PubMed:27814527
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 151-354 | DRI_Background | denotes | Cyanobacterial blooms threaten human health as well as the population of other living organisms in the aquatic environment, particularly due to the production of natural toxic components, the cyanotoxin. |
| T2 | 416-636 | DRI_Outcome | denotes | In this study, the hepatic alterations at histological, proteome and transcriptome levels were evaluated in female and male medaka fish chronically exposed to 1 and 5 μg L(-1) microcystin-LR (MC-LR) and to the extract of |
| T3 | 662-863 | DRI_Outcome | denotes | aeruginosa PCC 7820 (5 μg L(-1) of equivalent MC-LR) by balneation for 28 days, aiming at enhancing our understanding of the potential reproductive toxicity of cyanotoxins in aquatic vertebrate models. |
| T4 | 864-986 | DRI_Outcome | denotes | Indeed, both MC and Microcystis extract adversely affect reproductive parameters including fecundity and egg hatchability. |
| T5 | 987-1077 | DRI_Background | denotes | The liver of toxin treated female fish present glycogen storage loss and cellular damages. |
| T6 | 1078-1185 | DRI_Background | denotes | The quantitative proteomics analysis revealed that the quantities of 225 hepatic proteins are dysregulated. |
| T7 | 1186-1344 | DRI_Background | denotes | In particular, a notable decrease in protein quantities of vitellogenin and choriogenin was observed, which could explain the decrease in reproductive output. |
| T8 | 1345-1532 | DRI_Approach | denotes | Liver transcriptome analysis through Illumina RNA-seq reveals that over 100-400 genes are differentially expressed under 5 μg L(-1) MC-LR and Microcystis extract treatments, respectively. |
| T9 | 1533-1802 | DRI_Background | denotes | Ingenuity pathway analysis of the omic data attests that various metabolic pathways, such as energy production, protein biosynthesis and lipid metabolism, are disturbed by both MC-LR and the Microcystis extract, which could provoke the observed reproductive impairment. |
| T10 | 1803-1932 | DRI_Outcome | denotes | The transcriptomics analysis also constitutes the first report of the impairment of circadian rhythm-related gene induced by MCs. |
| T11 | 1933-2283 | DRI_Outcome | denotes | This study contributes to a better understanding of the potential consequences of chronic exposure of fish to environmental concentrations of cyanotoxins, suggesting that Microcystis extract could impact a wider range of biological pathways, compared with pure MC-LR, and even 1 μg L(-1) MC-LR potentially induces a health risk for aquatic organisms. |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-2 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | An |
| T2 | 0-2 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | An |
| T3 | 584-591 | CVCL_4207|Spontaneously_immortalized_cell_line|Gekko gecko | denotes | g L(-1) |
| T4 | 584-591 | CVCL_9175|Hybridoma|Mus musculus,Rattus norvegicus | denotes | g L(-1) |
| T5 | 584-587 | CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara | denotes | g L |
| T6 | 604-606 | CVCL_J367|Cancer_cell_line|Rattus norvegicus | denotes | LR |
| T7 | 604-606 | CVCL_ZC23|Cancer_cell_line|Homo sapiens | denotes | LR |
| T8 | 608-610 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T9 | 608-610 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T10 | 611-613 | CVCL_J367|Cancer_cell_line|Rattus norvegicus | denotes | LR |
| T11 | 611-613 | CVCL_ZC23|Cancer_cell_line|Homo sapiens | denotes | LR |
| T12 | 637-639 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T13 | 637-639 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T14 | 686-693 | CVCL_4207|Spontaneously_immortalized_cell_line|Gekko gecko | denotes | g L(-1) |
| T15 | 686-693 | CVCL_9175|Hybridoma|Mus musculus,Rattus norvegicus | denotes | g L(-1) |
| T16 | 686-689 | CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara | denotes | g L |
| T17 | 708-710 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T18 | 708-710 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T19 | 711-713 | CVCL_J367|Cancer_cell_line|Rattus norvegicus | denotes | LR |
| T20 | 711-713 | CVCL_ZC23|Cancer_cell_line|Homo sapiens | denotes | LR |
| T21 | 877-879 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T22 | 877-879 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T23 | 969-972 | CVCL_5739|Cancer_cell_line|Mus musculus | denotes | egg |
| T24 | 1147-1150 | CVCL_J594|Hybridoma|Mus musculus | denotes | 225 |
| T25 | 1201-1202 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T26 | 1469-1476 | CVCL_4207|Spontaneously_immortalized_cell_line|Gekko gecko | denotes | g L(-1) |
| T27 | 1469-1476 | CVCL_9175|Hybridoma|Mus musculus,Rattus norvegicus | denotes | g L(-1) |
| T28 | 1469-1472 | CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara | denotes | g L |
| T29 | 1477-1479 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T30 | 1477-1479 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T31 | 1480-1482 | CVCL_J367|Cancer_cell_line|Rattus norvegicus | denotes | LR |
| T32 | 1480-1482 | CVCL_ZC23|Cancer_cell_line|Homo sapiens | denotes | LR |
| T33 | 1710-1712 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T34 | 1710-1712 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T35 | 1713-1715 | CVCL_J367|Cancer_cell_line|Rattus norvegicus | denotes | LR |
| T36 | 1713-1715 | CVCL_ZC23|Cancer_cell_line|Homo sapiens | denotes | LR |
| T37 | 1959-1960 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T38 | 2137-2138 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T39 | 2194-2196 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T40 | 2194-2196 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T41 | 2197-2199 | CVCL_J367|Cancer_cell_line|Rattus norvegicus | denotes | LR |
| T42 | 2197-2199 | CVCL_ZC23|Cancer_cell_line|Homo sapiens | denotes | LR |
| T43 | 2213-2220 | CVCL_4207|Spontaneously_immortalized_cell_line|Gekko gecko | denotes | g L(-1) |
| T44 | 2213-2220 | CVCL_9175|Hybridoma|Mus musculus,Rattus norvegicus | denotes | g L(-1) |
| T45 | 2213-2216 | CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara | denotes | g L |
| T46 | 2221-2223 | CVCL_M543|Cancer_cell_line|Homo sapiens | denotes | MC |
| T47 | 2221-2223 | CVCL_W203|Cancer_cell_line|Homo sapiens | denotes | MC |
| T48 | 2224-2226 | CVCL_J367|Cancer_cell_line|Rattus norvegicus | denotes | LR |
| T49 | 2224-2226 | CVCL_ZC23|Cancer_cell_line|Homo sapiens | denotes | LR |
| T50 | 2247-2248 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 53-59 | D009990 | denotes | medaka |
| T2 | 53-59 | 8090 | denotes | medaka |
| T3 | 60-64 | PR:Q24533 | denotes | fish |
| T4 | 88-99 | CHEBI:88048 | denotes | cyanotoxins |
| T5 | 182-187 | D006801 | denotes | human |
| T6 | 343-353 | CHEBI:88048 | denotes | cyanotoxin |
| T7 | 380-391 | CHEBI:88048 | denotes | cyanotoxins |
| T8 | 396-408 | CHEBI:48041 | denotes | microcystins |
| T9 | 396-408 | D052998 | denotes | microcystins |
| T10 | 396-408 | D052998 | denotes | microcystins |
| T11 | 410-413 | PR:Q9CAK8 | denotes | MCs |
| T12 | 410-413 | Q14CH1 | denotes | MCs |
| T13 | 410-413 | Q7QFL7 | denotes | MCs |
| T14 | 410-413 | B0Y691 | denotes | MCs |
| T15 | 410-413 | Q655R6 | denotes | MCs |
| T16 | 410-413 | P45858 | denotes | MCs |
| T17 | 410-413 | Q29GM0 | denotes | MCs |
| T18 | 410-413 | PR:000010511 | denotes | MCs |
| T19 | 410-413 | B4JXP7 | denotes | MCs |
| T20 | 410-413 | B4H0S8 | denotes | MCs |
| T21 | 410-413 | A1CHL0 | denotes | MCs |
| T22 | 410-413 | H8F0D7 | denotes | MCs |
| T23 | 410-413 | A1CX75 | denotes | MCs |
| T24 | 410-413 | P31660 | denotes | MCs |
| T25 | 410-413 | PR:Q64298 | denotes | MCs |
| T26 | 410-413 | B4L340 | denotes | MCs |
| T27 | 410-413 | Q2HE65 | denotes | MCs |
| T28 | 410-413 | Q9VRA2 | denotes | MCs |
| T29 | 410-413 | PR:000015276 | denotes | MCs |
| T30 | 410-413 | O34002 | denotes | MCs |
| T31 | 410-413 | Q559G8 | denotes | MCs |
| T32 | 410-413 | Q56063 | denotes | MCs |
| T33 | 410-413 | Q8NSH7 | denotes | MCs |
| T34 | 410-413 | Q96EN8 | denotes | MCs |
| T35 | 410-413 | Q9N0E7 | denotes | MCs |
| T36 | 410-413 | A6SRX6 | denotes | MCs |
| T39 | 410-413 | PR:P15265 | denotes | MCs |
| T40 | 410-413 | B3MZN7 | denotes | MCs |
| T41 | 410-413 | B4PYH5 | denotes | MCs |
| T42 | 410-413 | Q937N9 | denotes | MCs |
| T43 | 410-413 | Q9C5X8 | denotes | MCs |
| T44 | 410-413 | B3NY19 | denotes | MCs |
| T45 | 410-413 | Q7SE17 | denotes | MCs |
| T46 | 410-413 | I6Y9Q3 | denotes | MCs |
| T47 | 410-413 | B4M3C9 | denotes | MCs |
| T48 | 410-413 | A4RK48 | denotes | MCs |
| T49 | 410-413 | A8X493 | denotes | MCs |
| T50 | 410-413 | A2VD33 | denotes | MCs |
| T51 | 410-413 | Q4WPE6 | denotes | MCs |
| T52 | 410-413 | Q2UH11 | denotes | MCs |
| T53 | 410-413 | Q9UV64 | denotes | MCs |
| T54 | 410-413 | PR:Q9CZU6 | denotes | MCs |
| T55 | 410-413 | Q8IU29 | denotes | MCs |
| T56 | 410-413 | A2QIK9 | denotes | MCs |
| T57 | 410-413 | Q21657 | denotes | MCs |
| T58 | 410-413 | Q8EJW2 | denotes | MCs |
| T59 | 410-413 | Q8NSL1 | denotes | MCs |
| T60 | 410-413 | B4N1V2 | denotes | MCs |
| T61 | 410-413 | Q0CLW8 | denotes | MCs |
| T62 | 410-413 | Q8LGM7 | denotes | MCs |
| T63 | 410-413 | PR:P49901 | denotes | MCs |
| T37 | 410-413 | GO:0044232 | denotes | MCs |
| T38 | 410-413 | C536703 | denotes | MCs |
| T64 | 472-480 | D020543 | denotes | proteome |
| T65 | 524-530 | UBERON:0003100 | denotes | female |
| T66 | 535-539 | UBERON:0003101 | denotes | male |
| T67 | 535-539 | CHEBI:30780 | denotes | male |
| T68 | 540-546 | D009990 | denotes | medaka |
| T69 | 540-546 | 8090 | denotes | medaka |
| T70 | 547-551 | PR:Q24533 | denotes | fish |
| T80 | 592-606 | C057862 | denotes | microcystin-LR |
| T81 | 592-606 | C057862 | denotes | microcystin-LR |
| T82 | 592-606 | C057862 | denotes | microcystin-LR |
| T83 | 592-606 | CHEBI:6925 | denotes | microcystin-LR |
| T85 | 650-672 | D046931 | denotes | Microcystis aeruginosa |
| T86 | 650-672 | 1126 | denotes | Microcystis aeruginosa |
| T89 | 673-676 | GO:0120205 | denotes | PCC |
| T88 | 673-676 | I3R7G3 | denotes | PCC |
| T90 | 673-676 | I3R7F1 | denotes | PCC |
| T91 | 673-676 | I3R7F2 | denotes | PCC |
| T87 | 673-676 | 115700 | denotes | PCC |
| T97 | 822-833 | CHEBI:88048 | denotes | cyanotoxins |
| T98 | 845-855 | D014714 | denotes | vertebrate |
| T99 | 884-895 | D046931 | denotes | Microcystis |
| T100 | 969-972 | PR:Q32KD2 | denotes | egg |
| T101 | 969-972 | UBERON:0007379 | denotes | egg |
| T102 | 969-972 | UBERON:2001109 | denotes | egg |
| T103 | 991-996 | UBERON:0002107 | denotes | liver |
| T104 | 1000-1005 | CHEBI:27026 | denotes | toxin |
| T105 | 1014-1020 | UBERON:0003100 | denotes | female |
| T106 | 1021-1025 | PR:Q24533 | denotes | fish |
| T107 | 1034-1042 | D006003 | denotes | glycogen |
| T108 | 1034-1042 | CHEBI:28087 | denotes | glycogen |
| T109 | 1034-1042 | D006003 | denotes | glycogen |
| T110 | 1034-1050 | D006008 | denotes | glycogen storage |
| T111 | 1034-1050 | D006008 | denotes | glycogen storage |
| T112 | 1043-1050 | GO:0051235 | denotes | storage |
| T113 | 1159-1167 | CHEBI:36080 | denotes | proteins |
| T117 | 1223-1230 | PR:000000001 | denotes | protein |
| T115 | 1223-1230 | CHEBI:36080 | denotes | protein |
| T116 | 1223-1230 | CHEBI:11122 | denotes | protein |
| T118 | 1223-1230 | SO:0000104 | denotes | protein |
| T114 | 1223-1230 | GO:0003675 | denotes | protein |
| T119 | 1245-1257 | Q05808 | denotes | vitellogenin |
| T120 | 1245-1257 | Q92093 | denotes | vitellogenin |
| T121 | 1245-1257 | Q7Z1M0 | denotes | vitellogenin |
| T122 | 1245-1257 | Q6RG02 | denotes | vitellogenin |
| T123 | 1245-1257 | A0A292G9J6 | denotes | vitellogenin |
| T124 | 1245-1257 | Q27309 | denotes | vitellogenin |
| T125 | 1245-1257 | Q868N5 | denotes | vitellogenin |
| T127 | 1245-1257 | Q90243 | denotes | vitellogenin |
| T128 | 1245-1257 | Q91062 | denotes | vitellogenin |
| T129 | 1245-1257 | P19615 | denotes | vitellogenin |
| T126 | 1245-1257 | D014819 | denotes | vitellogenin |
| T132 | 1391-1394 | GO:0005562 | denotes | RNA |
| T133 | 1391-1394 | SO:0000356 | denotes | RNA |
| T130 | 1391-1394 | CHEBI:33697 | denotes | RNA |
| T131 | 1391-1394 | D012313 | denotes | RNA |
| T139 | 1487-1498 | D046931 | denotes | Microcystis |
| T140 | 1543-1550 | CHEBI:34922 | denotes | pathway |
| T145 | 1645-1652 | SO:0000104 | denotes | protein |
| T144 | 1645-1652 | PR:000000001 | denotes | protein |
| T142 | 1645-1652 | CHEBI:36080 | denotes | protein |
| T143 | 1645-1652 | CHEBI:11122 | denotes | protein |
| T141 | 1645-1652 | GO:0003675 | denotes | protein |
| T146 | 1645-1665 | GO:0006412 | denotes | protein biosynthesis |
| T148 | 1670-1675 | CHEBI:18059 | denotes | lipid |
| T149 | 1670-1686 | GO:0006629 | denotes | lipid metabolism |
| T151 | 1724-1735 | D046931 | denotes | Microcystis |
| T152 | 1887-1903 | GO:0007623 | denotes | circadian rhythm |
| T154 | 1912-1916 | SO:0000704 | denotes | gene |
| T155 | 1928-1931 | PR:Q9CAK8 | denotes | MCs |
| T156 | 1928-1931 | Q14CH1 | denotes | MCs |
| T157 | 1928-1931 | Q7QFL7 | denotes | MCs |
| T158 | 1928-1931 | B0Y691 | denotes | MCs |
| T159 | 1928-1931 | Q655R6 | denotes | MCs |
| T160 | 1928-1931 | P45858 | denotes | MCs |
| T161 | 1928-1931 | Q29GM0 | denotes | MCs |
| T162 | 1928-1931 | PR:000010511 | denotes | MCs |
| T163 | 1928-1931 | B4JXP7 | denotes | MCs |
| T164 | 1928-1931 | B4H0S8 | denotes | MCs |
| T165 | 1928-1931 | A1CHL0 | denotes | MCs |
| T166 | 1928-1931 | H8F0D7 | denotes | MCs |
| T167 | 1928-1931 | A1CX75 | denotes | MCs |
| T168 | 1928-1931 | P31660 | denotes | MCs |
| T169 | 1928-1931 | PR:Q64298 | denotes | MCs |
| T170 | 1928-1931 | B4L340 | denotes | MCs |
| T171 | 1928-1931 | Q2HE65 | denotes | MCs |
| T172 | 1928-1931 | Q9VRA2 | denotes | MCs |
| T173 | 1928-1931 | PR:000015276 | denotes | MCs |
| T174 | 1928-1931 | O34002 | denotes | MCs |
| T175 | 1928-1931 | Q559G8 | denotes | MCs |
| T176 | 1928-1931 | Q56063 | denotes | MCs |
| T177 | 1928-1931 | Q8NSH7 | denotes | MCs |
| T178 | 1928-1931 | Q96EN8 | denotes | MCs |
| T179 | 1928-1931 | Q9N0E7 | denotes | MCs |
| T180 | 1928-1931 | A6SRX6 | denotes | MCs |
| T183 | 1928-1931 | PR:P15265 | denotes | MCs |
| T184 | 1928-1931 | B3MZN7 | denotes | MCs |
| T185 | 1928-1931 | B4PYH5 | denotes | MCs |
| T186 | 1928-1931 | Q937N9 | denotes | MCs |
| T187 | 1928-1931 | Q9C5X8 | denotes | MCs |
| T188 | 1928-1931 | B3NY19 | denotes | MCs |
| T189 | 1928-1931 | Q7SE17 | denotes | MCs |
| T190 | 1928-1931 | I6Y9Q3 | denotes | MCs |
| T191 | 1928-1931 | B4M3C9 | denotes | MCs |
| T192 | 1928-1931 | A4RK48 | denotes | MCs |
| T193 | 1928-1931 | A8X493 | denotes | MCs |
| T194 | 1928-1931 | A2VD33 | denotes | MCs |
| T195 | 1928-1931 | Q4WPE6 | denotes | MCs |
| T196 | 1928-1931 | Q2UH11 | denotes | MCs |
| T197 | 1928-1931 | Q9UV64 | denotes | MCs |
| T198 | 1928-1931 | PR:Q9CZU6 | denotes | MCs |
| T199 | 1928-1931 | Q8IU29 | denotes | MCs |
| T200 | 1928-1931 | A2QIK9 | denotes | MCs |
| T201 | 1928-1931 | Q21657 | denotes | MCs |
| T202 | 1928-1931 | Q8EJW2 | denotes | MCs |
| T203 | 1928-1931 | Q8NSL1 | denotes | MCs |
| T204 | 1928-1931 | B4N1V2 | denotes | MCs |
| T205 | 1928-1931 | Q0CLW8 | denotes | MCs |
| T206 | 1928-1931 | Q8LGM7 | denotes | MCs |
| T207 | 1928-1931 | PR:P49901 | denotes | MCs |
| T181 | 1928-1931 | GO:0044232 | denotes | MCs |
| T182 | 1928-1931 | C536703 | denotes | MCs |
| T209 | 2035-2039 | PR:Q24533 | denotes | fish |
| T210 | 2075-2086 | CHEBI:88048 | denotes | cyanotoxins |
| T211 | 2104-2115 | D046931 | denotes | Microcystis |
| T212 | 2130-2136 | PR:Q54JW9 | denotes | impact |
| T213 | 2130-2136 | PR:Q642J4 | denotes | impact |
| T214 | 2189-2193 | PR:Q8FYW3 | denotes | pure |
| T215 | 2189-2193 | PR:Q54QE4 | denotes | pure |
| T216 | 2189-2193 | PR:P52558 | denotes | pure |
| T217 | 2189-2193 | PR:P0AG18 | denotes | pure |
| T219 | 2189-2193 | PR:000023640 | denotes | pure |
| T218 | 2189-2193 | GO:0034023 | denotes | pure |
| T225 | 2265-2282 | D059001 | denotes | aquatic organisms |