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c_corpus

Id Subject Object Predicate Lexical cue
T1 23-28 D006801 denotes human
T2 29-35 UBERON:0000310 denotes breast
T3 36-42 UBERON:0000479 denotes tissue
T6 54-67 CVCL_5552 denotes MCF10DCIS.com
T7 59-63 D002285 denotes DCIS
T9 59-63 D002285 denotes DCIS
T11 64-67 CHEBI:17905 denotes com
T12 104-114 D009362 denotes metastasis
T13 104-114 D009362 denotes metastasis
T14 211-217 UBERON:0000310 denotes breast
T15 211-224 D001943 denotes breast cancer
T16 211-224 D001943 denotes breast cancer
T17 337-347 D009362 denotes metastasis
T18 337-347 D009362 denotes metastasis
T19 415-421 UBERON:0000310 denotes breast
T20 422-428 UBERON:0000479 denotes tissue
T23 464-477 CVCL_5552 denotes MCF10DCIS.com
T24 469-473 D002285 denotes DCIS
T26 469-473 D002285 denotes DCIS
T28 474-477 CHEBI:17905 denotes com
T29 540-543 C537267 denotes LMD
T30 545-551 UBERON:0000479 denotes tissue
T31 570-576 UBERON:0000310 denotes breast
T32 682-685 C537267 denotes LMD
T33 754-759 D006801 denotes Human
T36 760-773 CVCL_5552 denotes MCF10DCIS.com
T37 765-769 D002285 denotes DCIS
T39 765-769 D002285 denotes DCIS
T41 770-773 CHEBI:17905 denotes com
T44 792-816 D002285 denotes ductal carcinoma in situ
T45 792-816 D002285 denotes ductal carcinoma in situ
T51 818-822 CVCL_5552 denotes DCIS
T50 818-822 D002285 denotes DCIS
T52 818-822 D002285 denotes DCIS
T53 845-853 CHEBI:48140 denotes silicone
T54 845-853 D012828 denotes silicone
T55 845-853 D012828 denotes silicone
T56 845-853 CHEBI:61459 denotes silicone
T57 883-915 D016511 denotes severe combined immunodeficiency
T58 883-915 D016511 denotes severe combined immunodeficiency
T59 916-920 PR:000005054 denotes mice
T61 916-920 O89094 denotes mice
T60 916-920 D051379 denotes mice
T62 916-920 10095 denotes mice
T63 951-954 C537267 denotes LMD
T64 962-968 UBERON:0000479 denotes tissue
T65 1170-1180 P13129 denotes luciferase
T66 1170-1180 Q27757 denotes luciferase
T67 1170-1180 P08659 denotes luciferase
T68 1170-1180 Q01158 denotes luciferase
T70 1170-1180 Q26304 denotes luciferase
T69 1170-1180 D008156 denotes luciferase
T71 1247-1253 UBERON:0000310 denotes breast
T72 1254-1260 UBERON:0000479 denotes tissue
T74 1367-1371 CVCL_5552 denotes DCIS
T73 1367-1371 D002285 denotes DCIS
T75 1367-1371 D002285 denotes DCIS
T76 1411-1414 C537267 denotes LMD
T77 1475-1479 PR:000005054 denotes mice
T79 1475-1479 O89094 denotes mice
T78 1475-1479 D051379 denotes mice
T80 1475-1479 10095 denotes mice
T81 1502-1508 UBERON:0000479 denotes tissue
T82 1586-1589 C537267 denotes LMD
T83 1590-1595 D006801 denotes human
T84 1596-1602 UBERON:0000310 denotes breast
T85 1603-1609 UBERON:0000479 denotes tissue
T87 1781-1785 CVCL_5552 denotes DCIS
T86 1781-1785 D002285 denotes DCIS
T88 1781-1785 D002285 denotes DCIS

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-115 DRI_Outcome denotes Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis.
T2 128-286 DRI_Outcome denotes High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages.
T3 287-370 DRI_Background denotes However, it is unclear whether BC progression and metastasis are stimulated by HMD.
T4 371-552 DRI_Outcome denotes We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue.
T5 562-673 DRI_Approach denotes Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10).
T6 674-753 DRI_Background denotes HMD and LMD regions of each specimen were resected under radiological guidance.
T7 754-1003 DRI_Background denotes Human MCF10DCIS.com cells, a model of ductal carcinoma in situ (DCIS), were implanted into silicone biochambers in the groins of severe combined immunodeficiency mice, either alone or with matched LMD or HMD tissue (1:1), and maintained for 6 weeks.
T8 1004-1195 DRI_Approach denotes We assessed biochamber weight as a measure of primary tumour growth, histological grade of the biochamber material, circulating tumour cells and metastatic burden by luciferase and histology.
T9 1196-1233 DRI_Approach denotes All statistical tests were two-sided.
T10 1243-1415 DRI_Background denotes HMD breast tissue led to increased primary tumour take, increased biochamber weight and increased proportions of high-grade DCIS and grade 3 invasive BCs compared with LMD.
T11 1416-1509 DRI_Outcome denotes This correlated with an increased metastatic burden in the mice co-implanted with HMD tissue.
T12 1523-1667 DRI_Challenge denotes Our study is the first to explore the direct effect of HMD and LMD human breast tissue on the progression and dissemination of BC cells in vivo.
T13 1668-1794 DRI_Challenge denotes The results suggest that HMD status should be a consideration in decision-making for management of patients with DCIS lesions.

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 128-552 BACKGROUND denotes High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue.
T2 562-1233 METHODS denotes Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10). HMD and LMD regions of each specimen were resected under radiological guidance. Human MCF10DCIS.com cells, a model of ductal carcinoma in situ (DCIS), were implanted into silicone biochambers in the groins of severe combined immunodeficiency mice, either alone or with matched LMD or HMD tissue (1:1), and maintained for 6 weeks. We assessed biochamber weight as a measure of primary tumour growth, histological grade of the biochamber material, circulating tumour cells and metastatic burden by luciferase and histology. All statistical tests were two-sided.
T3 1243-1509 RESULTS denotes HMD breast tissue led to increased primary tumour take, increased biochamber weight and increased proportions of high-grade DCIS and grade 3 invasive BCs compared with LMD. This correlated with an increased metastatic burden in the mice co-implanted with HMD tissue.
T4 1523-1794 CONCLUSIONS denotes Our study is the first to explore the direct effect of HMD and LMD human breast tissue on the progression and dissemination of BC cells in vivo. The results suggest that HMD status should be a consideration in decision-making for management of patients with DCIS lesions.