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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain.
T2 129-304 Sentence denotes In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also contribute to central nervous system (CNS) diseases.
T3 305-439 Sentence denotes Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component.
T4 440-578 Sentence denotes DE contains more than 40 toxic air pollutants and is a major constituent of ambient particulate matter (PM), particularly of ultrafine-PM.
T5 579-688 Sentence denotes Limited information suggests that exposure to DE may cause oxidative stress and neuroinflammation in the CNS.
T6 689-897 Sentence denotes We hypothesized that males may be more susceptible than females to DE neurotoxicity, because of a lower level of expression of paraoxonase 2 (PON2), an intracellular anti-oxidant and anti-inflammatory enzyme.
T7 898-1149 Sentence denotes Acute exposure of C57BL/6 mice to DE (250-300μg/m(3) for 6h) caused significant increases in lipid peroxidation and of pro-inflammatory cytokines (IL-1α, IL-1β, IL-3, IL-6, TNF-α) in various brain regions (particularly olfactory bulb and hippocampus).
T8 1150-1241 Sentence denotes In a number of cases the observed effects were more pronounced in male than in female mice.
T9 1242-1418 Sentence denotes DE exposure also caused microglia activation, as measured by increased Iba1 (ionized calcium-binding adapter molecule 1) expression, and of TSPO (translocator protein) binding.
T10 1419-1656 Sentence denotes Mice heterozygotes for the modifier subunit of glutamate cysteine ligase (the limiting enzyme in glutathione biosynthesis; Gclm(+/-) mice) appeared to be significantly more susceptible to DE-induced neuroinflammation than wild type mice.
T11 1657-1881 Sentence denotes These findings indicate that acute exposure to DE causes neuroinflammation and oxidative stress in brain, and suggest that sex and genetic background may play important roles in modulating susceptibility to DE neurotoxicity.
T1 0-128 Sentence denotes Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain.
T2 129-304 Sentence denotes In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also contribute to central nervous system (CNS) diseases.
T3 305-439 Sentence denotes Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component.
T4 440-578 Sentence denotes DE contains more than 40 toxic air pollutants and is a major constituent of ambient particulate matter (PM), particularly of ultrafine-PM.
T5 579-688 Sentence denotes Limited information suggests that exposure to DE may cause oxidative stress and neuroinflammation in the CNS.
T6 689-897 Sentence denotes We hypothesized that males may be more susceptible than females to DE neurotoxicity, because of a lower level of expression of paraoxonase 2 (PON2), an intracellular anti-oxidant and anti-inflammatory enzyme.
T7 898-1149 Sentence denotes Acute exposure of C57BL/6 mice to DE (250-300μg/m(3) for 6h) caused significant increases in lipid peroxidation and of pro-inflammatory cytokines (IL-1α, IL-1β, IL-3, IL-6, TNF-α) in various brain regions (particularly olfactory bulb and hippocampus).
T8 1150-1241 Sentence denotes In a number of cases the observed effects were more pronounced in male than in female mice.
T9 1242-1418 Sentence denotes DE exposure also caused microglia activation, as measured by increased Iba1 (ionized calcium-binding adapter molecule 1) expression, and of TSPO (translocator protein) binding.
T10 1419-1656 Sentence denotes Mice heterozygotes for the modifier subunit of glutamate cysteine ligase (the limiting enzyme in glutathione biosynthesis; Gclm(+/-) mice) appeared to be significantly more susceptible to DE-induced neuroinflammation than wild type mice.
T11 1657-1881 Sentence denotes These findings indicate that acute exposure to DE causes neuroinflammation and oxidative stress in brain, and suggest that sex and genetic background may play important roles in modulating susceptibility to DE neurotoxicity.

Wangshuguang

Id Subject Object Predicate Lexical cue
T1 335-337 B-Regulation denotes is
T2 613-621 B-Interaction denotes exposure
T3 648-654 B-Negative_Function denotes stress
T4 904-912 B-Variation denotes exposure
T5 991-996 B-Molecular_Activity denotes lipid
T6 997-1009 B-Molecular_Activity denotes peroxidation
T7 1245-1253 B-Variation denotes exposure
T8 1388-1400 B-Variation denotes translocator
T9 1401-1408 I-Variation denotes protein
T10 1497-1505 B-Variation denotes limiting
T11 1506-1512 I-Variation denotes enzyme
T12 1736-1745 B-Molecular_Activity denotes oxidative
T13 1746-1752 I-Molecular_Activity denotes stress
T14 1881-1881 B-Variation denotes

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Id Subject Object Predicate Lexical cue
T1 335-337 B-Regulation denotes is
T2 613-621 B-Interaction denotes exposure
T3 648-654 B-Negative_Function denotes stress
T4 904-912 B-Variation denotes exposure
T5 991-996 B-Molecular_Activity denotes lipid
T6 997-1009 B-Molecular_Activity denotes peroxidation
T7 1245-1253 B-Variation denotes exposure
T8 1388-1400 B-Variation denotes translocator
T9 1401-1408 I-Variation denotes protein
T10 1497-1505 B-Variation denotes limiting
T11 1506-1512 I-Variation denotes enzyme
T12 1736-1745 B-Molecular_Activity denotes oxidative
T13 1746-1752 I-Molecular_Activity denotes stress
T14 1881-1881 B-Variation denotes