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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 170-875 BACKGROUND denotes Augmented reality (AR) is the fusion of computer-generated and real-time images. AR can be used in surgery as a navigation tool, by creating a patient-specific virtual model through 3D software manipulation of DICOM imaging (e.g., CT scan). The virtual model can be superimposed to real-time images enabling transparency visualization of internal anatomy and accurate localization of tumors. However, the 3D model is rigid and does not take into account inner structures' deformations. We present a concept of automated AR registration, while the organs undergo deformation during surgical manipulation, based on finite element modeling (FEM) coupled with optical imaging of fluorescent surface fiducials.
T2 885-1644 METHODS denotes Two 10 × 1 mm wires (pseudo-tumors) and six 10 × 0.9 mm fluorescent fiducials were placed in ex vivo porcine kidneys (n = 10). Biomechanical FEM-based models were generated from CT scan. Kidneys were deformed and the shape changes were identified by tracking the fiducials, using a near-infrared optical system. The changes were registered automatically with the virtual model, which was deformed accordingly. Accuracy of prediction of pseudo-tumors' location was evaluated with a CT scan in the deformed status (ground truth). In vivo: fluorescent fiducials were inserted under ultrasound guidance in the kidney of one pig, followed by a CT scan. The FEM-based virtual model was superimposed on laparoscopic images by automatic registration of the fiducials.
T3 1654-2079 RESULTS denotes Biomechanical models were successfully generated and accurately superimposed on optical images. The mean measured distance between the estimated tumor by biomechanical propagation and the scanned tumor (ground truth) was 0.84 ± 0.42 mm. All fiducials were successfully placed in in vivo kidney and well visualized in near-infrared mode enabling accurate automatic registration of the virtual model on the laparoscopic images.
T4 2093-2342 CONCLUSIONS denotes Our preliminary experiments showed the potential of a biomechanical model with fluorescent fiducials to propagate the deformation of solid organs' surface to their inner structures including tumors with good accuracy and automatized robust tracking.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 238-242 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T2 280-281 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 311-312 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 457-461 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T5 656-658 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T6 667-668 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 986-1001 CVCL_AZ81|Spontaneously_immortalized_cell_line|Sus scrofa denotes porcine kidneys
T8 1108-1115 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T9 1165-1166 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 1201-1208 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T11 1364-1365 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 1501-1504 CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis denotes one
T13 1522-1523 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 2145-2146 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T1 49-61 GO:0051179 denotes localization
T2 79-85 D009369 denotes tumors
T3 79-85 D009369 denotes tumors
T4 200-206 SO:0000806 denotes fusion
T5 538-550 GO:0051179 denotes localization
T6 554-560 D009369 denotes tumors
T7 554-560 D009369 denotes tumors
T8 790-797 UBERON:0000062 denotes element
T9 790-797 CHEBI:33250 denotes element
T10 913-919 D009369 denotes tumors
T11 913-919 D009369 denotes tumors
T12 1328-1334 D009369 denotes tumors
T13 1328-1334 D009369 denotes tumors
T14 1491-1497 UBERON:0002113 denotes kidney
T16 1505-1508 P30941 denotes pig
T15 1505-1508 9823 denotes pig
T17 1799-1804 D009369 denotes tumor
T18 1799-1804 D009369 denotes tumor
T19 1850-1855 D009369 denotes tumor
T20 1850-1855 D009369 denotes tumor
T21 1941-1947 UBERON:0002113 denotes kidney
T22 2284-2290 D009369 denotes tumors
T23 2284-2290 D009369 denotes tumors