotes Hn oligomers were undetectable in lyase digests, whereas JBH treatment created new H2-6m/z peaks (i.e. HA tetra- through dodeca-oligomers).
T11 1308-1436 Sentence denotes MS/MS of larger GnHn species produced chitin (2-5 GlcNAcs), HA oligomers and multiple smaller series members with fewer GlcNAcs.
T12 1437-1603 Sentence denotes All NR-ends (97%) started with GlcNAc, as a chitin trimer (three GlcNAcs), indicating that GlcNAc(β1,4)2GlcNAc(α1→)-UDP may be optimal for initiation of HA synthesis.
T13 1604-1674 Sentence denotes Also, HA made by live S. pyogenes cells had G4Hn chitin-oligo NR-ends.
T14 1675-1887 Sentence denotes We conclude that chitin-UDP functions in vitro and in live cells as a primer to initiate synthesis of all HA chains and these primers remain at the NR-ends of HA chains as residual chitin caps [(GlcNAc-β1,4)3-4].

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 121-127 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2 279-285 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T3 342-348 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T4 454-460 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T5 1346-1352 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T6 1481-1487 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T7 1653-1659 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T8 1692-1698 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T9 1856-1862 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 287-312 OrganismTaxon denotes Streptococcus equisimilis 119602
T2 613-625 OrganismTaxon denotes streptomyces 1883

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 575-584 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 140-145 Cell denotes a cap http://purl.obolibrary.org/obo/CL:4028003