> top > docs > PubMed:27645929 > annotations

PubMed:27645929 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Astragalus polysaccharide modulates ER stress response in an OVA-LPS induced murine model of severe asthma.
T2 108-229 Sentence denotes Endoplasmic reticulum (ER) stress has been recently revealed to play a pivotal role in the pathogenesis of severe asthma.
T3 230-460 Sentence denotes Astragalus polysaccharide (APS), a major bioactive component from Astragalus membranaceus, exerts immunomodulatory and anti-inflammatory effects and has been shown to suppress ER stress in chronic diseases such as type-2 diabetes.
T4 461-553 Sentence denotes However, the pharmaceutical application of APS in the treatment of severe asthma is unknown.
T5 554-810 Sentence denotes The results obtained here indicate that APS significantly attenuates eosinophils and neutrophil-dominant airway inflammation by reducing the mRNA levels of Cxcl5, Il8, and chemokine (C-C motif) ligand 20 (Ccl20) and the protein levels of IL13RA and IL17RA.
T6 811-1022 Sentence denotes APS also inhibits the activation of unfolded protein response by decreasing the levels of ER stress markers such as C/EBP homologous protein (CHOP), which was associated with a reduction of PERK phosphorylation.
T7 1023-1106 Sentence denotes Moreover, APS substantially blocks the nuclear translocation of ATF6 and NF-κB p65.
T8 1107-1360 Sentence denotes Interestingly, we observed that APS markedly suppresses mucus hypersecretion by decreasing the levels of mucin (MUC) 5AC and MUC5B, which might be due to inhibition of goblet cells differentiation by suppressing the expression of IRE1β-correlated genes.
T9 1361-1453 Sentence denotes In summary, APS can have potential pharmaceutical application in treatment of severe asthma.
T1 0-107 Sentence denotes Astragalus polysaccharide modulates ER stress response in an OVA-LPS induced murine model of severe asthma.
T2 108-229 Sentence denotes Endoplasmic reticulum (ER) stress has been recently revealed to play a pivotal role in the pathogenesis of severe asthma.
T3 230-460 Sentence denotes Astragalus polysaccharide (APS), a major bioactive component from Astragalus membranaceus, exerts immunomodulatory and anti-inflammatory effects and has been shown to suppress ER stress in chronic diseases such as type-2 diabetes.
T4 461-553 Sentence denotes However, the pharmaceutical application of APS in the treatment of severe asthma is unknown.
T5 554-810 Sentence denotes The results obtained here indicate that APS significantly attenuates eosinophils and neutrophil-dominant airway inflammation by reducing the mRNA levels of Cxcl5, Il8, and chemokine (C-C motif) ligand 20 (Ccl20) and the protein levels of IL13RA and IL17RA.
T6 811-1022 Sentence denotes APS also inhibits the activation of unfolded protein response by decreasing the levels of ER stress markers such as C/EBP homologous protein (CHOP), which was associated with a reduction of PERK phosphorylation.
T7 1023-1106 Sentence denotes Moreover, APS substantially blocks the nuclear translocation of ATF6 and NF-κB p65.
T8 1107-1360 Sentence denotes Interestingly, we observed that APS markedly suppresses mucus hypersecretion by decreasing the levels of mucin (MUC) 5AC and MUC5B, which might be due to inhibition of goblet cells differentiation by suppressing the expression of IRE1β-correlated genes.
T9 1361-1453 Sentence denotes In summary, APS can have potential pharmaceutical application in treatment of severe asthma.