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PubMed:27993978 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes.
T2 98-236 Sentence denotes Meiotic resumption (G2/M transition) and progression through meiosis I (MI) are two key stages for producing fertilization-competent eggs.
T3 237-369 Sentence denotes Here, we report that CenpH, a component of the kinetochore inner plate, is responsible for G2/M transition in meiotic mouse oocytes.
T4 370-559 Sentence denotes Depletion of CenpH by morpholino injection decreased cyclin B1 levels, resulting in attenuation of maturation-promoting factor (MPF) activation, and severely compromised meiotic resumption.
T5 560-747 Sentence denotes CenpH protects cyclin B1 from destruction by competing with the action of APC/C(Cdh1) Impaired G2/M transition after CenpH depletion could be rescued by expression of exogenous cyclin B1.
T6 748-881 Sentence denotes Unexpectedly, blocking CenpH did not affect spindle organization and meiotic cell cycle progression after germinal vesicle breakdown.
T7 882-1010 Sentence denotes Our findings reveal a novel role of CenpH in regulating meiotic G2/M transition by acting via the APC/C(Cdh1)-cyclin B1 pathway.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 355-360 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11980 0-5 GeneOrGeneProduct denotes CenpH NCBIGene:26886
11981 58-67 GeneOrGeneProduct denotes APC/CCdh1 NCBIGene:56371
11982 68-77 GeneOrGeneProduct denotes cyclin B1 NCBIGene:268697
11983 258-263 GeneOrGeneProduct denotes CenpH NCBIGene:26886
11984 355-360 OrganismTaxon denotes mouse NCBITaxon:10090
11985 383-388 GeneOrGeneProduct denotes CenpH NCBIGene:26886
11986 392-402 ChemicalEntity denotes morpholino MESH:D060172
11987 423-432 GeneOrGeneProduct denotes cyclin B1 NCBIGene:268697
11988 469-496 GeneOrGeneProduct denotes maturation-promoting factor NCBIGene:268697
11989 498-501 GeneOrGeneProduct denotes MPF NCBIGene:268697
11990 560-565 GeneOrGeneProduct denotes CenpH NCBIGene:26886
11991 575-584 GeneOrGeneProduct denotes cyclin B1 NCBIGene:268697
11992 634-639 GeneOrGeneProduct denotes APC/C NCBIGene:56371
11993 640-644 GeneOrGeneProduct denotes Cdh1 NCBIGene:56371
11994 677-682 GeneOrGeneProduct denotes CenpH NCBIGene:26886
11995 737-746 GeneOrGeneProduct denotes cyclin B1 NCBIGene:268697
11996 771-776 GeneOrGeneProduct denotes CenpH NCBIGene:26886
11997 918-923 GeneOrGeneProduct denotes CenpH NCBIGene:26886
11998 980-985 GeneOrGeneProduct denotes APC/C NCBIGene:56371
11999 986-990 GeneOrGeneProduct denotes Cdh1 NCBIGene:56371
12000 992-1001 GeneOrGeneProduct denotes cyclin B1 NCBIGene:268697

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes CenpH
T2 6-15 GeneOrGeneProduct denotes regulates
T3 58-61 GeneOrGeneProduct denotes APC
T4 68-77 GeneOrGeneProduct denotes cyclin B1
T5 258-263 GeneOrGeneProduct denotes CenpH
T6 370-379 GeneOrGeneProduct denotes Depletion
T7 383-388 GeneOrGeneProduct denotes CenpH
T8 423-432 GeneOrGeneProduct denotes cyclin B1
T9 454-465 GeneOrGeneProduct denotes attenuation
T10 469-496 GeneOrGeneProduct denotes maturation-promoting factor
T11 498-501 GeneOrGeneProduct denotes MPF
T12 503-513 GeneOrGeneProduct denotes activation
T13 560-565 GeneOrGeneProduct denotes CenpH
T14 575-584 GeneOrGeneProduct denotes cyclin B1
T15 634-639 GeneOrGeneProduct denotes APC/C
T16 640-644 GeneOrGeneProduct denotes Cdh1
T17 677-682 GeneOrGeneProduct denotes CenpH
T18 683-692 GeneOrGeneProduct denotes depletion
T19 737-746 GeneOrGeneProduct denotes cyclin B1
T20 762-770 GeneOrGeneProduct denotes blocking
T21 771-776 GeneOrGeneProduct denotes CenpH
T22 825-847 GeneOrGeneProduct denotes cell cycle progression
T23 854-862 GeneOrGeneProduct denotes germinal
T24 886-894 GeneOrGeneProduct denotes findings
T25 904-909 GeneOrGeneProduct denotes novel
T26 918-923 GeneOrGeneProduct denotes CenpH
T27 927-937 GeneOrGeneProduct denotes regulating
T28 965-971 GeneOrGeneProduct denotes acting
T29 980-985 GeneOrGeneProduct denotes APC/C
T30 986-990 GeneOrGeneProduct denotes Cdh1
T31 992-1001 GeneOrGeneProduct denotes cyclin B1

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes CenpH
T2 68-77 GeneOrGeneProduct denotes cyclin B1
T3 258-263 GeneOrGeneProduct denotes CenpH
T4 383-388 GeneOrGeneProduct denotes CenpH
T5 423-432 GeneOrGeneProduct denotes cyclin B1
T6 469-496 GeneOrGeneProduct denotes maturation-promoting factor
T7 498-501 GeneOrGeneProduct denotes MPF
T8 560-565 GeneOrGeneProduct denotes CenpH
T9 575-584 GeneOrGeneProduct denotes cyclin B1
T10 640-644 GeneOrGeneProduct denotes Cdh1
T11 677-682 GeneOrGeneProduct denotes CenpH
T12 737-746 GeneOrGeneProduct denotes cyclin B1
T13 771-776 GeneOrGeneProduct denotes CenpH
T14 825-847 GeneOrGeneProduct denotes cell cycle progression
T15 904-909 GeneOrGeneProduct denotes novel
T16 918-923 GeneOrGeneProduct denotes CenpH
T17 986-990 GeneOrGeneProduct denotes Cdh1
T18 992-1001 GeneOrGeneProduct denotes cyclin B1

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes CenpH
T2 68-77 GeneOrGeneProduct denotes cyclin B1
T3 258-263 GeneOrGeneProduct denotes CenpH
T4 383-388 GeneOrGeneProduct denotes CenpH
T5 423-432 GeneOrGeneProduct denotes cyclin B1
T6 469-496 GeneOrGeneProduct denotes maturation-promoting factor
T7 498-501 GeneOrGeneProduct denotes MPF
T8 560-565 GeneOrGeneProduct denotes CenpH
T9 575-584 GeneOrGeneProduct denotes cyclin B1
T10 640-644 GeneOrGeneProduct denotes Cdh1
T11 677-682 GeneOrGeneProduct denotes CenpH
T12 737-746 GeneOrGeneProduct denotes cyclin B1
T13 771-776 GeneOrGeneProduct denotes CenpH
T14 825-847 GeneOrGeneProduct denotes cell cycle progression
T15 918-923 GeneOrGeneProduct denotes CenpH
T16 986-990 GeneOrGeneProduct denotes Cdh1
T17 992-1001 GeneOrGeneProduct denotes cyclin B1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 170-172 DiseaseOrPhenotypicFeature denotes MI 0005068

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 392-402 ChemicalEntity denotes morpholino ChemicalEntity

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 355-360 OrganismTaxon denotes mouse

LitCoin-training-merged

Id Subject Object Predicate Lexical cue ID:
T1 392-402 ChemicalEntity denotes morpholino ChemicalEntity
T17 992-1001 GeneOrGeneProduct denotes cyclin B1
T16 986-990 GeneOrGeneProduct denotes Cdh1
T15 918-923 GeneOrGeneProduct denotes CenpH
T14 825-847 GeneOrGeneProduct denotes cell cycle progression
T13 771-776 GeneOrGeneProduct denotes CenpH
T12 737-746 GeneOrGeneProduct denotes cyclin B1
T11 677-682 GeneOrGeneProduct denotes CenpH
T10 640-644 GeneOrGeneProduct denotes Cdh1
T9 575-584 GeneOrGeneProduct denotes cyclin B1
T8 560-565 GeneOrGeneProduct denotes CenpH
T7 498-501 GeneOrGeneProduct denotes MPF
T6 469-496 GeneOrGeneProduct denotes maturation-promoting factor
T5 423-432 GeneOrGeneProduct denotes cyclin B1
T4 383-388 GeneOrGeneProduct denotes CenpH
T3 258-263 GeneOrGeneProduct denotes CenpH
T2 68-77 GeneOrGeneProduct denotes cyclin B1
T36206 0-5 GeneOrGeneProduct denotes CenpH
T71858 355-360 OrganismTaxon denotes mouse