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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus.
T2 126-145 Sentence denotes BACKGROUND AND AIM:
T3 146-285 Sentence denotes Total glucosides of paeony (TGP), an active compound extracted from dried roots of Paeonia lactiflora Pall, have anti-inflammatory effects.
T4 286-421 Sentence denotes This study investigated the efficacy and safety of TGP for treating diabetic kidney disease (DKD) in type 2 diabetes mellitus patients.
T5 422-430 Sentence denotes METHODS:
T6 431-536 Sentence denotes An open-label, prospective, randomized, parallel-group, single-site study involving 76 patients with DKD.
T7 537-740 Sentence denotes Patients were randomized into two groups: losartan group (n = 38), treated with losartan 100 mg/day for 6 months and TGP group (n = 38), treated with TGP 1800 mg/day and losartan 100 mg/day for 6 months.
T8 741-815 Sentence denotes Serum hs-CRP, MCP-1, and TNF-α were determined before and after treatment.
T9 816-929 Sentence denotes Urinary albumin excretion rate (UAER), fasting blood glucose, serum creatinine, and lipid profiles were examined.
T10 930-938 Sentence denotes RESULTS:
T11 939-1012 Sentence denotes At the end-point, UAER decreased in the TGP group compared with baseline.
T12 1013-1089 Sentence denotes UAER in the losartan group decreased to a level lower than before treatment.
T13 1090-1175 Sentence denotes The rate of decline in the losartan group was significantly lower than the TGP group.
T14 1176-1302 Sentence denotes There were no significant differences in serum creatinine and albumin levels between TGP and losartan groups at the end-point.
T15 1303-1397 Sentence denotes Serum hs-CRP, MCP-1, and TNF-α levels were significantly lower in both groups after treatment.
T16 1398-1502 Sentence denotes After treatment, serum hs-CRP, MCP-1, and TNF-α in the TGP group decreased more than the losartan group.
T17 1503-1581 Sentence denotes Positive correlations were observed between UAER and hs-CRP, MCP-1, and TNF-α.
T18 1582-1666 Sentence denotes No statistically significant difference in side effects was observed between groups.
T19 1667-1678 Sentence denotes CONCLUSION:
T20 1679-1815 Sentence denotes Our study showed that TGP treatment could reduce the albuminuria and inflammatory markers in type 2 diabetes mellitus patients with DKD.
T1 0-125 Sentence denotes Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus.
T2 126-145 Sentence denotes BACKGROUND AND AIM:
T3 146-285 Sentence denotes Total glucosides of paeony (TGP), an active compound extracted from dried roots of Paeonia lactiflora Pall, have anti-inflammatory effects.
T4 286-421 Sentence denotes This study investigated the efficacy and safety of TGP for treating diabetic kidney disease (DKD) in type 2 diabetes mellitus patients.
T5 422-430 Sentence denotes METHODS:
T6 431-536 Sentence denotes An open-label, prospective, randomized, parallel-group, single-site study involving 76 patients with DKD.
T7 537-740 Sentence denotes Patients were randomized into two groups: losartan group (n = 38), treated with losartan 100 mg/day for 6 months and TGP group (n = 38), treated with TGP 1800 mg/day and losartan 100 mg/day for 6 months.
T8 741-815 Sentence denotes Serum hs-CRP, MCP-1, and TNF-α were determined before and after treatment.
T9 816-929 Sentence denotes Urinary albumin excretion rate (UAER), fasting blood glucose, serum creatinine, and lipid profiles were examined.
T10 930-938 Sentence denotes RESULTS:
T11 939-1012 Sentence denotes At the end-point, UAER decreased in the TGP group compared with baseline.
T12 1013-1089 Sentence denotes UAER in the losartan group decreased to a level lower than before treatment.
T13 1090-1175 Sentence denotes The rate of decline in the losartan group was significantly lower than the TGP group.
T14 1176-1302 Sentence denotes There were no significant differences in serum creatinine and albumin levels between TGP and losartan groups at the end-point.
T15 1303-1397 Sentence denotes Serum hs-CRP, MCP-1, and TNF-α levels were significantly lower in both groups after treatment.
T16 1398-1502 Sentence denotes After treatment, serum hs-CRP, MCP-1, and TNF-α in the TGP group decreased more than the losartan group.
T17 1503-1581 Sentence denotes Positive correlations were observed between UAER and hs-CRP, MCP-1, and TNF-α.
T18 1582-1666 Sentence denotes No statistically significant difference in side effects was observed between groups.
T19 1667-1678 Sentence denotes CONCLUSION:
T20 1679-1815 Sentence denotes Our study showed that TGP treatment could reduce the albuminuria and inflammatory markers in type 2 diabetes mellitus patients with DKD.

maxiaofeng52_800_3

Id Subject Object Predicate Lexical cue
T1 66-89 DP denotes diabetic kidney disease
T2 354-377 DP denotes diabetic kidney disease
T3 379-382 DP denotes DKD
T4 532-535 DP denotes DKD
T5 1811-1814 DP denotes DKD
T6 18-44 CI denotes total glucosides of paeony
T7 337-340 CI denotes TGP
T8 174-177 CI denotes TGP
T9 654-657 CI denotes TGP
T10 687-690 CI denotes TGP
T11 979-982 CI denotes TGP
T12 1165-1168 CI denotes TGP
T13 1261-1264 CI denotes TGP
T14 1453-1456 CI denotes TGP
T15 1701-1704 CI denotes TGP
T16 579-587 CI denotes losartan
T17 617-625 CI denotes losartan
T18 707-715 CI denotes losartan
T19 1025-1033 CI denotes losartan
T20 1117-1125 CI denotes losartan
T21 1269-1277 CI denotes losartan
T22 1487-1495 CI denotes losartan
T23 146-172 CI denotes Total glucosides of paeony

wangzhuo19_800_3

Id Subject Object Predicate Lexical cue
T1 146-172 CI denotes Total glucosides of paeony
T2 174-177 CI denotes TGP
T3 337-340 CI denotes TGP
T4 654-657 CI denotes TGP
T5 687-690 CI denotes TGP
T6 979-982 CI denotes TGP
T7 1165-1168 CI denotes TGP
T8 1261-1264 CI denotes TGP
T9 1453-1456 CI denotes TGP
T10 1701-1704 CI denotes TGP
T11 579-587 CI denotes losartan
T12 617-625 CI denotes losartan
T13 707-715 CI denotes losartan
T14 1025-1033 CI denotes losartan
T15 1117-1125 CI denotes losartan
T16 1269-1277 CI denotes losartan
T17 1487-1495 CI denotes losartan
T18 18-44 CI denotes total glucosides of paeony
T19 354-377 DP denotes diabetic kidney disease
T20 66-89 DP denotes diabetic kidney disease
T21 379-382 DP denotes DKD
T22 532-535 DP denotes DKD
T23 1811-1814 DP denotes DKD