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c_corpus

Id Subject Object Predicate Lexical cue
T1 24-29 PR:000009131 denotes CD49f
T2 31-35 PR:P15379 denotes CD44
T3 31-35 PR:P26051 denotes CD44
T4 31-35 PR:000001307 denotes CD44
T5 31-35 PR:P16070 denotes CD44
T6 37-41 PR:Q07490 denotes CD24
T7 37-41 PR:P25063 denotes CD24
T8 37-41 PR:000001932 denotes CD24
T9 37-41 PR:P24807 denotes CD24
T10 63-72 CL:0000034 denotes stem cell
T12 98-102 CVCL_5552 denotes DCIS
T11 98-102 D002285 denotes DCIS
T13 98-102 D002285 denotes DCIS
T16 155-179 D002285 denotes Ductal Carcinoma in Situ
T17 155-179 D002285 denotes Ductal Carcinoma in Situ
T23 181-185 CVCL_5552 denotes DCIS
T22 181-185 D002285 denotes DCIS
T24 181-185 D002285 denotes DCIS
T25 196-212 D044584 denotes Ductal Carcinoma
T26 196-212 D044584 denotes Ductal Carcinoma
T29 219-229 SO:1000009 denotes transition
T30 268-272 PR:Q9V853 denotes lack
T32 319-323 CVCL_5552 denotes DCIS
T31 319-323 D002285 denotes DCIS
T33 319-323 D002285 denotes DCIS
T34 343-353 D012008 denotes recurrence
T35 343-353 D012008 denotes recurrence
T36 397-404 D009369 denotes cancers
T37 397-404 D009369 denotes cancers
T38 482-487 PR:000009131 denotes CD49f
T39 489-493 PR:P15379 denotes CD44
T40 489-493 PR:P26051 denotes CD44
T41 489-493 PR:000001307 denotes CD44
T42 489-493 PR:P16070 denotes CD44
T43 495-499 PR:Q07490 denotes CD24
T44 495-499 PR:P25063 denotes CD24
T45 495-499 PR:000001932 denotes CD24
T46 495-499 PR:P24807 denotes CD24
T47 639-644 D006801 denotes human
T49 645-649 CVCL_5552 denotes DCIS
T48 645-649 D002285 denotes DCIS
T50 645-649 D002285 denotes DCIS
T52 666-675 CVCL_5552 denotes MCF10DCIS
T53 671-675 D002285 denotes DCIS
T55 671-675 D002285 denotes DCIS
T63 712-716 GO:0004030 denotes ALDH
T70 712-717 PR:P13601 denotes ALDH1
T71 712-717 PR:P24549 denotes ALDH1
T72 712-717 P81178 denotes ALDH1
T73 712-717 PR:P00352 denotes ALDH1
T74 712-717 PR:P54115 denotes ALDH1
T75 712-717 PR:000003920 denotes ALDH1
T76 712-717 P11884 denotes ALDH1
T79 741-744 SO:0000352 denotes DNA
T77 741-744 GO:0005574 denotes DNA
T78 741-744 CHEBI:16991 denotes DNA
T80 741-744 D004247 denotes DNA
T81 741-756 GO:0006306 denotes DNA methylation
T82 745-756 MOP:0000364 denotes methylation
T84 785-794 CL:0000034 denotes stem cell
T96 846-850 Q6IUU3 denotes SOX2
T97 846-850 PR:P48432 denotes SOX2
T98 846-850 PR:P48431 denotes SOX2
T99 846-850 PR:Q6P0E1 denotes SOX2
T100 846-850 PR:000015426 denotes SOX2
T101 846-850 PR:Q21305 denotes SOX2
T102 846-850 PR:P48430 denotes SOX2
T103 846-850 PR:Q6IUU3 denotes SOX2
T104 849-854 PR:O64515 denotes 2/OCT
T107 851-855 P20263 denotes OCT4
T108 851-855 Q5TM49 denotes OCT4
T109 851-855 Q9TSV5 denotes OCT4
T110 851-855 PR:P20263 denotes OCT4
T111 851-855 PR:Q01860 denotes OCT4
T112 851-855 PR:Q9LHQ6 denotes OCT4
T113 851-855 Q01860 denotes OCT4
T114 851-855 PR:000013044 denotes OCT4
T115 936-943 SO:0001463 denotes lincRNA
T116 944-947 PR:Q24488 denotes RoR
T130 952-958 Q8N423 denotes miR-10
T131 952-958 PR:Q8N423 denotes miR-10
T132 952-958 PR:000009809 denotes miR-10
T134 956-959 PR:000002397 denotes 10b
T133 956-959 CHEBI:77014 denotes 10b
T135 956-959 CVCL_IR41 denotes 10b
T136 1165-1171 D009369 denotes tumors
T137 1165-1171 D009369 denotes tumors
T138 1175-1179 PR:Q9CZA6 denotes nude
T139 1175-1179 PR:Q9VT70 denotes nude
T140 1175-1179 Q9CZA6 denotes nude
T141 1175-1179 PR:000023423 denotes nude
T142 1175-1179 PR:P45799 denotes nude
T143 1175-1179 PR:000011051 denotes nude
T144 1175-1179 PR:Q9NXR1 denotes nude
T145 1175-1179 Q9ES39 denotes nude
T146 1175-1179 Q9NXR1 denotes nude
T147 1175-1179 PR:Q9ES39 denotes nude
T148 1175-1184 10090 denotes nude mice
T149 1175-1184 D008819 denotes nude mice
T150 1180-1184 PR:000005054 denotes mice
T152 1180-1184 O89094 denotes mice
T154 1248-1255 SO:0001463 denotes lincRNA
T155 1256-1259 PR:Q24488 denotes RoR
T169 1264-1269 Q8N423 denotes miR10
T170 1264-1269 PR:Q8N423 denotes miR10
T171 1264-1269 PR:000009809 denotes miR10
T173 1267-1270 PR:000002397 denotes 10b
T172 1267-1270 CHEBI:77014 denotes 10b
T174 1267-1270 CVCL_IR41 denotes 10b
T175 1370-1375 PR:000009131 denotes CD49f
T176 1377-1381 PR:P15379 denotes CD44
T177 1377-1381 PR:P26051 denotes CD44
T178 1377-1381 PR:000001307 denotes CD44
T179 1377-1381 PR:P16070 denotes CD44
T180 1383-1387 PR:Q07490 denotes CD24
T181 1383-1387 PR:P25063 denotes CD24
T182 1383-1387 PR:000001932 denotes CD24
T183 1383-1387 PR:P24807 denotes CD24
T184 1389-1393 D002285 denotes DCIS
T186 1389-1393 D002285 denotes DCIS
T185 1389-1393 CVCL_5552 denotes DCIS
T188 1489-1493 CVCL_5552 denotes DCIS
T187 1489-1493 D002285 denotes DCIS
T189 1489-1493 D002285 denotes DCIS
T190 1498-1508 SO:1000009 denotes transition

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 110-256 DRI_Background denotes The molecular mechanisms responsible for the Ductal Carcinoma in Situ (DCIS)-Invasive Ductal Carcinoma (IDC) transition have yet to be elucidated.
T2 257-405 DRI_Background denotes Due to the lack of molecularly targeted therapies, basal-like DCIS has a high risk of recurrence and progression to invasive and metastatic cancers.
T3 406-676 DRI_Background denotes In this study, by applying a novel single-cell clonogenic approach with the CD49f+/CD44+/CD24- surface markers, we characterized the aggressive clones that have enhanced self-renewal, migratory and invasive capacities derived from a human DCIS model cell line MCF10DCIS.
T4 677-856 DRI_Outcome denotes The aggressive clones had elevated ALDH1 activity, lower global DNA methylation and increased expression of stem cell related genes, especially concurrent activation of SOX2/OCT4.
T5 857-1051 DRI_Outcome denotes In addition, we showed that the aggressive clones have increased expression of lincRNA-RoR and miR-10b compared to non-aggressive clones, which enhance their self-renewal and invasive abilities.
T6 1052-1225 DRI_Outcome denotes Finally, we confirmed our in vitro results in vivo, demonstrating that aggressive clones were capable of forming tumors in nude mice, whereas non-aggressive clones were not.
T7 1226-1405 DRI_Outcome denotes Our data suggest that lincRNA-RoR and miR10b could be used to distinguish aggressive clones from non-aggressive clones within the heterogeneous CD49f+/CD44+/CD24- DCIS population.
T8 1406-1509 DRI_Approach denotes Our findings also provide the foundation to develop new chemoprevention agents for DCIS-IDC transition.