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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-77 Sentence denotes Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats.
T2 78-88 Sentence denotes OBJECTIVE:
T3 89-201 Sentence denotes Black tea and Nonileaf are among the dietary compounds that can benefit patients with bone resorption disorders.
T4 202-295 Sentence denotes Their bone regeneration effects and their mechanisms were studied in estrogen-deficient rats.
T5 296-304 Sentence denotes METHODS:
T6 305-633 Sentence denotes Noni leaves (three doses) and black tea water extracts were fed to ovariectomized rats for 4 mo, and their effects (analyzed via mechanical measurements, micro-computed tomography scan, and reverse transcriptase polymerase chain reaction mRNA) were compared with Remifemin (a commercial phytoestrogen product from black cohosh).
T7 634-642 Sentence denotes RESULTS:
T8 643-1067 Sentence denotes The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-α, nuclear factor [NF]-κB, and receptor activator of NF-κB ligand) mRNA expressions/levels in the rats.
T9 1068-1135 Sentence denotes The extracts also improved bone physical and mechanical properties.
T10 1136-1314 Sentence denotes The extracts demonstrated bone regeneration through improving bone size and structure, bone mechanical properties (strength and flexibility), and bone mineralization and density.
T11 1315-1327 Sentence denotes CONCLUSIONS:
T12 1328-1411 Sentence denotes The catechin-rich extract favored bone regeneration and suppressed bone resorption.
T13 1412-1655 Sentence denotes The mechanisms involved enhancing osteoblast generation and survival, inhibiting osteoclast growth and activities, suppressing inflammation, improving bone collagen synthesis and upregulating ESR1 expression to augment phytoestrogenic effects.
T14 1656-1842 Sentence denotes Estrogen deficiency bone loss and all extracts studied (best effect from Morinda leaf at 300 mg/kg body weight) mitigated the loss, indicating benefits for the aged and menopausal women.
T1 0-77 Sentence denotes Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats.
T2 78-88 Sentence denotes OBJECTIVE:
T3 89-201 Sentence denotes Black tea and Nonileaf are among the dietary compounds that can benefit patients with bone resorption disorders.
T4 202-295 Sentence denotes Their bone regeneration effects and their mechanisms were studied in estrogen-deficient rats.
T5 296-304 Sentence denotes METHODS:
T6 305-633 Sentence denotes Noni leaves (three doses) and black tea water extracts were fed to ovariectomized rats for 4 mo, and their effects (analyzed via mechanical measurements, micro-computed tomography scan, and reverse transcriptase polymerase chain reaction mRNA) were compared with Remifemin (a commercial phytoestrogen product from black cohosh).
T7 634-642 Sentence denotes RESULTS:
T8 643-1067 Sentence denotes The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-α, nuclear factor [NF]-κB, and receptor activator of NF-κB ligand) mRNA expressions/levels in the rats.
T9 1068-1135 Sentence denotes The extracts also improved bone physical and mechanical properties.
T10 1136-1314 Sentence denotes The extracts demonstrated bone regeneration through improving bone size and structure, bone mechanical properties (strength and flexibility), and bone mineralization and density.
T11 1315-1327 Sentence denotes CONCLUSIONS:
T12 1328-1411 Sentence denotes The catechin-rich extract favored bone regeneration and suppressed bone resorption.
T13 1412-1655 Sentence denotes The mechanisms involved enhancing osteoblast generation and survival, inhibiting osteoclast growth and activities, suppressing inflammation, improving bone collagen synthesis and upregulating ESR1 expression to augment phytoestrogenic effects.
T14 1656-1842 Sentence denotes Estrogen deficiency bone loss and all extracts studied (best effect from Morinda leaf at 300 mg/kg body weight) mitigated the loss, indicating benefits for the aged and menopausal women.