PubMed:27879642 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T2","span":{"begin":106,"end":117},"obj":"Sentence"},{"id":"T3","span":{"begin":118,"end":276},"obj":"Sentence"},{"id":"T4","span":{"begin":277,"end":352},"obj":"Sentence"},{"id":"T5","span":{"begin":353,"end":568},"obj":"Sentence"},{"id":"T6","span":{"begin":569,"end":577},"obj":"Sentence"},{"id":"T7","span":{"begin":578,"end":814},"obj":"Sentence"},{"id":"T8","span":{"begin":815,"end":1115},"obj":"Sentence"},{"id":"T9","span":{"begin":1116,"end":1262},"obj":"Sentence"},{"id":"T10","span":{"begin":1263,"end":1363},"obj":"Sentence"},{"id":"T11","span":{"begin":1364,"end":1376},"obj":"Sentence"},{"id":"T12","span":{"begin":1377,"end":1535},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T2","span":{"begin":106,"end":117},"obj":"Sentence"},{"id":"T3","span":{"begin":118,"end":276},"obj":"Sentence"},{"id":"T4","span":{"begin":277,"end":352},"obj":"Sentence"},{"id":"T5","span":{"begin":353,"end":568},"obj":"Sentence"},{"id":"T6","span":{"begin":569,"end":577},"obj":"Sentence"},{"id":"T7","span":{"begin":578,"end":814},"obj":"Sentence"},{"id":"T8","span":{"begin":815,"end":1115},"obj":"Sentence"},{"id":"T9","span":{"begin":1116,"end":1262},"obj":"Sentence"},{"id":"T10","span":{"begin":1263,"end":1363},"obj":"Sentence"},{"id":"T11","span":{"begin":1364,"end":1376},"obj":"Sentence"},{"id":"T12","span":{"begin":1377,"end":1535},"obj":"Sentence"}],"text":"Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes.\nBACKGROUND: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists.\nMETHODS: Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks.\nRESULTS: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups.\nCONCLUSIONS: Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes."}

{"project":"Zierdiyeerkenaili_800","denotations":[{"id":"T2","span":{"begin":394,"end":402},"obj":"CI"},{"id":"T3","span":{"begin":776,"end":784},"obj":"CI"},{"id":"T4","span":{"begin":794,"end":802},"obj":"CI"},{"id":"T5","span":{"begin":1201,"end":1209},"obj":"CI"},{"id":"T6","span":{"begin":1336,"end":1344},"obj":"CI"},{"id":"T7","span":{"begin":1436,"end":1444},"obj":"CI"},{"id":"T8","span":{"begin":407,"end":424},"obj":"CI"},{"id":"T9","span":{"begin":13,"end":30},"obj":"CI"},{"id":"T10","span":{"begin":0,"end":8},"obj":"CI"},{"id":"T11","span":{"begin":277,"end":285},"obj":"CI"},{"id":"T12","span":{"begin":426,"end":429},"obj":"CI"},{"id":"T13","span":{"begin":789,"end":792},"obj":"CI"},{"id":"T14","span":{"begin":803,"end":806},"obj":"CI"},{"id":"T15","span":{"begin":1210,"end":1213},"obj":"CI"},{"id":"T16","span":{"begin":1345,"end":1348},"obj":"CI"},{"id":"T17","span":{"begin":1449,"end":1452},"obj":"CI"}],"text":"Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes.\nBACKGROUND: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists.\nMETHODS: Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks.\nRESULTS: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups.\nCONCLUSIONS: Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes."}

{"project":"yangbin123xm_800_3","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"CI"},{"id":"T2","span":{"begin":277,"end":285},"obj":"CI"},{"id":"T3","span":{"begin":13,"end":30},"obj":"CI"},{"id":"T4","span":{"begin":407,"end":424},"obj":"CI"},{"id":"T5","span":{"begin":426,"end":429},"obj":"CI"},{"id":"T6","span":{"begin":789,"end":792},"obj":"CI"},{"id":"T7","span":{"begin":803,"end":806},"obj":"CI"},{"id":"T8","span":{"begin":1210,"end":1213},"obj":"CI"},{"id":"T9","span":{"begin":1345,"end":1348},"obj":"CI"},{"id":"T10","span":{"begin":1449,"end":1452},"obj":"CI"},{"id":"T11","span":{"begin":1201,"end":1209},"obj":"CI"},{"id":"T12","span":{"begin":394,"end":402},"obj":"CI"},{"id":"T13","span":{"begin":776,"end":784},"obj":"CI"},{"id":"T14","span":{"begin":794,"end":802},"obj":"CI"},{"id":"T15","span":{"begin":1336,"end":1344},"obj":"CI"},{"id":"T16","span":{"begin":1436,"end":1444},"obj":"CI"}],"text":"Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes.\nBACKGROUND: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists.\nMETHODS: Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks.\nRESULTS: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups.\nCONCLUSIONS: Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes."}

{"project":"chenxin_473849_800_3","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"CI"},{"id":"T2","span":{"begin":277,"end":285},"obj":"CI"},{"id":"T3","span":{"begin":394,"end":402},"obj":"CI"},{"id":"T4","span":{"begin":776,"end":784},"obj":"CI"},{"id":"T5","span":{"begin":794,"end":802},"obj":"CI"},{"id":"T6","span":{"begin":1201,"end":1209},"obj":"CI"},{"id":"T7","span":{"begin":1336,"end":1344},"obj":"CI"},{"id":"T8","span":{"begin":1436,"end":1444},"obj":"CI"},{"id":"T9","span":{"begin":13,"end":30},"obj":"CI"},{"id":"T10","span":{"begin":407,"end":424},"obj":"CI"},{"id":"T11","span":{"begin":426,"end":429},"obj":"CI"},{"id":"T12","span":{"begin":789,"end":792},"obj":"CI"},{"id":"T13","span":{"begin":803,"end":806},"obj":"CI"},{"id":"T14","span":{"begin":1210,"end":1213},"obj":"CI"},{"id":"T15","span":{"begin":1345,"end":1348},"obj":"CI"},{"id":"T16","span":{"begin":1449,"end":1452},"obj":"CI"}],"text":"Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes.\nBACKGROUND: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists.\nMETHODS: Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks.\nRESULTS: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups.\nCONCLUSIONS: Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes."}