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PubMed:27643404 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11570 0-7 ChemicalEntity denotes Alcohol MESH:D000438
11571 24-39 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11572 100-115 DiseaseOrPhenotypicFeature denotes Prostate cancer MESH:D011471
11573 135-141 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
11574 145-148 OrganismTaxon denotes men NCBITaxon:9606
11575 235-242 ChemicalEntity denotes alcohol MESH:D000438
11576 258-273 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11577 456-463 ChemicalEntity denotes alcohol MESH:D000438
11578 488-503 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11579 557-560 OrganismTaxon denotes men NCBITaxon:9606
11580 566-581 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11581 743-750 ChemicalEntity denotes alcohol MESH:D000438
11582 771-793 GeneOrGeneProduct denotes Alcohol Dehydrogenases NCBIGene:125
11583 795-799 GeneOrGeneProduct denotes ADHs NCBIGene:125
11584 805-828 GeneOrGeneProduct denotes Aldehyde Dehydrogenases NCBIGene:8854
11585 830-835 GeneOrGeneProduct denotes ALDHs NCBIGene:8854
11586 843-858 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11587 873-888 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11588 1127-1134 ChemicalEntity denotes alcohol MESH:D000438
11589 1175-1190 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11590 1291-1306 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11591 1360-1367 GeneOrGeneProduct denotes ALDH1A2 NCBIGene:8854
11592 1384-1399 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11593 1415-1424 SequenceVariant denotes rs1441817 DBSNP:rs1441817
11594 1533-1543 SequenceVariant denotes rs12910509 DBSNP:rs12910509
11595 1602-1611 SequenceVariant denotes rs8041922 DBSNP:rs8041922
11596 1728-1735 GeneOrGeneProduct denotes ALDH1B1 NCBIGene:219
11597 1737-1747 SequenceVariant denotes rs10973794 DBSNP:rs10973794
11598 1821-1836 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11599 1850-1853 OrganismTaxon denotes men NCBITaxon:9606
11600 1869-1884 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
11601 1913-1920 ChemicalEntity denotes alcohol MESH:D000438
11602 1955-1970 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes Alcohol consumption and prostate cancer incidence and progression:
T2 67-99 Sentence denotes A Mendelian randomisation study.
T3 100-219 Sentence denotes Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies.
T4 220-384 Sentence denotes The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially due to methodological limitations of observational studies.
T5 385-527 Sentence denotes In this study, we investigated the associations of genetic variants in alcohol-metabolising genes with prostate cancer incidence and survival.
T6 528-664 Sentence denotes We analysed data from 23,868 men with prostate cancer and 23,051 controls from 25 studies within the international PRACTICAL Consortium.
T7 665-988 Sentence denotes Study-specific associations of 68 single nucleotide polymorphisms (SNPs) in 8 alcohol-metabolising genes (Alcohol Dehydrogenases (ADHs) and Aldehyde Dehydrogenases (ALDHs)) with prostate cancer diagnosis and prostate cancer-specific mortality, by grade, were assessed using logistic and Cox regression models, respectively.
T8 989-1084 Sentence denotes The data across the 25 studies were meta-analysed using fixed-effect and random-effects models.
T9 1085-1201 Sentence denotes We found little evidence that variants in alcohol metabolising genes were associated with prostate cancer diagnosis.
T10 1202-1347 Sentence denotes Four variants in two genes exceeded the multiple testing threshold for associations with prostate cancer mortality in fixed-effect meta-analyses.
T11 1348-1665 Sentence denotes SNPs within ALDH1A2 associated with prostate cancer mortality were rs1441817 (fixed effects hazard ratio, HRfixed  = 0.78; 95% confidence interval (95%CI):0.66,0.91; p values = 0.002); rs12910509, HRfixed  = 0.76; 95%CI:0.64,0.91; p values = 0.003); and rs8041922 (HRfixed  = 0.76; 95%CI:0.64,0.91; p values = 0.002).
T12 1666-1724 Sentence denotes These SNPs were in linkage disequilibrium with each other.
T13 1725-1885 Sentence denotes In ALDH1B1, rs10973794 (HRfixed  = 1.43; 95%CI:1.14,1.79; p values = 0.002) was associated with prostate cancer mortality in men with low-grade prostate cancer.
T14 1886-2023 Sentence denotes These results suggest that alcohol consumption is unlikely to affect prostate cancer incidence, but it may influence disease progression.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 24-39 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T2 33-39 DiseaseOrPhenotypicFeature denotes cancer 0004992
T3 100-115 DiseaseOrPhenotypicFeature denotes Prostate cancer 0008315
T4 109-115 DiseaseOrPhenotypicFeature denotes cancer 0004992
T5 135-141 DiseaseOrPhenotypicFeature denotes cancer 0004992
T6 258-273 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T7 267-273 DiseaseOrPhenotypicFeature denotes cancer 0004992
T8 488-503 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T9 497-503 DiseaseOrPhenotypicFeature denotes cancer 0004992
T10 566-581 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T11 575-581 DiseaseOrPhenotypicFeature denotes cancer 0004992
T12 843-858 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T13 852-858 DiseaseOrPhenotypicFeature denotes cancer 0004992
T14 873-888 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T15 882-888 DiseaseOrPhenotypicFeature denotes cancer 0004992
T16 1175-1190 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T17 1184-1190 DiseaseOrPhenotypicFeature denotes cancer 0004992
T18 1291-1306 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T19 1300-1306 DiseaseOrPhenotypicFeature denotes cancer 0004992
T20 1384-1399 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T21 1393-1399 DiseaseOrPhenotypicFeature denotes cancer 0004992
T22 1821-1836 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T23 1830-1836 DiseaseOrPhenotypicFeature denotes cancer 0004992
T24 1869-1884 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T25 1878-1884 DiseaseOrPhenotypicFeature denotes cancer 0004992
T26 1955-1970 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T27 1964-1970 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 1415-1424 SequenceVariant denotes rs1441817
T2 1533-1543 SequenceVariant denotes rs12910509
T3 1602-1611 SequenceVariant denotes rs8041922
T4 1737-1747 SequenceVariant denotes rs10973794

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-7 GeneOrGeneProduct denotes Alcohol
T2 235-242 GeneOrGeneProduct denotes alcohol
T3 304-311 GeneOrGeneProduct denotes unclear
T4 347-358 GeneOrGeneProduct denotes limitations
T5 456-463 GeneOrGeneProduct denotes alcohol
T6 738-742 GeneOrGeneProduct denotes in 8
T7 743-750 GeneOrGeneProduct denotes alcohol
T8 771-793 GeneOrGeneProduct denotes Alcohol Dehydrogenases
T9 795-799 GeneOrGeneProduct denotes ADHs
T10 805-828 GeneOrGeneProduct denotes Aldehyde Dehydrogenases
T11 830-835 GeneOrGeneProduct denotes ALDHs
T12 1025-1029 GeneOrGeneProduct denotes meta
T13 1094-1100 GeneOrGeneProduct denotes little
T14 1127-1134 GeneOrGeneProduct denotes alcohol
T15 1242-1250 GeneOrGeneProduct denotes multiple
T16 1251-1258 GeneOrGeneProduct denotes testing
T17 1333-1337 GeneOrGeneProduct denotes meta
T18 1360-1367 GeneOrGeneProduct denotes ALDH1A2
T19 1516-1522 GeneOrGeneProduct denotes values
T20 1581-1587 GeneOrGeneProduct denotes values
T21 1649-1655 GeneOrGeneProduct denotes values
T22 1718-1723 GeneOrGeneProduct denotes other
T23 1728-1735 GeneOrGeneProduct denotes ALDH1B1
T24 1785-1791 GeneOrGeneProduct denotes values
T25 1913-1920 GeneOrGeneProduct denotes alcohol

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-7 GeneOrGeneProduct denotes Alcohol
T2 235-242 GeneOrGeneProduct denotes alcohol
T3 304-311 GeneOrGeneProduct denotes unclear
T4 456-463 GeneOrGeneProduct denotes alcohol
T5 743-750 GeneOrGeneProduct denotes alcohol
T6 771-793 GeneOrGeneProduct denotes Alcohol Dehydrogenases
T7 795-799 GeneOrGeneProduct denotes ADHs
T8 805-828 GeneOrGeneProduct denotes Aldehyde Dehydrogenases
T9 830-835 GeneOrGeneProduct denotes ALDHs
T10 1094-1100 GeneOrGeneProduct denotes little
T11 1127-1134 GeneOrGeneProduct denotes alcohol
T12 1242-1250 GeneOrGeneProduct denotes multiple
T13 1360-1367 GeneOrGeneProduct denotes ALDH1A2
T14 1718-1723 GeneOrGeneProduct denotes other
T15 1728-1735 GeneOrGeneProduct denotes ALDH1B1
T16 1913-1920 GeneOrGeneProduct denotes alcohol

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 24-39 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T2 100-115 DiseaseOrPhenotypicFeature denotes Prostate cancer D011471
T3 135-141 DiseaseOrPhenotypicFeature denotes cancer D009369
T4 235-242 DiseaseOrPhenotypicFeature denotes alcohol D000437
T5 258-273 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T6 456-463 DiseaseOrPhenotypicFeature denotes alcohol D000437
T7 488-503 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T8 566-581 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T9 743-750 DiseaseOrPhenotypicFeature denotes alcohol D000437
T10 843-858 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T11 873-888 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T12 1127-1134 DiseaseOrPhenotypicFeature denotes alcohol D000437
T13 1175-1190 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T14 1291-1306 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T15 1384-1399 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T16 1821-1836 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T17 1869-1884 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T18 1913-1920 DiseaseOrPhenotypicFeature denotes alcohol D000437
T19 1955-1970 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T20 2003-2022 DiseaseOrPhenotypicFeature denotes disease progression D018450

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 771-793 GeneOrGeneProduct denotes Alcohol Dehydrogenases
T2 795-799 GeneOrGeneProduct denotes ADHs
T3 805-828 GeneOrGeneProduct denotes Aldehyde Dehydrogenases
T4 830-835 GeneOrGeneProduct denotes ALDHs
T5 1360-1367 GeneOrGeneProduct denotes ALDH1A2
T6 1728-1735 GeneOrGeneProduct denotes ALDH1B1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 24-39 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T2 100-115 DiseaseOrPhenotypicFeature denotes Prostate cancer 0008315
T3 145-148 DiseaseOrPhenotypicFeature denotes men 0017169
T4 258-273 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T5 488-503 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T6 557-560 DiseaseOrPhenotypicFeature denotes men 0017169
T7 566-581 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T8 843-858 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T9 873-888 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T10 1175-1190 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T11 1291-1306 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T12 1384-1399 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T13 1821-1836 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T14 1850-1853 DiseaseOrPhenotypicFeature denotes men 0017169
T15 1869-1884 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T16 1955-1970 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 24-39 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T2 100-115 DiseaseOrPhenotypicFeature denotes Prostate cancer D011471
T3 135-141 DiseaseOrPhenotypicFeature denotes cancer D009369
T4 258-273 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T5 488-503 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T6 566-581 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T7 843-858 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T8 873-888 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T9 1175-1190 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T10 1291-1306 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T11 1384-1399 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T12 1821-1836 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T13 1869-1884 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T14 1955-1970 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T15 2003-2022 DiseaseOrPhenotypicFeature denotes disease progression D018450

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 24-39 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T2 100-115 DiseaseOrPhenotypicFeature denotes Prostate cancer D011471
T3 135-141 DiseaseOrPhenotypicFeature denotes cancer D009369
T4 258-273 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T5 488-503 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T6 566-581 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T7 843-858 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T8 873-888 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T9 1175-1190 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T10 1291-1306 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T11 1384-1399 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T12 1821-1836 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T13 1869-1884 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T14 1955-1970 DiseaseOrPhenotypicFeature denotes prostate cancer D011471

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-7 ChemicalEntity denotes Alcohol http://purl.obolibrary.org/obo/CHEBI_30879
T2 235-242 ChemicalEntity denotes alcohol http://purl.obolibrary.org/obo/CHEBI_30879|http://purl.obolibrary.org/obo/CHEBI_16236|ChemicalEntity
T5 456-463 ChemicalEntity denotes alcohol http://purl.obolibrary.org/obo/CHEBI_30879|http://purl.obolibrary.org/obo/CHEBI_16236|ChemicalEntity
T8 743-750 ChemicalEntity denotes alcohol http://purl.obolibrary.org/obo/CHEBI_30879|http://purl.obolibrary.org/obo/CHEBI_16236|ChemicalEntity
T11 771-778 ChemicalEntity denotes Alcohol http://purl.obolibrary.org/obo/CHEBI_30879
T12 779-793 ChemicalEntity denotes Dehydrogenases D010088
T13 805-813 ChemicalEntity denotes Aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T14 814-828 ChemicalEntity denotes Dehydrogenases D010088
T15 1127-1134 ChemicalEntity denotes alcohol http://purl.obolibrary.org/obo/CHEBI_30879|http://purl.obolibrary.org/obo/CHEBI_16236|ChemicalEntity
T18 1913-1920 ChemicalEntity denotes alcohol http://purl.obolibrary.org/obo/CHEBI_30879|http://purl.obolibrary.org/obo/CHEBI_16236|ChemicalEntity

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 145-148 OrganismTaxon denotes men
T2 557-560 OrganismTaxon denotes men
T3 1850-1853 OrganismTaxon denotes men

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T18 1913-1920 ChemicalEntity denotes alcohol ChemicalEntity|http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T15 1127-1134 ChemicalEntity denotes alcohol ChemicalEntity|http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T14 814-828 ChemicalEntity denotes Dehydrogenases D010088
T13 805-813 ChemicalEntity denotes Aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T12 779-793 ChemicalEntity denotes Dehydrogenases D010088
T11 771-778 ChemicalEntity denotes Alcohol http://purl.obolibrary.org/obo/CHEBI_30879
T8 743-750 ChemicalEntity denotes alcohol ChemicalEntity|http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T5 456-463 ChemicalEntity denotes alcohol ChemicalEntity|http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T2 235-242 ChemicalEntity denotes alcohol ChemicalEntity|http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T1 0-7 ChemicalEntity denotes Alcohol http://purl.obolibrary.org/obo/CHEBI_30879
T6 1728-1735 GeneOrGeneProduct denotes ALDH1B1
T57780 1360-1367 GeneOrGeneProduct denotes ALDH1A2
T4 830-835 GeneOrGeneProduct denotes ALDHs
T3 805-828 GeneOrGeneProduct denotes Aldehyde Dehydrogenases
T27409 795-799 GeneOrGeneProduct denotes ADHs
T44645 771-793 GeneOrGeneProduct denotes Alcohol Dehydrogenases
T65812 1955-1970 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T46454 1869-1884 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T21619 1821-1836 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T88518 1384-1399 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T10 1291-1306 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T9 1175-1190 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T53558 873-888 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T7 843-858 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T11356 566-581 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T6402 488-503 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T51538 258-273 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T31196 135-141 DiseaseOrPhenotypicFeature denotes cancer D009369
T75782 100-115 DiseaseOrPhenotypicFeature denotes Prostate cancer D011471
T23550 24-39 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T95376 1850-1853 OrganismTaxon denotes men
T43298 557-560 OrganismTaxon denotes men
T81201 145-148 OrganismTaxon denotes men
T46907 1737-1747 SequenceVariant denotes rs10973794
T31857 1602-1611 SequenceVariant denotes rs8041922
T39333 1533-1543 SequenceVariant denotes rs12910509
T96964 1415-1424 SequenceVariant denotes rs1441817