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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11530 11-14 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11531 15-20 GeneOrGeneProduct denotes IFN-γ NCBIGene:15978
11532 54-57 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11533 58-63 GeneOrGeneProduct denotes IFN-γ NCBIGene:15978
11534 64-69 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11535 94-99 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11536 168-185 DiseaseOrPhenotypicFeature denotes Malaria Infection MESH:D008288
11537 187-190 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11538 215-220 GeneOrGeneProduct denotes IFN-γ NCBIGene:15978
11539 255-260 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11540 276-285 DiseaseOrPhenotypicFeature denotes infection MESH:D007239
11541 368-371 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11542 374-379 GeneOrGeneProduct denotes IFN-γ NCBIGene:15978
11543 382-387 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11544 430-439 DiseaseOrPhenotypicFeature denotes infection MESH:D007239
11545 565-570 GeneOrGeneProduct denotes IFN-γ NCBIGene:15978
11546 608-613 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11547 632-636 OrganismTaxon denotes mice NCBITaxon:10090
11548 659-676 DiseaseOrPhenotypicFeature denotes malaria infection MESH:D008288
11549 685-688 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11550 765-770 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11551 828-831 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11552 904-907 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11553 1062-1066 GeneOrGeneProduct denotes PD-1 NCBIGene:18566
11554 1068-1073 GeneOrGeneProduct denotes Lag-3 NCBIGene:16768
11555 1079-1084 GeneOrGeneProduct denotes TIGIT NCBIGene:100043314
11556 1149-1152 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11557 1269-1278 DiseaseOrPhenotypicFeature denotes infection MESH:D007239
11558 1293-1296 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11559 1366-1371 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11560 1400-1409 DiseaseOrPhenotypicFeature denotes infection MESH:D007239
11561 1428-1431 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11562 1504-1509 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11563 1555-1572 DiseaseOrPhenotypicFeature denotes malaria infection MESH:D008288
11564 1583-1588 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11565 1654-1657 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11566 1820-1825 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11567 1836-1839 GeneOrGeneProduct denotes CD4 NCBIGene:12504
11568 1896-1901 GeneOrGeneProduct denotes IL-10 NCBIGene:16153
11569 2007-2025 DiseaseOrPhenotypicFeature denotes malaria infections MESH:D008288

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-186 Sentence denotes Long-Lived CD4+IFN-γ+ T Cells rather than Short-Lived CD4+IFN-γ+IL-10+ T Cells Initiate Rapid IL-10 Production To Suppress Anamnestic T Cell Responses during Secondary Malaria Infection.
T2 187-349 Sentence denotes CD4(+) T cells that produce IFN-γ are the source of host-protective IL-10 during primary infection with a number of different pathogens, including Plasmodium spp.
T3 350-539 Sentence denotes The fate of these CD4(+)IFN-γ(+)IL-10(+) T cells following clearance of primary infection and their subsequent influence on the course of repeated infections is, however, presently unknown.
T4 540-903 Sentence denotes In this study, utilizing IFN-γ-yellow fluorescent protein (YFP) and IL-10-GFP dual reporter mice, we show that primary malaria infection-induced CD4(+)YFP(+)GFP(+) T cells have limited memory potential, do not stably express IL-10, and are disproportionately lost from the Ag-experienced CD4(+) T cell memory population during the maintenance phase postinfection.
T5 904-1120 Sentence denotes CD4(+)YFP(+)GFP(+) T cells generally exhibited a short-lived effector rather than effector memory T cell phenotype postinfection and expressed high levels of PD-1, Lag-3, and TIGIT, indicative of cellular exhaustion.
T6 1121-1279 Sentence denotes Consistently, the surviving CD4(+)YFP(+)GFP(+) T cell-derived cells were unresponsive and failed to proliferate during the early phase of secondary infection.
T7 1280-1410 Sentence denotes In contrast, CD4(+)YFP(+)GFP(-) T cell-derived cells expanded rapidly and upregulated IL-10 expression during secondary infection.
T8 1411-1573 Sentence denotes Correspondingly, CD4(+) T cells were the major producers within an accelerated and amplified IL-10 response during the early stage of secondary malaria infection.
T9 1574-1732 Sentence denotes Notably, IL-10 exerted quantitatively stronger regulatory effects on innate and CD4(+) T cell responses during primary and secondary infections, respectively.
T10 1733-2026 Sentence denotes The results in this study significantly improve our understanding of the durability of IL-10-producing CD4(+) T cells postinfection and provide information on how IL-10 may contribute to optimized parasite control and prevention of immune-mediated pathology during repeated malaria infections.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 334-344 OrganismTaxon denotes Plasmodium NCBItxid:5820|NCBItxid:418103
T3 632-636 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 168-175 DiseaseOrPhenotypicFeature denotes Malaria 0005136
T2 659-666 DiseaseOrPhenotypicFeature denotes malaria 0005136
T3 1555-1562 DiseaseOrPhenotypicFeature denotes malaria 0005136
T4 2007-2014 DiseaseOrPhenotypicFeature denotes malaria 0005136

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 610-617 SequenceVariant denotes -10-GFP

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-10 GeneOrGeneProduct denotes Long-Lived
T2 11-14 GeneOrGeneProduct denotes CD4
T3 15-18 GeneOrGeneProduct denotes IFN
T4 24-29 GeneOrGeneProduct denotes Cells
T5 54-57 GeneOrGeneProduct denotes CD4
T6 58-61 GeneOrGeneProduct denotes IFN
T7 64-69 GeneOrGeneProduct denotes IL-10
T8 73-78 GeneOrGeneProduct denotes Cells
T9 79-87 GeneOrGeneProduct denotes Initiate
T10 94-99 GeneOrGeneProduct denotes IL-10
T11 100-110 GeneOrGeneProduct denotes Production
T12 136-140 GeneOrGeneProduct denotes Cell
T13 187-190 GeneOrGeneProduct denotes CD4
T14 196-201 GeneOrGeneProduct denotes cells
T15 215-218 GeneOrGeneProduct denotes IFN
T16 255-260 GeneOrGeneProduct denotes IL-10
T17 354-358 GeneOrGeneProduct denotes fate
T18 368-371 GeneOrGeneProduct denotes CD4
T19 374-377 GeneOrGeneProduct denotes IFN
T20 382-387 GeneOrGeneProduct denotes IL-10
T21 393-398 GeneOrGeneProduct denotes cells
T22 531-538 GeneOrGeneProduct denotes unknown
T23 565-568 GeneOrGeneProduct denotes IFN
T24 571-577 GeneOrGeneProduct denotes yellow
T25 590-597 GeneOrGeneProduct denotes protein
T26 608-613 GeneOrGeneProduct denotes IL-10
T27 632-636 GeneOrGeneProduct denotes mice
T28 677-684 GeneOrGeneProduct denotes induced
T29 685-688 GeneOrGeneProduct denotes CD4
T30 697-705 GeneOrGeneProduct denotes GFP(+) T
T31 706-711 GeneOrGeneProduct denotes cells
T32 717-724 GeneOrGeneProduct denotes limited
T33 765-770 GeneOrGeneProduct denotes IL-10
T34 799-803 GeneOrGeneProduct denotes lost
T35 828-831 GeneOrGeneProduct denotes CD4
T36 837-841 GeneOrGeneProduct denotes cell
T37 904-907 GeneOrGeneProduct denotes CD4
T38 916-924 GeneOrGeneProduct denotes GFP(+) T
T39 925-930 GeneOrGeneProduct denotes cells
T40 965-973 GeneOrGeneProduct denotes effector
T41 986-994 GeneOrGeneProduct denotes effector
T42 1004-1008 GeneOrGeneProduct denotes cell
T43 1047-1051 GeneOrGeneProduct denotes high
T44 1062-1066 GeneOrGeneProduct denotes PD-1
T45 1068-1073 GeneOrGeneProduct denotes Lag-3
T46 1079-1084 GeneOrGeneProduct denotes TIGIT
T47 1149-1152 GeneOrGeneProduct denotes CD4
T48 1161-1169 GeneOrGeneProduct denotes GFP(+) T
T49 1170-1174 GeneOrGeneProduct denotes cell
T50 1183-1188 GeneOrGeneProduct denotes cells
T51 1244-1249 GeneOrGeneProduct denotes early
T52 1283-1291 GeneOrGeneProduct denotes contrast
T53 1293-1296 GeneOrGeneProduct denotes CD4
T54 1305-1313 GeneOrGeneProduct denotes GFP(-) T
T55 1314-1318 GeneOrGeneProduct denotes cell
T56 1327-1332 GeneOrGeneProduct denotes cells
T57 1333-1341 GeneOrGeneProduct denotes expanded
T58 1366-1371 GeneOrGeneProduct denotes IL-10
T59 1428-1431 GeneOrGeneProduct denotes CD4
T60 1437-1442 GeneOrGeneProduct denotes cells
T61 1452-1457 GeneOrGeneProduct denotes major
T62 1504-1509 GeneOrGeneProduct denotes IL-10
T63 1530-1535 GeneOrGeneProduct denotes early
T64 1583-1588 GeneOrGeneProduct denotes IL-10
T65 1654-1657 GeneOrGeneProduct denotes CD4
T66 1663-1667 GeneOrGeneProduct denotes cell
T67 1820-1825 GeneOrGeneProduct denotes IL-10
T68 1836-1839 GeneOrGeneProduct denotes CD4
T69 1845-1850 GeneOrGeneProduct denotes cells
T70 1896-1901 GeneOrGeneProduct denotes IL-10
T71 1965-1971 GeneOrGeneProduct denotes immune
T72 1972-1980 GeneOrGeneProduct denotes mediated

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-10 GeneOrGeneProduct denotes Long-Lived
T2 64-69 GeneOrGeneProduct denotes IL-10
T3 94-99 GeneOrGeneProduct denotes IL-10
T4 255-260 GeneOrGeneProduct denotes IL-10
T5 382-387 GeneOrGeneProduct denotes IL-10
T6 531-538 GeneOrGeneProduct denotes unknown
T7 571-577 GeneOrGeneProduct denotes yellow
T8 590-597 GeneOrGeneProduct denotes protein
T9 608-613 GeneOrGeneProduct denotes IL-10
T10 697-705 GeneOrGeneProduct denotes GFP(+) T
T11 717-724 GeneOrGeneProduct denotes limited
T12 765-770 GeneOrGeneProduct denotes IL-10
T13 799-803 GeneOrGeneProduct denotes lost
T14 837-841 GeneOrGeneProduct denotes cell
T15 916-924 GeneOrGeneProduct denotes GFP(+) T
T16 965-973 GeneOrGeneProduct denotes effector
T17 986-994 GeneOrGeneProduct denotes effector
T18 1004-1008 GeneOrGeneProduct denotes cell
T19 1047-1051 GeneOrGeneProduct denotes high
T20 1062-1066 GeneOrGeneProduct denotes PD-1
T21 1068-1073 GeneOrGeneProduct denotes Lag-3
T22 1079-1084 GeneOrGeneProduct denotes TIGIT
T23 1161-1169 GeneOrGeneProduct denotes GFP(+) T
T24 1170-1174 GeneOrGeneProduct denotes cell
T25 1244-1249 GeneOrGeneProduct denotes early
T26 1305-1313 GeneOrGeneProduct denotes GFP(-) T
T27 1314-1318 GeneOrGeneProduct denotes cell
T28 1333-1341 GeneOrGeneProduct denotes expanded
T29 1366-1371 GeneOrGeneProduct denotes IL-10
T30 1452-1457 GeneOrGeneProduct denotes major
T31 1504-1509 GeneOrGeneProduct denotes IL-10
T32 1530-1535 GeneOrGeneProduct denotes early
T33 1583-1588 GeneOrGeneProduct denotes IL-10
T34 1663-1667 GeneOrGeneProduct denotes cell
T35 1820-1825 GeneOrGeneProduct denotes IL-10
T36 1896-1901 GeneOrGeneProduct denotes IL-10

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 168-175 DiseaseOrPhenotypicFeature denotes Malaria D008288
T2 176-185 DiseaseOrPhenotypicFeature denotes Infection D007239
T3 276-285 DiseaseOrPhenotypicFeature denotes infection D007239
T4 430-439 DiseaseOrPhenotypicFeature denotes infection D007239
T5 497-507 DiseaseOrPhenotypicFeature denotes infections D007239
T6 659-666 DiseaseOrPhenotypicFeature denotes malaria D008288
T7 667-676 DiseaseOrPhenotypicFeature denotes infection D007239
T8 1259-1278 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T9 1390-1409 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T10 1555-1562 DiseaseOrPhenotypicFeature denotes malaria D008288
T11 1563-1572 DiseaseOrPhenotypicFeature denotes infection D007239
T12 1697-1717 DiseaseOrPhenotypicFeature denotes secondary infections D060085
T13 2007-2014 DiseaseOrPhenotypicFeature denotes malaria D008288
T14 2015-2025 DiseaseOrPhenotypicFeature denotes infections D007239

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-10 GeneOrGeneProduct denotes Long-Lived
T2 15-20 GeneOrGeneProduct denotes IFN-γ
T3 58-63 GeneOrGeneProduct denotes IFN-γ
T4 64-69 GeneOrGeneProduct denotes IL-10
T5 94-99 GeneOrGeneProduct denotes IL-10
T6 215-220 GeneOrGeneProduct denotes IFN-γ
T7 255-260 GeneOrGeneProduct denotes IL-10
T8 374-379 GeneOrGeneProduct denotes IFN-γ
T9 382-387 GeneOrGeneProduct denotes IL-10
T10 565-570 GeneOrGeneProduct denotes IFN-γ
T11 571-577 GeneOrGeneProduct denotes yellow
T12 608-613 GeneOrGeneProduct denotes IL-10
T13 765-770 GeneOrGeneProduct denotes IL-10
T14 1062-1066 GeneOrGeneProduct denotes PD-1
T15 1068-1073 GeneOrGeneProduct denotes Lag-3
T16 1079-1084 GeneOrGeneProduct denotes TIGIT
T17 1366-1371 GeneOrGeneProduct denotes IL-10
T18 1504-1509 GeneOrGeneProduct denotes IL-10
T19 1583-1588 GeneOrGeneProduct denotes IL-10
T20 1820-1825 GeneOrGeneProduct denotes IL-10
T21 1896-1901 GeneOrGeneProduct denotes IL-10

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 168-175 DiseaseOrPhenotypicFeature denotes Malaria 0005136
T2 176-185 DiseaseOrPhenotypicFeature denotes Infection 0005550
T3 276-285 DiseaseOrPhenotypicFeature denotes infection 0005550
T4 430-439 DiseaseOrPhenotypicFeature denotes infection 0005550
T5 659-666 DiseaseOrPhenotypicFeature denotes malaria 0005136
T6 667-676 DiseaseOrPhenotypicFeature denotes infection 0005550
T7 1062-1064 DiseaseOrPhenotypicFeature denotes PD 0015873|0008199
T9 1269-1278 DiseaseOrPhenotypicFeature denotes infection 0005550
T10 1400-1409 DiseaseOrPhenotypicFeature denotes infection 0005550
T11 1555-1562 DiseaseOrPhenotypicFeature denotes malaria 0005136
T12 1563-1572 DiseaseOrPhenotypicFeature denotes infection 0005550
T13 2007-2014 DiseaseOrPhenotypicFeature denotes malaria 0005136

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 168-175 DiseaseOrPhenotypicFeature denotes Malaria D008288
T2 176-185 DiseaseOrPhenotypicFeature denotes Infection D007239
T3 276-285 DiseaseOrPhenotypicFeature denotes infection D007239
T4 430-439 DiseaseOrPhenotypicFeature denotes infection D007239
T5 497-507 DiseaseOrPhenotypicFeature denotes infections D007239
T6 659-666 DiseaseOrPhenotypicFeature denotes malaria D008288
T7 667-676 DiseaseOrPhenotypicFeature denotes infection D007239
T8 1259-1278 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T9 1390-1409 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T10 1555-1562 DiseaseOrPhenotypicFeature denotes malaria D008288
T11 1563-1572 DiseaseOrPhenotypicFeature denotes infection D007239
T12 1697-1717 DiseaseOrPhenotypicFeature denotes secondary infections D060085
T13 2007-2014 DiseaseOrPhenotypicFeature denotes malaria D008288
T14 2015-2025 DiseaseOrPhenotypicFeature denotes infections D007239

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 168-175 DiseaseOrPhenotypicFeature denotes Malaria D008288
T2 659-666 DiseaseOrPhenotypicFeature denotes malaria D008288
T3 1259-1278 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T4 1390-1409 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T5 1555-1562 DiseaseOrPhenotypicFeature denotes malaria D008288
T6 1697-1717 DiseaseOrPhenotypicFeature denotes secondary infections D060085
T7 2007-2014 DiseaseOrPhenotypicFeature denotes malaria D008288

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 334-344 OrganismTaxon denotes Plasmodium
T2 632-636 OrganismTaxon denotes mice

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label
T21 1896-1901 GeneOrGeneProduct denotes IL-10
T20 1820-1825 GeneOrGeneProduct denotes IL-10
T19 1583-1588 GeneOrGeneProduct denotes IL-10
T18 1504-1509 GeneOrGeneProduct denotes IL-10
T17 1366-1371 GeneOrGeneProduct denotes IL-10
T16 1079-1084 GeneOrGeneProduct denotes TIGIT
T15 1068-1073 GeneOrGeneProduct denotes Lag-3
T14 1062-1066 GeneOrGeneProduct denotes PD-1
T13 765-770 GeneOrGeneProduct denotes IL-10
T12 608-613 GeneOrGeneProduct denotes IL-10
T11 571-577 GeneOrGeneProduct denotes yellow
T10 565-570 GeneOrGeneProduct denotes IFN-γ
T9 382-387 GeneOrGeneProduct denotes IL-10
T8 374-379 GeneOrGeneProduct denotes IFN-γ
T7 255-260 GeneOrGeneProduct denotes IL-10
T6 215-220 GeneOrGeneProduct denotes IFN-γ
T5 94-99 GeneOrGeneProduct denotes IL-10
T4 64-69 GeneOrGeneProduct denotes IL-10
T3 58-63 GeneOrGeneProduct denotes IFN-γ
T2 15-20 GeneOrGeneProduct denotes IFN-γ
T1 0-10 GeneOrGeneProduct denotes Long-Lived
T40239 2007-2014 DiseaseOrPhenotypicFeature denotes malaria D008288
T16149 1697-1717 DiseaseOrPhenotypicFeature denotes secondary infections D060085
T62517 1555-1562 DiseaseOrPhenotypicFeature denotes malaria D008288
T71002 1390-1409 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T41846 1259-1278 DiseaseOrPhenotypicFeature denotes secondary infection D060085
T87857 659-666 DiseaseOrPhenotypicFeature denotes malaria D008288
T73555 168-175 DiseaseOrPhenotypicFeature denotes Malaria D008288
T60724 632-636 OrganismTaxon denotes mice
T35515 334-344 OrganismTaxon denotes Plasmodium
T93856 610-617 SequenceVariant denotes -10-GFP