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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome:
T2 90-143 Sentence denotes A post-hoc analysis of a randomized controlled trial.
T3 144-155 Sentence denotes BACKGROUND:
T4 156-270 Sentence denotes Cytokines are involved in the development of metabolic abnormalities that may result in metabolic syndrome (MetS).
T5 271-459 Sentence denotes Since curcumin has shown anti-inflammatory properties, the aim of this study was to evaluate the effect of curcumin supplementation on serum cytokines concentrations in subjects with MetS.
T6 460-468 Sentence denotes METHODS:
T7 469-719 Sentence denotes This study was a post-hoc analysis of a randomized controlled trial in which males and females with diagnosis of MetS, according to the criteria defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines, were studied.
T8 720-870 Sentence denotes Subjects who met the inclusion criteria were randomly assigned to either curcumin (daily dose of 1g/day) or a matched placebo for a period of 8 weeks.
T9 871-879 Sentence denotes RESULTS:
T10 880-980 Sentence denotes One hundred and seventeen subjects were assigned to either curcumin (n=59) or placebo (n=58) groups.
T11 981-1136 Sentence denotes Within-group analysis revealed significant reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 following curcumin supplementation (p<0.001).
T12 1137-1310 Sentence denotes In the placebo group, serum levels of TGF-β were decreased (p=0.003) but those of IL-6 (p=0.735), TNF-α (p=0.138) and MCP-1 (p=0.832) remained unaltered by the end of study.
T13 1311-1482 Sentence denotes Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 in the curcumin versus placebo group (p<0.001).
T14 1483-1710 Sentence denotes Apart from IL-6, changes in other parameters remained statistically significant after adjustment for potential confounders including changes in serum lipids and glucose levels, and baseline serum concentration of the cytokines.
T15 1711-1722 Sentence denotes CONCLUSION:
T16 1723-1887 Sentence denotes Results of the present study suggest that curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.
T1 0-89 Sentence denotes Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome:
T2 90-143 Sentence denotes A post-hoc analysis of a randomized controlled trial.
T3 144-155 Sentence denotes BACKGROUND:
T4 156-270 Sentence denotes Cytokines are involved in the development of metabolic abnormalities that may result in metabolic syndrome (MetS).
T5 271-459 Sentence denotes Since curcumin has shown anti-inflammatory properties, the aim of this study was to evaluate the effect of curcumin supplementation on serum cytokines concentrations in subjects with MetS.
T6 460-468 Sentence denotes METHODS:
T7 469-719 Sentence denotes This study was a post-hoc analysis of a randomized controlled trial in which males and females with diagnosis of MetS, according to the criteria defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines, were studied.
T8 720-870 Sentence denotes Subjects who met the inclusion criteria were randomly assigned to either curcumin (daily dose of 1g/day) or a matched placebo for a period of 8 weeks.
T9 871-879 Sentence denotes RESULTS:
T10 880-980 Sentence denotes One hundred and seventeen subjects were assigned to either curcumin (n=59) or placebo (n=58) groups.
T11 981-1136 Sentence denotes Within-group analysis revealed significant reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 following curcumin supplementation (p<0.001).
T12 1137-1310 Sentence denotes In the placebo group, serum levels of TGF-β were decreased (p=0.003) but those of IL-6 (p=0.735), TNF-α (p=0.138) and MCP-1 (p=0.832) remained unaltered by the end of study.
T13 1311-1482 Sentence denotes Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 in the curcumin versus placebo group (p<0.001).
T14 1483-1710 Sentence denotes Apart from IL-6, changes in other parameters remained statistically significant after adjustment for potential confounders including changes in serum lipids and glucose levels, and baseline serum concentration of the cytokines.
T15 1711-1722 Sentence denotes CONCLUSION:
T16 1723-1887 Sentence denotes Results of the present study suggest that curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.

yangbin123xm_800_3

Id Subject Object Predicate Lexical cue
T1 70-88 DP denotes metabolic syndrome
T2 244-262 DP denotes metabolic syndrome
T3 264-268 DP denotes MetS
T4 454-458 DP denotes MetS
T5 582-586 DP denotes MetS
T6 1882-1886 DP denotes MetS
T7 11-19 CI denotes curcumin
T8 277-285 CI denotes curcumin
T9 378-386 CI denotes curcumin
T10 793-801 CI denotes curcumin
T11 939-947 CI denotes curcumin
T12 1101-1109 CI denotes curcumin
T13 1442-1450 CI denotes curcumin
T14 1765-1773 CI denotes curcumin
T15 1458-1465 CI denotes placebo
T16 838-845 CI denotes placebo
T17 958-965 CI denotes placebo
T18 1144-1151 CI denotes placebo

chenxin_473849_800_3

Id Subject Object Predicate Lexical cue
T1 939-947 CI denotes curcumin
T2 11-19 CI denotes curcumin
T3 277-285 CI denotes curcumin
T4 378-386 CI denotes curcumin
T5 793-801 CI denotes curcumin
T6 1101-1109 CI denotes curcumin
T7 1442-1450 CI denotes curcumin
T8 1765-1773 CI denotes curcumin
T9 958-965 CI denotes placebo
T10 838-845 CI denotes placebo
T11 1144-1151 CI denotes placebo
T12 1458-1465 CI denotes placebo
T13 244-262 DP denotes metabolic syndrome
T14 70-88 DP denotes metabolic syndrome
T15 264-268 DP denotes MetS
T16 454-458 DP denotes MetS
T17 582-586 DP denotes MetS
T18 1882-1886 DP denotes MetS