Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-113 |
Sentence |
denotes |
Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity. |
T2 |
114-247 |
Sentence |
denotes |
Perfluorodecanoic acid (PFDA) is widely used in production of many daily necessities based on their surface properties and stability. |
T3 |
248-445 |
Sentence |
denotes |
It was assigned as a Persistent Organic Pollutant in 2009 and became a public concern partly because of its potential for activation of the peroxisome proliferator-activated receptor alpha (PPARα). |
T4 |
446-525 |
Sentence |
denotes |
In this study, wild-type and Ppara-null mice were administered PFDA (80 mg/kg). |
T5 |
526-630 |
Sentence |
denotes |
Blood and liver tissues were collected and subjected to systemic toxicological and mechanistic analysis. |
T6 |
631-798 |
Sentence |
denotes |
UPLC-ESI-QTOFMS-based metabolomics was used to explore the contributing components of the serum metabolome that led to variation between wild-type and Pparα-null mice. |
T7 |
799-968 |
Sentence |
denotes |
Bile acid homeostasis was disrupted, and slight hepatocyte injury in wild-type mice accompanied by adaptive regulation of bile acid synthesis and transport was observed. |
T8 |
969-1102 |
Sentence |
denotes |
The serum metabolome in wild-type clustered differently from that in Pparα-null, featured by sharp increases in bile acid components. |
T9 |
1103-1274 |
Sentence |
denotes |
Differential toxicokinetic tendency was supported by regulation of UDP-glucuronosyltransferases dependent on PPARα, but it did not contribute to the hepatotoxic responses. |
T10 |
1275-1419 |
Sentence |
denotes |
Increase in Il-10 and activation of the JNK pathway indicated inflammation was induced by disruption of bile acid homeostasis in wild-type mice. |
T11 |
1420-1582 |
Sentence |
denotes |
Inhibition of p-p65 dependent on PPARα activation by PFDA stopped the inflammatory cascade, as indicated by negative response of Il-6, Tnf-α, and STAT3 signaling. |
T12 |
1583-1679 |
Sentence |
denotes |
These data suggest disruptive and protective role of PPARα in hepatic responses induced by PFDA. |
T1 |
0-113 |
Sentence |
denotes |
Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity. |
T2 |
114-247 |
Sentence |
denotes |
Perfluorodecanoic acid (PFDA) is widely used in production of many daily necessities based on their surface properties and stability. |
T3 |
248-445 |
Sentence |
denotes |
It was assigned as a Persistent Organic Pollutant in 2009 and became a public concern partly because of its potential for activation of the peroxisome proliferator-activated receptor alpha (PPARα). |
T4 |
446-525 |
Sentence |
denotes |
In this study, wild-type and Ppara-null mice were administered PFDA (80 mg/kg). |
T5 |
526-630 |
Sentence |
denotes |
Blood and liver tissues were collected and subjected to systemic toxicological and mechanistic analysis. |
T6 |
631-798 |
Sentence |
denotes |
UPLC-ESI-QTOFMS-based metabolomics was used to explore the contributing components of the serum metabolome that led to variation between wild-type and Pparα-null mice. |
T7 |
799-968 |
Sentence |
denotes |
Bile acid homeostasis was disrupted, and slight hepatocyte injury in wild-type mice accompanied by adaptive regulation of bile acid synthesis and transport was observed. |
T8 |
969-1102 |
Sentence |
denotes |
The serum metabolome in wild-type clustered differently from that in Pparα-null, featured by sharp increases in bile acid components. |
T9 |
1103-1274 |
Sentence |
denotes |
Differential toxicokinetic tendency was supported by regulation of UDP-glucuronosyltransferases dependent on PPARα, but it did not contribute to the hepatotoxic responses. |
T10 |
1275-1419 |
Sentence |
denotes |
Increase in Il-10 and activation of the JNK pathway indicated inflammation was induced by disruption of bile acid homeostasis in wild-type mice. |
T11 |
1420-1582 |
Sentence |
denotes |
Inhibition of p-p65 dependent on PPARα activation by PFDA stopped the inflammatory cascade, as indicated by negative response of Il-6, Tnf-α, and STAT3 signaling. |
T12 |
1583-1679 |
Sentence |
denotes |
These data suggest disruptive and protective role of PPARα in hepatic responses induced by PFDA. |