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PubMed:27833150 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 120-194 DRI_Outcome denotes Emergency granulopoiesis occurs in response to severe microbial infection.
T2 195-439 DRI_Challenge denotes However, whether and how other blood components, particularly monocytes/macrophages and their progenitors, including hematopoietic stem/progenitor cells (HSPCs), participate in the process and the underlying molecular mechanisms remain unknown.
T3 440-606 DRI_Outcome denotes In this study, we challenged zebrafish larvae via direct injection of Escherichia coli into the bloodstream, which resulted in systemic inoculation with this microbe.
T4 607-719 DRI_Background denotes The reaction of hematopoietic cells, including HSPCs, in the caudal hematopoietic tissue was carefully analysed.
T5 720-794 DRI_Approach denotes Both macrophages and neutrophils clearly expanded following the challenge.
T6 795-915 DRI_Background denotes Thus, emergency myelopoiesis, including monopoiesis and granulopoiesis, occurred following systemic bacterial infection.
T7 916-1113 DRI_Challenge denotes The HSPC reaction was dependent on the bacterial burden, manifesting as a slight increase under low burden, but an obvious reduction following the administration of an excessive volume of bacteria.
T8 1114-1237 DRI_Outcome denotes Pu.1 was important for the effective elimination of the microbes to prevent excessive HSPC apoptosis in response to stress.
T9 1238-1312 DRI_Approach denotes Moreover, Pu.1 played different roles in steady and emergency monopoiesis.
T10 1313-1429 DRI_Background denotes Although Pu.1 was essential for normal macrophage development, it played suppressive roles in emergency monopoiesis.
T11 1430-1611 DRI_Outcome denotes Overall, our study established a systemic bacterial infection model that led to emergency myelopoiesis, thereby improving our understanding of the function of Pu.1 in this scenario.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 455-457 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T2 988-989 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 1028-1030 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T4 1028-1030 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T5 1081-1083 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T6 1081-1083 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T7 1114-1116 CVCL_0C75|Cancer_cell_line|Canis lupus familiaris denotes Pu
T8 1248-1250 CVCL_0C75|Cancer_cell_line|Canis lupus familiaris denotes Pu
T9 1322-1324 CVCL_0C75|Cancer_cell_line|Canis lupus familiaris denotes Pu
T10 1461-1462 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T11 1589-1591 CVCL_0C75|Cancer_cell_line|Canis lupus familiaris denotes Pu
T12 1592-1596 CVCL_W473|Cancer_cell_line|Homo sapiens denotes 1 in

GoldHamster

Id Subject Object Predicate Lexical cue
T2 24-40 D004926 denotes Escherichia coli
T3 24-40 562 denotes Escherichia coli
T4 74-83 7955 denotes zebrafish
T5 74-83 D015027 denotes zebrafish
T6 91-118 UBERON:0003061 denotes caudal hematopoietic tissue
T9 184-193 D007239 denotes infection
T10 184-193 D007239 denotes infection
T11 431-438 32644 denotes unknown
T12 469-478 7955 denotes zebrafish
T13 469-478 D015027 denotes zebrafish
T14 479-485 D007814 denotes larvae
T16 510-526 D004926 denotes Escherichia coli
T17 510-526 562 denotes Escherichia coli
T18 668-695 UBERON:0003061 denotes caudal hematopoietic tissue
T21 895-914 D001424 denotes bacterial infection
T22 895-914 D001424 denotes bacterial infection
T25 920-924 PR:O14818 denotes HSPC
T26 920-924 PR:P54658 denotes HSPC
T27 920-924 PR:000013366 denotes HSPC
T28 1039-1048 MOP:0000569 denotes reduction
T29 1114-1118 PR:Q8GTR4 denotes Pu.1
T30 1114-1118 UBERON:2000557 denotes Pu.1
T31 1200-1204 PR:O14818 denotes HSPC
T32 1200-1204 PR:P54658 denotes HSPC
T33 1200-1204 PR:000013366 denotes HSPC
T34 1205-1214 GO:0097194 denotes apoptosis
T35 1205-1214 GO:0006915 denotes apoptosis
T36 1218-1236 GO:0006950 denotes response to stress
T37 1248-1252 PR:Q8GTR4 denotes Pu.1
T38 1248-1252 UBERON:2000557 denotes Pu.1
T39 1322-1326 PR:Q8GTR4 denotes Pu.1
T40 1322-1326 UBERON:2000557 denotes Pu.1
T41 1352-1362 CL:0000235 denotes macrophage
T42 1472-1491 D001424 denotes bacterial infection
T43 1472-1491 D001424 denotes bacterial infection
T46 1589-1593 PR:Q8GTR4 denotes Pu.1
T47 1589-1593 UBERON:2000557 denotes Pu.1

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 184-193 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T2 895-914 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T3 1472-1491 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 226-231 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 326-330 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 24-40 OrganismTaxon denotes Escherichia coli 562
T2 74-83 OrganismTaxon denotes zebrafish 7955
T3 469-478 OrganismTaxon denotes zebrafish 7955
T4 510-526 OrganismTaxon denotes Escherichia coli 562
T5 1104-1112 OrganismTaxon denotes bacteria 2|629395

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 91-118 Body_part denotes caudal hematopoietic tissue http://purl.obolibrary.org/obo/UBERON_0003061
T2 226-231 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T3 257-266 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T5 267-278 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T6 331-347 Body_part denotes progenitor cells http://purl.obolibrary.org/obo/CL_0011026
T7 623-642 Body_part denotes hematopoietic cells http://purl.obolibrary.org/obo/CL_0000988
T8 668-695 Body_part denotes caudal hematopoietic tissue http://purl.obolibrary.org/obo/UBERON_0003061
T9 725-736 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T10 741-752 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T11 1352-1362 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 257-266 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 267-278 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 331-347 Cell denotes progenitor cells http://purl.obolibrary.org/obo/CL:0011026
T6 623-642 Cell denotes hematopoietic cells http://purl.obolibrary.org/obo/CL:0000988
T7 725-736 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T9 741-752 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T10 1352-1362 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394