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PubMed:27798239 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11643 0-33 GeneOrGeneProduct denotes Phosphatidylinositol 4-kinase IIβ NCBIGene:55300
11644 128-165 GeneOrGeneProduct denotes type II phosphatidylinositol 4-kinase NCBIGene:55300|NCBIGene:55361
11645 167-173 GeneOrGeneProduct denotes PI4KII NCBIGene:55300|NCBIGene:55361
11646 198-203 ChemicalEntity denotes lipid MESH:D008055
11647 204-236 ChemicalEntity denotes phosphatidylinositol 4-phosphate MESH:C037178
11648 238-244 ChemicalEntity denotes PI(4)P MESH:C037178
11649 332-340 GeneOrGeneProduct denotes clathrin NCBIGene:1213
11650 483-490 GeneOrGeneProduct denotes PI4KIIα NCBIGene:55361
11651 495-502 GeneOrGeneProduct denotes PI4KIIβ NCBIGene:55300
11652 538-543 GeneOrGeneProduct denotes actin NCBIGene:60
11653 569-576 GeneOrGeneProduct denotes PI4KIIβ NCBIGene:55300
11654 630-670 GeneOrGeneProduct denotes membrane type I matrix metalloproteinase NCBIGene:4323
11655 672-679 GeneOrGeneProduct denotes MT1-MMP NCBIGene:4323
11656 695-701 GeneOrGeneProduct denotes PI4KII NCBIGene:55300|NCBIGene:55361
11657 775-781 ChemicalEntity denotes PI(4)P MESH:C037178
11658 804-811 GeneOrGeneProduct denotes PI4KIIβ NCBIGene:55300
11659 839-846 GeneOrGeneProduct denotes MT1-MMP NCBIGene:4323
11660 954-961 GeneOrGeneProduct denotes MT1-MMP NCBIGene:4323
11661 1010-1014 GeneOrGeneProduct denotes Rab5 NCBIGene:5868
11662 1019-1023 GeneOrGeneProduct denotes Rab7 NCBIGene:338382
11663 1069-1073 GeneOrGeneProduct denotes Rab8 NCBIGene:4218
11664 1088-1095 GeneOrGeneProduct denotes PI4KIIβ NCBIGene:55300
11665 1176-1180 CellLine denotes HeLa NCBITaxon:9606
11666 1185-1190 CellLine denotes MCF-7 NCBITaxon:9606
11667 1258-1264 GeneOrGeneProduct denotes PI4K2B NCBIGene:55300
11668 1295-1302 GeneOrGeneProduct denotes PI4KIIβ NCBIGene:55300
11669 1328-1333 OrganismTaxon denotes human NCBITaxon:9606
11670 1334-1341 DiseaseOrPhenotypicFeature denotes cancers MESH:D009369
11671 1397-1404 GeneOrGeneProduct denotes PI4KIIβ NCBIGene:55300
11672 1477-1484 GeneOrGeneProduct denotes PI4KIIβ NCBIGene:55300
11673 1507-1513 ChemicalEntity denotes PI(4)P MESH:C037178
11674 1529-1536 GeneOrGeneProduct denotes MT1-MMP NCBIGene:4323

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype.
T2 124-350 Sentence denotes The type II phosphatidylinositol 4-kinase (PI4KII) enzymes synthesize the lipid phosphatidylinositol 4-phosphate (PI(4)P), which has been detected at the Golgi complex and endosomal compartments and recruits clathrin adaptors.
T3 351-455 Sentence denotes Despite common mechanistic similarities between the isoforms, the extent of their redundancy is unclear.
T4 456-555 Sentence denotes We found that depletion of PI4KIIα and PI4KIIβ using small interfering RNA led to actin remodeling.
T5 556-681 Sentence denotes Depletion of PI4KIIβ also induced the formation of invadopodia containing membrane type I matrix metalloproteinase (MT1-MMP).
T6 682-803 Sentence denotes Depletion of PI4KII isoforms also differentially affected trans-Golgi network (TGN) pools of PI(4)P and post-TGN traffic.
T7 804-1074 Sentence denotes PI4KIIβ depletion caused increased MT1-MMP trafficking to invasive structures at the plasma membrane and was accompanied by reduced colocalization of MT1-MMP with membranes containing the endosomal markers Rab5 and Rab7 but increased localization with the exocytic Rab8.
T8 1075-1202 Sentence denotes Depletion of PI4KIIβ was sufficient to confer an aggressive invasive phenotype on minimally invasive HeLa and MCF-7 cell lines.
T9 1203-1342 Sentence denotes Mining oncogenomic databases revealed that loss of the PI4K2B allele and underexpression of PI4KIIβ mRNA are associated with human cancers.
T10 1343-1460 Sentence denotes This finding supports the cell data and suggests that PI4KIIβ may be a clinically significant suppressor of invasion.
T11 1461-1616 Sentence denotes We propose that PI4KIIβ synthesizes a pool of PI(4)P that maintains MT1-MMP traffic in the degradative pathway and suppresses the formation of invadopodia.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 1185-1188 OrganismTaxon denotes MCF NCBItxid:11785
T2 1328-1333 OrganismTaxon denotes human NCBItxid:9606

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 1334-1341 DiseaseOrPhenotypicFeature denotes cancers 0004992

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-29 GeneOrGeneProduct denotes Phosphatidylinositol 4-kinase
T2 30-32 GeneOrGeneProduct denotes II
T3 45-54 GeneOrGeneProduct denotes regulates
T4 67-76 GeneOrGeneProduct denotes formation
T5 128-135 GeneOrGeneProduct denotes type II
T6 136-165 GeneOrGeneProduct denotes phosphatidylinositol 4-kinase
T7 167-173 GeneOrGeneProduct denotes PI4KII
T8 175-182 GeneOrGeneProduct denotes enzymes
T9 204-226 GeneOrGeneProduct denotes phosphatidylinositol 4
T10 238-243 GeneOrGeneProduct denotes PI(4)
T11 332-340 GeneOrGeneProduct denotes clathrin
T12 341-349 GeneOrGeneProduct denotes adaptors
T13 378-390 GeneOrGeneProduct denotes similarities
T14 447-454 GeneOrGeneProduct denotes unclear
T15 470-479 GeneOrGeneProduct denotes depletion
T16 483-489 GeneOrGeneProduct denotes PI4KII
T17 495-501 GeneOrGeneProduct denotes PI4KII
T18 509-514 GeneOrGeneProduct denotes small
T19 538-543 GeneOrGeneProduct denotes actin
T20 556-565 GeneOrGeneProduct denotes Depletion
T21 569-575 GeneOrGeneProduct denotes PI4KII
T22 582-589 GeneOrGeneProduct denotes induced
T23 594-603 GeneOrGeneProduct denotes formation
T24 639-645 GeneOrGeneProduct denotes type I
T25 646-670 GeneOrGeneProduct denotes matrix metalloproteinase
T26 672-679 GeneOrGeneProduct denotes MT1-MMP
T27 682-691 GeneOrGeneProduct denotes Depletion
T28 695-701 GeneOrGeneProduct denotes PI4KII
T29 740-745 GeneOrGeneProduct denotes trans
T30 775-780 GeneOrGeneProduct denotes PI(4)
T31 786-790 GeneOrGeneProduct denotes post
T32 804-810 GeneOrGeneProduct denotes PI4KII
T33 812-821 GeneOrGeneProduct denotes depletion
T34 839-846 GeneOrGeneProduct denotes MT1-MMP
T35 889-904 GeneOrGeneProduct denotes plasma membrane
T36 928-935 GeneOrGeneProduct denotes reduced
T37 954-961 GeneOrGeneProduct denotes MT1-MMP
T38 1010-1014 GeneOrGeneProduct denotes Rab5
T39 1019-1023 GeneOrGeneProduct denotes Rab7
T40 1069-1073 GeneOrGeneProduct denotes Rab8
T41 1075-1084 GeneOrGeneProduct denotes Depletion
T42 1088-1094 GeneOrGeneProduct denotes PI4KII
T43 1176-1180 GeneOrGeneProduct denotes HeLa
T44 1191-1195 GeneOrGeneProduct denotes cell
T45 1196-1201 GeneOrGeneProduct denotes lines
T46 1203-1209 GeneOrGeneProduct denotes Mining
T47 1258-1264 GeneOrGeneProduct denotes PI4K2B
T48 1295-1301 GeneOrGeneProduct denotes PI4KII
T49 1303-1307 GeneOrGeneProduct denotes mRNA
T50 1348-1355 GeneOrGeneProduct denotes finding
T51 1369-1373 GeneOrGeneProduct denotes cell
T52 1397-1403 GeneOrGeneProduct denotes PI4KII
T53 1405-1413 GeneOrGeneProduct denotes may be a
T54 1437-1450 GeneOrGeneProduct denotes suppressor of
T55 1477-1483 GeneOrGeneProduct denotes PI4KII
T56 1497-1503 GeneOrGeneProduct denotes a pool
T57 1507-1512 GeneOrGeneProduct denotes PI(4)
T58 1529-1536 GeneOrGeneProduct denotes MT1-MMP
T59 1591-1600 GeneOrGeneProduct denotes formation

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-29 GeneOrGeneProduct denotes Phosphatidylinositol 4-kinase
T2 128-135 GeneOrGeneProduct denotes type II
T3 136-165 GeneOrGeneProduct denotes phosphatidylinositol 4-kinase
T4 167-173 GeneOrGeneProduct denotes PI4KII
T5 204-226 GeneOrGeneProduct denotes phosphatidylinositol 4
T6 332-340 GeneOrGeneProduct denotes clathrin
T7 447-454 GeneOrGeneProduct denotes unclear
T8 483-489 GeneOrGeneProduct denotes PI4KII
T9 495-501 GeneOrGeneProduct denotes PI4KII
T10 509-514 GeneOrGeneProduct denotes small
T11 538-543 GeneOrGeneProduct denotes actin
T12 569-575 GeneOrGeneProduct denotes PI4KII
T13 639-645 GeneOrGeneProduct denotes type I
T14 646-670 GeneOrGeneProduct denotes matrix metalloproteinase
T15 672-679 GeneOrGeneProduct denotes MT1-MMP
T16 695-701 GeneOrGeneProduct denotes PI4KII
T17 786-790 GeneOrGeneProduct denotes post
T18 804-810 GeneOrGeneProduct denotes PI4KII
T19 839-846 GeneOrGeneProduct denotes MT1-MMP
T20 889-904 GeneOrGeneProduct denotes plasma membrane
T21 928-935 GeneOrGeneProduct denotes reduced
T22 954-961 GeneOrGeneProduct denotes MT1-MMP
T23 1010-1014 GeneOrGeneProduct denotes Rab5
T24 1019-1023 GeneOrGeneProduct denotes Rab7
T25 1069-1073 GeneOrGeneProduct denotes Rab8
T26 1088-1094 GeneOrGeneProduct denotes PI4KII
T27 1191-1195 GeneOrGeneProduct denotes cell
T28 1196-1201 GeneOrGeneProduct denotes lines
T29 1258-1264 GeneOrGeneProduct denotes PI4K2B
T30 1295-1301 GeneOrGeneProduct denotes PI4KII
T31 1303-1307 GeneOrGeneProduct denotes mRNA
T32 1369-1373 GeneOrGeneProduct denotes cell
T33 1397-1403 GeneOrGeneProduct denotes PI4KII
T34 1437-1450 GeneOrGeneProduct denotes suppressor of
T35 1477-1483 GeneOrGeneProduct denotes PI4KII
T36 1497-1503 GeneOrGeneProduct denotes a pool
T37 1529-1536 GeneOrGeneProduct denotes MT1-MMP

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 1334-1341 DiseaseOrPhenotypicFeature denotes cancers D009369

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-29 GeneOrGeneProduct denotes Phosphatidylinositol 4-kinase
T2 136-165 GeneOrGeneProduct denotes phosphatidylinositol 4-kinase
T3 167-173 GeneOrGeneProduct denotes PI4KII
T4 204-226 GeneOrGeneProduct denotes phosphatidylinositol 4
T5 332-340 GeneOrGeneProduct denotes clathrin
T6 483-489 GeneOrGeneProduct denotes PI4KII
T7 495-501 GeneOrGeneProduct denotes PI4KII
T8 538-543 GeneOrGeneProduct denotes actin
T9 569-575 GeneOrGeneProduct denotes PI4KII
T10 646-670 GeneOrGeneProduct denotes matrix metalloproteinase
T11 672-679 GeneOrGeneProduct denotes MT1-MMP
T12 695-701 GeneOrGeneProduct denotes PI4KII
T13 804-810 GeneOrGeneProduct denotes PI4KII
T14 839-846 GeneOrGeneProduct denotes MT1-MMP
T15 889-904 GeneOrGeneProduct denotes plasma membrane
T16 954-961 GeneOrGeneProduct denotes MT1-MMP
T17 1010-1014 GeneOrGeneProduct denotes Rab5
T18 1019-1023 GeneOrGeneProduct denotes Rab7
T19 1069-1073 GeneOrGeneProduct denotes Rab8
T20 1088-1094 GeneOrGeneProduct denotes PI4KII
T21 1258-1264 GeneOrGeneProduct denotes PI4K2B
T22 1295-1301 GeneOrGeneProduct denotes PI4KII
T23 1397-1403 GeneOrGeneProduct denotes PI4KII
T24 1437-1447 GeneOrGeneProduct denotes suppressor
T25 1477-1483 GeneOrGeneProduct denotes PI4KII
T26 1497-1503 GeneOrGeneProduct denotes a pool
T27 1529-1536 GeneOrGeneProduct denotes MT1-MMP

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 1185-1188 OrganismTaxon denotes MCF
T2 1328-1333 OrganismTaxon denotes human

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 1334-1341 DiseaseOrPhenotypicFeature denotes cancers D009369

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 1334-1341 DiseaseOrPhenotypicFeature denotes cancers D009369

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 1176-1180 CellLine denotes HeLa CVCL_0030
T2 1185-1190 CellLine denotes MCF-7 CVCL_0031

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-29 ChemicalEntity denotes Phosphatidylinositol 4-kinase D019870
T2 136-165 ChemicalEntity denotes phosphatidylinositol 4-kinase D019870
T3 167-173 ChemicalEntity denotes PI4KII D019870
T4 204-236 ChemicalEntity denotes phosphatidylinositol 4-phosphate C037178|http://purl.obolibrary.org/obo/CHEBI_37530
T6 238-244 ChemicalEntity denotes PI(4)P http://purl.obolibrary.org/obo/CHEBI_37530
T7 483-489 ChemicalEntity denotes PI4KII D019870
T8 495-501 ChemicalEntity denotes PI4KII D019870
T9 569-575 ChemicalEntity denotes PI4KII D019870
T10 646-670 ChemicalEntity denotes matrix metalloproteinase D020782
T11 672-679 ChemicalEntity denotes MT1-MMP D053511
T12 695-701 ChemicalEntity denotes PI4KII D019870
T13 775-781 ChemicalEntity denotes PI(4)P http://purl.obolibrary.org/obo/CHEBI_37530
T14 804-810 ChemicalEntity denotes PI4KII D019870
T15 839-846 ChemicalEntity denotes MT1-MMP D053511
T16 954-961 ChemicalEntity denotes MT1-MMP D053511
T17 1088-1094 ChemicalEntity denotes PI4KII D019870
T18 1295-1301 ChemicalEntity denotes PI4KII D019870
T19 1397-1403 ChemicalEntity denotes PI4KII D019870
T20 1477-1483 ChemicalEntity denotes PI4KII D019870
T21 1507-1513 ChemicalEntity denotes PI(4)P http://purl.obolibrary.org/obo/CHEBI_37530
T22 1529-1536 ChemicalEntity denotes MT1-MMP D053511

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T2 1185-1190 CellLine denotes MCF-7 CVCL_0031
T1 1176-1180 CellLine denotes HeLa CVCL_0030
T22 1529-1536 ChemicalEntity denotes MT1-MMP D053511
T21 1507-1513 ChemicalEntity denotes PI(4)P http://purl.obolibrary.org/obo/CHEBI_37530
T20 1477-1483 ChemicalEntity denotes PI4KII D019870
T19 1397-1403 ChemicalEntity denotes PI4KII D019870
T18 1295-1301 ChemicalEntity denotes PI4KII D019870
T17 1088-1094 ChemicalEntity denotes PI4KII D019870
T16 954-961 ChemicalEntity denotes MT1-MMP D053511
T15 839-846 ChemicalEntity denotes MT1-MMP D053511
T14 804-810 ChemicalEntity denotes PI4KII D019870
T13 775-781 ChemicalEntity denotes PI(4)P http://purl.obolibrary.org/obo/CHEBI_37530
T12 695-701 ChemicalEntity denotes PI4KII D019870
T11 672-679 ChemicalEntity denotes MT1-MMP D053511
T10 646-670 ChemicalEntity denotes matrix metalloproteinase D020782
T9 569-575 ChemicalEntity denotes PI4KII D019870
T8 495-501 ChemicalEntity denotes PI4KII D019870
T7 483-489 ChemicalEntity denotes PI4KII D019870
T6 238-244 ChemicalEntity denotes PI(4)P http://purl.obolibrary.org/obo/CHEBI_37530
T4 204-236 ChemicalEntity denotes phosphatidylinositol 4-phosphate http://purl.obolibrary.org/obo/CHEBI_37530|C037178
T3 167-173 ChemicalEntity denotes PI4KII D019870
T40858 136-165 ChemicalEntity denotes phosphatidylinositol 4-kinase D019870
T1084 0-29 ChemicalEntity denotes Phosphatidylinositol 4-kinase D019870
T27 1529-1536 GeneOrGeneProduct denotes MT1-MMP
T26 1497-1503 GeneOrGeneProduct denotes a pool
T25 1477-1483 GeneOrGeneProduct denotes PI4KII
T24 1437-1447 GeneOrGeneProduct denotes suppressor
T23 1397-1403 GeneOrGeneProduct denotes PI4KII
T5170 1295-1301 GeneOrGeneProduct denotes PI4KII
T19130 1258-1264 GeneOrGeneProduct denotes PI4K2B
T60513 1088-1094 GeneOrGeneProduct denotes PI4KII
T69353 1069-1073 GeneOrGeneProduct denotes Rab8
T40965 1019-1023 GeneOrGeneProduct denotes Rab7
T85860 1010-1014 GeneOrGeneProduct denotes Rab5
T95831 954-961 GeneOrGeneProduct denotes MT1-MMP
T16605 889-904 GeneOrGeneProduct denotes plasma membrane
T26974 839-846 GeneOrGeneProduct denotes MT1-MMP
T90392 804-810 GeneOrGeneProduct denotes PI4KII
T42251 695-701 GeneOrGeneProduct denotes PI4KII
T45643 672-679 GeneOrGeneProduct denotes MT1-MMP
T73012 646-670 GeneOrGeneProduct denotes matrix metalloproteinase
T73917 569-575 GeneOrGeneProduct denotes PI4KII
T48717 538-543 GeneOrGeneProduct denotes actin
T79673 495-501 GeneOrGeneProduct denotes PI4KII
T31286 483-489 GeneOrGeneProduct denotes PI4KII
T5 332-340 GeneOrGeneProduct denotes clathrin
T90105 204-226 GeneOrGeneProduct denotes phosphatidylinositol 4
T85791 167-173 GeneOrGeneProduct denotes PI4KII
T23571 136-165 GeneOrGeneProduct denotes phosphatidylinositol 4-kinase
T84874 0-29 GeneOrGeneProduct denotes Phosphatidylinositol 4-kinase
T89681 1334-1341 DiseaseOrPhenotypicFeature denotes cancers D009369
T81094 1328-1333 OrganismTaxon denotes human
T20123 1185-1188 OrganismTaxon denotes MCF