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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Molecular basis of the liver and lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.
T2 113-272 Sentence denotes Alpha 1-Antitrypsin (alpha 1AT) deficiency is characterized by reduced serum levels of alpha 1AT and a risk for the development of emphysema and liver disease.
T3 273-566 Sentence denotes However, whereas there is an increased risk for emphysema associated with at least 10 alpha 1AT deficiency and null alleles, the hepatic disease is observed only in a subset of these alleles, suggesting that it is not the reduced serum levels of alpha 1AT per se which cause the liver disease.
T4 567-774 Sentence denotes The present study characterizes the alpha 1AT deficiency allele Mmalton, an allele that like the common Z deficiency mutation (Glu342----Lys) is associated with both alpha 1AT deficiency and hepatic disease.
T5 775-1099 Sentence denotes Capitalizing on the identification of the homozygous inheritance of the rare Mmalton alpha 1AT deficiency allele, it was demonstrated that although caused by a very different mutation, the Mmalton allele shares with the Z allele the association of liver disease with the same type of abnormalities of alpha 1AT biosynthesis.
T6 1100-1271 Sentence denotes Cloning of the Mmalton gene and sequence analysis demonstrated that it differs from the normal alpha 1AT M2 allele by deletion of the entire codon (TTC) for residue Phe52.
T7 1272-1395 Sentence denotes Liver biopsy of the Mmalton homozygote revealed inflammation, mild fibrosis, and intrahepatocyte accumulation of alpha 1AT.
T8 1396-1712 Sentence denotes Evaluation of de novo alpha 1AT biosynthesis in alpha 1AT-synthesizing cells of this individual demonstrated normal levels of alpha 1AT mRNA transcripts but abnormal intracellular accumulation of newly synthesized alpha 1AT at the level of the rough endoplasmic reticulum with consequent reduced alpha 1AT secretion.
T9 1713-2091 Sentence denotes Finally, retroviral gene transfer of a normal alpha 1AT cDNA and an alpha 1AT cDNA with the Mmalton Phe52 deletion into murine cells demonstrated that the Mmalton cells reproduced the abnormal accumulation of newly synthesized alpha 1AT, thus directly demonstrating that the deletion mutation is responsible for the intracellular accumulation of the newly synthesized alpha 1AT.
T10 2092-2446 Sentence denotes Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury.
T1 0-112 Sentence denotes Molecular basis of the liver and lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.
T2 113-272 Sentence denotes Alpha 1-Antitrypsin (alpha 1AT) deficiency is characterized by reduced serum levels of alpha 1AT and a risk for the development of emphysema and liver disease.
T3 273-566 Sentence denotes However, whereas there is an increased risk for emphysema associated with at least 10 alpha 1AT deficiency and null alleles, the hepatic disease is observed only in a subset of these alleles, suggesting that it is not the reduced serum levels of alpha 1AT per se which cause the liver disease.
T4 567-774 Sentence denotes The present study characterizes the alpha 1AT deficiency allele Mmalton, an allele that like the common Z deficiency mutation (Glu342----Lys) is associated with both alpha 1AT deficiency and hepatic disease.
T5 775-1099 Sentence denotes Capitalizing on the identification of the homozygous inheritance of the rare Mmalton alpha 1AT deficiency allele, it was demonstrated that although caused by a very different mutation, the Mmalton allele shares with the Z allele the association of liver disease with the same type of abnormalities of alpha 1AT biosynthesis.
T6 1100-1271 Sentence denotes Cloning of the Mmalton gene and sequence analysis demonstrated that it differs from the normal alpha 1AT M2 allele by deletion of the entire codon (TTC) for residue Phe52.
T7 1272-1395 Sentence denotes Liver biopsy of the Mmalton homozygote revealed inflammation, mild fibrosis, and intrahepatocyte accumulation of alpha 1AT.
T8 1396-1712 Sentence denotes Evaluation of de novo alpha 1AT biosynthesis in alpha 1AT-synthesizing cells of this individual demonstrated normal levels of alpha 1AT mRNA transcripts but abnormal intracellular accumulation of newly synthesized alpha 1AT at the level of the rough endoplasmic reticulum with consequent reduced alpha 1AT secretion.
T9 1713-2091 Sentence denotes Finally, retroviral gene transfer of a normal alpha 1AT cDNA and an alpha 1AT cDNA with the Mmalton Phe52 deletion into murine cells demonstrated that the Mmalton cells reproduced the abnormal accumulation of newly synthesized alpha 1AT, thus directly demonstrating that the deletion mutation is responsible for the intracellular accumulation of the newly synthesized alpha 1AT.
T10 2092-2446 Sentence denotes Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-112 Sentence denotes Molecular basis of the liver and lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.
TextSentencer_T2 113-272 Sentence denotes Alpha 1-Antitrypsin (alpha 1AT) deficiency is characterized by reduced serum levels of alpha 1AT and a risk for the development of emphysema and liver disease.
TextSentencer_T3 273-566 Sentence denotes However, whereas there is an increased risk for emphysema associated with at least 10 alpha 1AT deficiency and null alleles, the hepatic disease is observed only in a subset of these alleles, suggesting that it is not the reduced serum levels of alpha 1AT per se which cause the liver disease.
TextSentencer_T4 567-774 Sentence denotes The present study characterizes the alpha 1AT deficiency allele Mmalton, an allele that like the common Z deficiency mutation (Glu342----Lys) is associated with both alpha 1AT deficiency and hepatic disease.
TextSentencer_T5 775-1099 Sentence denotes Capitalizing on the identification of the homozygous inheritance of the rare Mmalton alpha 1AT deficiency allele, it was demonstrated that although caused by a very different mutation, the Mmalton allele shares with the Z allele the association of liver disease with the same type of abnormalities of alpha 1AT biosynthesis.
TextSentencer_T6 1100-1271 Sentence denotes Cloning of the Mmalton gene and sequence analysis demonstrated that it differs from the normal alpha 1AT M2 allele by deletion of the entire codon (TTC) for residue Phe52.
TextSentencer_T7 1272-1395 Sentence denotes Liver biopsy of the Mmalton homozygote revealed inflammation, mild fibrosis, and intrahepatocyte accumulation of alpha 1AT.
TextSentencer_T8 1396-1712 Sentence denotes Evaluation of de novo alpha 1AT biosynthesis in alpha 1AT-synthesizing cells of this individual demonstrated normal levels of alpha 1AT mRNA transcripts but abnormal intracellular accumulation of newly synthesized alpha 1AT at the level of the rough endoplasmic reticulum with consequent reduced alpha 1AT secretion.
TextSentencer_T9 1713-2091 Sentence denotes Finally, retroviral gene transfer of a normal alpha 1AT cDNA and an alpha 1AT cDNA with the Mmalton Phe52 deletion into murine cells demonstrated that the Mmalton cells reproduced the abnormal accumulation of newly synthesized alpha 1AT, thus directly demonstrating that the deletion mutation is responsible for the intracellular accumulation of the newly synthesized alpha 1AT.
TextSentencer_T10 2092-2446 Sentence denotes Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury.
T1 0-112 Sentence denotes Molecular basis of the liver and lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.
T2 113-272 Sentence denotes Alpha 1-Antitrypsin (alpha 1AT) deficiency is characterized by reduced serum levels of alpha 1AT and a risk for the development of emphysema and liver disease.
T3 273-566 Sentence denotes However, whereas there is an increased risk for emphysema associated with at least 10 alpha 1AT deficiency and null alleles, the hepatic disease is observed only in a subset of these alleles, suggesting that it is not the reduced serum levels of alpha 1AT per se which cause the liver disease.
T4 567-774 Sentence denotes The present study characterizes the alpha 1AT deficiency allele Mmalton, an allele that like the common Z deficiency mutation (Glu342----Lys) is associated with both alpha 1AT deficiency and hepatic disease.
T5 775-1099 Sentence denotes Capitalizing on the identification of the homozygous inheritance of the rare Mmalton alpha 1AT deficiency allele, it was demonstrated that although caused by a very different mutation, the Mmalton allele shares with the Z allele the association of liver disease with the same type of abnormalities of alpha 1AT biosynthesis.
T6 1100-1271 Sentence denotes Cloning of the Mmalton gene and sequence analysis demonstrated that it differs from the normal alpha 1AT M2 allele by deletion of the entire codon (TTC) for residue Phe52.
T7 1272-1395 Sentence denotes Liver biopsy of the Mmalton homozygote revealed inflammation, mild fibrosis, and intrahepatocyte accumulation of alpha 1AT.
T8 1396-1712 Sentence denotes Evaluation of de novo alpha 1AT biosynthesis in alpha 1AT-synthesizing cells of this individual demonstrated normal levels of alpha 1AT mRNA transcripts but abnormal intracellular accumulation of newly synthesized alpha 1AT at the level of the rough endoplasmic reticulum with consequent reduced alpha 1AT secretion.
T9 1713-2091 Sentence denotes Finally, retroviral gene transfer of a normal alpha 1AT cDNA and an alpha 1AT cDNA with the Mmalton Phe52 deletion into murine cells demonstrated that the Mmalton cells reproduced the abnormal accumulation of newly synthesized alpha 1AT, thus directly demonstrating that the deletion mutation is responsible for the intracellular accumulation of the newly synthesized alpha 1AT.
T10 2092-2446 Sentence denotes Thus, not only is the liver disease associated with alpha 1AT deficiency restricted to a subset of alpha 1AT deficiency alleles, it appears to be restricted to those alleles associated with intracellular accumulation of newly synthesized alpha 1AT, suggesting that it is the abnormal intrahepatocyte alpha 1AT accumulation which incites the liver injury.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 23-28 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 33-37 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T3 258-263 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T4 552-557 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T5 1023-1028 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T6 1272-1277 http://purl.obolibrary.org/obo/MAT_0000097 denotes Liver
T7 2114-2119 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T8 2433-2438 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

DisGeNET

Id Subject Object Predicate Lexical cue
T0 113-132 gene:5265 denotes Alpha 1-Antitrypsin
T1 244-253 disease:C0034067 denotes emphysema
T2 113-132 gene:5265 denotes Alpha 1-Antitrypsin
T3 258-271 disease:C0023895 denotes liver disease
R1 T0 T1 associated_with Alpha 1-Antitrypsin,emphysema
R2 T2 T3 associated_with Alpha 1-Antitrypsin,liver disease

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 244-253 HP_0002097 denotes emphysema
T2 321-330 HP_0002097 denotes emphysema

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
2788166-1#0#19#gene5265 113-132 gene5265 denotes Alpha 1-Antitrypsin
2788166-1#131#140#diseaseC0034067 244-253 diseaseC0034067 denotes emphysema
2788166-1#145#158#diseaseC0023895 258-271 diseaseC0023895 denotes liver disease
0#19#gene5265131#140#diseaseC0034067 2788166-1#0#19#gene5265 2788166-1#131#140#diseaseC0034067 associated_with Alpha 1-Antitrypsin,emphysema
0#19#gene5265145#158#diseaseC0023895 2788166-1#0#19#gene5265 2788166-1#145#158#diseaseC0023895 associated_with Alpha 1-Antitrypsin,liver disease

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 23-28 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 258-263 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 552-557 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 1023-1028 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T5 2114-2119 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T6 2433-2438 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T7 33-37 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T8 184-189 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T9 503-508 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 244-253 HP:0002097 denotes emphysema
AB2 321-330 HP:0002097 denotes emphysema

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 66-96 ORDO:60 denotes alpha 1-antitrypsin deficiency

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 23-28 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 258-263 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 552-557 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 1023-1028 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T5 1272-1277 http://purl.obolibrary.org/obo/UBERON_0002107 denotes Liver
PD-UBERON-AE-B_T6 2114-2119 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T7 2433-2438 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T8 184-189 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T9 503-508 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T10 33-37 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 33-45 Phenotype denotes lung disease HP:0002088
T2 244-253 Phenotype denotes emphysema HP:0002097
T3 258-271 Phenotype denotes liver disease HP:0001392
T4 321-330 Phenotype denotes emphysema HP:0002097
T5 552-565 Phenotype denotes liver disease HP:0001392
T6 1023-1036 Phenotype denotes liver disease HP:0001392
T7 2114-2127 Phenotype denotes liver disease HP:0001392

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 33-45 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T2 66-96 Disease denotes alpha 1-antitrypsin deficiency http://purl.obolibrary.org/obo/MONDO_0013282
T3 244-253 Disease denotes emphysema http://purl.obolibrary.org/obo/MONDO_0004849
T4 258-271 Disease denotes liver disease http://purl.obolibrary.org/obo/MONDO_0005154
T5 321-330 Disease denotes emphysema http://purl.obolibrary.org/obo/MONDO_0004849
T6 402-417 Disease denotes hepatic disease http://purl.obolibrary.org/obo/MONDO_0005154
T7 552-565 Disease denotes liver disease http://purl.obolibrary.org/obo/MONDO_0005154
T8 758-773 Disease denotes hepatic disease http://purl.obolibrary.org/obo/MONDO_0005154
T9 1023-1036 Disease denotes liver disease http://purl.obolibrary.org/obo/MONDO_0005154
T10 1320-1332 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T11 2114-2127 Disease denotes liver disease http://purl.obolibrary.org/obo/MONDO_0005154
T12 2439-2445 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 23-28 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 33-37 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 258-263 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T4 552-557 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T5 1023-1028 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T6 1272-1277 Body_part denotes Liver http://purl.obolibrary.org/obo/UBERON_0002107
T7 1562-1575 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T8 1658-1667 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T9 2029-2042 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T10 2114-2119 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T11 2282-2295 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T12 2433-2438 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 23-28 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 33-37 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T3 258-263 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T4 552-557 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T5 1023-1028 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T6 1272-1277 Body_part denotes Liver http://purl.obolibrary.org/obo/MAT_0000097
T7 2114-2119 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T8 2433-2438 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097