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PubMed:28098423 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 128-225 DRI_Background denotes The clinical application of doxorubicin (Dox) is limited by its adverse effect of cardiotoxicity.
T2 226-330 DRI_Background denotes Previous studies have suggested the cardioprotective effect of brain-derived neurotrophic factor (BDNF).
T3 331-405 DRI_Approach denotes We hypothesize that BDNF could protect against Dox-induced cardiotoxicity.
T4 406-479 DRI_Background denotes Sprague Dawley rats were injected with Dox (2.5 mg/kg, 3 times/week, i.p.
T5 479-546 DRI_Background denotes ), in the presence or absence of recombinant BDNF (0.4 μg/kg, i.v.)
T6 560-635 DRI_Background denotes H9c2 cells were treated with Dox (1 μM) and/or BDNF (400 ng/ml) for 24 hrs.
T7 636-736 DRI_Background denotes Functional roles of BDNF against Dox-induced cardiac injury were examined both in vivo and in vitro.
T8 737-921 DRI_Background denotes Protein level of BDNF was reduced in Dox-treated rat ventricles, whereas BDNF and its receptor tropomyosin-related kinase B (TrkB) were markedly up-regulated after BDNF administration.
T9 922-979 DRI_Background denotes Brain-derived neurotrophic factor significantly inhibited
T10 1006-1066 DRI_Background denotes apoptosis, oxidative stress and cardiac dysfunction in rats.
T11 1067-1146 DRI_Background denotes Meanwhile, BDNF increased cell viability, inhibited apoptosis and DNA damage of
T12 1164-1170 DRI_Background denotes cells.
T13 1171-1426 DRI_Background denotes Investigations of the underlying mechanisms revealed that BDNF activated Akt and preserved phosphorylation of mammalian target of rapamycin and Bad without affecting p38 mitogen-activated protein kinase and extracellular regulated protein kinase pathways.
T14 1427-1527 DRI_Background denotes Furthermore, the beneficial effect of BDNF was abolished by BDNF scavenger TrkB-Fc or Akt inhibitor.
T15 1528-1722 DRI_Outcome denotes In conclusion, our findings reveal a potent protective role of BDNF against Dox-induced cardiotoxicity by activating Akt signalling, which may facilitate the safe use of Dox in cancer treatment.

TEST-CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 560-564 CellLine denotes H9c2 CVCL_0286
T2 1159-1163 CellLine denotes H9c2 CVCL_0286

TEST-DiseaseOrPhenotypicFeature

Id Subject Object Predicate Lexical cue #label
T1 65-84 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T2 210-224 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T3 390-404 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T4 1038-1057 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T5 1616-1630 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T6 1705-1711 DiseaseOrPhenotypicFeature denotes cancer D009369

TEST-ChemicalEntity

Id Subject Object Predicate Lexical cue ID:
T1 45-56 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T4 156-167 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T7 169-172 ChemicalEntity denotes Dox D004317
T8 378-381 ChemicalEntity denotes Dox D004317
T9 445-448 ChemicalEntity denotes Dox D004317
T10 589-592 ChemicalEntity denotes Dox D004317
T11 669-672 ChemicalEntity denotes Dox D004317
T12 774-777 ChemicalEntity denotes Dox D004317
T13 980-983 ChemicalEntity denotes Dox D004317
T14 1147-1150 ChemicalEntity denotes Dox D004317
T15 1301-1310 ChemicalEntity denotes rapamycin D020123|http://purl.obolibrary.org/obo/CHEBI_9168
T17 1604-1607 ChemicalEntity denotes Dox D004317
T18 1698-1701 ChemicalEntity denotes Dox D004317

TEST-OrganismTaxon

Id Subject Object Predicate Lexical cue
T1 122-126 OrganismTaxon denotes rats
T2 421-425 OrganismTaxon denotes rats
T3 786-789 OrganismTaxon denotes rat
T4 1061-1065 OrganismTaxon denotes rats
T5 1492-1501 OrganismTaxon denotes scavenger

Test-GeneOrGeneProduct

Id Subject Object Predicate Lexical cue
T1 0-33 GeneOrGeneProduct denotes Brain-derived neurotrophic factor
T2 104-107 GeneOrGeneProduct denotes Akt
T3 289-322 GeneOrGeneProduct denotes brain-derived neurotrophic factor
T4 324-328 GeneOrGeneProduct denotes BDNF
T5 351-355 GeneOrGeneProduct denotes BDNF
T6 524-528 GeneOrGeneProduct denotes BDNF
T7 607-611 GeneOrGeneProduct denotes BDNF
T8 656-660 GeneOrGeneProduct denotes BDNF
T9 754-758 GeneOrGeneProduct denotes BDNF
T10 810-814 GeneOrGeneProduct denotes BDNF
T11 832-860 GeneOrGeneProduct denotes tropomyosin-related kinase B
T12 862-866 GeneOrGeneProduct denotes TrkB
T13 901-905 GeneOrGeneProduct denotes BDNF
T14 922-955 GeneOrGeneProduct denotes Brain-derived neurotrophic factor
T15 1078-1082 GeneOrGeneProduct denotes BDNF
T16 1229-1233 GeneOrGeneProduct denotes BDNF
T17 1244-1247 GeneOrGeneProduct denotes Akt
T18 1281-1310 GeneOrGeneProduct denotes mammalian target of rapamycin
T19 1337-1373 GeneOrGeneProduct denotes p38 mitogen-activated protein kinase
T20 1402-1416 GeneOrGeneProduct denotes protein kinase
T21 1465-1469 GeneOrGeneProduct denotes BDNF
T22 1487-1491 GeneOrGeneProduct denotes BDNF
T23 1502-1506 GeneOrGeneProduct denotes TrkB
T24 1513-1516 GeneOrGeneProduct denotes Akt
T25 1591-1595 GeneOrGeneProduct denotes BDNF
T26 1645-1648 GeneOrGeneProduct denotes Akt

Test-merged-2

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T76897 560-564 CellLine denotes H9c2 CVCL_0286
T53828 1159-1163 CellLine denotes H9c2 CVCL_0286
T50828 45-56 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T82753 156-167 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T35177 169-172 ChemicalEntity denotes Dox D004317
T94477 378-381 ChemicalEntity denotes Dox D004317
T32643 445-448 ChemicalEntity denotes Dox D004317
T83544 589-592 ChemicalEntity denotes Dox D004317
T32743 669-672 ChemicalEntity denotes Dox D004317
T94993 774-777 ChemicalEntity denotes Dox D004317
T7562 980-983 ChemicalEntity denotes Dox D004317
T76263 1147-1150 ChemicalEntity denotes Dox D004317
T13159 1301-1310 ChemicalEntity denotes rapamycin D020123|http://purl.obolibrary.org/obo/CHEBI_9168
T53775 1604-1607 ChemicalEntity denotes Dox D004317
T14330 1698-1701 ChemicalEntity denotes Dox D004317
T96953 0-33 GeneOrGeneProduct denotes Brain-derived neurotrophic factor
T55833 104-107 GeneOrGeneProduct denotes Akt
T73727 289-322 GeneOrGeneProduct denotes brain-derived neurotrophic factor
T71999 324-328 GeneOrGeneProduct denotes BDNF
T82549 351-355 GeneOrGeneProduct denotes BDNF
T53089 524-528 GeneOrGeneProduct denotes BDNF
T7 607-611 GeneOrGeneProduct denotes BDNF
T8 656-660 GeneOrGeneProduct denotes BDNF
T9 754-758 GeneOrGeneProduct denotes BDNF
T10 810-814 GeneOrGeneProduct denotes BDNF
T11 832-860 GeneOrGeneProduct denotes tropomyosin-related kinase B
T12 862-866 GeneOrGeneProduct denotes TrkB
T13 901-905 GeneOrGeneProduct denotes BDNF
T14 922-955 GeneOrGeneProduct denotes Brain-derived neurotrophic factor
T15 1078-1082 GeneOrGeneProduct denotes BDNF
T16 1229-1233 GeneOrGeneProduct denotes BDNF
T17 1244-1247 GeneOrGeneProduct denotes Akt
T18 1281-1310 GeneOrGeneProduct denotes mammalian target of rapamycin
T19 1337-1373 GeneOrGeneProduct denotes p38 mitogen-activated protein kinase
T20 1402-1416 GeneOrGeneProduct denotes protein kinase
T21 1465-1469 GeneOrGeneProduct denotes BDNF
T22 1487-1491 GeneOrGeneProduct denotes BDNF
T23 1502-1506 GeneOrGeneProduct denotes TrkB
T24 1513-1516 GeneOrGeneProduct denotes Akt
T25 1591-1595 GeneOrGeneProduct denotes BDNF
T26 1645-1648 GeneOrGeneProduct denotes Akt
T34613 122-126 OrganismTaxon denotes rats
T14845 421-425 OrganismTaxon denotes rats
T92457 786-789 OrganismTaxon denotes rat
T25610 1061-1065 OrganismTaxon denotes rats
T4363 1492-1501 OrganismTaxon denotes scavenger
T1 65-84 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T2 210-224 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T3 390-404 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T4 1038-1057 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T5 1616-1630 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T6 1705-1711 DiseaseOrPhenotypicFeature denotes cancer D009369

Test-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T6 1705-1711 DiseaseOrPhenotypicFeature denotes cancer D009369
T5 1616-1630 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T4 1038-1057 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T3 390-404 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T2 210-224 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T1 65-84 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T4363 1492-1501 OrganismTaxon denotes scavenger
T25610 1061-1065 OrganismTaxon denotes rats
T92457 786-789 OrganismTaxon denotes rat
T14845 421-425 OrganismTaxon denotes rats
T34613 122-126 OrganismTaxon denotes rats
T26 1645-1648 GeneOrGeneProduct denotes Akt
T25 1591-1595 GeneOrGeneProduct denotes BDNF
T24 1513-1516 GeneOrGeneProduct denotes Akt
T23 1502-1506 GeneOrGeneProduct denotes TrkB
T22 1487-1491 GeneOrGeneProduct denotes BDNF
T21 1465-1469 GeneOrGeneProduct denotes BDNF
T20 1402-1416 GeneOrGeneProduct denotes protein kinase
T19 1337-1373 GeneOrGeneProduct denotes p38 mitogen-activated protein kinase
T18 1281-1310 GeneOrGeneProduct denotes mammalian target of rapamycin
T17 1244-1247 GeneOrGeneProduct denotes Akt
T16 1229-1233 GeneOrGeneProduct denotes BDNF
T15 1078-1082 GeneOrGeneProduct denotes BDNF
T14 922-955 GeneOrGeneProduct denotes Brain-derived neurotrophic factor
T13 901-905 GeneOrGeneProduct denotes BDNF
T12 862-866 GeneOrGeneProduct denotes TrkB
T11 832-860 GeneOrGeneProduct denotes tropomyosin-related kinase B
T10 810-814 GeneOrGeneProduct denotes BDNF
T9 754-758 GeneOrGeneProduct denotes BDNF
T8 656-660 GeneOrGeneProduct denotes BDNF
T7 607-611 GeneOrGeneProduct denotes BDNF
T53089 524-528 GeneOrGeneProduct denotes BDNF
T82549 351-355 GeneOrGeneProduct denotes BDNF
T71999 324-328 GeneOrGeneProduct denotes BDNF
T73727 289-322 GeneOrGeneProduct denotes brain-derived neurotrophic factor
T55833 104-107 GeneOrGeneProduct denotes Akt
T96953 0-33 GeneOrGeneProduct denotes Brain-derived neurotrophic factor
T14330 1698-1701 ChemicalEntity denotes Dox D004317
T53775 1604-1607 ChemicalEntity denotes Dox D004317
T76263 1147-1150 ChemicalEntity denotes Dox D004317
T7562 980-983 ChemicalEntity denotes Dox D004317
T94993 774-777 ChemicalEntity denotes Dox D004317
T32743 669-672 ChemicalEntity denotes Dox D004317
T83544 589-592 ChemicalEntity denotes Dox D004317
T32643 445-448 ChemicalEntity denotes Dox D004317
T94477 378-381 ChemicalEntity denotes Dox D004317
T35177 169-172 ChemicalEntity denotes Dox D004317
T82753 156-167 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T50828 45-56 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T53828 1159-1163 CellLine denotes H9c2 CVCL_0286
T76897 560-564 CellLine denotes H9c2 CVCL_0286