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PubMed:2760054 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 70-77 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 91-98 Glycan_Motif denotes Heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 236-243 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-90 Sentence denotes Antithrombin activity of a peptide corresponding to residues 54-75 of heparin cofactor II.
T2 91-265 Sentence denotes Heparin cofactor II (HCII) is a highly specific serine proteinase inhibitor, which complexes covalently with thrombin in a reaction catalyzed by heparin and other polyanions.
T3 266-428 Sentence denotes The molecular basis for the thrombin specificity may be explained by the identification here of a segment of HCII including residues 54-75 that binds to thrombin.
T4 429-627 Sentence denotes A synthetic peptide, HCII(54-75), based on this segment of HCII, Gly-Glu-Glu-Asp-Asp-Asp-Tyr-Leu-Asp-Leu-Glu- Lys-Ile-Phe-Ala-Glu-Asp-Asp-Asp-Tyr-Ile-Asp inhibited thrombin's cleavage of fibrinogen.
T5 628-708 Sentence denotes Clotting activity of thrombin was inhibited 50% at a concentration of 28 microM.
T6 709-856 Sentence denotes Polyacrylamide gel electrophoresis showed that HCII(54-75) inhibited thrombin's cleavage of both the A alpha and B beta polypeptides in fibrinogen.
T7 857-974 Sentence denotes However, the peptide did not block thrombin's active site, as hydrolysis of chromogenic substrates was not inhibited.
T8 975-1108 Sentence denotes HCII(54-75) probably binds to the same site on thrombin as do carboxyl-terminal residues of hirudins, thrombin inhibitors of leeches.
T9 1109-1306 Sentence denotes HCII(54-75) inhibited binding of thrombin to a synthetic peptide corresponding to residues 54-66 of hirudin PA, but the hirudin peptide was about 30-fold more potent in binding and clotting assays.
T10 1307-1442 Sentence denotes Both synthetic peptides, as a result of their polyanionic character, might be expected to stimulate the reaction of HCII with thrombin.
T11 1443-1586 Sentence denotes However, the hirudin-related peptide inhibited this reaction, suggesting that it blocked a site on thrombin required for interaction with HCII.
T12 1587-1778 Sentence denotes HCII(54-75) had a net stimulatory effect on the thrombin-HCII reaction as a consequence of its lower affinity for thrombin and greater negative charge relative to the hirudin-related peptide.
T13 1779-1965 Sentence denotes These studies suggest that residues 54-75 of HCII interact with a noncatalytic binding site on thrombin and that this interaction contributes to efficient inhibition of thrombin by HCII.
T1 0-90 Sentence denotes Antithrombin activity of a peptide corresponding to residues 54-75 of heparin cofactor II.
T2 91-265 Sentence denotes Heparin cofactor II (HCII) is a highly specific serine proteinase inhibitor, which complexes covalently with thrombin in a reaction catalyzed by heparin and other polyanions.
T3 266-428 Sentence denotes The molecular basis for the thrombin specificity may be explained by the identification here of a segment of HCII including residues 54-75 that binds to thrombin.
T4 429-627 Sentence denotes A synthetic peptide, HCII(54-75), based on this segment of HCII, Gly-Glu-Glu-Asp-Asp-Asp-Tyr-Leu-Asp-Leu-Glu- Lys-Ile-Phe-Ala-Glu-Asp-Asp-Asp-Tyr-Ile-Asp inhibited thrombin's cleavage of fibrinogen.
T5 628-708 Sentence denotes Clotting activity of thrombin was inhibited 50% at a concentration of 28 microM.
T6 709-856 Sentence denotes Polyacrylamide gel electrophoresis showed that HCII(54-75) inhibited thrombin's cleavage of both the A alpha and B beta polypeptides in fibrinogen.
T7 857-974 Sentence denotes However, the peptide did not block thrombin's active site, as hydrolysis of chromogenic substrates was not inhibited.
T8 975-1108 Sentence denotes HCII(54-75) probably binds to the same site on thrombin as do carboxyl-terminal residues of hirudins, thrombin inhibitors of leeches.
T9 1109-1306 Sentence denotes HCII(54-75) inhibited binding of thrombin to a synthetic peptide corresponding to residues 54-66 of hirudin PA, but the hirudin peptide was about 30-fold more potent in binding and clotting assays.
T10 1307-1442 Sentence denotes Both synthetic peptides, as a result of their polyanionic character, might be expected to stimulate the reaction of HCII with thrombin.
T11 1443-1586 Sentence denotes However, the hirudin-related peptide inhibited this reaction, suggesting that it blocked a site on thrombin required for interaction with HCII.
T12 1587-1778 Sentence denotes HCII(54-75) had a net stimulatory effect on the thrombin-HCII reaction as a consequence of its lower affinity for thrombin and greater negative charge relative to the hirudin-related peptide.
T13 1779-1965 Sentence denotes These studies suggest that residues 54-75 of HCII interact with a noncatalytic binding site on thrombin and that this interaction contributes to efficient inhibition of thrombin by HCII.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 70-77 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 70-77 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 91-98 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T4 91-98 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T5 236-243 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 236-243 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

2015-BEL-Sample

Id Subject Object Predicate Lexical cue
T1 91-264 a(CHEBI:heparin) increases complex(p(MGI:Serpind1),p(MGI:F2)) denotes Heparin cofactor II (HCII) is a highly specific serine proteinase inhibitor, which complexes covalently with thrombin in a reaction catalyzed by heparin and other polyanions

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20000002 91-264 a(CHEBI:heparin) increases complex(p(MGI:Serpind1),p(MGI:F2)) denotes Heparin cofactor II (HCII) is a highly specific serine proteinase inhibitor, which complexes covalently with thrombin in a reaction catalyzed by heparin and other polyanions

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1100-1107 Disease denotes leeches http://purl.obolibrary.org/obo/MONDO_0001191

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 364-371 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914
T2 477-484 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914