
PubMed:28100567
Annnotations
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 80-92 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 942-953 | Glycan_Motif | denotes | Tn antigens | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G57321FI |
T2 | 1023-1039 | Glycan_Motif | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 942-953 | https://glytoucan.org/Structures/Glycans/G57321FI | denotes | Tn antigens |
T2 | 1023-1039 | https://glytoucan.org/Structures/Glycans/G20420WT | denotes | lactosylceramide |
T3 | 1023-1039 | https://glytoucan.org/Structures/Glycans/G74621DY | denotes | lactosylceramide |
T4 | 1023-1039 | https://glytoucan.org/Structures/Glycans/G84224TW | denotes | lactosylceramide |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1023-1039 | http://www.glycoepitope.jp/epitopes/EP0078 | denotes | lactosylceramide |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-93 | Sentence | denotes | MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells. |
TextSentencer_T2 | 94-306 | Sentence | denotes | Aberrant glycogene and glycan expression is intimately associated with carcinogenesis, invasion, and metastasis of gastric cancer (GC); however the regulatory mechanisms for glycogenes in GC cells remain unclear. |
TextSentencer_T3 | 307-512 | Sentence | denotes | Methyl-CpG-binding protein 2 (MeCP2) regulates genes by binding to methylated promoters, and in our previous work we found that it is overexpressed in GC cell lines and tissues, functioning as an oncogene. |
TextSentencer_T4 | 513-713 | Sentence | denotes | In this study we detected the expression of 212 glycogenes in MeCP2 silenced GC cells versus control using the Agilent Whole Human Genome Microarray and mining the data through bioinformatic analysis. |
TextSentencer_T5 | 714-1082 | Sentence | denotes | A total of 10 glycogenes exhibited increased expression (FC ≥ 2, P < 0.05), while 16 showed decreased expression (FC ≤ 2, P < 0.05) in the MeCP2 silenced cells, which corresponded to down-regulation of Lewis antigens (UEA-I), T/Tn antigens (PNA), and mature N-glycans (PHA-E and PHA-E+L) and up-regulation of lactosylceramide, a precursor oligosaccharide of N-glycans. |
TextSentencer_T6 | 1083-1331 | Sentence | denotes | Examination of the TCGA Gastric Cancer databases demonstrated that nine glycogenes (24.6%) were oppositely regulated by MeCP2 in MeCP2 knockdown BGC-823 cells relative to their expression level in GC tissues, and might be downstream genes of MeCP2. |
TextSentencer_T7 | 1332-1478 | Sentence | denotes | Individual gene analysis suggested that neutral alpha-glucosidase AB (GANAB) knockdown can rescue the effects of MeCP2 overexpression on GC cells. |
TextSentencer_T8 | 1479-1596 | Sentence | denotes | MeCP2 promotes GANAB by binding to the second methylated CpG island (206 bp, -12916 to -13122) of the GANAB promoter. |
TextSentencer_T9 | 1597-1775 | Sentence | denotes | In conclusion, glycogenes can be either up- or down-regulated by MeCP2 directly or indirectly to alter the glycopatterning and affect the proliferation and apoptosis of GC cells. |
T1 | 0-93 | Sentence | denotes | MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells. |
T2 | 94-306 | Sentence | denotes | Aberrant glycogene and glycan expression is intimately associated with carcinogenesis, invasion, and metastasis of gastric cancer (GC); however the regulatory mechanisms for glycogenes in GC cells remain unclear. |
T3 | 307-512 | Sentence | denotes | Methyl-CpG-binding protein 2 (MeCP2) regulates genes by binding to methylated promoters, and in our previous work we found that it is overexpressed in GC cell lines and tissues, functioning as an oncogene. |
T4 | 513-713 | Sentence | denotes | In this study we detected the expression of 212 glycogenes in MeCP2 silenced GC cells versus control using the Agilent Whole Human Genome Microarray and mining the data through bioinformatic analysis. |
T5 | 714-1082 | Sentence | denotes | A total of 10 glycogenes exhibited increased expression (FC ≥ 2, P < 0.05), while 16 showed decreased expression (FC ≤ 2, P < 0.05) in the MeCP2 silenced cells, which corresponded to down-regulation of Lewis antigens (UEA-I), T/Tn antigens (PNA), and mature N-glycans (PHA-E and PHA-E+L) and up-regulation of lactosylceramide, a precursor oligosaccharide of N-glycans. |
T6 | 1083-1331 | Sentence | denotes | Examination of the TCGA Gastric Cancer databases demonstrated that nine glycogenes (24.6%) were oppositely regulated by MeCP2 in MeCP2 knockdown BGC-823 cells relative to their expression level in GC tissues, and might be downstream genes of MeCP2. |
T7 | 1332-1478 | Sentence | denotes | Individual gene analysis suggested that neutral alpha-glucosidase AB (GANAB) knockdown can rescue the effects of MeCP2 overexpression on GC cells. |
T8 | 1479-1596 | Sentence | denotes | MeCP2 promotes GANAB by binding to the second methylated CpG island (206 bp, -12916 to -13122) of the GANAB promoter. |
T9 | 1597-1775 | Sentence | denotes | In conclusion, glycogenes can be either up- or down-regulated by MeCP2 directly or indirectly to alter the glycopatterning and affect the proliferation and apoptosis of GC cells. |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 72-86 | Disease | denotes | gastric cancer | http://purl.obolibrary.org/obo/MONDO_0001056 |
T2 | 209-223 | Disease | denotes | gastric cancer | http://purl.obolibrary.org/obo/MONDO_0001056 |
T3 | 225-227 | Disease | denotes | GC | http://purl.obolibrary.org/obo/MONDO_0001056 |
T4 | 282-284 | Disease | denotes | GC | http://purl.obolibrary.org/obo/MONDO_0001056 |
T5 | 458-460 | Disease | denotes | GC | http://purl.obolibrary.org/obo/MONDO_0001056 |
T6 | 590-592 | Disease | denotes | GC | http://purl.obolibrary.org/obo/MONDO_0001056 |
T7 | 983-986 | Disease | denotes | PHA | http://purl.obolibrary.org/obo/MONDO_0007710|http://purl.obolibrary.org/obo/MONDO_0008214 |
T9 | 993-996 | Disease | denotes | PHA | http://purl.obolibrary.org/obo/MONDO_0007710|http://purl.obolibrary.org/obo/MONDO_0008214 |
T11 | 1107-1121 | Disease | denotes | Gastric Cancer | http://purl.obolibrary.org/obo/MONDO_0001056 |
T12 | 1280-1282 | Disease | denotes | GC | http://purl.obolibrary.org/obo/MONDO_0001056 |
T13 | 1469-1471 | Disease | denotes | GC | http://purl.obolibrary.org/obo/MONDO_0001056 |
T14 | 1766-1768 | Disease | denotes | GC | http://purl.obolibrary.org/obo/MONDO_0001056 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 72-86 | Phenotype | denotes | gastric cancer | HP:0012126 |
T2 | 209-223 | Phenotype | denotes | gastric cancer | HP:0012126 |
T3 | 225-227 | Phenotype | denotes | GC | HP:0012126 |
T4 | 282-284 | Phenotype | denotes | GC | HP:0012126 |
T5 | 458-460 | Phenotype | denotes | GC | HP:0012126 |
T6 | 590-592 | Phenotype | denotes | GC | HP:0012126 |
T7 | 1107-1121 | Phenotype | denotes | Gastric Cancer | HP:0012126 |
T8 | 1280-1282 | Phenotype | denotes | GC | HP:0012126 |
T9 | 1469-1471 | Phenotype | denotes | GC | HP:0012126 |
T10 | 1766-1768 | Phenotype | denotes | GC | HP:0012126 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1023-1039 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 72-86 | Phenotype | denotes | gastric cancer | HP:0012126 |
T2 | 209-223 | Phenotype | denotes | gastric cancer | HP:0012126 |
T3 | 225-227 | Phenotype | denotes | GC | HP:0012126 |
T4 | 282-284 | Phenotype | denotes | GC | HP:0012126 |
T5 | 458-460 | Phenotype | denotes | GC | HP:0012126 |
T6 | 590-592 | Phenotype | denotes | GC | HP:0012126 |
T7 | 1107-1121 | Phenotype | denotes | Gastric Cancer | HP:0012126 |
T8 | 1280-1282 | Phenotype | denotes | GC | HP:0012126 |
T9 | 1469-1471 | Phenotype | denotes | GC | HP:0012126 |
T10 | 1766-1768 | Phenotype | denotes | GC | HP:0012126 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 638-643 | OrganismTaxon | denotes | Human | 9606 |
GlyCosmos15-CL
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 80-92 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-93 | Sentence | denotes | MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells. |
TextSentencer_T2 | 94-306 | Sentence | denotes | Aberrant glycogene and glycan expression is intimately associated with carcinogenesis, invasion, and metastasis of gastric cancer (GC); however the regulatory mechanisms for glycogenes in GC cells remain unclear. |
TextSentencer_T3 | 307-512 | Sentence | denotes | Methyl-CpG-binding protein 2 (MeCP2) regulates genes by binding to methylated promoters, and in our previous work we found that it is overexpressed in GC cell lines and tissues, functioning as an oncogene. |
TextSentencer_T4 | 513-713 | Sentence | denotes | In this study we detected the expression of 212 glycogenes in MeCP2 silenced GC cells versus control using the Agilent Whole Human Genome Microarray and mining the data through bioinformatic analysis. |
TextSentencer_T5 | 714-1082 | Sentence | denotes | A total of 10 glycogenes exhibited increased expression (FC ≥ 2, P < 0.05), while 16 showed decreased expression (FC ≤ 2, P < 0.05) in the MeCP2 silenced cells, which corresponded to down-regulation of Lewis antigens (UEA-I), T/Tn antigens (PNA), and mature N-glycans (PHA-E and PHA-E+L) and up-regulation of lactosylceramide, a precursor oligosaccharide of N-glycans. |
TextSentencer_T6 | 1083-1331 | Sentence | denotes | Examination of the TCGA Gastric Cancer databases demonstrated that nine glycogenes (24.6%) were oppositely regulated by MeCP2 in MeCP2 knockdown BGC-823 cells relative to their expression level in GC tissues, and might be downstream genes of MeCP2. |
TextSentencer_T7 | 1332-1478 | Sentence | denotes | Individual gene analysis suggested that neutral alpha-glucosidase AB (GANAB) knockdown can rescue the effects of MeCP2 overexpression on GC cells. |
TextSentencer_T8 | 1479-1596 | Sentence | denotes | MeCP2 promotes GANAB by binding to the second methylated CpG island (206 bp, -12916 to -13122) of the GANAB promoter. |
TextSentencer_T9 | 1597-1775 | Sentence | denotes | In conclusion, glycogenes can be either up- or down-regulated by MeCP2 directly or indirectly to alter the glycopatterning and affect the proliferation and apoptosis of GC cells. |
T1 | 0-93 | Sentence | denotes | MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells. |
T2 | 94-306 | Sentence | denotes | Aberrant glycogene and glycan expression is intimately associated with carcinogenesis, invasion, and metastasis of gastric cancer (GC); however the regulatory mechanisms for glycogenes in GC cells remain unclear. |
T3 | 307-512 | Sentence | denotes | Methyl-CpG-binding protein 2 (MeCP2) regulates genes by binding to methylated promoters, and in our previous work we found that it is overexpressed in GC cell lines and tissues, functioning as an oncogene. |
T4 | 513-713 | Sentence | denotes | In this study we detected the expression of 212 glycogenes in MeCP2 silenced GC cells versus control using the Agilent Whole Human Genome Microarray and mining the data through bioinformatic analysis. |
T5 | 714-1082 | Sentence | denotes | A total of 10 glycogenes exhibited increased expression (FC ≥ 2, P < 0.05), while 16 showed decreased expression (FC ≤ 2, P < 0.05) in the MeCP2 silenced cells, which corresponded to down-regulation of Lewis antigens (UEA-I), T/Tn antigens (PNA), and mature N-glycans (PHA-E and PHA-E+L) and up-regulation of lactosylceramide, a precursor oligosaccharide of N-glycans. |
T6 | 1083-1331 | Sentence | denotes | Examination of the TCGA Gastric Cancer databases demonstrated that nine glycogenes (24.6%) were oppositely regulated by MeCP2 in MeCP2 knockdown BGC-823 cells relative to their expression level in GC tissues, and might be downstream genes of MeCP2. |
T7 | 1332-1478 | Sentence | denotes | Individual gene analysis suggested that neutral alpha-glucosidase AB (GANAB) knockdown can rescue the effects of MeCP2 overexpression on GC cells. |
T8 | 1479-1596 | Sentence | denotes | MeCP2 promotes GANAB by binding to the second methylated CpG island (206 bp, -12916 to -13122) of the GANAB promoter. |
T9 | 1597-1775 | Sentence | denotes | In conclusion, glycogenes can be either up- or down-regulated by MeCP2 directly or indirectly to alter the glycopatterning and affect the proliferation and apoptosis of GC cells. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-93 | Sentence | denotes | MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells. |
T2 | 94-306 | Sentence | denotes | Aberrant glycogene and glycan expression is intimately associated with carcinogenesis, invasion, and metastasis of gastric cancer (GC); however the regulatory mechanisms for glycogenes in GC cells remain unclear. |
T3 | 307-512 | Sentence | denotes | Methyl-CpG-binding protein 2 (MeCP2) regulates genes by binding to methylated promoters, and in our previous work we found that it is overexpressed in GC cell lines and tissues, functioning as an oncogene. |
T4 | 513-713 | Sentence | denotes | In this study we detected the expression of 212 glycogenes in MeCP2 silenced GC cells versus control using the Agilent Whole Human Genome Microarray and mining the data through bioinformatic analysis. |
T5 | 714-1082 | Sentence | denotes | A total of 10 glycogenes exhibited increased expression (FC ≥ 2, P < 0.05), while 16 showed decreased expression (FC ≤ 2, P < 0.05) in the MeCP2 silenced cells, which corresponded to down-regulation of Lewis antigens (UEA-I), T/Tn antigens (PNA), and mature N-glycans (PHA-E and PHA-E+L) and up-regulation of lactosylceramide, a precursor oligosaccharide of N-glycans. |
T6 | 1083-1331 | Sentence | denotes | Examination of the TCGA Gastric Cancer databases demonstrated that nine glycogenes (24.6%) were oppositely regulated by MeCP2 in MeCP2 knockdown BGC-823 cells relative to their expression level in GC tissues, and might be downstream genes of MeCP2. |
T7 | 1332-1478 | Sentence | denotes | Individual gene analysis suggested that neutral alpha-glucosidase AB (GANAB) knockdown can rescue the effects of MeCP2 overexpression on GC cells. |
T8 | 1479-1596 | Sentence | denotes | MeCP2 promotes GANAB by binding to the second methylated CpG island (206 bp, -12916 to -13122) of the GANAB promoter. |
T9 | 1597-1775 | Sentence | denotes | In conclusion, glycogenes can be either up- or down-regulated by MeCP2 directly or indirectly to alter the glycopatterning and affect the proliferation and apoptosis of GC cells. |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 1023-1039 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
GlyCosmos15-Lectin-Jamboree
Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
---|---|---|---|---|---|
T1 | 955-958 | Lectin | denotes | PNA | GL_003655 |
T2 | 983-988 | Lectin | denotes | PHA-E | GL_002666 |
T3 | 993-998 | Lectin | denotes | PHA-E | GL_002666 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 72-86 | Disease | denotes | gastric cancer | MONDO:0001056|MONDO:0004950 |
T3 | 209-223 | Disease | denotes | gastric cancer | MONDO:0001056|MONDO:0004950 |
T5 | 225-227 | Disease | denotes | GC | MONDO:0001056 |
T6 | 282-284 | Disease | denotes | GC | MONDO:0001056 |
T7 | 458-460 | Disease | denotes | GC | MONDO:0001056 |
T8 | 590-592 | Disease | denotes | GC | MONDO:0001056 |
T9 | 1107-1121 | Disease | denotes | Gastric Cancer | MONDO:0001056|MONDO:0004950 |
T11 | 1280-1282 | Disease | denotes | GC | MONDO:0001056 |
T12 | 1469-1471 | Disease | denotes | GC | MONDO:0001056 |
T13 | 1766-1768 | Disease | denotes | GC | MONDO:0001056 |
GlyCosmos15-FMA
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 476-483 | Body_part | denotes | tissues | FMA:9637 |
T2 | 644-650 | Body_part | denotes | Genome | FMA:84116 |
T3 | 1283-1290 | Body_part | denotes | tissues | FMA:9637 |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1023-1039 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 638-643 | OrganismTaxon | denotes | Human | 9606 |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 1023-1039 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |