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PubMed:27999109 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.
T2 97-259 Sentence denotes The pathogenesis of human type 1 diabetes, characterized by immune-mediated damage of insulin-producing β-cells of pancreatic islets, may involve viral infection.
T3 260-473 Sentence denotes Essential components of the innate immune antiviral response, including type I interferon (IFN) and IFN receptor-mediated signaling pathways, are candidates for determining susceptibility to human type 1 diabetes.
T4 474-573 Sentence denotes Numerous aspects of human type 1 diabetes pathogenesis are recapitulated in the LEW.1WR1 rat model.
T5 574-715 Sentence denotes Diabetes can be induced in LEW.1WR1 weanling rats challenged with virus or with the viral mimetic polyinosinic:polycytidylic acid (poly I:C).
T6 716-906 Sentence denotes We hypothesized that disrupting the cognate type I IFN receptor (type I IFN α/β receptor [IFNAR]) to interrupt IFN signaling would prevent or delay the development of virus-induced diabetes.
T7 907-1128 Sentence denotes We generated IFNAR1 subunit-deficient LEW.1WR1 rats using CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) genome editing and confirmed functional disruption of the Ifnar1 gene.
T8 1129-1277 Sentence denotes IFNAR1 deficiency significantly delayed the onset and frequency of diabetes and greatly reduced the intensity of insulitis after poly I:C treatment.
T9 1278-1378 Sentence denotes The occurrence of Kilham rat virus-induced diabetes was also diminished in IFNAR1-deficient animals.
T10 1379-1589 Sentence denotes These findings firmly establish that alterations in innate immunity influence the course of autoimmune diabetes and support the use of targeted strategies to limit or prevent the development of type 1 diabetes.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 91-95 OrganismTaxon denotes Rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T4 117-122 OrganismTaxon denotes human NCBItxid:9606
T5 451-456 OrganismTaxon denotes human NCBItxid:9606
T6 494-499 OrganismTaxon denotes human NCBItxid:9606
T7 563-566 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T9 619-623 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T12 954-958 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T15 1296-1312 OrganismTaxon denotes Kilham rat virus NCBItxid:12441

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
12001 24-50 GeneOrGeneProduct denotes Type I Interferon Receptor NCBIGene:288264|NCBIGene:686326
12002 68-87 DiseaseOrPhenotypicFeature denotes Autoimmune Diabetes MESH:D003922
12003 91-95 OrganismTaxon denotes Rats NCBITaxon:10116
12004 117-122 OrganismTaxon denotes human NCBITaxon:9606
12005 123-138 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922
12006 183-190 GeneOrGeneProduct denotes insulin NCBIGene:3630
12007 243-258 DiseaseOrPhenotypicFeature denotes viral infection MESH:D014777
12008 332-349 GeneOrGeneProduct denotes type I interferon NCBIGene:3456
12009 351-354 GeneOrGeneProduct denotes IFN NCBIGene:3439
12010 360-372 GeneOrGeneProduct denotes IFN receptor NCBIGene:3454
12011 451-456 OrganismTaxon denotes human NCBITaxon:9606
12012 457-472 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922
12013 494-499 OrganismTaxon denotes human NCBITaxon:9606
12014 500-515 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922
12015 563-566 OrganismTaxon denotes rat NCBITaxon:10116
12016 574-582 DiseaseOrPhenotypicFeature denotes Diabetes MESH:D003920
12017 619-623 OrganismTaxon denotes rats NCBITaxon:10116
12018 672-703 ChemicalEntity denotes polyinosinic:polycytidylic acid MESH:D011070
12019 705-713 ChemicalEntity denotes poly I:C MESH:D011070
12020 760-779 GeneOrGeneProduct denotes type I IFN receptor NCBIGene:288264|NCBIGene:686326
12021 781-804 GeneOrGeneProduct denotes type I IFN α/β receptor NCBIGene:288264|NCBIGene:686326
12022 806-811 GeneOrGeneProduct denotes IFNAR NCBIGene:288264|NCBIGene:686326
12023 827-830 GeneOrGeneProduct denotes IFN NCBIGene:25712
12024 897-905 DiseaseOrPhenotypicFeature denotes diabetes MESH:D003920
12025 920-926 GeneOrGeneProduct denotes IFNAR1 NCBIGene:288264
12026 954-958 OrganismTaxon denotes rats NCBITaxon:10116
12027 1116-1122 GeneOrGeneProduct denotes Ifnar1 NCBIGene:288264
12028 1129-1135 GeneOrGeneProduct denotes IFNAR1 NCBIGene:288264
12029 1196-1204 DiseaseOrPhenotypicFeature denotes diabetes MESH:D003920
12030 1242-1251 DiseaseOrPhenotypicFeature denotes insulitis MESH:D007410
12031 1258-1266 ChemicalEntity denotes poly I:C MESH:D011070
12032 1296-1312 OrganismTaxon denotes Kilham rat virus NCBITaxon:12441
12033 1321-1329 DiseaseOrPhenotypicFeature denotes diabetes MESH:D003920
12034 1353-1359 GeneOrGeneProduct denotes IFNAR1 NCBIGene:288264
12035 1471-1490 DiseaseOrPhenotypicFeature denotes autoimmune diabetes MESH:D003922
12036 1573-1588 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 212-222 DiseaseOrPhenotypicFeature denotes pancreatic 0004982

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 24-30 GeneOrGeneProduct denotes Type I
T2 31-41 GeneOrGeneProduct denotes Interferon
T3 42-50 GeneOrGeneProduct denotes Receptor
T4 60-67 GeneOrGeneProduct denotes Induced
T5 79-87 GeneOrGeneProduct denotes Diabetes
T6 130-138 GeneOrGeneProduct denotes diabetes
T7 154-163 GeneOrGeneProduct denotes by immune
T8 164-172 GeneOrGeneProduct denotes mediated
T9 173-179 GeneOrGeneProduct denotes damage
T10 183-190 GeneOrGeneProduct denotes insulin
T11 203-208 GeneOrGeneProduct denotes cells
T12 223-229 GeneOrGeneProduct denotes islets
T13 295-301 GeneOrGeneProduct denotes immune
T14 332-349 GeneOrGeneProduct denotes type I interferon
T15 351-354 GeneOrGeneProduct denotes IFN
T16 360-363 GeneOrGeneProduct denotes IFN
T17 364-372 GeneOrGeneProduct denotes receptor
T18 373-381 GeneOrGeneProduct denotes mediated
T19 421-432 GeneOrGeneProduct denotes determining
T20 464-472 GeneOrGeneProduct denotes diabetes
T21 507-515 GeneOrGeneProduct denotes diabetes
T22 574-582 GeneOrGeneProduct denotes Diabetes
T23 587-597 GeneOrGeneProduct denotes be induced
T24 699-703 GeneOrGeneProduct denotes acid
T25 705-709 GeneOrGeneProduct denotes poly
T26 737-747 GeneOrGeneProduct denotes disrupting
T27 760-766 GeneOrGeneProduct denotes type I
T28 767-770 GeneOrGeneProduct denotes IFN
T29 771-779 GeneOrGeneProduct denotes receptor
T30 781-787 GeneOrGeneProduct denotes type I
T31 788-791 GeneOrGeneProduct denotes IFN
T32 796-804 GeneOrGeneProduct denotes receptor
T33 806-811 GeneOrGeneProduct denotes IFNAR
T34 827-830 GeneOrGeneProduct denotes IFN
T35 889-896 GeneOrGeneProduct denotes induced
T36 897-905 GeneOrGeneProduct denotes diabetes
T37 920-926 GeneOrGeneProduct denotes IFNAR1
T38 972-976 GeneOrGeneProduct denotes Cas9
T39 988-997 GeneOrGeneProduct denotes regularly
T40 1047-1054 GeneOrGeneProduct denotes protein
T41 1098-1108 GeneOrGeneProduct denotes disruption
T42 1116-1122 GeneOrGeneProduct denotes Ifnar1
T43 1129-1135 GeneOrGeneProduct denotes IFNAR1
T44 1183-1192 GeneOrGeneProduct denotes frequency
T45 1196-1204 GeneOrGeneProduct denotes diabetes
T46 1209-1216 GeneOrGeneProduct denotes greatly
T47 1217-1224 GeneOrGeneProduct denotes reduced
T48 1258-1262 GeneOrGeneProduct denotes poly
T49 1313-1320 GeneOrGeneProduct denotes induced
T50 1321-1329 GeneOrGeneProduct denotes diabetes
T51 1353-1359 GeneOrGeneProduct denotes IFNAR1
T52 1385-1393 GeneOrGeneProduct denotes findings
T53 1394-1400 GeneOrGeneProduct denotes firmly
T54 1438-1446 GeneOrGeneProduct denotes immunity
T55 1482-1490 GeneOrGeneProduct denotes diabetes
T56 1537-1542 GeneOrGeneProduct denotes limit
T57 1580-1588 GeneOrGeneProduct denotes diabetes

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 24-30 GeneOrGeneProduct denotes Type I
T2 31-41 GeneOrGeneProduct denotes Interferon
T3 42-50 GeneOrGeneProduct denotes Receptor
T4 79-87 GeneOrGeneProduct denotes Diabetes
T5 130-138 GeneOrGeneProduct denotes diabetes
T6 183-190 GeneOrGeneProduct denotes insulin
T7 332-349 GeneOrGeneProduct denotes type I interferon
T8 351-354 GeneOrGeneProduct denotes IFN
T9 360-363 GeneOrGeneProduct denotes IFN
T10 364-372 GeneOrGeneProduct denotes receptor
T11 464-472 GeneOrGeneProduct denotes diabetes
T12 507-515 GeneOrGeneProduct denotes diabetes
T13 574-582 GeneOrGeneProduct denotes Diabetes
T14 699-703 GeneOrGeneProduct denotes acid
T15 705-709 GeneOrGeneProduct denotes poly
T16 760-766 GeneOrGeneProduct denotes type I
T17 767-770 GeneOrGeneProduct denotes IFN
T18 771-779 GeneOrGeneProduct denotes receptor
T19 781-787 GeneOrGeneProduct denotes type I
T20 788-791 GeneOrGeneProduct denotes IFN
T21 796-804 GeneOrGeneProduct denotes receptor
T22 806-811 GeneOrGeneProduct denotes IFNAR
T23 827-830 GeneOrGeneProduct denotes IFN
T24 897-905 GeneOrGeneProduct denotes diabetes
T25 920-926 GeneOrGeneProduct denotes IFNAR1
T26 1047-1054 GeneOrGeneProduct denotes protein
T27 1116-1122 GeneOrGeneProduct denotes Ifnar1
T28 1129-1135 GeneOrGeneProduct denotes IFNAR1
T29 1183-1192 GeneOrGeneProduct denotes frequency
T30 1196-1204 GeneOrGeneProduct denotes diabetes
T31 1217-1224 GeneOrGeneProduct denotes reduced
T32 1258-1262 GeneOrGeneProduct denotes poly
T33 1321-1329 GeneOrGeneProduct denotes diabetes
T34 1353-1359 GeneOrGeneProduct denotes IFNAR1
T35 1438-1446 GeneOrGeneProduct denotes immunity
T36 1482-1490 GeneOrGeneProduct denotes diabetes
T37 1580-1588 GeneOrGeneProduct denotes diabetes

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 68-87 DiseaseOrPhenotypicFeature denotes Autoimmune Diabetes D003922
T2 123-138 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T3 212-222 DiseaseOrPhenotypicFeature denotes pancreatic D010195
T4 243-258 DiseaseOrPhenotypicFeature denotes viral infection D014777
T5 457-472 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T6 500-515 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T7 574-582 DiseaseOrPhenotypicFeature denotes Diabetes DISEASE
T8 897-905 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T9 1196-1204 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T10 1321-1329 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T11 1471-1490 DiseaseOrPhenotypicFeature denotes autoimmune diabetes D003922
T12 1573-1588 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 31-50 GeneOrGeneProduct denotes Interferon Receptor
T2 332-349 GeneOrGeneProduct denotes type I interferon
T3 705-709 GeneOrGeneProduct denotes poly
T4 765-770 GeneOrGeneProduct denotes I IFN
T5 786-791 GeneOrGeneProduct denotes I IFN
T6 806-811 GeneOrGeneProduct denotes IFNAR
T7 920-926 GeneOrGeneProduct denotes IFNAR1
T8 1116-1122 GeneOrGeneProduct denotes Ifnar1
T9 1129-1135 GeneOrGeneProduct denotes IFNAR1
T10 1258-1262 GeneOrGeneProduct denotes poly
T11 1353-1359 GeneOrGeneProduct denotes IFNAR1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 79-87 DiseaseOrPhenotypicFeature denotes Diabetes 0005015
T2 123-138 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147
T3 243-258 DiseaseOrPhenotypicFeature denotes viral infection 0005108
T4 457-472 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147
T5 500-515 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147
T6 574-582 DiseaseOrPhenotypicFeature denotes Diabetes 0005015
T7 583-586 DiseaseOrPhenotypicFeature denotes can 0012833
T8 897-905 DiseaseOrPhenotypicFeature denotes diabetes 0005015
T9 1196-1204 DiseaseOrPhenotypicFeature denotes diabetes 0005015
T10 1321-1329 DiseaseOrPhenotypicFeature denotes diabetes 0005015
T11 1482-1490 DiseaseOrPhenotypicFeature denotes diabetes 0005015
T12 1573-1588 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 68-87 DiseaseOrPhenotypicFeature denotes Autoimmune Diabetes D003922
T2 123-138 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T3 243-258 DiseaseOrPhenotypicFeature denotes viral infection D014777
T4 457-472 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T5 500-515 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T6 574-582 DiseaseOrPhenotypicFeature denotes Diabetes DISEASE
T7 897-905 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T8 1196-1204 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T9 1242-1251 DiseaseOrPhenotypicFeature denotes insulitis DISEASE
T10 1321-1329 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T11 1471-1490 DiseaseOrPhenotypicFeature denotes autoimmune diabetes D003922
T12 1573-1588 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 68-87 DiseaseOrPhenotypicFeature denotes Autoimmune Diabetes D003922
T2 123-138 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T3 243-258 DiseaseOrPhenotypicFeature denotes viral infection D014777
T4 457-472 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T5 500-515 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T6 574-582 DiseaseOrPhenotypicFeature denotes Diabetes DISEASE
T7 897-905 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T8 1196-1204 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T9 1242-1251 DiseaseOrPhenotypicFeature denotes insulitis DISEASE
T10 1321-1329 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T11 1471-1490 DiseaseOrPhenotypicFeature denotes autoimmune diabetes D003922
T12 1573-1588 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 672-703 ChemicalEntity denotes polyinosinic:polycytidylic acid http://purl.obolibrary.org/obo/CHEBI_84491
T2 705-713 ChemicalEntity denotes poly I:C http://purl.obolibrary.org/obo/CHEBI_84491
T3 1258-1266 ChemicalEntity denotes poly I:C http://purl.obolibrary.org/obo/CHEBI_84491

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 54-59 OrganismTaxon denotes Virus
T2 91-95 OrganismTaxon denotes Rats
T3 117-122 OrganismTaxon denotes human
T4 451-456 OrganismTaxon denotes human
T5 494-499 OrganismTaxon denotes human
T6 563-566 OrganismTaxon denotes rat
T7 619-623 OrganismTaxon denotes rats
T8 640-645 OrganismTaxon denotes virus
T9 883-888 OrganismTaxon denotes virus
T10 954-958 OrganismTaxon denotes rats
T11 1296-1312 OrganismTaxon denotes Kilham rat virus

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T3 1258-1266 ChemicalEntity denotes poly I:C http://purl.obolibrary.org/obo/CHEBI_84491
T2 705-713 ChemicalEntity denotes poly I:C http://purl.obolibrary.org/obo/CHEBI_84491
T1 672-703 ChemicalEntity denotes polyinosinic:polycytidylic acid http://purl.obolibrary.org/obo/CHEBI_84491
T11 1353-1359 GeneOrGeneProduct denotes IFNAR1
T10 1258-1262 GeneOrGeneProduct denotes poly
T9 1129-1135 GeneOrGeneProduct denotes IFNAR1
T8 1116-1122 GeneOrGeneProduct denotes Ifnar1
T7 920-926 GeneOrGeneProduct denotes IFNAR1
T6 806-811 GeneOrGeneProduct denotes IFNAR
T5 786-791 GeneOrGeneProduct denotes I IFN
T4 765-770 GeneOrGeneProduct denotes I IFN
T38556 705-709 GeneOrGeneProduct denotes poly
T9565 332-349 GeneOrGeneProduct denotes type I interferon
T66752 31-50 GeneOrGeneProduct denotes Interferon Receptor
T12 1573-1588 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T7162 1471-1490 DiseaseOrPhenotypicFeature denotes autoimmune diabetes D003922
T32444 1321-1329 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T55743 1242-1251 DiseaseOrPhenotypicFeature denotes insulitis DISEASE
T45780 1196-1204 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T24021 897-905 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T96152 574-582 DiseaseOrPhenotypicFeature denotes Diabetes DISEASE
T11099 500-515 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T54100 457-472 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T53188 243-258 DiseaseOrPhenotypicFeature denotes viral infection D014777
T20756 123-138 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T66731 68-87 DiseaseOrPhenotypicFeature denotes Autoimmune Diabetes D003922
T92537 1296-1312 OrganismTaxon denotes Kilham rat virus
T53181 954-958 OrganismTaxon denotes rats
T85094 883-888 OrganismTaxon denotes virus
T76213 640-645 OrganismTaxon denotes virus
T48394 619-623 OrganismTaxon denotes rats
T4742 563-566 OrganismTaxon denotes rat
T21506 494-499 OrganismTaxon denotes human
T62805 451-456 OrganismTaxon denotes human
T17065 117-122 OrganismTaxon denotes human
T85836 91-95 OrganismTaxon denotes Rats
T81678 54-59 OrganismTaxon denotes Virus