PubMed:27825100 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/27825100","sourcedb":"PubMed","sourceid":"27825100","text":"High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy.\nPodocytes play a key role in diabetic nephropathy pathogenesis, but alteration of their metabolism remains unknown in human kidney. By using a conditionally differentiating human podocyte cell line, we addressed the functional and molecular changes in podocyte energetics during in vitro development or under high glucose conditions. In 5 mM glucose medium, we observed a stepwise activation of oxidative metabolism during cell differentiation that was characterized by peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α)-dependent stimulation of mitochondrial biogenesis and function, with concomitant reduction of the glycolytic enzyme content. Conversely, when podocytes were cultured in high glucose (20 mM), stepwise oxidative phosphorylation biogenesis was aborted, and a glycolytic switch occurred, with consecutive lactic acidosis. Expression of the master regulators of oxidative metabolism transcription factor A mitochondrial, PGC-1α, AMPK, and serine-threonine liver kinase B1 was altered by high glucose, as well as their downstream signaling networks. Focused transcriptomics revealed that myocyte-specific enhancer factor 2C (MEF2C) and myogenic factor 5 (MYF5) expression was inhibited by high glucose levels, and endoribonuclease-prepared small interfering RNA-mediated combined inhibition of those transcription factors phenocopied the glycolytic shift that was observed in high glucose conditions. Accordingly, a reduced expression of MEF2C, MYF5, and PGC-1α was found in kidney tissue sections that were obtained from patients with diabetic nephropathy. These findings obtained in human samples demonstrate that MEF2C-MYF5-dependent bioenergetic dedifferentiation occurs in podocytes that are confronted with a high-glucose milieu.-Imasawa, T., Obre, E., Bellance, N., Lavie, J., Imasawa, T., Rigothier, C., Delmas, Y., Combe, C., Lacombe, D., Benard, G., Claverol, S., Bonneu, M., Rossignol, R. High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy.","tracks":[{"project":"Test-GeneOrGeneProduct","denotations":[{"id":"T1","span":{"begin":84,"end":104},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":135,"end":155},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":576,"end":618},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":637,"end":642},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":670,"end":694},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":743,"end":760},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1023,"end":1045},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1061,"end":1066},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1069,"end":1073},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1096,"end":1111},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1227,"end":1262},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1264,"end":1269},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1275,"end":1292},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1294,"end":1298},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1333,"end":1347},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1353,"end":1369},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1577,"end":1582},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1584,"end":1588},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1594,"end":1599},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1675,"end":1695},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1755,"end":1760},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1761,"end":1765},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":2123,"end":2143},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T2","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T3","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T4","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T5","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T6","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T7","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T8","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T9","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T10","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T11","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T12","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T13","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T14","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T15","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T16","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T17","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T18","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T19","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T20","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T21","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T22","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T23","pred":"source","obj":"Test-GeneOrGeneProduct"}]},{"project":"TEST-ChemicalEntity","denotations":[{"id":"T1","span":{"begin":5,"end":12},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":420,"end":427},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":448,"end":455},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":637,"end":640},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":819,"end":826},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":1061,"end":1064},"obj":"ChemicalEntity"},{"id":"T15","span":{"begin":1079,"end":1085},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":1086,"end":1095},"obj":"ChemicalEntity"},{"id":"T17","span":{"begin":1132,"end":1139},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":1333,"end":1340},"obj":"ChemicalEntity"},{"id":"T23","span":{"begin":1353,"end":1369},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":1520,"end":1527},"obj":"ChemicalEntity"},{"id":"T27","span":{"begin":1594,"end":1597},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":1859,"end":1866},"obj":"ChemicalEntity"},{"id":"T31","span":{"begin":2044,"end":2051},"obj":"ChemicalEntity"}],"attributes":[{"id":"A14","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_26336"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D005947"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A26","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D005947"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A13","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A17","pred":"ID:","subj":"T17","obj":"D005947"},{"id":"A18","pred":"ID:","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A19","pred":"ID:","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A15","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_17822"},{"id":"A16","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_26986"},{"id":"A28","pred":"ID:","subj":"T28","obj":"D005947"},{"id":"A29","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A30","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D005947"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A9","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A20","pred":"ID:","subj":"T20","obj":"D005947"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_26336"},{"id":"A23","pred":"ID:","subj":"T23","obj":"D004722"},{"id":"A27","pred":"ID:","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_26336"},{"id":"A31","pred":"ID:","subj":"T31","obj":"D005947"},{"id":"A32","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A33","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D005947"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A6","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D005947"},{"subj":"T1","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T4","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T7","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T10","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T11","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T14","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T15","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T16","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T17","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T20","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T23","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T24","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T27","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T28","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T31","pred":"source","obj":"TEST-ChemicalEntity"}]},{"project":"TEST-DiseaseOrPhenotypicFeature","denotations":[{"id":"T1","span":{"begin":84,"end":104},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":135,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":946,"end":961},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1675,"end":1695},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":2123,"end":2143},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D003928"},{"id":"A5","pred":"#label","subj":"T5","obj":"D003928"},{"id":"A4","pred":"#label","subj":"T4","obj":"D003928"},{"id":"A3","pred":"#label","subj":"T3","obj":"D000140"},{"id":"A2","pred":"#label","subj":"T2","obj":"D003928"},{"subj":"T1","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T2","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T3","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T4","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T5","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"}]},{"project":"TEST-OrganismTaxon","denotations":[{"id":"T1","span":{"begin":24,"end":29},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":224,"end":229},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":279,"end":284},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":1661,"end":1669},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1724,"end":1729},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":2063,"end":2068},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T2","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T3","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T4","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T5","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T6","pred":"source","obj":"TEST-OrganismTaxon"}]},{"project":"Test-merged-2","denotations":[{"id":"T66694","span":{"begin":5,"end":12},"obj":"ChemicalEntity"},{"id":"T79736","span":{"begin":420,"end":427},"obj":"ChemicalEntity"},{"id":"T62669","span":{"begin":448,"end":455},"obj":"ChemicalEntity"},{"id":"T18123","span":{"begin":637,"end":640},"obj":"ChemicalEntity"},{"id":"T89027","span":{"begin":819,"end":826},"obj":"ChemicalEntity"},{"id":"T42280","span":{"begin":1061,"end":1064},"obj":"ChemicalEntity"},{"id":"T91397","span":{"begin":1079,"end":1085},"obj":"ChemicalEntity"},{"id":"T13709","span":{"begin":1086,"end":1095},"obj":"ChemicalEntity"},{"id":"T67620","span":{"begin":1132,"end":1139},"obj":"ChemicalEntity"},{"id":"T75901","span":{"begin":1333,"end":1340},"obj":"ChemicalEntity"},{"id":"T35660","span":{"begin":1353,"end":1369},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":1520,"end":1527},"obj":"ChemicalEntity"},{"id":"T27","span":{"begin":1594,"end":1597},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":1859,"end":1866},"obj":"ChemicalEntity"},{"id":"T31","span":{"begin":2044,"end":2051},"obj":"ChemicalEntity"},{"id":"T54833","span":{"begin":84,"end":104},"obj":"GeneOrGeneProduct"},{"id":"T42259","span":{"begin":135,"end":155},"obj":"GeneOrGeneProduct"},{"id":"T66846","span":{"begin":576,"end":618},"obj":"GeneOrGeneProduct"},{"id":"T81493","span":{"begin":637,"end":642},"obj":"GeneOrGeneProduct"},{"id":"T88848","span":{"begin":670,"end":694},"obj":"GeneOrGeneProduct"},{"id":"T41508","span":{"begin":743,"end":760},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1023,"end":1045},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1061,"end":1066},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1069,"end":1073},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1096,"end":1111},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1227,"end":1262},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1264,"end":1269},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1275,"end":1292},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1294,"end":1298},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1333,"end":1347},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1353,"end":1369},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1577,"end":1582},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1584,"end":1588},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1594,"end":1599},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1675,"end":1695},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1755,"end":1760},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1761,"end":1765},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":2123,"end":2143},"obj":"GeneOrGeneProduct"},{"id":"T15934","span":{"begin":24,"end":29},"obj":"OrganismTaxon"},{"id":"T83124","span":{"begin":224,"end":229},"obj":"OrganismTaxon"},{"id":"T12969","span":{"begin":279,"end":284},"obj":"OrganismTaxon"},{"id":"T35976","span":{"begin":1661,"end":1669},"obj":"OrganismTaxon"},{"id":"T83352","span":{"begin":1724,"end":1729},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":2063,"end":2068},"obj":"OrganismTaxon"},{"id":"T1","span":{"begin":84,"end":104},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":135,"end":155},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":946,"end":961},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1675,"end":1695},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":2123,"end":2143},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A2","pred":"#label","subj":"T2","obj":"D003928"},{"id":"A28","pred":"ID:","subj":"T28","obj":"D005947"},{"id":"A29","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A30","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A1","pred":"#label","subj":"T1","obj":"D003928"},{"id":"A10","pred":"ID:","subj":"T18123","obj":"http://purl.obolibrary.org/obo/CHEBI_26336"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D005947"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A26","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A14","pred":"ID:","subj":"T42280","obj":"http://purl.obolibrary.org/obo/CHEBI_26336"},{"id":"A31","pred":"ID:","subj":"T31","obj":"D005947"},{"id":"A32","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A33","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A11","pred":"ID:","subj":"T89027","obj":"D005947"},{"id":"A12","pred":"ID:","subj":"T89027","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A13","pred":"ID:","subj":"T89027","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A27","pred":"ID:","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_26336"},{"id":"A75387","pred":"ID:","subj":"T66694","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A63112","pred":"ID:","subj":"T66694","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A87934","pred":"ID:","subj":"T79736","obj":"D005947"},{"id":"A10199","pred":"ID:","subj":"T79736","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A6","pred":"ID:","subj":"T79736","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A7","pred":"ID:","subj":"T62669","obj":"D005947"},{"id":"A8","pred":"ID:","subj":"T62669","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A9","pred":"ID:","subj":"T62669","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A67807","pred":"ID:","subj":"T66694","obj":"D005947"},{"id":"A5","pred":"#label","subj":"T5","obj":"D003928"},{"id":"A20","pred":"ID:","subj":"T75901","obj":"D005947"},{"id":"A21","pred":"ID:","subj":"T75901","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A22","pred":"ID:","subj":"T75901","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A23","pred":"ID:","subj":"T35660","obj":"D004722"},{"id":"A16","pred":"ID:","subj":"T13709","obj":"http://purl.obolibrary.org/obo/CHEBI_26986"},{"id":"A3","pred":"#label","subj":"T3","obj":"D000140"},{"id":"A15","pred":"ID:","subj":"T91397","obj":"http://purl.obolibrary.org/obo/CHEBI_17822"},{"id":"A17","pred":"ID:","subj":"T67620","obj":"D005947"},{"id":"A18","pred":"ID:","subj":"T67620","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A19","pred":"ID:","subj":"T67620","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A4","pred":"#label","subj":"T4","obj":"D003928"},{"subj":"T66694","pred":"source","obj":"Test-merged-2"},{"subj":"T79736","pred":"source","obj":"Test-merged-2"},{"subj":"T62669","pred":"source","obj":"Test-merged-2"},{"subj":"T18123","pred":"source","obj":"Test-merged-2"},{"subj":"T89027","pred":"source","obj":"Test-merged-2"},{"subj":"T42280","pred":"source","obj":"Test-merged-2"},{"subj":"T91397","pred":"source","obj":"Test-merged-2"},{"subj":"T13709","pred":"source","obj":"Test-merged-2"},{"subj":"T67620","pred":"source","obj":"Test-merged-2"},{"subj":"T75901","pred":"source","obj":"Test-merged-2"},{"subj":"T35660","pred":"source","obj":"Test-merged-2"},{"subj":"T24","pred":"source","obj":"Test-merged-2"},{"subj":"T27","pred":"source","obj":"Test-merged-2"},{"subj":"T28","pred":"source","obj":"Test-merged-2"},{"subj":"T31","pred":"source","obj":"Test-merged-2"},{"subj":"T54833","pred":"source","obj":"Test-merged-2"},{"subj":"T42259","pred":"source","obj":"Test-merged-2"},{"subj":"T66846","pred":"source","obj":"Test-merged-2"},{"subj":"T81493","pred":"source","obj":"Test-merged-2"},{"subj":"T88848","pred":"source","obj":"Test-merged-2"},{"subj":"T41508","pred":"source","obj":"Test-merged-2"},{"subj":"T7","pred":"source","obj":"Test-merged-2"},{"subj":"T8","pred":"source","obj":"Test-merged-2"},{"subj":"T9","pred":"source","obj":"Test-merged-2"},{"subj":"T10","pred":"source","obj":"Test-merged-2"},{"subj":"T11","pred":"source","obj":"Test-merged-2"},{"subj":"T12","pred":"source","obj":"Test-merged-2"},{"subj":"T13","pred":"source","obj":"Test-merged-2"},{"subj":"T14","pred":"source","obj":"Test-merged-2"},{"subj":"T15","pred":"source","obj":"Test-merged-2"},{"subj":"T16","pred":"source","obj":"Test-merged-2"},{"subj":"T17","pred":"source","obj":"Test-merged-2"},{"subj":"T18","pred":"source","obj":"Test-merged-2"},{"subj":"T19","pred":"source","obj":"Test-merged-2"},{"subj":"T20","pred":"source","obj":"Test-merged-2"},{"subj":"T21","pred":"source","obj":"Test-merged-2"},{"subj":"T22","pred":"source","obj":"Test-merged-2"},{"subj":"T23","pred":"source","obj":"Test-merged-2"},{"subj":"T15934","pred":"source","obj":"Test-merged-2"},{"subj":"T83124","pred":"source","obj":"Test-merged-2"},{"subj":"T12969","pred":"source","obj":"Test-merged-2"},{"subj":"T35976","pred":"source","obj":"Test-merged-2"},{"subj":"T83352","pred":"source","obj":"Test-merged-2"},{"subj":"T6","pred":"source","obj":"Test-merged-2"},{"subj":"T1","pred":"source","obj":"Test-merged-2"},{"subj":"T2","pred":"source","obj":"Test-merged-2"},{"subj":"T3","pred":"source","obj":"Test-merged-2"},{"subj":"T4","pred":"source","obj":"Test-merged-2"},{"subj":"T5","pred":"source","obj":"Test-merged-2"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Test-GeneOrGeneProduct","color":"#c293ec","default":true},{"id":"TEST-ChemicalEntity","color":"#93eca8"},{"id":"TEST-DiseaseOrPhenotypicFeature","color":"#ec9397"},{"id":"TEST-OrganismTaxon","color":"#93b1ec"},{"id":"Test-merged-2","color":"#cbec93"}]}]}}