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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 128-340 BACKGROUND AND PURPOSE denotes Animal studies suggest that cooling improves outcome after ischemic stroke. We assessed the feasibility and safety of surface cooling to different target temperatures in awake patients with acute ischemic stroke.
T2 350-833 METHODS denotes A multicenter, randomized, open, phase II, clinical trial, comparing standard treatment with surface cooling to 34.0°C, 34.5°C, or 35.0°C in awake patients with acute ischemic stroke and an National Institutes of Health Stroke Scale score of ≥6, initiated within 4.5 hours after symptom onset and maintained for 24 hours. The primary outcome was feasibility, defined as the proportion of patients who had successfully completed the assigned treatment. Safety was a secondary outcome.
T3 843-1345 RESULTS denotes Inclusion was terminated after 22 patients because of slow recruitment. Five patients were randomized to 34.0°C, 6 to 34.5°C, 5 to 35.0°C (cooling was initiated in 4), and 6 to standard care. No (0%), 1 (17%), and 3 (75%) patients, respectively, completed the assigned treatment (P=0.03). No (0%), 2 (33%), and 4 (100%) patients reached the target temperature (P=0.01). Pneumonia occurred in 8 cooled patients but not in controls (absolute risk increase, 53%; 95% confidence interval, 28-79%; P=0.002).
T4 1359-1532 CONCLUSIONS denotes In awake patients with acute ischemic stroke, surface cooling is feasible to 35.0°C, but not to 34.5°C and 34.0°C. Cooling is associated with an increased risk of pneumonia.
T5 1562-1623 CLINICAL TRIAL REGISTRATION denotes URL: http://www.trialregister.nl. Unique identifier: NTR2616.

yangbin123xm_800_3

Id Subject Object Predicate Lexical cue
T1 187-202 DP denotes ischemic stroke
T2 324-339 DP denotes ischemic stroke
T3 517-532 DP denotes ischemic stroke
T4 1388-1403 DP denotes ischemic stroke

chenxin_473849_800_3

Id Subject Object Predicate Lexical cue
T2 187-202 DP denotes ischemic stroke
T3 324-339 DP denotes ischemic stroke
T4 517-532 DP denotes ischemic stroke
T5 1388-1403 DP denotes ischemic stroke