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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity.
T2 114-247 Sentence denotes Perfluorodecanoic acid (PFDA) is widely used in production of many daily necessities based on their surface properties and stability.
T3 248-445 Sentence denotes It was assigned as a Persistent Organic Pollutant in 2009 and became a public concern partly because of its potential for activation of the peroxisome proliferator-activated receptor alpha (PPARα).
T4 446-525 Sentence denotes In this study, wild-type and Ppara-null mice were administered PFDA (80 mg/kg).
T5 526-630 Sentence denotes Blood and liver tissues were collected and subjected to systemic toxicological and mechanistic analysis.
T6 631-798 Sentence denotes UPLC-ESI-QTOFMS-based metabolomics was used to explore the contributing components of the serum metabolome that led to variation between wild-type and Pparα-null mice.
T7 799-968 Sentence denotes Bile acid homeostasis was disrupted, and slight hepatocyte injury in wild-type mice accompanied by adaptive regulation of bile acid synthesis and transport was observed.
T8 969-1102 Sentence denotes The serum metabolome in wild-type clustered differently from that in Pparα-null, featured by sharp increases in bile acid components.
T9 1103-1274 Sentence denotes Differential toxicokinetic tendency was supported by regulation of UDP-glucuronosyltransferases dependent on PPARα, but it did not contribute to the hepatotoxic responses.
T10 1275-1419 Sentence denotes Increase in Il-10 and activation of the JNK pathway indicated inflammation was induced by disruption of bile acid homeostasis in wild-type mice.
T11 1420-1582 Sentence denotes Inhibition of p-p65 dependent on PPARα activation by PFDA stopped the inflammatory cascade, as indicated by negative response of Il-6, Tnf-α, and STAT3 signaling.
T12 1583-1679 Sentence denotes These data suggest disruptive and protective role of PPARα in hepatic responses induced by PFDA.
T1 0-113 Sentence denotes Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity.
T2 114-247 Sentence denotes Perfluorodecanoic acid (PFDA) is widely used in production of many daily necessities based on their surface properties and stability.
T3 248-445 Sentence denotes It was assigned as a Persistent Organic Pollutant in 2009 and became a public concern partly because of its potential for activation of the peroxisome proliferator-activated receptor alpha (PPARα).
T4 446-525 Sentence denotes In this study, wild-type and Ppara-null mice were administered PFDA (80 mg/kg).
T5 526-630 Sentence denotes Blood and liver tissues were collected and subjected to systemic toxicological and mechanistic analysis.
T6 631-798 Sentence denotes UPLC-ESI-QTOFMS-based metabolomics was used to explore the contributing components of the serum metabolome that led to variation between wild-type and Pparα-null mice.
T7 799-968 Sentence denotes Bile acid homeostasis was disrupted, and slight hepatocyte injury in wild-type mice accompanied by adaptive regulation of bile acid synthesis and transport was observed.
T8 969-1102 Sentence denotes The serum metabolome in wild-type clustered differently from that in Pparα-null, featured by sharp increases in bile acid components.
T9 1103-1274 Sentence denotes Differential toxicokinetic tendency was supported by regulation of UDP-glucuronosyltransferases dependent on PPARα, but it did not contribute to the hepatotoxic responses.
T10 1275-1419 Sentence denotes Increase in Il-10 and activation of the JNK pathway indicated inflammation was induced by disruption of bile acid homeostasis in wild-type mice.
T11 1420-1582 Sentence denotes Inhibition of p-p65 dependent on PPARα activation by PFDA stopped the inflammatory cascade, as indicated by negative response of Il-6, Tnf-α, and STAT3 signaling.
T12 1583-1679 Sentence denotes These data suggest disruptive and protective role of PPARα in hepatic responses induced by PFDA.

Wangshuguang

Id Subject Object Predicate Lexical cue
T1 114-131 I-Variation denotes Perfluorodecanoic
T2 132-136 I-Variation denotes acid
T3 370-380 B-Negative_Function denotes activation
T4 670-674 B-Regulation denotes used
T5 675-677 I-Regulation denotes to
T6 678-685 I-Regulation denotes explore
T7 743-746 B-Regulation denotes led
T8 747-749 I-Regulation denotes to
T9 898-906 B-Molecular_Activity denotes adaptive
T10 907-917 I-Molecular_Activity denotes regulation
T11 926-930 B-Cell_Physiological_Activity denotes acid
T12 931-940 I-Cell_Physiological_Activity denotes synthesis
T13 1199-1208 B-Variation denotes dependent
T14 1297-1307 B-Molecular_Activity denotes activation
T15 1319-1326 B-Molecular_Activity denotes pathway
T16 1389-1400 B-Variation denotes homeostasis
T17 1440-1449 B-Molecular_Activity denotes dependent
T18 1459-1469 B-Molecular_Activity denotes activation
T19 1617-1627 B-Molecular_Activity denotes protective
T20 1628-1632 I-Molecular_Activity denotes role

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Id Subject Object Predicate Lexical cue
T1 114-131 I-Variation denotes Perfluorodecanoic
T2 132-136 I-Variation denotes acid
T3 370-380 B-Negative_Function denotes activation
T4 670-674 B-Regulation denotes used
T5 675-677 I-Regulation denotes to
T6 678-685 I-Regulation denotes explore
T7 743-746 B-Regulation denotes led
T8 747-749 I-Regulation denotes to
T9 898-906 B-Molecular_Activity denotes adaptive
T10 907-917 I-Molecular_Activity denotes regulation
T11 926-930 B-Cell_Physiological_Activity denotes acid
T12 931-940 I-Cell_Physiological_Activity denotes synthesis
T13 1199-1208 B-Variation denotes dependent
T14 1297-1307 B-Molecular_Activity denotes activation
T15 1319-1326 B-Molecular_Activity denotes pathway
T16 1389-1400 B-Variation denotes homeostasis
T17 1440-1449 B-Molecular_Activity denotes dependent
T18 1459-1469 B-Molecular_Activity denotes activation
T19 1617-1627 B-Molecular_Activity denotes protective
T20 1628-1632 I-Molecular_Activity denotes role