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PubMed:27816838 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1047-1054 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1047-1054 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 1047-1054 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1010-1015 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 1010-1015 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-110 Sentence denotes Utilization of bench-stable and readily available nickel(II) triflate for access to 1,2-cis-2-aminoglycosides.
TextSentencer_T2 111-396 Sentence denotes The utilization of substoichiometric amounts of commercially available nickel(II) triflate as an activator in the reagent-controlled glycosylation reaction for the stereoselective construction of biologically relevant targets containing 1,2-cis-2-amino glycosidic linkages is reported.
TextSentencer_T3 397-631 Sentence denotes This straightforward and accessible methodology is mild, operationally simple and safe through catalytic activation by readily available Ni(OTf)2 in comparison to systems employing our previously in-house prepared Ni(4-F-PhCN)4(OTf)2.
TextSentencer_T4 632-908 Sentence denotes We anticipate that the bench-stable and inexpensive Ni(OTf)2, coupled with little to no extra laboratory training to set up the glycosylation reaction and no requirement of specialized equipment, should make this methodology be readily adopted by non-carbohydrate specialists.
TextSentencer_T5 909-1258 Sentence denotes This report further highlights the efficacy of Ni(OTf)2 to prepare several bioactive motifs, such as blood type A-type V and VI antigens, heparin sulfate disaccharide repeating unit, aminooxy glycosides, and α-GalNAc-Serine conjugate, which cannot be achieved in high yield and α-selectivity utilizing in-house prepared Ni(4-F-PhCN)4(OTf)2 catalyst.
TextSentencer_T6 1259-1382 Sentence denotes The newly-developed protocol eliminates the need for the synthesis of Ni(4-F-PhCN)4(OTf)2 and is scalable and reproducible.
TextSentencer_T7 1383-1698 Sentence denotes Furthermore, computational simulations in combination with (1)H NMR studies analyzed the effects of various solvents on the intramolecular hydrogen bonding network of tumor-associated mucin Fmoc-protected GalNAc-threonine amino acid antigen derivative, verifying discrepancies found that were previously unreported.
T1 0-110 Sentence denotes Utilization of bench-stable and readily available nickel(II) triflate for access to 1,2-cis-2-aminoglycosides.
T2 111-396 Sentence denotes The utilization of substoichiometric amounts of commercially available nickel(II) triflate as an activator in the reagent-controlled glycosylation reaction for the stereoselective construction of biologically relevant targets containing 1,2-cis-2-amino glycosidic linkages is reported.
T3 397-631 Sentence denotes This straightforward and accessible methodology is mild, operationally simple and safe through catalytic activation by readily available Ni(OTf)2 in comparison to systems employing our previously in-house prepared Ni(4-F-PhCN)4(OTf)2.
T4 632-908 Sentence denotes We anticipate that the bench-stable and inexpensive Ni(OTf)2, coupled with little to no extra laboratory training to set up the glycosylation reaction and no requirement of specialized equipment, should make this methodology be readily adopted by non-carbohydrate specialists.
T5 909-1258 Sentence denotes This report further highlights the efficacy of Ni(OTf)2 to prepare several bioactive motifs, such as blood type A-type V and VI antigens, heparin sulfate disaccharide repeating unit, aminooxy glycosides, and α-GalNAc-Serine conjugate, which cannot be achieved in high yield and α-selectivity utilizing in-house prepared Ni(4-F-PhCN)4(OTf)2 catalyst.
T6 1259-1382 Sentence denotes The newly-developed protocol eliminates the need for the synthesis of Ni(4-F-PhCN)4(OTf)2 and is scalable and reproducible.
T7 1383-1698 Sentence denotes Furthermore, computational simulations in combination with (1)H NMR studies analyzed the effects of various solvents on the intramolecular hydrogen bonding network of tumor-associated mucin Fmoc-protected GalNAc-threonine amino acid antigen derivative, verifying discrepancies found that were previously unreported.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1119-1125 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 1588-1594 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1550-1555 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1010-1015 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1119-1125 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 1588-1594 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1550-1555 Phenotype denotes tumor HP:0002664

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1010-1015 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1550-1555 Disease denotes tumor MONDO:0005070

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Utilization of bench-stable and readily available nickel(II) triflate for access to 1,2-cis-2-aminoglycosides.
T2 111-396 Sentence denotes The utilization of substoichiometric amounts of commercially available nickel(II) triflate as an activator in the reagent-controlled glycosylation reaction for the stereoselective construction of biologically relevant targets containing 1,2-cis-2-amino glycosidic linkages is reported.
T3 397-631 Sentence denotes This straightforward and accessible methodology is mild, operationally simple and safe through catalytic activation by readily available Ni(OTf)2 in comparison to systems employing our previously in-house prepared Ni(4-F-PhCN)4(OTf)2.
T4 632-908 Sentence denotes We anticipate that the bench-stable and inexpensive Ni(OTf)2, coupled with little to no extra laboratory training to set up the glycosylation reaction and no requirement of specialized equipment, should make this methodology be readily adopted by non-carbohydrate specialists.
T5 909-1258 Sentence denotes This report further highlights the efficacy of Ni(OTf)2 to prepare several bioactive motifs, such as blood type A-type V and VI antigens, heparin sulfate disaccharide repeating unit, aminooxy glycosides, and α-GalNAc-Serine conjugate, which cannot be achieved in high yield and α-selectivity utilizing in-house prepared Ni(4-F-PhCN)4(OTf)2 catalyst.
T6 1259-1382 Sentence denotes The newly-developed protocol eliminates the need for the synthesis of Ni(4-F-PhCN)4(OTf)2 and is scalable and reproducible.
T7 1383-1698 Sentence denotes Furthermore, computational simulations in combination with (1)H NMR studies analyzed the effects of various solvents on the intramolecular hydrogen bonding network of tumor-associated mucin Fmoc-protected GalNAc-threonine amino acid antigen derivative, verifying discrepancies found that were previously unreported.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 1010-1015 Body_part denotes blood FMA:9670

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1010-1015 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1010-1015 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1550-1555 Phenotype denotes tumor HP:0002664