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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Hsp90β is involved in the development of high salt-diet-induced nephropathy via interaction with various signalling proteins.
T2 126-297 Sentence denotes A high-salt diet often leads to a local intrarenal increase in renal hypoxia and oxidative stress, which are responsible for an excess production of pathogenic substances.
T3 298-501 Sentence denotes Here, Wistar Kyoto/spontaneous hypertensive (WKY/SHR) rats fed a high-salt diet developed severe proteinuria, resulting from pronounced renal inflammation, fibrosis and tubular epithelial cell apoptosis.
T4 502-553 Sentence denotes All these were mainly non-pressure-related effects.
T5 554-661 Sentence denotes Hsp90β, TGF-β, HIF-1α, TNF-α, IL-6 and MCP-1 were shown to be highly expressed in response to salt loading.
T6 662-868 Sentence denotes Next, we found that Hsp90β might play the key role in non-pressure-related effects of salt loading through a series of cellular signalling events, including the NF-κB, p38 activation and Bcl-2 inactivation.
T7 869-1027 Sentence denotes Hsp90β was previously proven to regulate the upstream mediators in multiple cellular signalling cascades through stabilizing and maintaining their activities.
T8 1028-1323 Sentence denotes In our study, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) or Hsp90β knockdown dramatically alleviated the high-salt-diet-induced proteinuria and renal damage without altering blood pressure significantly, when it reversed activations of NF-κB, mTOR and p38 signalling cascades.
T9 1324-1497 Sentence denotes Meanwhile, Co-IP results demonstrated that Hsp90β could interact with and stabilize TAK1, AMPKα, IKKα/β, HIF-1α and Raptor, whereas Hsp90β inhibition disrupted this process.
T10 1498-1614 Sentence denotes In addition, Hsp90β inhibition-mediated renal improvements also accompanied the reduction of renal oxidative stress.
T11 1615-1742 Sentence denotes In conclusion, salt loading indeed exhibited non-pressure-related impacts on proteinuria and renal dysfunction in WKY/SHR rats.
T12 1743-1945 Sentence denotes Hsp90β inhibition caused the destabilization of upstream mediators in various pathogenic signalling events, thereby effectively ameliorating this nephropathy owing to renal hypoxia and oxidative stress.
T1 0-125 Sentence denotes Hsp90β is involved in the development of high salt-diet-induced nephropathy via interaction with various signalling proteins.
T2 126-297 Sentence denotes A high-salt diet often leads to a local intrarenal increase in renal hypoxia and oxidative stress, which are responsible for an excess production of pathogenic substances.
T3 298-501 Sentence denotes Here, Wistar Kyoto/spontaneous hypertensive (WKY/SHR) rats fed a high-salt diet developed severe proteinuria, resulting from pronounced renal inflammation, fibrosis and tubular epithelial cell apoptosis.
T4 502-553 Sentence denotes All these were mainly non-pressure-related effects.
T5 554-661 Sentence denotes Hsp90β, TGF-β, HIF-1α, TNF-α, IL-6 and MCP-1 were shown to be highly expressed in response to salt loading.
T6 662-868 Sentence denotes Next, we found that Hsp90β might play the key role in non-pressure-related effects of salt loading through a series of cellular signalling events, including the NF-κB, p38 activation and Bcl-2 inactivation.
T7 869-1027 Sentence denotes Hsp90β was previously proven to regulate the upstream mediators in multiple cellular signalling cascades through stabilizing and maintaining their activities.
T8 1028-1323 Sentence denotes In our study, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) or Hsp90β knockdown dramatically alleviated the high-salt-diet-induced proteinuria and renal damage without altering blood pressure significantly, when it reversed activations of NF-κB, mTOR and p38 signalling cascades.
T9 1324-1497 Sentence denotes Meanwhile, Co-IP results demonstrated that Hsp90β could interact with and stabilize TAK1, AMPKα, IKKα/β, HIF-1α and Raptor, whereas Hsp90β inhibition disrupted this process.
T10 1498-1614 Sentence denotes In addition, Hsp90β inhibition-mediated renal improvements also accompanied the reduction of renal oxidative stress.
T11 1615-1742 Sentence denotes In conclusion, salt loading indeed exhibited non-pressure-related impacts on proteinuria and renal dysfunction in WKY/SHR rats.
T12 1743-1945 Sentence denotes Hsp90β inhibition caused the destabilization of upstream mediators in various pathogenic signalling events, thereby effectively ameliorating this nephropathy owing to renal hypoxia and oxidative stress.

TEST-DiseaseOrPhenotypicFeature

Id Subject Object Predicate Lexical cue #label
T1 64-75 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T2 195-202 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T3 395-406 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T4 440-452 DiseaseOrPhenotypicFeature denotes inflammation D007249
T5 454-462 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T6 1175-1186 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T7 1191-1203 DiseaseOrPhenotypicFeature denotes renal damage DISEASE
T8 1692-1703 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T9 1708-1725 DiseaseOrPhenotypicFeature denotes renal dysfunction DISEASE
T10 1889-1900 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T11 1916-1923 DiseaseOrPhenotypicFeature denotes hypoxia D000860

TEST-ChemicalEntity

Id Subject Object Predicate Lexical cue ID:
T1 593-596 ChemicalEntity denotes MCP http://purl.obolibrary.org/obo/CHEBI_50099|http://purl.obolibrary.org/obo/CHEBI_132592
T3 1042-1093 ChemicalEntity denotes 17-dimethylaminoethylamino-17-demethoxygeldanamycin C448659|http://purl.obolibrary.org/obo/CHEBI_65324
T5 1095-1102 ChemicalEntity denotes 17-DMAG C448659|http://purl.obolibrary.org/obo/CHEBI_65324
T7 1440-1446 ChemicalEntity denotes Raptor http://purl.obolibrary.org/obo/CHEBI_133232

TEST-OrganismTaxon

Id Subject Object Predicate Lexical cue
T1 352-356 OrganismTaxon denotes rats
T2 1737-1741 OrganismTaxon denotes rats

Test-GeneOrGeneProduct

Id Subject Object Predicate Lexical cue
T1 0-6 GeneOrGeneProduct denotes Hsp90β
T2 105-124 GeneOrGeneProduct denotes signalling proteins
T3 554-560 GeneOrGeneProduct denotes Hsp90β
T4 562-567 GeneOrGeneProduct denotes TGF-β
T5 569-575 GeneOrGeneProduct denotes HIF-1α
T6 577-582 GeneOrGeneProduct denotes TNF-α
T7 584-588 GeneOrGeneProduct denotes IL-6
T8 593-598 GeneOrGeneProduct denotes MCP-1
T9 682-688 GeneOrGeneProduct denotes Hsp90β
T10 849-854 GeneOrGeneProduct denotes Bcl-2
T11 869-875 GeneOrGeneProduct denotes Hsp90β
T12 1107-1113 GeneOrGeneProduct denotes Hsp90β
T13 1290-1294 GeneOrGeneProduct denotes mTOR
T14 1367-1373 GeneOrGeneProduct denotes Hsp90β
T15 1408-1412 GeneOrGeneProduct denotes TAK1
T16 1414-1419 GeneOrGeneProduct denotes AMPKα
T17 1429-1435 GeneOrGeneProduct denotes HIF-1α
T18 1440-1446 GeneOrGeneProduct denotes Raptor
T19 1456-1462 GeneOrGeneProduct denotes Hsp90β
T20 1511-1517 GeneOrGeneProduct denotes Hsp90β
T21 1743-1749 GeneOrGeneProduct denotes Hsp90β

Test-merged-2

Id Subject Object Predicate Lexical cue #label ID:
T5305 593-596 ChemicalEntity denotes MCP http://purl.obolibrary.org/obo/CHEBI_50099|http://purl.obolibrary.org/obo/CHEBI_132592
T64169 1042-1093 ChemicalEntity denotes 17-dimethylaminoethylamino-17-demethoxygeldanamycin C448659|http://purl.obolibrary.org/obo/CHEBI_65324
T95904 1095-1102 ChemicalEntity denotes 17-DMAG C448659|http://purl.obolibrary.org/obo/CHEBI_65324
T1852 1440-1446 ChemicalEntity denotes Raptor http://purl.obolibrary.org/obo/CHEBI_133232
T86225 0-6 GeneOrGeneProduct denotes Hsp90β
T85960 105-124 GeneOrGeneProduct denotes signalling proteins
T57553 554-560 GeneOrGeneProduct denotes Hsp90β
T66276 562-567 GeneOrGeneProduct denotes TGF-β
T19229 569-575 GeneOrGeneProduct denotes HIF-1α
T69838 577-582 GeneOrGeneProduct denotes TNF-α
T8038 584-588 GeneOrGeneProduct denotes IL-6
T60319 593-598 GeneOrGeneProduct denotes MCP-1
T51792 682-688 GeneOrGeneProduct denotes Hsp90β
T35801 849-854 GeneOrGeneProduct denotes Bcl-2
T94349 869-875 GeneOrGeneProduct denotes Hsp90β
T12 1107-1113 GeneOrGeneProduct denotes Hsp90β
T13 1290-1294 GeneOrGeneProduct denotes mTOR
T14 1367-1373 GeneOrGeneProduct denotes Hsp90β
T15 1408-1412 GeneOrGeneProduct denotes TAK1
T16 1414-1419 GeneOrGeneProduct denotes AMPKα
T17 1429-1435 GeneOrGeneProduct denotes HIF-1α
T18 1440-1446 GeneOrGeneProduct denotes Raptor
T19 1456-1462 GeneOrGeneProduct denotes Hsp90β
T20 1511-1517 GeneOrGeneProduct denotes Hsp90β
T21 1743-1749 GeneOrGeneProduct denotes Hsp90β
T27141 352-356 OrganismTaxon denotes rats
T83519 1737-1741 OrganismTaxon denotes rats
T1 64-75 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T2 195-202 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T3 395-406 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T4 440-452 DiseaseOrPhenotypicFeature denotes inflammation D007249
T5 454-462 DiseaseOrPhenotypicFeature denotes fibrosis D005355
T6 1175-1186 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T7 1191-1203 DiseaseOrPhenotypicFeature denotes renal damage DISEASE
T8 1692-1703 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T9 1708-1725 DiseaseOrPhenotypicFeature denotes renal dysfunction DISEASE
T10 1889-1900 DiseaseOrPhenotypicFeature denotes nephropathy DISEASE
T11 1916-1923 DiseaseOrPhenotypicFeature denotes hypoxia D000860