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PubMed:27783941 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 98-180 DRI_Challenge denotes Malignant brain tumors are the leading cause of cancer-related deaths in children.
T2 181-309 DRI_Background denotes Primitive neuroectodermal tumors of the CNS (CNS-PNETs) are particularly aggressive embryonal tumors of unknown cellular origin.
T3 310-564 DRI_Background denotes Recent genomic studies have classified CNS-PNETs into molecularly distinct subgroups that promise to improve diagnosis and treatment; however, the lack of cell- or animal-based models for these subgroups prevents testing of rationally designed therapies.
T4 565-595 DRI_Outcome denotes Here, we show that a subset of
T5 629-760 DRI_Outcome denotes precursor cell (OPC) markers OLIG2 and SOX10 with coincident activation of the RAS/MAPK (mitogen-activated protein kinase) pathway.
T6 761-878 DRI_Outcome denotes Modeling NRAS activation in embryonic OPCs generated malignant brain tumors in zebrafish that closely mimic the human
T7 909-960 DRI_Outcome denotes subgroup by histology and comparative oncogenomics.
T8 961-1134 DRI_Outcome denotes The zebrafish CNS-PNET model was used to show that MEK inhibitors selectively eliminate Olig2(+)/Sox10(+) CNS-PNET tumors in vivo without impacting normal brain development.
T9 1135-1233 DRI_Approach denotes Thus, MEK inhibitors represent a promising rationally designed therapy for children afflicted with
T10 1264-1265 DRI_Approach denotes .

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 146-152 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes cancer
T2 230-235 CVCL_4431|Cancer_cell_line|Homo sapiens denotes PNETs
T3 353-358 CVCL_4431|Cancer_cell_line|Homo sapiens denotes PNETs
T4 571-573 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T5 584-585 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 600-605 CVCL_4431|Cancer_cell_line|Homo sapiens denotes PNETs
T7 606-608 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T8 690-700 CVCL_C410|Hybridoma|Mus musculus denotes activation
T9 726-735 CVCL_C410|Hybridoma|Mus musculus denotes activated
T10 775-785 CVCL_C410|Hybridoma|Mus musculus denotes activation
T11 863-868 CVCL_Z366|Spontaneously_immortalized_cell_line|Spodoptera frugiperda denotes mimic
T12 904-908 CVCL_4431|Cancer_cell_line|Homo sapiens denotes PNET
T13 979-983 CVCL_4431|Cancer_cell_line|Homo sapiens denotes PNET
T14 1071-1075 CVCL_4431|Cancer_cell_line|Homo sapiens denotes PNET
T15 1166-1167 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 1259-1264 CVCL_4431|Cancer_cell_line|Homo sapiens denotes PNETs

GoldHamster

Id Subject Object Predicate Lexical cue
T2 0-14 CHEBI:88286 denotes MEK Inhibitors
T3 0-14 CHEBI:79091 denotes MEK Inhibitors
T5 15-22 SO:0001031 denotes Reverse
T6 43-55 D001932 denotes Brain Tumors
T7 43-55 D001932 denotes Brain Tumors
T10 81-90 PR:000000230 denotes Precursor
T11 81-90 PR:000000291 denotes Precursor
T12 108-113 UBERON:6110636 denotes brain
T13 108-113 UBERON:0000955 denotes brain
T14 108-120 D001932 denotes brain tumors
T15 108-120 D001932 denotes brain tumors
T18 181-213 D018242 denotes Primitive neuroectodermal tumors
T19 181-213 D018242 denotes Primitive neuroectodermal tumors
T24 221-224 UBERON:0001017 denotes CNS
T25 226-229 UBERON:0001017 denotes CNS
T26 230-235 D018242 denotes PNETs
T27 230-235 D018242 denotes PNETs
T28 275-281 D009369 denotes tumors
T29 275-281 D009369 denotes tumors
T30 285-292 32644 denotes unknown
T31 349-352 UBERON:0001017 denotes CNS
T32 353-358 D018242 denotes PNETs
T33 353-358 D018242 denotes PNETs
T34 457-461 PR:Q9V853 denotes lack
T35 474-480 UBERON:3010325 denotes animal
T36 474-480 UBERON:0000468 denotes animal
T37 596-599 UBERON:0001017 denotes CNS
T38 600-605 D018242 denotes PNETs
T39 600-605 D018242 denotes PNETs
T40 629-638 PR:000000230 denotes precursor
T41 629-638 PR:000000291 denotes precursor
T42 629-643 CL:0011115 denotes precursor cell
T43 658-663 PR:Q9EQW6 denotes OLIG2
T44 658-663 PR:000011632 denotes OLIG2
T45 658-663 PR:Q90XB3 denotes OLIG2
T46 658-663 PR:Q13516 denotes OLIG2
T58 668-673 PR:Q04888 denotes SOX10
T59 668-673 PR:P56693 denotes SOX10
T60 668-673 PR:O55170 denotes SOX10
T61 668-673 PR:Q9W757 denotes SOX10
T62 668-673 PR:000015418 denotes SOX10
T64 708-711 PR:P03967 denotes RAS
T65 708-711 PR:Q07152 denotes RAS
T63 708-711 CHEBI:63620 denotes RAS
T66 712-716 PR:P63086 denotes MAPK
T67 712-716 PR:P63085 denotes MAPK
T68 712-716 P27638 denotes MAPK
T69 712-716 PR:000000103 denotes MAPK
T71 712-716 PR:P40417 denotes MAPK
T72 712-716 PR:000000019 denotes MAPK
T70 712-716 GO:0004707 denotes MAPK
T73 718-725 CHEBI:52290 denotes mitogen
T74 718-750 PR:000000019 denotes mitogen-activated protein kinase
T75 718-750 Q00859 denotes mitogen-activated protein kinase
T80 736-743 SO:0000104 denotes protein
T76 736-743 GO:0003675 denotes protein
T81 736-750 D011494 denotes protein kinase
T82 752-759 CHEBI:34922 denotes pathway
T83 770-774 PR:000011416 denotes NRAS
T84 770-774 PR:P01111 denotes NRAS
T85 770-774 PR:P79737 denotes NRAS
T86 770-774 PR:Q04970 denotes NRAS
T87 770-774 PR:P08556 denotes NRAS
T88 770-774 PR:Q5F352 denotes NRAS
T89 789-798 P02301 denotes embryonic
T90 789-798 PR:000029532 denotes embryonic
T91 824-829 UBERON:6110636 denotes brain
T92 824-829 UBERON:0000955 denotes brain
T93 824-836 D001932 denotes brain tumors
T94 824-836 D001932 denotes brain tumors
T97 840-849 7955 denotes zebrafish
T98 840-849 D015027 denotes zebrafish
T99 863-868 CVCL_Z366 denotes mimic
T100 873-878 D006801 denotes human
T101 894-899 PR:Q3UM89 denotes FOXR2
T102 894-899 PR:000007648 denotes FOXR2
T103 894-899 PR:Q6PJQ5 denotes FOXR2
T104 900-903 UBERON:0001017 denotes CNS
T107 904-908 CVCL_4431 denotes PNET
T105 904-908 D018242 denotes PNET
T106 904-908 D018242 denotes PNET
T108 965-974 7955 denotes zebrafish
T109 965-974 D015027 denotes zebrafish
T110 975-978 UBERON:0001017 denotes CNS
T113 979-983 CVCL_4431 denotes PNET
T111 979-983 D018242 denotes PNET
T112 979-983 D018242 denotes PNET
T115 1012-1026 CHEBI:88286 denotes MEK inhibitors
T116 1012-1026 CHEBI:79091 denotes MEK inhibitors
T118 1049-1054 PR:Q9EQW6 denotes Olig2
T119 1049-1054 PR:000011632 denotes Olig2
T120 1049-1054 PR:Q90XB3 denotes Olig2
T121 1049-1054 PR:Q13516 denotes Olig2
T133 1058-1063 PR:Q04888 denotes Sox10
T134 1058-1063 PR:P56693 denotes Sox10
T135 1058-1063 PR:O55170 denotes Sox10
T136 1058-1063 PR:Q9W757 denotes Sox10
T137 1058-1063 PR:000015418 denotes Sox10
T138 1067-1070 UBERON:0001017 denotes CNS
T141 1071-1075 CVCL_4431 denotes PNET
T139 1071-1075 D018242 denotes PNET
T140 1071-1075 D018242 denotes PNET
T142 1076-1082 D009369 denotes tumors
T143 1076-1082 D009369 denotes tumors
T144 1116-1121 UBERON:6110636 denotes brain
T145 1116-1121 UBERON:0000955 denotes brain
T146 1116-1133 GO:0007420 denotes brain development
T148 1141-1155 CHEBI:88286 denotes MEK inhibitors
T149 1141-1155 CHEBI:79091 denotes MEK inhibitors
T151 1249-1254 PR:Q3UM89 denotes FOXR2
T152 1249-1254 PR:000007648 denotes FOXR2
T153 1249-1254 PR:Q6PJQ5 denotes FOXR2
T154 1255-1258 UBERON:0001017 denotes CNS
T155 1259-1264 D018242 denotes PNETs
T156 1259-1264 D018242 denotes PNETs