PubMed:27290989
Annnotations
GlyCosmos15-Species
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 8825 | 422-427 | Species | denotes | human | 9606 |
| 8827 | 530-538 | Species | denotes | patients | 9606 |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 206-225 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T2 | 227-233 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 266-272 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T4 | 1238-1244 | chem:24139 | denotes | GlcNAc |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 68-86 | Disease | denotes | cholangiocarcinoma | http://purl.obolibrary.org/obo/MONDO_0019087 |
| T2 | 469-474 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 505-523 | Disease | denotes | cholangiocarcinoma | http://purl.obolibrary.org/obo/MONDO_0019087 |
| T4 | 525-528 | Disease | denotes | CCA | http://purl.obolibrary.org/obo/MONDO_0019087 |
| T5 | 615-620 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 661-664 | Disease | denotes | CCA | http://purl.obolibrary.org/obo/MONDO_0019087 |
| T7 | 805-808 | Disease | denotes | CCA | http://purl.obolibrary.org/obo/MONDO_0019087 |
| T8 | 1374-1377 | Disease | denotes | CCA | http://purl.obolibrary.org/obo/MONDO_0019087 |
| T9 | 1560-1563 | Disease | denotes | CCA | http://purl.obolibrary.org/obo/MONDO_0019087 |
| T10 | 1658-1661 | Disease | denotes | CCA | http://purl.obolibrary.org/obo/MONDO_0019087 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 264-272 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 1236-1244 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 264-272 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 1236-1244 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 68-86 | Phenotype | denotes | cholangiocarcinoma | HP:0030153 |
| T2 | 469-474 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 505-523 | Phenotype | denotes | cholangiocarcinoma | HP:0030153 |
| T4 | 525-528 | Phenotype | denotes | CCA | HP:0030153 |
| T5 | 615-620 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 661-664 | Phenotype | denotes | CCA | HP:0030153 |
| T7 | 805-808 | Phenotype | denotes | CCA | HP:0030153 |
| T8 | 1374-1377 | Phenotype | denotes | CCA | HP:0030153 |
| T9 | 1560-1563 | Phenotype | denotes | CCA | HP:0030153 |
| T10 | 1658-1661 | Phenotype | denotes | CCA | HP:0030153 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 264-272 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 1236-1244 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 422-427 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 68-86 | Disease | denotes | cholangiocarcinoma | MONDO:0019087 |
| T2 | 469-474 | Disease | denotes | tumor | MONDO:0005070 |
| T3 | 505-523 | Disease | denotes | cholangiocarcinoma | MONDO:0019087 |
| T4 | 525-528 | Disease | denotes | CCA | MONDO:0019087 |
| T5 | 615-620 | Disease | denotes | tumor | MONDO:0005070 |
| T6 | 661-664 | Disease | denotes | CCA | MONDO:0019087 |
| T7 | 805-808 | Disease | denotes | CCA | MONDO:0019087 |
| T8 | 1374-1377 | Disease | denotes | CCA | MONDO:0019087 |
| T9 | 1560-1563 | Disease | denotes | CCA | MONDO:0019087 |
| T10 | 1658-1661 | Disease | denotes | CCA | MONDO:0019087 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 264-272 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 1236-1244 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-128 | Sentence | denotes | Mechanistic insights of O-GlcNAcylation that promote progression of cholangiocarcinoma cells via nuclear translocation of NF-κB. |
| T2 | 129-328 | Sentence | denotes | O-GlcNAcylation, an O-linked protein glycosylation with a single molecule of N-acetylglucosamine (GlcNAc), is reversibly controlled by O-GlcNAc transferase (OGT) and N-acetyl D-glucosaminidase (OGA). |
| T3 | 329-436 | Sentence | denotes | Aberrant O-GlcNAcylation contributes an important role in initiation and progression of many human cancers. |
| T4 | 437-558 | Sentence | denotes | Elevation of O-GlcNAcylation in tumor tissues and poor prognosis of cholangiocarcinoma (CCA) patients have been reported. |
| T5 | 559-676 | Sentence | denotes | In this study, the role of O-GlcNAcylation in promoting tumor progression was further investigated in CCA cell lines. |
| T6 | 677-870 | Sentence | denotes | Suppression of O-GlcNAcylation using small interfering RNAs of OGT (siOGT) significantly reduced cell migration and invasion of CCA cells whereas siOGA treated cells exhibited opposite effects. |
| T7 | 871-1041 | Sentence | denotes | Manipulating levels of O-GlcNAcylation did affect the nuclear translocation of NF-κB and Akt-phosphorylation together with expression of matrix-metalloproteinases (MMPs). |
| T8 | 1042-1189 | Sentence | denotes | O-GlcNAcylation and nuclear translocation of NF-κB, the upstream signaling cascade of MMP activation were shown to be important for MMP activation. |
| T9 | 1190-1300 | Sentence | denotes | Immunoprecipitation revealed the elevation of O-GlcNAc-modified NF-κB with increased cellular O-GlcNAcylation. |
| T10 | 1301-1455 | Sentence | denotes | Involvement of O-GlcNAcylation in MMP-mediated migration and invasion of CCA cells was shown to be via O-GlcNAcylation and nuclear translocation of NF-κB. |
| T11 | 1456-1662 | Sentence | denotes | This information indicates the significance of O-GlcNAcylation in controlling the metastatic ability of CCA cells, hence, O-GlcNAcylation and its products may be new targets for treatment of metastatic CCA. |
GlyCosmos15-Lectin-Jamboree
| Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
|---|---|---|---|---|---|
| T1 | 525-528 | Lectin | denotes | CCA | GL_004787 |
| T2 | 661-664 | Lectin | denotes | CCA | GL_004787 |
| T3 | 805-808 | Lectin | denotes | CCA | GL_004787 |
| T4 | 1374-1377 | Lectin | denotes | CCA | GL_004787 |
| T5 | 1560-1563 | Lectin | denotes | CCA | GL_004787 |
| T6 | 1658-1661 | Lectin | denotes | CCA | GL_004787 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 475-482 | Body_part | denotes | tissues | FMA:9637 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 422-427 | OrganismTaxon | denotes | human | 9606 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 68-86 | Phenotype | denotes | cholangiocarcinoma | HP:0030153 |
| T2 | 469-474 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 505-523 | Phenotype | denotes | cholangiocarcinoma | HP:0030153 |
| T4 | 525-528 | Phenotype | denotes | CCA | HP:0030153 |
| T5 | 615-620 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 661-664 | Phenotype | denotes | CCA | HP:0030153 |
| T7 | 805-808 | Phenotype | denotes | CCA | HP:0030153 |
| T8 | 1374-1377 | Phenotype | denotes | CCA | HP:0030153 |
| T9 | 1560-1563 | Phenotype | denotes | CCA | HP:0030153 |
| T10 | 1658-1661 | Phenotype | denotes | CCA | HP:0030153 |