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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Epithelial Cholesterol Deficiency Attenuates Human Antigen R-linked Pro-inflammatory Stimulation via an SREBP2-linked Circuit.
T2 127-304 Sentence denotes Patients with chronic intestinal ulcerative diseases, such as inflammatory bowel disease, tend to exhibit abnormal lipid profiles, which may affect the gut epithelial integrity.
T3 305-528 Sentence denotes We hypothesized that epithelial cholesterol depletion may trigger inflammation-checking machinery via cholesterol sentinel signaling molecules whose disruption in patients may aggravate inflammation and disease progression.
T4 529-742 Sentence denotes In the present study, sterol regulatory element-binding protein 2 (SREBP2) as the cholesterol sentinel was assessed for its involvement in the epithelial inflammatory responses in cholesterol-depleted enterocytes.
T5 743-853 Sentence denotes Patients and experimental animals with intestinal ulcerative injuries showed suppression in epithelial SREBP2.
T6 854-1040 Sentence denotes Moreover, SREBP2-deficient enterocytes showed enhanced pro-inflammatory signals in response to inflammatory insults, indicating regulatory roles of SREBP2 in gut epithelial inflammation.
T7 1041-1213 Sentence denotes However, epithelial cholesterol depletion transiently induced pro-inflammatory chemokine expression regardless of the well known pro-inflammatory nuclear factor-κB signals.
T8 1214-1404 Sentence denotes In contrast, cholesterol depletion also exerts regulatory actions to maintain epithelial homeostasis against excessive inflammation via SREBP2-associated signals in a negative feedback loop.
T9 1405-1609 Sentence denotes Mechanistically, SREBP2 and its induced target EGR-1 were positively involved in induction of peroxisome proliferator-activated receptor γ (PPARγ), a representative anti-inflammatory transcription factor.
T10 1610-1825 Sentence denotes As a crucial target of the SREBP2-EGR-1-PPARγ-associated signaling pathways, the mRNA stabilizer, human antigen R (HuR) was retained in nuclei, leading to reduced stability of pro-inflammatory chemokine transcripts.
T11 1826-2084 Sentence denotes This mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR circuit, although the deficiency triggers transient pro-inflammatory signals.
T1 0-126 Sentence denotes Epithelial Cholesterol Deficiency Attenuates Human Antigen R-linked Pro-inflammatory Stimulation via an SREBP2-linked Circuit.
T2 127-304 Sentence denotes Patients with chronic intestinal ulcerative diseases, such as inflammatory bowel disease, tend to exhibit abnormal lipid profiles, which may affect the gut epithelial integrity.
T3 305-528 Sentence denotes We hypothesized that epithelial cholesterol depletion may trigger inflammation-checking machinery via cholesterol sentinel signaling molecules whose disruption in patients may aggravate inflammation and disease progression.
T4 529-742 Sentence denotes In the present study, sterol regulatory element-binding protein 2 (SREBP2) as the cholesterol sentinel was assessed for its involvement in the epithelial inflammatory responses in cholesterol-depleted enterocytes.
T5 743-853 Sentence denotes Patients and experimental animals with intestinal ulcerative injuries showed suppression in epithelial SREBP2.
T6 854-1040 Sentence denotes Moreover, SREBP2-deficient enterocytes showed enhanced pro-inflammatory signals in response to inflammatory insults, indicating regulatory roles of SREBP2 in gut epithelial inflammation.
T7 1041-1213 Sentence denotes However, epithelial cholesterol depletion transiently induced pro-inflammatory chemokine expression regardless of the well known pro-inflammatory nuclear factor-κB signals.
T8 1214-1404 Sentence denotes In contrast, cholesterol depletion also exerts regulatory actions to maintain epithelial homeostasis against excessive inflammation via SREBP2-associated signals in a negative feedback loop.
T9 1405-1609 Sentence denotes Mechanistically, SREBP2 and its induced target EGR-1 were positively involved in induction of peroxisome proliferator-activated receptor γ (PPARγ), a representative anti-inflammatory transcription factor.
T10 1610-1825 Sentence denotes As a crucial target of the SREBP2-EGR-1-PPARγ-associated signaling pathways, the mRNA stabilizer, human antigen R (HuR) was retained in nuclei, leading to reduced stability of pro-inflammatory chemokine transcripts.
T11 1826-2084 Sentence denotes This mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR circuit, although the deficiency triggers transient pro-inflammatory signals.

sentences

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Epithelial Cholesterol Deficiency Attenuates Human Antigen R-linked Pro-inflammatory Stimulation via an SREBP2-linked Circuit.
T2 127-304 Sentence denotes Patients with chronic intestinal ulcerative diseases, such as inflammatory bowel disease, tend to exhibit abnormal lipid profiles, which may affect the gut epithelial integrity.
T3 305-528 Sentence denotes We hypothesized that epithelial cholesterol depletion may trigger inflammation-checking machinery via cholesterol sentinel signaling molecules whose disruption in patients may aggravate inflammation and disease progression.
T4 529-742 Sentence denotes In the present study, sterol regulatory element-binding protein 2 (SREBP2) as the cholesterol sentinel was assessed for its involvement in the epithelial inflammatory responses in cholesterol-depleted enterocytes.
T5 743-853 Sentence denotes Patients and experimental animals with intestinal ulcerative injuries showed suppression in epithelial SREBP2.
T6 854-1040 Sentence denotes Moreover, SREBP2-deficient enterocytes showed enhanced pro-inflammatory signals in response to inflammatory insults, indicating regulatory roles of SREBP2 in gut epithelial inflammation.
T7 1041-1213 Sentence denotes However, epithelial cholesterol depletion transiently induced pro-inflammatory chemokine expression regardless of the well known pro-inflammatory nuclear factor-κB signals.
T8 1214-1404 Sentence denotes In contrast, cholesterol depletion also exerts regulatory actions to maintain epithelial homeostasis against excessive inflammation via SREBP2-associated signals in a negative feedback loop.
T9 1405-1609 Sentence denotes Mechanistically, SREBP2 and its induced target EGR-1 were positively involved in induction of peroxisome proliferator-activated receptor γ (PPARγ), a representative anti-inflammatory transcription factor.
T10 1610-1825 Sentence denotes As a crucial target of the SREBP2-EGR-1-PPARγ-associated signaling pathways, the mRNA stabilizer, human antigen R (HuR) was retained in nuclei, leading to reduced stability of pro-inflammatory chemokine transcripts.
T11 1826-2084 Sentence denotes This mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR circuit, although the deficiency triggers transient pro-inflammatory signals.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 149-159 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T2 279-282 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut
T3 782-792 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T4 1012-1015 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 160-170 Disease denotes ulcerative http://purl.obolibrary.org/obo/MONDO_0043839
T2 189-215 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T3 371-383 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T4 491-503 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T5 793-803 Disease denotes ulcerative http://purl.obolibrary.org/obo/MONDO_0043839
T6 1027-1039 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T7 1333-1345 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 189-215 Phenotype denotes inflammatory bowel disease HP:0002037

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 45-50 OrganismTaxon denotes Human 9606
T2 1708-1713 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 202-207 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T2 279-282 Body_part denotes gut http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907
T5 1012-1015 Body_part denotes gut http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 149-159 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T2 279-282 Body_part denotes gut http://purl.obolibrary.org/obo/MAT_0000043
T3 782-792 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T4 1012-1015 Body_part denotes gut http://purl.obolibrary.org/obo/MAT_0000043

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 730-741 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T2 881-892 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584