PubMed:27786439 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/27786439","sourcedb":"PubMed","sourceid":"27786439","text":"Pd-Catalyzed γ-C(sp(3))-H Arylation of Free Amines Using a Transient Directing Group.\nPd(II)-catalyzed γ-C(sp(3))-H arylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.","tracks":[{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":496,"end":501},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"8895"},{"subj":"T1","pred":"source","obj":"NCBITAXON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NCBITAXON","color":"#93ecb2","default":true}]}]}}