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PubMed:27959382 JSONTXT

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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 94-98 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T3 382-392 OrganismTaxon denotes adenovirus NCBItxid:10535
T4 516-520 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T6 554-559 OrganismTaxon denotes Mouse NCBItxid:10090|NCBItxid:10088
T8 692-702 OrganismTaxon denotes adenovirus NCBItxid:10535
T9 754-764 OrganismTaxon denotes adenovirus NCBItxid:10535
T10 906-911 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T12 1005-1009 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T14 1545-1549 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T16 1904-1908 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice.
T2 100-170 Sentence denotes Oxidative stress plays an essential role in inflammation and fibrosis.
T3 171-338 Sentence denotes Bach1 is an important transcriptional repressor that acts by modulating oxidative stress and represents a potential target in the treatment of pulmonary fibrosis (PF).
T4 339-553 Sentence denotes In this study, we knocked down Bach1 using adenovirus-mediated small interfering RNA (siRNA) to determine whether the use of Bach1 siRNA is an effective therapeutic strategy in mice with bleomycin (BLM)‑induced PF.
T5 554-805 Sentence denotes Mouse lung fibroblasts (MLFs) were incubated with transforming growth factor (TGF)-β1 (5 ng/ml) and subsequently infected with recombined adenovirus-like Bach1 siRNA1 and Bach1 siRNA2, while an empty adenovirus vector was used as the negative control.
T6 806-903 Sentence denotes The selected Bach1 siRNA with higher interference efficiency was used for the animal experiments.
T7 904-1028 Sentence denotes A mouse model of BLM-induced PF was established, and Bach1 siRNA (1x109 pfu) was administered to the mice via the tail vein.
T8 1029-1137 Sentence denotes The results revealed that the Bach1 mRNA and protein levels were significantly downregulated by Bach1 siRNA.
T9 1138-1413 Sentence denotes Furthermore, the MLFs infected with Bach1 siRNA exhibited increased mRNA and protein expression levels of heme oxygenase-1 and glutathione peroxidase 1, but decreased levels of TGF-β1 and interleukin-6 in the cell supernatants compared with the cells exposed to TGF-β1 alone.
T10 1414-1578 Sentence denotes Bach1 knockdown by siRNA also enhanced the expression of antioxidant factors, but suppressed that of fibrosis‑related cytokines in mice compared with the BLM group.
T11 1579-1795 Sentence denotes Finally, the inflammatory infiltration of alveolar and interstitial cells and the destruction of lung structure were significantly attenuated in the mide administered Bach1 siRNA compared with those in the BLM group.
T12 1796-1909 Sentence denotes On the whole, our findings demonstrate that Bach1 siRNA exerts protective effects against BLM-induced PF in mice.
T13 1910-2009 Sentence denotes Our data may provide the basis for the development of novel targeted therapeutic strategies for PF.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11887 0-5 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11888 23-32 ChemicalEntity denotes bleomycin MESH:D001761
11889 41-59 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis MESH:D011658
11890 94-98 OrganismTaxon denotes mice NCBITaxon:10090
11891 144-156 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249
11892 161-169 DiseaseOrPhenotypicFeature denotes fibrosis MESH:D005355
11893 171-176 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11894 314-332 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis MESH:D011658
11895 334-336 DiseaseOrPhenotypicFeature denotes PF MESH:D011658
11896 370-375 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11897 464-469 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11898 516-520 OrganismTaxon denotes mice NCBITaxon:10090
11899 526-535 ChemicalEntity denotes bleomycin MESH:D001761
11900 537-540 ChemicalEntity denotes BLM MESH:D001761
11901 550-552 DiseaseOrPhenotypicFeature denotes PF MESH:D011658
11902 554-559 OrganismTaxon denotes Mouse NCBITaxon:10090
11903 604-639 GeneOrGeneProduct denotes transforming growth factor (TGF)-β1 NCBIGene:21803
11904 708-713 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11905 725-730 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11906 819-824 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11907 906-911 OrganismTaxon denotes mouse NCBITaxon:10090
11908 921-924 ChemicalEntity denotes BLM MESH:D001761
11909 933-935 DiseaseOrPhenotypicFeature denotes PF MESH:D011658
11910 957-962 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11911 1005-1009 OrganismTaxon denotes mice NCBITaxon:10090
11912 1059-1064 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11913 1125-1130 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11914 1174-1179 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11915 1244-1260 GeneOrGeneProduct denotes heme oxygenase-1 NCBIGene:15368
11916 1265-1289 GeneOrGeneProduct denotes glutathione peroxidase 1 NCBIGene:14775
11917 1315-1321 GeneOrGeneProduct denotes TGF-β1 NCBIGene:21803
11918 1326-1339 GeneOrGeneProduct denotes interleukin-6 NCBIGene:16193
11919 1400-1406 GeneOrGeneProduct denotes TGF-β1 NCBIGene:21803
11920 1414-1419 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11921 1471-1490 GeneOrGeneProduct denotes antioxidant factors NCBIGene:14775|NCBIGene:15368
11922 1515-1523 DiseaseOrPhenotypicFeature denotes fibrosis MESH:D005355
11923 1545-1549 OrganismTaxon denotes mice NCBITaxon:10090
11924 1568-1571 ChemicalEntity denotes BLM MESH:D001761
11925 1592-1604 DiseaseOrPhenotypicFeature denotes inflammatory MESH:D007249
11926 1746-1751 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11927 1785-1788 ChemicalEntity denotes BLM MESH:D001761
11928 1840-1845 GeneOrGeneProduct denotes Bach1 NCBIGene:12013
11929 1886-1889 ChemicalEntity denotes BLM MESH:D001761
11930 1898-1900 DiseaseOrPhenotypicFeature denotes PF MESH:D011658
11931 1904-1908 OrganismTaxon denotes mice NCBITaxon:10090
11932 2006-2008 DiseaseOrPhenotypicFeature denotes PF MESH:D011658

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 41-59 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis 0002771
T2 314-332 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis 0002771

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes Bach1
T2 12-22 GeneOrGeneProduct denotes attenuates
T3 33-40 GeneOrGeneProduct denotes induced
T4 94-98 GeneOrGeneProduct denotes mice
T5 171-176 GeneOrGeneProduct denotes Bach1
T6 193-218 GeneOrGeneProduct denotes transcriptional repressor
T7 224-228 GeneOrGeneProduct denotes acts
T8 334-336 GeneOrGeneProduct denotes PF
T9 357-369 GeneOrGeneProduct denotes knocked down
T10 370-375 GeneOrGeneProduct denotes Bach1
T11 393-401 GeneOrGeneProduct denotes mediated
T12 402-407 GeneOrGeneProduct denotes small
T13 435-444 GeneOrGeneProduct denotes determine
T14 464-469 GeneOrGeneProduct denotes Bach1
T15 516-520 GeneOrGeneProduct denotes mice
T16 542-549 GeneOrGeneProduct denotes induced
T17 550-552 GeneOrGeneProduct denotes PF
T18 560-564 GeneOrGeneProduct denotes lung
T19 617-630 GeneOrGeneProduct denotes growth factor
T20 646-648 GeneOrGeneProduct denotes ml
T21 681-691 GeneOrGeneProduct denotes recombined
T22 703-707 GeneOrGeneProduct denotes like
T23 708-713 GeneOrGeneProduct denotes Bach1
T24 725-730 GeneOrGeneProduct denotes Bach1
T25 819-824 GeneOrGeneProduct denotes Bach1
T26 925-932 GeneOrGeneProduct denotes induced
T27 933-935 GeneOrGeneProduct denotes PF
T28 957-962 GeneOrGeneProduct denotes Bach1
T29 1005-1009 GeneOrGeneProduct denotes mice
T30 1018-1022 GeneOrGeneProduct denotes tail
T31 1023-1027 GeneOrGeneProduct denotes vein
T32 1059-1064 GeneOrGeneProduct denotes Bach1
T33 1065-1069 GeneOrGeneProduct denotes mRNA
T34 1074-1081 GeneOrGeneProduct denotes protein
T35 1125-1130 GeneOrGeneProduct denotes Bach1
T36 1174-1179 GeneOrGeneProduct denotes Bach1
T37 1206-1210 GeneOrGeneProduct denotes mRNA
T38 1215-1222 GeneOrGeneProduct denotes protein
T39 1244-1260 GeneOrGeneProduct denotes heme oxygenase-1
T40 1265-1287 GeneOrGeneProduct denotes glutathione peroxidase
T41 1326-1339 GeneOrGeneProduct denotes interleukin-6
T42 1347-1351 GeneOrGeneProduct denotes cell
T43 1383-1388 GeneOrGeneProduct denotes cells
T44 1414-1419 GeneOrGeneProduct denotes Bach1
T45 1420-1429 GeneOrGeneProduct denotes knockdown
T46 1483-1490 GeneOrGeneProduct denotes factors
T47 1545-1549 GeneOrGeneProduct denotes mice
T48 1647-1652 GeneOrGeneProduct denotes cells
T49 1676-1680 GeneOrGeneProduct denotes lung
T50 1710-1720 GeneOrGeneProduct denotes attenuated
T51 1746-1751 GeneOrGeneProduct denotes Bach1
T52 1814-1822 GeneOrGeneProduct denotes findings
T53 1840-1845 GeneOrGeneProduct denotes Bach1
T54 1890-1897 GeneOrGeneProduct denotes induced
T55 1898-1900 GeneOrGeneProduct denotes PF
T56 1904-1908 GeneOrGeneProduct denotes mice
T57 1935-1940 GeneOrGeneProduct denotes basis
T58 1964-1969 GeneOrGeneProduct denotes novel
T59 2006-2008 GeneOrGeneProduct denotes PF

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes Bach1
T2 171-176 GeneOrGeneProduct denotes Bach1
T3 193-218 GeneOrGeneProduct denotes transcriptional repressor
T4 370-375 GeneOrGeneProduct denotes Bach1
T5 402-407 GeneOrGeneProduct denotes small
T6 464-469 GeneOrGeneProduct denotes Bach1
T7 617-630 GeneOrGeneProduct denotes growth factor
T8 703-707 GeneOrGeneProduct denotes like
T9 708-713 GeneOrGeneProduct denotes Bach1
T10 725-730 GeneOrGeneProduct denotes Bach1
T11 819-824 GeneOrGeneProduct denotes Bach1
T12 957-962 GeneOrGeneProduct denotes Bach1
T13 1018-1022 GeneOrGeneProduct denotes tail
T14 1023-1027 GeneOrGeneProduct denotes vein
T15 1059-1064 GeneOrGeneProduct denotes Bach1
T16 1065-1069 GeneOrGeneProduct denotes mRNA
T17 1074-1081 GeneOrGeneProduct denotes protein
T18 1125-1130 GeneOrGeneProduct denotes Bach1
T19 1174-1179 GeneOrGeneProduct denotes Bach1
T20 1206-1210 GeneOrGeneProduct denotes mRNA
T21 1215-1222 GeneOrGeneProduct denotes protein
T22 1244-1260 GeneOrGeneProduct denotes heme oxygenase-1
T23 1265-1287 GeneOrGeneProduct denotes glutathione peroxidase
T24 1326-1339 GeneOrGeneProduct denotes interleukin-6
T25 1347-1351 GeneOrGeneProduct denotes cell
T26 1414-1419 GeneOrGeneProduct denotes Bach1
T27 1420-1429 GeneOrGeneProduct denotes knockdown
T28 1710-1720 GeneOrGeneProduct denotes attenuated
T29 1746-1751 GeneOrGeneProduct denotes Bach1
T30 1840-1845 GeneOrGeneProduct denotes Bach1
T31 1964-1969 GeneOrGeneProduct denotes novel

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 41-59 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T2 144-156 DiseaseOrPhenotypicFeature denotes inflammation D007249
T3 161-169 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T4 314-332 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T5 334-336 DiseaseOrPhenotypicFeature denotes PF D011658
T6 550-552 DiseaseOrPhenotypicFeature denotes PF D011658
T7 933-935 DiseaseOrPhenotypicFeature denotes PF D011658
T8 1515-1523 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T9 1592-1604 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T10 1898-1900 DiseaseOrPhenotypicFeature denotes PF D011658
T11 2006-2008 DiseaseOrPhenotypicFeature denotes PF D011658

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes Bach1
T2 171-176 GeneOrGeneProduct denotes Bach1
T3 193-218 GeneOrGeneProduct denotes transcriptional repressor
T4 370-375 GeneOrGeneProduct denotes Bach1
T5 464-469 GeneOrGeneProduct denotes Bach1
T6 617-630 GeneOrGeneProduct denotes growth factor
T7 632-635 GeneOrGeneProduct denotes TGF
T8 708-713 GeneOrGeneProduct denotes Bach1
T9 725-730 GeneOrGeneProduct denotes Bach1
T10 819-824 GeneOrGeneProduct denotes Bach1
T11 957-962 GeneOrGeneProduct denotes Bach1
T12 1059-1064 GeneOrGeneProduct denotes Bach1
T13 1125-1130 GeneOrGeneProduct denotes Bach1
T14 1174-1179 GeneOrGeneProduct denotes Bach1
T15 1215-1233 GeneOrGeneProduct denotes protein expression
T16 1244-1260 GeneOrGeneProduct denotes heme oxygenase-1
T17 1277-1287 GeneOrGeneProduct denotes peroxidase
T18 1315-1318 GeneOrGeneProduct denotes TGF
T19 1326-1339 GeneOrGeneProduct denotes interleukin-6
T20 1400-1403 GeneOrGeneProduct denotes TGF
T21 1414-1419 GeneOrGeneProduct denotes Bach1
T22 1746-1751 GeneOrGeneProduct denotes Bach1
T23 1840-1845 GeneOrGeneProduct denotes Bach1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 41-59 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis 0002771
T2 314-332 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis 0002771
T3 334-336 DiseaseOrPhenotypicFeature denotes PF 0019324|0002771
T5 537-540 DiseaseOrPhenotypicFeature denotes BLM 0008876
T6 550-552 DiseaseOrPhenotypicFeature denotes PF 0019324|0002771
T8 560-564 DiseaseOrPhenotypicFeature denotes lung 0021117
T9 921-924 DiseaseOrPhenotypicFeature denotes BLM 0008876
T10 933-935 DiseaseOrPhenotypicFeature denotes PF 0019324|0002771
T12 1568-1571 DiseaseOrPhenotypicFeature denotes BLM 0008876
T13 1676-1680 DiseaseOrPhenotypicFeature denotes lung 0021117
T14 1785-1788 DiseaseOrPhenotypicFeature denotes BLM 0008876
T15 1886-1889 DiseaseOrPhenotypicFeature denotes BLM 0008876
T16 1898-1900 DiseaseOrPhenotypicFeature denotes PF 0019324|0002771
T18 2006-2008 DiseaseOrPhenotypicFeature denotes PF 0019324|0002771

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 41-59 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T2 144-156 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T4 161-169 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T5 314-332 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T6 334-336 DiseaseOrPhenotypicFeature denotes PF D011658
T7 550-552 DiseaseOrPhenotypicFeature denotes PF D011658
T8 933-935 DiseaseOrPhenotypicFeature denotes PF D011658
T9 1515-1523 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T10 1592-1604 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T11 1898-1900 DiseaseOrPhenotypicFeature denotes PF D011658
T12 2006-2008 DiseaseOrPhenotypicFeature denotes PF D011658

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 41-59 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T2 144-156 DiseaseOrPhenotypicFeature denotes inflammation D007249
T3 161-169 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T4 314-332 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T5 334-336 DiseaseOrPhenotypicFeature denotes PF D011658
T6 550-552 DiseaseOrPhenotypicFeature denotes PF D011658
T7 933-935 DiseaseOrPhenotypicFeature denotes PF D011658
T8 1515-1523 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T9 1898-1900 DiseaseOrPhenotypicFeature denotes PF D011658
T10 2006-2008 DiseaseOrPhenotypicFeature denotes PF D011658

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 23-32 ChemicalEntity denotes bleomycin http://purl.obolibrary.org/obo/CHEBI_22907
T2 526-535 ChemicalEntity denotes bleomycin http://purl.obolibrary.org/obo/CHEBI_22907
T3 537-540 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T4 921-924 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T5 1244-1260 ChemicalEntity denotes heme oxygenase-1 D051547
T6 1265-1289 ChemicalEntity denotes glutathione peroxidase 1 C117216
T7 1471-1482 ChemicalEntity denotes antioxidant ChemicalEntity
T8 1568-1571 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T9 1785-1788 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T10 1886-1889 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 94-98 OrganismTaxon denotes mice
T2 382-392 OrganismTaxon denotes adenovirus
T3 516-520 OrganismTaxon denotes mice
T4 554-559 OrganismTaxon denotes Mouse
T5 692-702 OrganismTaxon denotes adenovirus
T6 754-764 OrganismTaxon denotes adenovirus
T7 906-911 OrganismTaxon denotes mouse
T8 1005-1009 OrganismTaxon denotes mice
T9 1545-1549 OrganismTaxon denotes mice
T10 1904-1908 OrganismTaxon denotes mice

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T10 1886-1889 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T9 1785-1788 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T8 1568-1571 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T7 1471-1482 ChemicalEntity denotes antioxidant ChemicalEntity
T6 1265-1289 ChemicalEntity denotes glutathione peroxidase 1 C117216
T5 1244-1260 ChemicalEntity denotes heme oxygenase-1 D051547
T4 921-924 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T3 537-540 ChemicalEntity denotes BLM http://purl.obolibrary.org/obo/CHEBI_22907
T2 526-535 ChemicalEntity denotes bleomycin http://purl.obolibrary.org/obo/CHEBI_22907
T1 23-32 ChemicalEntity denotes bleomycin http://purl.obolibrary.org/obo/CHEBI_22907
T23 1840-1845 GeneOrGeneProduct denotes Bach1
T22 1746-1751 GeneOrGeneProduct denotes Bach1
T21 1414-1419 GeneOrGeneProduct denotes Bach1
T20 1400-1403 GeneOrGeneProduct denotes TGF
T19 1326-1339 GeneOrGeneProduct denotes interleukin-6
T18 1315-1318 GeneOrGeneProduct denotes TGF
T17 1277-1287 GeneOrGeneProduct denotes peroxidase
T16 1244-1260 GeneOrGeneProduct denotes heme oxygenase-1
T15 1215-1233 GeneOrGeneProduct denotes protein expression
T14 1174-1179 GeneOrGeneProduct denotes Bach1
T13 1125-1130 GeneOrGeneProduct denotes Bach1
T12 1059-1064 GeneOrGeneProduct denotes Bach1
T11 957-962 GeneOrGeneProduct denotes Bach1
T89023 819-824 GeneOrGeneProduct denotes Bach1
T72149 725-730 GeneOrGeneProduct denotes Bach1
T78898 708-713 GeneOrGeneProduct denotes Bach1
T14974 632-635 GeneOrGeneProduct denotes TGF
T9270 617-630 GeneOrGeneProduct denotes growth factor
T29798 464-469 GeneOrGeneProduct denotes Bach1
T16161 370-375 GeneOrGeneProduct denotes Bach1
T98733 193-218 GeneOrGeneProduct denotes transcriptional repressor
T99365 171-176 GeneOrGeneProduct denotes Bach1
T87078 0-5 GeneOrGeneProduct denotes Bach1
T41643 2006-2008 DiseaseOrPhenotypicFeature denotes PF D011658
T14208 1898-1900 DiseaseOrPhenotypicFeature denotes PF D011658
T8526 1515-1523 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T36629 933-935 DiseaseOrPhenotypicFeature denotes PF D011658
T15095 550-552 DiseaseOrPhenotypicFeature denotes PF D011658
T3664 334-336 DiseaseOrPhenotypicFeature denotes PF D011658
T37729 314-332 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T72281 161-169 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T96728 144-156 DiseaseOrPhenotypicFeature denotes inflammation D007249
T18710 41-59 DiseaseOrPhenotypicFeature denotes pulmonary fibrosis D011658
T68956 1904-1908 OrganismTaxon denotes mice
T43400 1545-1549 OrganismTaxon denotes mice
T11316 1005-1009 OrganismTaxon denotes mice
T29746 906-911 OrganismTaxon denotes mouse
T66011 754-764 OrganismTaxon denotes adenovirus
T24357 692-702 OrganismTaxon denotes adenovirus
T30581 554-559 OrganismTaxon denotes Mouse
T7449 516-520 OrganismTaxon denotes mice
T63918 382-392 OrganismTaxon denotes adenovirus
T96832 94-98 OrganismTaxon denotes mice

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice.
T2 100-170 Sentence denotes Oxidative stress plays an essential role in inflammation and fibrosis.
T3 171-338 Sentence denotes Bach1 is an important transcriptional repressor that acts by modulating oxidative stress and represents a potential target in the treatment of pulmonary fibrosis (PF).
T4 339-553 Sentence denotes In this study, we knocked down Bach1 using adenovirus-mediated small interfering RNA (siRNA) to determine whether the use of Bach1 siRNA is an effective therapeutic strategy in mice with bleomycin (BLM)‑induced PF.
T5 554-805 Sentence denotes Mouse lung fibroblasts (MLFs) were incubated with transforming growth factor (TGF)-β1 (5 ng/ml) and subsequently infected with recombined adenovirus-like Bach1 siRNA1 and Bach1 siRNA2, while an empty adenovirus vector was used as the negative control.
T6 806-903 Sentence denotes The selected Bach1 siRNA with higher interference efficiency was used for the animal experiments.
T7 904-1028 Sentence denotes A mouse model of BLM-induced PF was established, and Bach1 siRNA (1x109 pfu) was administered to the mice via the tail vein.
T8 1029-1137 Sentence denotes The results revealed that the Bach1 mRNA and protein levels were significantly downregulated by Bach1 siRNA.
T9 1138-1413 Sentence denotes Furthermore, the MLFs infected with Bach1 siRNA exhibited increased mRNA and protein expression levels of heme oxygenase-1 and glutathione peroxidase 1, but decreased levels of TGF-β1 and interleukin-6 in the cell supernatants compared with the cells exposed to TGF-β1 alone.
T10 1414-1578 Sentence denotes Bach1 knockdown by siRNA also enhanced the expression of antioxidant factors, but suppressed that of fibrosis‑related cytokines in mice compared with the BLM group.
T11 1579-1795 Sentence denotes Finally, the inflammatory infiltration of alveolar and interstitial cells and the destruction of lung structure were significantly attenuated in the mide administered Bach1 siRNA compared with those in the BLM group.
T12 1796-1909 Sentence denotes On the whole, our findings demonstrate that Bach1 siRNA exerts protective effects against BLM-induced PF in mice.
T13 1910-2009 Sentence denotes Our data may provide the basis for the development of novel targeted therapeutic strategies for PF.
T1 0-99 Sentence denotes Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice.
T2 100-170 Sentence denotes Oxidative stress plays an essential role in inflammation and fibrosis.
T3 171-338 Sentence denotes Bach1 is an important transcriptional repressor that acts by modulating oxidative stress and represents a potential target in the treatment of pulmonary fibrosis (PF).
T4 339-553 Sentence denotes In this study, we knocked down Bach1 using adenovirus-mediated small interfering RNA (siRNA) to determine whether the use of Bach1 siRNA is an effective therapeutic strategy in mice with bleomycin (BLM)‑induced PF.
T5 554-805 Sentence denotes Mouse lung fibroblasts (MLFs) were incubated with transforming growth factor (TGF)-β1 (5 ng/ml) and subsequently infected with recombined adenovirus-like Bach1 siRNA1 and Bach1 siRNA2, while an empty adenovirus vector was used as the negative control.
T6 806-903 Sentence denotes The selected Bach1 siRNA with higher interference efficiency was used for the animal experiments.
T7 904-1028 Sentence denotes A mouse model of BLM-induced PF was established, and Bach1 siRNA (1x109 pfu) was administered to the mice via the tail vein.
T8 1029-1137 Sentence denotes The results revealed that the Bach1 mRNA and protein levels were significantly downregulated by Bach1 siRNA.
T9 1138-1413 Sentence denotes Furthermore, the MLFs infected with Bach1 siRNA exhibited increased mRNA and protein expression levels of heme oxygenase-1 and glutathione peroxidase 1, but decreased levels of TGF-β1 and interleukin-6 in the cell supernatants compared with the cells exposed to TGF-β1 alone.
T10 1414-1578 Sentence denotes Bach1 knockdown by siRNA also enhanced the expression of antioxidant factors, but suppressed that of fibrosis‑related cytokines in mice compared with the BLM group.
T11 1579-1795 Sentence denotes Finally, the inflammatory infiltration of alveolar and interstitial cells and the destruction of lung structure were significantly attenuated in the mide administered Bach1 siRNA compared with those in the BLM group.
T12 1796-1909 Sentence denotes On the whole, our findings demonstrate that Bach1 siRNA exerts protective effects against BLM-induced PF in mice.
T13 1910-2009 Sentence denotes Our data may provide the basis for the development of novel targeted therapeutic strategies for PF.