PubMed:2788166 / 2092-2446 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T10","span":{"begin":0,"end":354},"obj":"Sentence"},{"id":"T10","span":{"begin":0,"end":354},"obj":"Sentence"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T10","span":{"begin":0,"end":354},"obj":"Sentence"},{"id":"T10","span":{"begin":0,"end":354},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T7","span":{"begin":22,"end":27},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T8","span":{"begin":341,"end":346},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T5","span":{"begin":22,"end":27},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":341,"end":346},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T6","span":{"begin":22,"end":27},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":341,"end":346},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"HP-phenotype","denotations":[{"id":"T7","span":{"begin":22,"end":35},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"HP:0001392"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"mondo_disease","denotations":[{"id":"T11","span":{"begin":22,"end":35},"obj":"Disease"},{"id":"T12","span":{"begin":347,"end":353},"obj":"Disease"}],"attributes":[{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005154"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T10","span":{"begin":22,"end":27},"obj":"Body_part"},{"id":"T11","span":{"begin":190,"end":203},"obj":"Body_part"},{"id":"T12","span":{"begin":341,"end":346},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/GO_0005622"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}

{"project":"Anatomy-MAT","denotations":[{"id":"T7","span":{"begin":22,"end":27},"obj":"Body_part"},{"id":"T8","span":{"begin":341,"end":346},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"mat_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"A8","pred":"mat_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MAT_0000097"}],"text":"Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury."}