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PubMed:27792889 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 85-210 DRI_Outcome denotes This study tested the hypothesis that salsolinol, a derivative of dopamine, affects GnRH and LH secretion in lactating sheep.
T2 211-451 DRI_Outcome denotes In the in vivo experiment, the structural analogue of salsolinol, 1-methyl-3,4-dihydroisoquinoline (1-MeDIQ), was infused into the infundibular nucleus-median eminence of sheep at the fifth wk of lactation to antagonize salsolinol's action.
T3 452-617 DRI_Background denotes Simultaneously, cerebrospinal fluid from the third brain ventricle, to determine GnRH concentration, and plasma samples, to measure LH concentration, were collected.
T4 618-814 DRI_Background denotes In the in vitro experiment, the anterior pituitary (AP) explants from weaned sheep were incubated in culture medium containing 2 doses of salsolinol, 20 and 100 μg/mL (S20 and S100, respectively).
T5 815-950 DRI_Background denotes The concentration of LH in the collected media and relative expression of LHβ subunit messenger RNA in the AP explants were determined.
T6 951-1203 DRI_Approach denotes No significant difference was found in mean GnRH concentration in response to 1-MeDIQ infusion, but both mean plasma LH concentration and LH pulse frequency increased significantly (P < 0.001 and P < 0.05, respectively) compared with those in controls.
T7 1204-1346 DRI_Approach denotes Significantly higher LH concentrations occurred during the first (P < 0.001), second (P < 0.001), and fourth (P < 0.05) h of 1-MeDIQ infusion.
T8 1347-1551 DRI_Approach denotes In the in vitro study, both the S20 and S100 doses of salsolinol caused a significant decrease in the mean medium LH concentration compared with that in the control (P < 0.01 and P < 0.001, respectively).
T9 1552-1654 DRI_Approach denotes Salsolinol had no effect on the relative LHβ subunit messenger RNA expression in the incubated tissue.
T10 1655-1802 DRI_Outcome denotes In conclusion, salsolinol is a potential inhibitor of the secretory activity of the gonadotropic axis in lactating sheep, at least at the AP level.
T11 1803-1977 DRI_Background denotes Although no significant changes in GnRH release were directly confirmed, an increase in the frequency of LH pulses does not allow to exclude the central action of salsolinol.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 11-12 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 135-136 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 178-180 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T4 178-180 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T5 401-403 CVCL_A665|Cancer_cell_line|Homo sapiens denotes wk
T6 584-586 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T7 584-586 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T8 670-672 CVCL_E457|Transformed_cell_line|Homo sapiens denotes AP
T9 768-770 CVCL_J923|Hybridoma|Mus musculus denotes 20
T10 782-784 CVCL_F566|Transformed_cell_line|Homo sapiens denotes mL
T11 782-784 CVCL_W799|Cancer_cell_line|Homo sapiens denotes mL
T12 786-789 CVCL_VN74|Induced_pluripotent_stem_cell|Homo sapiens denotes S20
T13 786-789 CVCL_VU14|Cancer_cell_line|Mus musculus denotes S20
T14 836-838 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T15 836-838 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T16 889-891 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T17 889-891 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T18 922-924 CVCL_E457|Transformed_cell_line|Homo sapiens denotes AP
T19 1068-1070 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T20 1068-1070 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T21 1089-1091 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T22 1089-1091 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T23 1225-1227 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T24 1225-1227 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T25 1379-1382 CVCL_VN74|Induced_pluripotent_stem_cell|Homo sapiens denotes S20
T26 1379-1382 CVCL_VU14|Cancer_cell_line|Mus musculus denotes S20
T27 1419-1420 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T28 1461-1463 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T29 1461-1463 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T30 1593-1595 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T31 1593-1595 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH
T32 1684-1685 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T33 1723-1731 CVCL_C410|Hybridoma|Mus musculus denotes activity
T34 1793-1795 CVCL_E457|Transformed_cell_line|Homo sapiens denotes AP
T35 1827-1834 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T36 1876-1878 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T37 1876-1878 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T38 1908-1910 CVCL_M541|Cancer_cell_line|Homo sapiens denotes LH
T39 1908-1910 CVCL_V626|Transformed_cell_line|Homo sapiens denotes LH

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-10 C036617 denotes Salsolinol
T2 0-10 CHEBI:113 denotes Salsolinol
T3 0-10 C036617 denotes Salsolinol
T4 0-10 CHEBI:88801 denotes Salsolinol
T5 23-32 CHEBI:35222 denotes inhibitor
T6 53-57 UBERON:0001093 denotes axis
T7 61-66 9940 denotes sheep
T8 61-66 D012756 denotes sheep
T9 74-83 GO:0007595 denotes lactation
T10 123-133 C036617 denotes salsolinol
T11 123-133 CHEBI:113 denotes salsolinol
T12 123-133 C036617 denotes salsolinol
T13 123-133 CHEBI:88801 denotes salsolinol
T18 151-159 3628 denotes dopamine
T14 151-159 CHEBI:59905 denotes dopamine
T15 151-159 CHEBI:18243 denotes dopamine
T16 151-159 D004298 denotes dopamine
T17 151-159 D004298 denotes dopamine
T19 169-173 PR:P07490 denotes GnRH
T20 169-173 PR:000008127 denotes GnRH
T21 169-173 PR:P13562 denotes GnRH
T22 169-173 P27429 denotes GnRH
T25 169-173 PR:P01148 denotes GnRH
T23 169-173 D007987 denotes GnRH
T24 169-173 D007987 denotes GnRH
T26 181-190 GO:0046903 denotes secretion
T27 181-190 UBERON:0000456 denotes secretion
T28 204-209 9940 denotes sheep
T29 204-209 D012756 denotes sheep
T30 265-275 C036617 denotes salsolinol
T31 265-275 CHEBI:113 denotes salsolinol
T32 265-275 C036617 denotes salsolinol
T33 265-275 CHEBI:88801 denotes salsolinol
T34 277-309 C486859 denotes 1-methyl-3,4-dihydroisoquinoline
T35 277-309 C486859 denotes 1-methyl-3,4-dihydroisoquinoline
T43 342-362 UBERON:0001932 denotes infundibular nucleus
T46 355-362 GO:0005634 denotes nucleus
T44 355-362 CHEBI:33252 denotes nucleus
T47 363-378 UBERON:0002197 denotes median eminence
T48 382-387 9940 denotes sheep
T49 382-387 D012756 denotes sheep
T50 407-416 GO:0007595 denotes lactation
T51 431-441 C036617 denotes salsolinol
T52 431-441 CHEBI:113 denotes salsolinol
T53 431-441 C036617 denotes salsolinol
T54 431-441 CHEBI:88801 denotes salsolinol
T55 468-487 UBERON:0001359 denotes cerebrospinal fluid
T59 503-518 UBERON:0004086 denotes brain ventricle
T61 533-537 PR:P07490 denotes GnRH
T62 533-537 PR:000008127 denotes GnRH
T63 533-537 PR:P13562 denotes GnRH
T64 533-537 P27429 denotes GnRH
T67 533-537 PR:P01148 denotes GnRH
T65 533-537 D007987 denotes GnRH
T66 533-537 D007987 denotes GnRH
T68 557-563 UBERON:0001969 denotes plasma
T69 650-668 UBERON:0002196 denotes anterior pituitary
T70 650-668 D010900 denotes anterior pituitary
T71 650-668 D010900 denotes anterior pituitary
T73 695-700 9940 denotes sheep
T74 695-700 D012756 denotes sheep
T75 756-766 C036617 denotes salsolinol
T76 756-766 CHEBI:113 denotes salsolinol
T77 756-766 C036617 denotes salsolinol
T78 756-766 CHEBI:88801 denotes salsolinol
T84 786-789 CVCL_VU14 denotes S20
T85 786-789 CVCL_VN74 denotes S20
T88 901-914 SO:0000234 denotes messenger RNA
T86 901-914 D012333 denotes messenger RNA
T87 901-914 CHEBI:33699 denotes messenger RNA
T91 911-914 GO:0005562 denotes RNA
T93 995-999 PR:P07490 denotes GnRH
T94 995-999 PR:000008127 denotes GnRH
T95 995-999 PR:P13562 denotes GnRH
T96 995-999 P27429 denotes GnRH
T99 995-999 PR:P01148 denotes GnRH
T97 995-999 D007987 denotes GnRH
T98 995-999 D007987 denotes GnRH
T101 1061-1067 UBERON:0001969 denotes plasma
T103 1379-1382 CVCL_VU14 denotes S20
T104 1379-1382 CVCL_VN74 denotes S20
T105 1401-1411 C036617 denotes salsolinol
T106 1401-1411 CHEBI:113 denotes salsolinol
T107 1401-1411 C036617 denotes salsolinol
T108 1401-1411 CHEBI:88801 denotes salsolinol
T109 1552-1562 C036617 denotes Salsolinol
T110 1552-1562 CHEBI:113 denotes Salsolinol
T111 1552-1562 C036617 denotes Salsolinol
T112 1552-1562 CHEBI:88801 denotes Salsolinol
T115 1605-1618 SO:0000234 denotes messenger RNA
T113 1605-1618 D012333 denotes messenger RNA
T114 1605-1618 CHEBI:33699 denotes messenger RNA
T118 1615-1618 GO:0005562 denotes RNA
T120 1647-1653 UBERON:0000479 denotes tissue
T121 1670-1680 C036617 denotes salsolinol
T122 1670-1680 CHEBI:113 denotes salsolinol
T123 1670-1680 C036617 denotes salsolinol
T124 1670-1680 CHEBI:88801 denotes salsolinol
T125 1696-1705 CHEBI:35222 denotes inhibitor
T126 1752-1756 UBERON:0001093 denotes axis
T127 1770-1775 9940 denotes sheep
T128 1770-1775 D012756 denotes sheep
T129 1838-1842 PR:P07490 denotes GnRH
T130 1838-1842 PR:000008127 denotes GnRH
T131 1838-1842 PR:P13562 denotes GnRH
T132 1838-1842 P27429 denotes GnRH
T135 1838-1842 PR:P01148 denotes GnRH
T133 1838-1842 D007987 denotes GnRH
T134 1838-1842 D007987 denotes GnRH
T136 1966-1976 C036617 denotes salsolinol
T137 1966-1976 CHEBI:113 denotes salsolinol
T138 1966-1976 C036617 denotes salsolinol
T139 1966-1976 CHEBI:88801 denotes salsolinol