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PubMed:27292643 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.
T2 144-258 Sentence denotes Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies.
T3 259-327 Sentence denotes Despite this correlation, CIN can also lead to growth disadvantages.
T4 328-542 Sentence denotes Here, we show that simultaneous overexpression of the mitotic checkpoint protein Mad2 with Kras(G12D) or Her2 in mammary glands of adult mice results in mitotic checkpoint overactivation and a delay in tumor onset.
T5 543-699 Sentence denotes Time-lapse imaging of organotypic cultures and pathologic analysis prior to tumor establishment reveals error-prone mitosis, mitotic arrest, and cell death.
T6 700-788 Sentence denotes Nonetheless, Mad2 expression persists and increases karyotype complexity in Kras tumors.
T7 789-969 Sentence denotes Faced with the selective pressure of oncogene withdrawal, Mad2-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 465-469 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11364 23-45 DiseaseOrPhenotypicFeature denotes Chromosome Instability MESH:D043171
11365 57-61 GeneOrGeneProduct denotes Mad2 NCBIGene:56150
11366 83-96 DiseaseOrPhenotypicFeature denotes Breast Cancer MESH:D001943
11367 144-166 DiseaseOrPhenotypicFeature denotes Chromosome instability MESH:D043171
11368 168-171 DiseaseOrPhenotypicFeature denotes CIN MESH:D043171
11369 245-257 DiseaseOrPhenotypicFeature denotes malignancies MESH:D009369
11370 285-288 DiseaseOrPhenotypicFeature denotes CIN MESH:D043171
11371 409-413 GeneOrGeneProduct denotes Mad2 NCBIGene:56150
11372 419-423 GeneOrGeneProduct denotes Kras NCBIGene:16653
11373 424-428 GeneOrGeneProduct denotes G12D NCBIGene:16653
11374 433-437 GeneOrGeneProduct denotes Her2 NCBIGene:13866
11375 465-469 OrganismTaxon denotes mice NCBITaxon:10090
11376 530-535 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
11377 619-624 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
11378 713-717 GeneOrGeneProduct denotes Mad2 NCBIGene:56150
11379 776-780 GeneOrGeneProduct denotes Kras NCBIGene:16653
11380 781-787 DiseaseOrPhenotypicFeature denotes tumors MESH:D009369
11381 847-851 GeneOrGeneProduct denotes Mad2 NCBIGene:56150
11382 861-867 DiseaseOrPhenotypicFeature denotes tumors MESH:D009369

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 83-96 DiseaseOrPhenotypicFeature denotes Breast Cancer 0007254

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 424-428 SequenceVariant denotes G12D

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 46-53 GeneOrGeneProduct denotes Induced
T2 57-61 GeneOrGeneProduct denotes Mad2
T3 112-120 GeneOrGeneProduct denotes Oncogene
T4 230-234 GeneOrGeneProduct denotes in a
T5 306-312 GeneOrGeneProduct denotes growth
T6 382-408 GeneOrGeneProduct denotes mitotic checkpoint protein
T7 409-413 GeneOrGeneProduct denotes Mad2
T8 419-423 GeneOrGeneProduct denotes Kras
T9 433-437 GeneOrGeneProduct denotes Her2
T10 465-469 GeneOrGeneProduct denotes mice
T11 481-499 GeneOrGeneProduct denotes mitotic checkpoint
T12 530-535 GeneOrGeneProduct denotes tumor
T13 543-547 GeneOrGeneProduct denotes Time
T14 619-624 GeneOrGeneProduct denotes tumor
T15 676-682 GeneOrGeneProduct denotes arrest
T16 688-692 GeneOrGeneProduct denotes cell
T17 713-717 GeneOrGeneProduct denotes Mad2
T18 729-737 GeneOrGeneProduct denotes persists
T19 776-780 GeneOrGeneProduct denotes Kras
T20 781-787 GeneOrGeneProduct denotes tumors
T21 789-794 GeneOrGeneProduct denotes Faced
T22 826-834 GeneOrGeneProduct denotes oncogene
T23 847-851 GeneOrGeneProduct denotes Mad2
T24 861-867 GeneOrGeneProduct denotes tumors
T25 882-891 GeneOrGeneProduct denotes frequency
T26 906-916 GeneOrGeneProduct denotes persistent
T27 964-968 GeneOrGeneProduct denotes grow

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 57-61 GeneOrGeneProduct denotes Mad2
T2 112-120 GeneOrGeneProduct denotes Oncogene
T3 306-312 GeneOrGeneProduct denotes growth
T4 382-408 GeneOrGeneProduct denotes mitotic checkpoint protein
T5 409-413 GeneOrGeneProduct denotes Mad2
T6 419-423 GeneOrGeneProduct denotes Kras
T7 433-437 GeneOrGeneProduct denotes Her2
T8 481-499 GeneOrGeneProduct denotes mitotic checkpoint
T9 543-547 GeneOrGeneProduct denotes Time
T10 676-682 GeneOrGeneProduct denotes arrest
T11 688-692 GeneOrGeneProduct denotes cell
T12 713-717 GeneOrGeneProduct denotes Mad2
T13 776-780 GeneOrGeneProduct denotes Kras
T14 826-834 GeneOrGeneProduct denotes oncogene
T15 847-851 GeneOrGeneProduct denotes Mad2
T16 882-891 GeneOrGeneProduct denotes frequency

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 23-45 DiseaseOrPhenotypicFeature denotes Chromosome Instability D043171
T2 83-96 DiseaseOrPhenotypicFeature denotes Breast Cancer D001943
T3 144-166 DiseaseOrPhenotypicFeature denotes Chromosome instability D043171
T4 168-171 DiseaseOrPhenotypicFeature denotes CIN D043171
T5 245-257 DiseaseOrPhenotypicFeature denotes malignancies D009369
T6 285-288 DiseaseOrPhenotypicFeature denotes CIN D043171
T7 530-535 DiseaseOrPhenotypicFeature denotes tumor D009369
T8 619-624 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 693-698 DiseaseOrPhenotypicFeature denotes death D003643
T10 781-787 DiseaseOrPhenotypicFeature denotes tumors D009369
T11 861-867 DiseaseOrPhenotypicFeature denotes tumors D009369

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 57-61 GeneOrGeneProduct denotes Mad2
T2 382-408 GeneOrGeneProduct denotes mitotic checkpoint protein
T3 409-413 GeneOrGeneProduct denotes Mad2
T4 419-423 GeneOrGeneProduct denotes Kras
T5 433-437 GeneOrGeneProduct denotes Her2
T6 481-499 GeneOrGeneProduct denotes mitotic checkpoint
T7 543-547 GeneOrGeneProduct denotes Time
T8 713-717 GeneOrGeneProduct denotes Mad2
T9 776-780 GeneOrGeneProduct denotes Kras
T10 847-851 GeneOrGeneProduct denotes Mad2

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 168-171 DiseaseOrPhenotypicFeature denotes CIN 0042491
T2 285-288 DiseaseOrPhenotypicFeature denotes CIN 0042491
T3 289-292 DiseaseOrPhenotypicFeature denotes can 0012833
T4 530-535 DiseaseOrPhenotypicFeature denotes tumor 0005070
T5 619-624 DiseaseOrPhenotypicFeature denotes tumor 0005070

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 23-45 DiseaseOrPhenotypicFeature denotes Chromosome Instability D043171
T2 83-96 DiseaseOrPhenotypicFeature denotes Breast Cancer D001943
T3 144-166 DiseaseOrPhenotypicFeature denotes Chromosome instability D043171
T4 168-171 DiseaseOrPhenotypicFeature denotes CIN DISEASE|D043171
T6 245-257 DiseaseOrPhenotypicFeature denotes malignancies D009369
T7 285-288 DiseaseOrPhenotypicFeature denotes CIN DISEASE|D043171
T9 530-535 DiseaseOrPhenotypicFeature denotes tumor D009369
T10 619-624 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 693-698 DiseaseOrPhenotypicFeature denotes death D003643
T12 781-787 DiseaseOrPhenotypicFeature denotes tumors DISEASE|D009369
T14 861-867 DiseaseOrPhenotypicFeature denotes tumors DISEASE|D009369

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 23-45 DiseaseOrPhenotypicFeature denotes Chromosome Instability D043171
T2 83-96 DiseaseOrPhenotypicFeature denotes Breast Cancer D001943
T3 144-166 DiseaseOrPhenotypicFeature denotes Chromosome instability D043171
T4 168-171 DiseaseOrPhenotypicFeature denotes CIN DISEASE|D043171
T6 245-257 DiseaseOrPhenotypicFeature denotes malignancies D009369
T7 285-288 DiseaseOrPhenotypicFeature denotes CIN DISEASE|D043171
T9 530-535 DiseaseOrPhenotypicFeature denotes tumor D009369
T10 619-624 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 781-787 DiseaseOrPhenotypicFeature denotes tumors D009369
T12 861-867 DiseaseOrPhenotypicFeature denotes tumors D009369

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 298-302 ChemicalEntity denotes lead D007854

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 465-469 OrganismTaxon denotes mice

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T1 298-302 ChemicalEntity denotes lead D007854
T10 847-851 GeneOrGeneProduct denotes Mad2
T9 776-780 GeneOrGeneProduct denotes Kras
T8 713-717 GeneOrGeneProduct denotes Mad2
T7 543-547 GeneOrGeneProduct denotes Time
T6 481-499 GeneOrGeneProduct denotes mitotic checkpoint
T5 433-437 GeneOrGeneProduct denotes Her2
T4 419-423 GeneOrGeneProduct denotes Kras
T3 409-413 GeneOrGeneProduct denotes Mad2
T2 382-408 GeneOrGeneProduct denotes mitotic checkpoint protein
T21387 57-61 GeneOrGeneProduct denotes Mad2
T12 861-867 DiseaseOrPhenotypicFeature denotes tumors D009369
T11 781-787 DiseaseOrPhenotypicFeature denotes tumors D009369
T25202 619-624 DiseaseOrPhenotypicFeature denotes tumor D009369
T76370 530-535 DiseaseOrPhenotypicFeature denotes tumor D009369
T33086 285-288 DiseaseOrPhenotypicFeature denotes CIN D043171|DISEASE
T8783 245-257 DiseaseOrPhenotypicFeature denotes malignancies D009369
T14504 168-171 DiseaseOrPhenotypicFeature denotes CIN D043171|DISEASE
T87263 144-166 DiseaseOrPhenotypicFeature denotes Chromosome instability D043171
T20078 83-96 DiseaseOrPhenotypicFeature denotes Breast Cancer D001943
T3910 23-45 DiseaseOrPhenotypicFeature denotes Chromosome Instability D043171
T11650 465-469 OrganismTaxon denotes mice
T18995 424-428 SequenceVariant denotes G12D