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c_corpus

Id Subject Object Predicate Lexical cue
T2 0-7 6308 denotes Leucine
T3 0-7 SO:0001437 denotes Leucine
T1 0-7 CHEBI:15603 denotes Leucine
T4 0-7 D007930 denotes Leucine
T5 0-7 CHEBI:25017 denotes Leucine
T6 0-7 D007930 denotes Leucine
T7 13-19 SO:0001068 denotes repeat
T8 71-86 GO:0016310 denotes phosphorylation
T13 90-111 Q6P6W3 denotes histone deacetylase 3
T14 90-111 O88895 denotes histone deacetylase 3
T15 90-111 Q7Y0Y6 denotes histone deacetylase 3
T16 90-111 P56520 denotes histone deacetylase 3
T17 90-111 Q803C3 denotes histone deacetylase 3
T18 90-111 O15379 denotes histone deacetylase 3
T20 90-111 Q5RB76 denotes histone deacetylase 3
T21 90-111 PR:000008482 denotes histone deacetylase 3
T22 90-111 Q28DV3 denotes histone deacetylase 3
T23 90-111 Q4SFA0 denotes histone deacetylase 3
T24 90-111 Q6IRL9 denotes histone deacetylase 3
T19 90-111 C438596 denotes histone deacetylase 3
T26 116-123 PR:000041244 denotes histone
T25 116-123 D006657 denotes histone
T27 116-123 CHEBI:15358 denotes histone
T28 116-137 GO:0016575 denotes histone deacetylation
T29 124-137 MOP:0001030 denotes deacetylation
T30 151-158 D004194 denotes disease
T31 151-158 D004194 denotes disease
T32 246-262 UBERON:0002038 denotes substantia nigra
T33 309-316 32644 denotes unknown
T35 354-361 6308 denotes leucine
T36 354-361 SO:0001437 denotes leucine
T34 354-361 CHEBI:15603 denotes leucine
T37 354-361 D007930 denotes leucine
T38 354-361 CHEBI:25017 denotes leucine
T39 354-361 D007930 denotes leucine
T40 367-373 SO:0001068 denotes repeat
T41 384-389 PR:Q5S006 denotes LRRK2
T42 384-389 PR:000003033 denotes LRRK2
T43 384-389 PR:Q5S007 denotes LRRK2
T44 414-419 PR:Q5S006 denotes LRRK2
T45 414-419 PR:000003033 denotes LRRK2
T46 414-419 PR:Q5S007 denotes LRRK2
T47 424-433 D006151 denotes guanosine
T48 424-433 CHEBI:16750 denotes guanosine
T49 424-433 D006151 denotes guanosine
T50 434-448 Q9SIY3 denotes triphosphatase
T51 450-456 D020558 denotes GTPase
T52 498-503 PR:Q5S006 denotes LRRK2
T53 498-503 PR:000003033 denotes LRRK2
T54 498-503 PR:Q5S007 denotes LRRK2
T55 527-545 C566739 denotes autosomal-dominant
T57 559-566 PR:000041244 denotes Histone
T59 559-579 D006655 denotes Histone deacetylases
T60 595-601 CHEBI:40574 denotes acetyl
T61 595-601 CHEBI:46887 denotes acetyl
T62 614-620 SO:0001450 denotes lysine
T63 614-620 CHEBI:25094 denotes lysine
T64 614-620 D008239 denotes lysine
T66 614-620 D008239 denotes lysine
T67 614-620 CHEBI:18019 denotes lysine
T65 614-620 6536 denotes lysine
T69 633-640 PR:000041244 denotes histone
T68 633-640 D006657 denotes histone
T70 633-640 CHEBI:15358 denotes histone
T72 705-714 GO:0000785 denotes chromatin
T71 705-714 D002843 denotes chromatin
T73 742-747 PR:Q5S006 denotes LRRK2
T74 742-747 PR:000003033 denotes LRRK2
T75 742-747 PR:Q5S007 denotes LRRK2
T77 785-790 PR:Q6P6W3 denotes HDAC3
T78 785-790 PR:O88895 denotes HDAC3
T79 785-790 PR:O15379 denotes HDAC3
T80 785-790 PR:000008482 denotes HDAC3
T81 785-790 PR:P56520 denotes HDAC3
T82 785-790 PR:Q803C3 denotes HDAC3
T83 789-793 Q9MBC1 denotes 3 at
T84 789-793 CHEBI:40036 denotes 3 at
T89 794-797 Q62230 denotes Ser
T90 794-797 PR:000001931 denotes Ser
T93 794-797 PR:P18168 denotes Ser
T87 794-797 GO:0005790 denotes Ser
T91 794-797 SO:0001444 denotes Ser
T85 794-797 CHEBI:32838 denotes Ser
T86 794-797 CHEBI:32839 denotes Ser
T88 794-797 CHEBI:29999 denotes Ser
T92 794-797 CHEBI:17115 denotes Ser
T94 823-827 PR:Q54VQ7 denotes HDAC
T95 852-857 PR:Q5S006 denotes LRRK2
T96 852-857 PR:000003033 denotes LRRK2
T97 852-857 PR:Q5S007 denotes LRRK2
T98 871-884 MOP:0001030 denotes deacetylation
T100 888-891 CHEBI:25094 denotes Lys
T101 888-891 CHEBI:32563 denotes Lys
T102 888-891 CHEBI:133538 denotes Lys
T103 888-891 CHEBI:32553 denotes Lys
T104 888-891 CHEBI:32554 denotes Lys
T105 888-891 CHEBI:29967 denotes Lys
T106 888-891 CHEBI:18019 denotes Lys
T99 888-891 SO:0001450 denotes Lys
T107 888-893 PR:P50113 denotes Lys-5
T108 888-893 PR:Q20967 denotes Lys-5
T110 898-901 CHEBI:25094 denotes Lys
T111 898-901 CHEBI:32563 denotes Lys
T112 898-901 CHEBI:133538 denotes Lys
T113 898-901 CHEBI:32553 denotes Lys
T114 898-901 CHEBI:32554 denotes Lys
T115 898-901 CHEBI:29967 denotes Lys
T116 898-901 CHEBI:18019 denotes Lys
T109 898-901 SO:0001450 denotes Lys
T117 898-904 PR:P40495 denotes Lys-12
T118 898-904 PR:O14104 denotes Lys-12
T122 908-918 Q8SQP4 denotes histone H4
T123 908-918 P62802 denotes histone H4
T124 908-918 P80739 denotes histone H4
T125 908-918 Q28DR4 denotes histone H4
T126 908-918 Q8NIG3 denotes histone H4
T127 908-918 P82888 denotes histone H4
T128 908-918 P62790 denotes histone H4
T129 908-918 P84049 denotes histone H4
T130 908-918 P62793 denotes histone H4
T131 908-918 Q7LKT3 denotes histone H4
T132 908-918 P62792 denotes histone H4
T133 908-918 Q76NW2 denotes histone H4
T134 908-918 Q76FE7 denotes histone H4
T135 908-918 Q6WV73 denotes histone H4
T136 908-918 P62791 denotes histone H4
T137 908-918 Q6WZ83 denotes histone H4
T138 908-918 P62798 denotes histone H4
T139 908-918 P62776 denotes histone H4
T140 908-918 P62796 denotes histone H4
T141 908-918 P27996 denotes histone H4
T143 908-918 P62806 denotes histone H4
T144 908-918 P04915 denotes histone H4
T145 908-918 Q6ZXX3 denotes histone H4
T146 908-918 Q8I0Y4 denotes histone H4
T147 908-918 P80738 denotes histone H4
T148 908-918 P59259 denotes histone H4
T149 908-918 P62800 denotes histone H4
T150 908-918 P62803 denotes histone H4
T151 908-918 P50566 denotes histone H4
T152 908-918 P62805 denotes histone H4
T153 908-918 Q76H85 denotes histone H4
T154 908-918 P35057 denotes histone H4
T155 908-918 P62779 denotes histone H4
T156 908-918 P62795 denotes histone H4
T157 908-918 P62780 denotes histone H4
T158 908-918 Q76FF5 denotes histone H4
T159 908-918 Q76FF1 denotes histone H4
T160 908-918 P84050 denotes histone H4
T161 908-918 Q6WV90 denotes histone H4
T162 908-918 Q9U7D0 denotes histone H4
T163 908-918 P62778 denotes histone H4
T164 908-918 P84043 denotes histone H4
T165 908-918 P62804 denotes histone H4
T166 908-918 P62799 denotes histone H4
T167 908-918 P84046 denotes histone H4
T168 908-918 P84042 denotes histone H4
T169 908-918 Q6PMI5 denotes histone H4
T170 908-918 P0CG89 denotes histone H4
T171 908-918 P84041 denotes histone H4
T172 908-918 P62782 denotes histone H4
T173 908-918 Q7KQD1 denotes histone H4
T174 908-918 P62784 denotes histone H4
T175 908-918 Q27443 denotes histone H4
T176 908-918 Q43083 denotes histone H4
T177 908-918 Q76MU7 denotes histone H4
T178 908-918 P83865 denotes histone H4
T179 908-918 P62783 denotes histone H4
T180 908-918 P84047 denotes histone H4
T181 908-918 P09322 denotes histone H4
T182 908-918 Q6WV74 denotes histone H4
T183 908-918 P69152 denotes histone H4
T184 908-918 P62887 denotes histone H4
T185 908-918 P90516 denotes histone H4
T186 908-918 Q27765 denotes histone H4
T187 908-918 P02309 denotes histone H4
T188 908-918 P62797 denotes histone H4
T189 908-918 P91890 denotes histone H4
T190 908-918 P62781 denotes histone H4
T191 908-918 Q6V9I2 denotes histone H4
T192 908-918 P62777 denotes histone H4
T193 908-918 P84048 denotes histone H4
T194 908-918 Q4R362 denotes histone H4
T195 908-918 Q6LAF1 denotes histone H4
T196 908-918 P04914 denotes histone H4
T197 908-918 Q7M3Z5 denotes histone H4
T198 908-918 P62787 denotes histone H4
T199 908-918 P35059 denotes histone H4
T200 908-918 P62801 denotes histone H4
T201 908-918 P62789 denotes histone H4
T202 908-918 Q6LAF3 denotes histone H4
T203 908-918 PR:000008603 denotes histone H4
T204 908-918 Q8MTV8 denotes histone H4
T205 908-918 Q6WV72 denotes histone H4
T206 908-918 P84045 denotes histone H4
T207 908-918 Q5RCS7 denotes histone H4
T208 908-918 P91882 denotes histone H4
T209 908-918 P85945 denotes histone H4
T210 908-918 P84044 denotes histone H4
T211 908-918 P91849 denotes histone H4
T212 908-918 P84040 denotes histone H4
T213 908-918 Q9HDF5 denotes histone H4
T214 908-918 Q71V09 denotes histone H4
T215 908-918 Q76FD9 denotes histone H4
T216 908-918 P62788 denotes histone H4
T217 908-918 Q8J1L3 denotes histone H4
T218 908-918 P62794 denotes histone H4
T219 908-918 Q8T7J8 denotes histone H4
T220 908-918 P40287 denotes histone H4
T221 908-918 Q7K8C0 denotes histone H4
T222 908-918 P08436 denotes histone H4
T142 908-918 D006657 denotes histone H4
T223 942-946 SO:0000704 denotes gene
T224 947-960 GO:0006351 denotes transcription
T225 972-977 PR:Q5S006 denotes LRRK2
T226 972-977 PR:000003033 denotes LRRK2
T227 972-977 PR:Q5S007 denotes LRRK2
T228 997-1010 SO:0000199 denotes translocation
T230 1014-1019 PR:Q6P6W3 denotes HDAC3
T231 1014-1019 PR:O88895 denotes HDAC3
T232 1014-1019 PR:O15379 denotes HDAC3
T233 1014-1019 PR:000008482 denotes HDAC3
T234 1014-1019 PR:P56520 denotes HDAC3
T235 1014-1019 PR:Q803C3 denotes HDAC3
T236 1046-1057 GO:0005646 denotes karyopherin
T245 1077-1082 PR:Q6P6W3 denotes HDAC3
T246 1077-1082 PR:O88895 denotes HDAC3
T247 1077-1082 PR:O15379 denotes HDAC3
T248 1077-1082 PR:000008482 denotes HDAC3
T249 1077-1082 PR:P56520 denotes HDAC3
T250 1077-1082 PR:Q803C3 denotes HDAC3
T251 1083-1098 GO:0016310 denotes phosphorylation
T252 1115-1128 SO:0000199 denotes translocation
T253 1159-1176 D016627 denotes 6-hydroxydopamine
T254 1159-1176 D016627 denotes 6-hydroxydopamine
T255 1159-1176 CHEBI:78741 denotes 6-hydroxydopamine
T259 1178-1184 D016627 denotes 6-OHDA
T260 1178-1184 D016627 denotes 6-OHDA
T261 1178-1184 CHEBI:78741 denotes 6-OHDA
T262 1197-1202 PR:Q5S006 denotes LRRK2
T263 1197-1202 PR:000003033 denotes LRRK2
T264 1197-1202 PR:Q5S007 denotes LRRK2
T265 1218-1225 CL:0000187 denotes myocyte
T268 1218-1253 O89038 denotes myocyte-specific enhancer factor 2D
T269 1218-1253 Q63943 denotes myocyte-specific enhancer factor 2D
T271 1218-1253 PR:000010312 denotes myocyte-specific enhancer factor 2D
T272 1218-1253 Q14814 denotes myocyte-specific enhancer factor 2D
T270 1218-1253 D064326 denotes myocyte-specific enhancer factor 2D
T273 1235-1243 SO:0000165 denotes enhancer
T274 1305-1310 PR:Q5S006 denotes LRRK2
T275 1305-1310 PR:000003033 denotes LRRK2
T276 1305-1310 PR:Q5S007 denotes LRRK2
T277 1331-1337 D016627 denotes 6-OHDA
T278 1331-1337 D016627 denotes 6-OHDA
T279 1331-1337 CHEBI:78741 denotes 6-OHDA
T280 1346-1356 GO:0008219 denotes cell death
T282 1384-1389 PR:Q6P6W3 denotes HDAC3
T283 1384-1389 PR:O88895 denotes HDAC3
T284 1384-1389 PR:O15379 denotes HDAC3
T285 1384-1389 PR:000008482 denotes HDAC3
T286 1384-1389 PR:P56520 denotes HDAC3
T287 1384-1389 PR:Q803C3 denotes HDAC3
T288 1419-1424 PR:Q5S006 denotes LRRK2
T289 1419-1424 PR:000003033 denotes LRRK2
T290 1419-1424 PR:Q5S007 denotes LRRK2
T292 1444-1451 PR:000041244 denotes histone
T291 1444-1451 D006657 denotes histone
T293 1444-1451 CHEBI:15358 denotes histone
T294 1444-1464 SO:0001700 denotes histone modification
T295 1444-1464 GO:0016570 denotes histone modification
T297 1503-1508 PR:Q6P6W3 denotes HDAC3
T298 1503-1508 PR:O88895 denotes HDAC3
T299 1503-1508 PR:O15379 denotes HDAC3
T300 1503-1508 PR:000008482 denotes HDAC3
T301 1503-1508 PR:P56520 denotes HDAC3
T302 1503-1508 PR:Q803C3 denotes HDAC3
T303 1537-1549 GO:0051179 denotes localization

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 139-263 DRI_Background denotes Parkinson's disease (PD) is characterized by slow, progressive degeneration of dopaminergic neurons in the substantia nigra.
T2 264-413 DRI_Background denotes The cause of neuronal death in PD is largely unknown, but several genetic loci, including leucine-rich repeat kinase 2 (LRRK2), have been identified.
T3 414-558 DRI_Background denotes LRRK2 has guanosine triphosphatase (GTPase) and kinase activities, and mutations in LRRK2 are the major cause of autosomal-dominant familial PD.
T4 559-715 DRI_Background denotes Histone deacetylases (HDACs) remove acetyl groups from lysine residues on histone tails, promoting transcriptional repression via condensation of chromatin.
T5 716-837 DRI_Outcome denotes Here, we demonstrate that LRRK2 binds to and directly phosphorylates HDAC3 at Ser-424, thereby stimulating HDAC activity.
T6 838-961 DRI_Background denotes Specifically, LRRK2 promoted the deacetylation of Lys-5 and Lys-12 on histone H4, causing repression of gene transcription.
T7 962-1076 DRI_Background denotes Moreover, LRRK2 stimulated nuclear translocation of HDAC3 via the phoshorylation of karyopherin subunit α2 and α6.
T8 1077-1196 DRI_Background denotes HDAC3 phosphorylation and its nuclear translocation were increased in response to 6-hydroxydopamine (6-OHDA) treatment.
T9 1197-1304 DRI_Outcome denotes LRRK2 also inhibited myocyte-specific enhancer factor 2D activity, which is required for neuronal survival.
T10 1391-1550 DRI_Background denotes These findings suggest that LRRK2 affects epigenetic histone modification and neuronal survival by facilitating HDAC3 activity and regulating its localization.