PubMed:27184800
Annnotations
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 989-994 | OrganismTaxon | denotes | human | NCBItxid:9606 |
| T2 | 1345-1354 | OrganismTaxon | denotes | erythroid | NCBItxid:94794 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T11 | 1097-1375 | Sentence | denotes | We identified the minimal region of the MT1G promoter that confers inducibility by sorafenib to a 133 base pair region containing an Anti-oxidant Response Element (ARE) and showed the essential role of the transcription factor NRF2 (Nuclear factor erythroid 2-Related Factor 2). |
| T1 | 0-116 | Sentence | denotes | Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib. |
| T2 | 117-128 | Sentence | denotes | BACKGROUND: |
| T3 | 129-294 | Sentence | denotes | Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. |
| T4 | 295-417 | Sentence | denotes | Clinically-applicable biomarkers that reflect the impact of sorafenib on the redox metabolism of cancer cells are lacking. |
| T5 | 418-426 | Sentence | denotes | METHODS: |
| T6 | 427-637 | Sentence | denotes | We used gene expression microarrays, real-time PCR, immunoblot, protein-specific ELISA, and gene reporter constructs encoding the enzyme luciferase to study the response of a panel of cancer cells to sorafenib. |
| T7 | 638-796 | Sentence | denotes | Tumour explants prepared from surgical hepatocellular carcinoma (HCC) samples and serum samples obtained from HCC patients receiving sorafenib were also used. |
| T8 | 797-805 | Sentence | denotes | RESULTS: |
| T9 | 806-926 | Sentence | denotes | We observed that genes of the metallothionein-1 (MT1) family are induced in the HCC cell line Huh7 exposed to sorafenib. |
| T10 | 927-1096 | Sentence | denotes | Sorafenib increased the expression of MT1G mRNA in a panel of human cancer cells, an effect that was not observed with eight other clinically-approved kinase inhibitors. |
| T12 | 1376-1522 | Sentence | denotes | We examined the clinical relevance of our findings by analysing the regulation of MT1G in five tumour explants prepared from surgical HCC samples. |
| T13 | 1523-1692 | Sentence | denotes | Finally, we showed that the protein levels of MT1 increase in the serum of some HCC patients receiving sorafenib, and found an association with reduced overall survival. |
| T14 | 1693-1704 | Sentence | denotes | CONCLUSION: |
| T15 | 1705-1847 | Sentence | denotes | These findings indicate that MT1 constitute a biomarker adapted for exploring the impact of sorafenib on the redox metabolism of cancer cells. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 11324 | 0-17 | GeneOrGeneProduct | denotes | Metallothionein-1 | NCBIGene:4495 |
| 11325 | 64-88 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | MESH:D006528 |
| 11326 | 106-115 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11327 | 129-138 | ChemicalEntity | denotes | Sorafenib | MESH:D000077157 |
| 11328 | 188-195 | DiseaseOrPhenotypicFeature | denotes | tumours | MESH:D009369 |
| 11329 | 263-271 | DiseaseOrPhenotypicFeature | denotes | necrosis | MESH:D009336 |
| 11330 | 281-287 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
| 11331 | 355-364 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11332 | 392-398 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
| 11333 | 611-617 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
| 11334 | 627-636 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11335 | 638-644 | DiseaseOrPhenotypicFeature | denotes | Tumour | MESH:D009369 |
| 11336 | 677-701 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | MESH:D006528 |
| 11337 | 703-706 | DiseaseOrPhenotypicFeature | denotes | HCC | MESH:D006528 |
| 11338 | 748-751 | DiseaseOrPhenotypicFeature | denotes | HCC | MESH:D006528 |
| 11339 | 752-760 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 11340 | 771-780 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11341 | 836-853 | GeneOrGeneProduct | denotes | metallothionein-1 | NCBIGene:4495 |
| 11342 | 855-858 | GeneOrGeneProduct | denotes | MT1 | NCBIGene:4495 |
| 11343 | 886-889 | DiseaseOrPhenotypicFeature | denotes | HCC | MESH:D006528 |
| 11344 | 900-904 | CellLine | denotes | Huh7 | NCBITaxon:9606 |
| 11345 | 916-925 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11346 | 927-936 | ChemicalEntity | denotes | Sorafenib | MESH:D000077157 |
| 11347 | 965-969 | GeneOrGeneProduct | denotes | MT1G | NCBIGene:4495 |
| 11348 | 989-994 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
| 11349 | 995-1001 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
| 11350 | 1137-1141 | GeneOrGeneProduct | denotes | MT1G | NCBIGene:4495 |
| 11351 | 1180-1189 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11352 | 1324-1328 | GeneOrGeneProduct | denotes | NRF2 | NCBIGene:4780 |
| 11353 | 1330-1373 | GeneOrGeneProduct | denotes | Nuclear factor erythroid 2-Related Factor 2 | NCBIGene:4780 |
| 11354 | 1458-1462 | GeneOrGeneProduct | denotes | MT1G | NCBIGene:4495 |
| 11355 | 1471-1477 | DiseaseOrPhenotypicFeature | denotes | tumour | MESH:D009369 |
| 11356 | 1510-1513 | DiseaseOrPhenotypicFeature | denotes | HCC | MESH:D006528 |
| 11357 | 1569-1572 | GeneOrGeneProduct | denotes | MT1 | NCBIGene:4495 |
| 11358 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | HCC | MESH:D006528 |
| 11359 | 1607-1615 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 11360 | 1626-1635 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11361 | 1734-1737 | GeneOrGeneProduct | denotes | MT1 | NCBIGene:4495 |
| 11362 | 1797-1806 | ChemicalEntity | denotes | sorafenib | MESH:D000077157 |
| 11363 | 1834-1840 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 64-88 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | 0007256 |
| T2 | 79-88 | DiseaseOrPhenotypicFeature | denotes | carcinoma | 0004993 |
| T3 | 281-287 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
| T4 | 392-398 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
| T5 | 611-617 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
| T6 | 677-701 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | 0007256 |
| T7 | 692-701 | DiseaseOrPhenotypicFeature | denotes | carcinoma | 0004993 |
| T8 | 995-1001 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
| T9 | 1834-1840 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-17 | GeneOrGeneProduct | denotes | Metallothionein-1 |
| T2 | 89-94 | GeneOrGeneProduct | denotes | cells |
| T3 | 142-158 | GeneOrGeneProduct | denotes | kinase inhibitor |
| T4 | 159-165 | GeneOrGeneProduct | denotes | active |
| T5 | 197-204 | GeneOrGeneProduct | denotes | induces |
| T6 | 288-293 | GeneOrGeneProduct | denotes | cells |
| T7 | 345-351 | GeneOrGeneProduct | denotes | impact |
| T8 | 399-404 | GeneOrGeneProduct | denotes | cells |
| T9 | 409-416 | GeneOrGeneProduct | denotes | lacking |
| T10 | 418-425 | GeneOrGeneProduct | denotes | METHODS |
| T11 | 464-473 | GeneOrGeneProduct | denotes | real-time |
| T12 | 491-498 | GeneOrGeneProduct | denotes | protein |
| T13 | 557-563 | GeneOrGeneProduct | denotes | enzyme |
| T14 | 564-574 | GeneOrGeneProduct | denotes | luciferase |
| T15 | 618-623 | GeneOrGeneProduct | denotes | cells |
| T16 | 836-853 | GeneOrGeneProduct | denotes | metallothionein-1 |
| T17 | 855-858 | GeneOrGeneProduct | denotes | MT1 |
| T18 | 871-878 | GeneOrGeneProduct | denotes | induced |
| T19 | 890-894 | GeneOrGeneProduct | denotes | cell |
| T20 | 895-899 | GeneOrGeneProduct | denotes | line |
| T21 | 900-904 | GeneOrGeneProduct | denotes | Huh7 |
| T22 | 965-969 | GeneOrGeneProduct | denotes | MT1G |
| T23 | 970-974 | GeneOrGeneProduct | denotes | mRNA |
| T24 | 1002-1007 | GeneOrGeneProduct | denotes | cells |
| T25 | 1052-1057 | GeneOrGeneProduct | denotes | other |
| T26 | 1078-1084 | GeneOrGeneProduct | denotes | kinase |
| T27 | 1085-1095 | GeneOrGeneProduct | denotes | inhibitors |
| T28 | 1137-1141 | GeneOrGeneProduct | denotes | MT1G |
| T29 | 1164-1176 | GeneOrGeneProduct | denotes | inducibility |
| T30 | 1199-1203 | GeneOrGeneProduct | denotes | base |
| T31 | 1204-1208 | GeneOrGeneProduct | denotes | pair |
| T32 | 1303-1323 | GeneOrGeneProduct | denotes | transcription factor |
| T33 | 1324-1328 | GeneOrGeneProduct | denotes | NRF2 |
| T34 | 1330-1344 | GeneOrGeneProduct | denotes | Nuclear factor |
| T35 | 1365-1371 | GeneOrGeneProduct | denotes | Factor |
| T36 | 1418-1426 | GeneOrGeneProduct | denotes | findings |
| T37 | 1444-1454 | GeneOrGeneProduct | denotes | regulation |
| T38 | 1458-1462 | GeneOrGeneProduct | denotes | MT1G |
| T39 | 1551-1558 | GeneOrGeneProduct | denotes | protein |
| T40 | 1569-1572 | GeneOrGeneProduct | denotes | MT1 |
| T41 | 1667-1674 | GeneOrGeneProduct | denotes | reduced |
| T42 | 1711-1719 | GeneOrGeneProduct | denotes | findings |
| T43 | 1734-1737 | GeneOrGeneProduct | denotes | MT1 |
| T44 | 1787-1793 | GeneOrGeneProduct | denotes | impact |
| T45 | 1841-1846 | GeneOrGeneProduct | denotes | cells |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-17 | GeneOrGeneProduct | denotes | Metallothionein-1 |
| T2 | 142-158 | GeneOrGeneProduct | denotes | kinase inhibitor |
| T3 | 345-351 | GeneOrGeneProduct | denotes | impact |
| T4 | 464-473 | GeneOrGeneProduct | denotes | real-time |
| T5 | 491-498 | GeneOrGeneProduct | denotes | protein |
| T6 | 557-563 | GeneOrGeneProduct | denotes | enzyme |
| T7 | 564-574 | GeneOrGeneProduct | denotes | luciferase |
| T8 | 836-853 | GeneOrGeneProduct | denotes | metallothionein-1 |
| T9 | 855-858 | GeneOrGeneProduct | denotes | MT1 |
| T10 | 890-894 | GeneOrGeneProduct | denotes | cell |
| T11 | 900-904 | GeneOrGeneProduct | denotes | Huh7 |
| T12 | 965-969 | GeneOrGeneProduct | denotes | MT1G |
| T13 | 970-974 | GeneOrGeneProduct | denotes | mRNA |
| T14 | 1052-1057 | GeneOrGeneProduct | denotes | other |
| T15 | 1078-1084 | GeneOrGeneProduct | denotes | kinase |
| T16 | 1085-1095 | GeneOrGeneProduct | denotes | inhibitors |
| T17 | 1137-1141 | GeneOrGeneProduct | denotes | MT1G |
| T18 | 1303-1323 | GeneOrGeneProduct | denotes | transcription factor |
| T19 | 1324-1328 | GeneOrGeneProduct | denotes | NRF2 |
| T20 | 1330-1344 | GeneOrGeneProduct | denotes | Nuclear factor |
| T21 | 1365-1371 | GeneOrGeneProduct | denotes | Factor |
| T22 | 1458-1462 | GeneOrGeneProduct | denotes | MT1G |
| T23 | 1551-1558 | GeneOrGeneProduct | denotes | protein |
| T24 | 1569-1572 | GeneOrGeneProduct | denotes | MT1 |
| T25 | 1667-1674 | GeneOrGeneProduct | denotes | reduced |
| T26 | 1734-1737 | GeneOrGeneProduct | denotes | MT1 |
| T27 | 1787-1793 | GeneOrGeneProduct | denotes | impact |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 64-88 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 |
| T2 | 188-195 | DiseaseOrPhenotypicFeature | denotes | tumours | DISEASE |
| T3 | 263-271 | DiseaseOrPhenotypicFeature | denotes | necrosis | D009336 |
| T4 | 281-287 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T5 | 392-398 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T6 | 611-617 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T7 | 638-644 | DiseaseOrPhenotypicFeature | denotes | Tumour | DISEASE |
| T8 | 677-701 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 |
| T9 | 703-706 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T11 | 748-751 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T13 | 886-889 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T15 | 995-1001 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T16 | 1471-1477 | DiseaseOrPhenotypicFeature | denotes | tumour | DISEASE |
| T17 | 1510-1513 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T19 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T21 | 1834-1840 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-17 | GeneOrGeneProduct | denotes | Metallothionein-1 |
| T2 | 142-158 | GeneOrGeneProduct | denotes | kinase inhibitor |
| T3 | 836-853 | GeneOrGeneProduct | denotes | metallothionein-1 |
| T4 | 855-858 | GeneOrGeneProduct | denotes | MT1 |
| T5 | 900-904 | GeneOrGeneProduct | denotes | Huh7 |
| T6 | 965-969 | GeneOrGeneProduct | denotes | MT1G |
| T7 | 1078-1095 | GeneOrGeneProduct | denotes | kinase inhibitors |
| T8 | 1137-1141 | GeneOrGeneProduct | denotes | MT1G |
| T9 | 1324-1328 | GeneOrGeneProduct | denotes | NRF2 |
| T10 | 1330-1344 | GeneOrGeneProduct | denotes | Nuclear factor |
| T11 | 1458-1462 | GeneOrGeneProduct | denotes | MT1G |
| T12 | 1569-1572 | GeneOrGeneProduct | denotes | MT1 |
| T13 | 1734-1737 | GeneOrGeneProduct | denotes | MT1 |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 64-88 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | 0007256 |
| T2 | 677-701 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | 0007256 |
| T3 | 703-706 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
| T4 | 748-751 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
| T5 | 886-889 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
| T6 | 1510-1513 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
| T7 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 64-88 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 |
| T2 | 188-195 | DiseaseOrPhenotypicFeature | denotes | tumours | DISEASE |
| T3 | 263-271 | DiseaseOrPhenotypicFeature | denotes | necrosis | D009336 |
| T4 | 281-287 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T5 | 392-398 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T6 | 611-617 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T7 | 638-644 | DiseaseOrPhenotypicFeature | denotes | Tumour | DISEASE |
| T8 | 677-701 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 |
| T9 | 703-706 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T11 | 748-751 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T13 | 886-889 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T15 | 995-1001 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T16 | 1471-1477 | DiseaseOrPhenotypicFeature | denotes | tumour | DISEASE |
| T17 | 1510-1513 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T19 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T21 | 1834-1840 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 64-88 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 |
| T2 | 188-195 | DiseaseOrPhenotypicFeature | denotes | tumours | DISEASE |
| T3 | 281-287 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T4 | 392-398 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T5 | 611-617 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T6 | 638-644 | DiseaseOrPhenotypicFeature | denotes | Tumour | DISEASE |
| T7 | 677-701 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 |
| T8 | 703-706 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T10 | 748-751 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T12 | 886-889 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T14 | 995-1001 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T15 | 1471-1477 | DiseaseOrPhenotypicFeature | denotes | tumour | DISEASE |
| T16 | 1510-1513 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T18 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | HCC | DISEASE|D006528 |
| T20 | 1834-1840 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
LitCoin_CellLine
| Id | Subject | Object | Predicate | Lexical cue | cellosaurus_accession_id |
|---|---|---|---|---|---|
| T1 | 900-904 | CellLine | denotes | Huh7 | CVCL_0336 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 752-760 | OrganismTaxon | denotes | patients |
| T2 | 989-994 | OrganismTaxon | denotes | human |
| T3 | 1345-1354 | OrganismTaxon | denotes | erythroid |
| T4 | 1607-1615 | OrganismTaxon | denotes | patients |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 0-15 | ChemicalEntity | denotes | Metallothionein | ChemicalEntity |
| T2 | 106-115 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T4 | 129-138 | ChemicalEntity | denotes | Sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T6 | 355-364 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T8 | 627-636 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T10 | 771-780 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T12 | 836-851 | ChemicalEntity | denotes | metallothionein | ChemicalEntity |
| T13 | 916-925 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T15 | 927-936 | ChemicalEntity | denotes | Sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T17 | 1180-1189 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T19 | 1230-1242 | ChemicalEntity | denotes | Anti-oxidant | ChemicalEntity |
| T20 | 1626-1635 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
| T22 | 1797-1806 | ChemicalEntity | denotes | sorafenib | D000077157|http://purl.obolibrary.org/obo/CHEBI_50924 |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: | cellosaurus_accession_id |
|---|---|---|---|---|---|---|---|
| T1 | 900-904 | CellLine | denotes | Huh7 | CVCL_0336 | ||
| T22 | 1797-1806 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T20 | 1626-1635 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T19 | 1230-1242 | ChemicalEntity | denotes | Anti-oxidant | ChemicalEntity | ||
| T17 | 1180-1189 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T15 | 927-936 | ChemicalEntity | denotes | Sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T13 | 916-925 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T12 | 836-851 | ChemicalEntity | denotes | metallothionein | ChemicalEntity | ||
| T10 | 771-780 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T8 | 627-636 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T6 | 355-364 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T4 | 129-138 | ChemicalEntity | denotes | Sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T2 | 106-115 | ChemicalEntity | denotes | sorafenib | http://purl.obolibrary.org/obo/CHEBI_50924|D000077157 | ||
| T91597 | 0-15 | ChemicalEntity | denotes | Metallothionein | ChemicalEntity | ||
| T33532 | 1734-1737 | GeneOrGeneProduct | denotes | MT1 | |||
| T66692 | 1569-1572 | GeneOrGeneProduct | denotes | MT1 | |||
| T11 | 1458-1462 | GeneOrGeneProduct | denotes | MT1G | |||
| T11649 | 1330-1344 | GeneOrGeneProduct | denotes | Nuclear factor | |||
| T9 | 1324-1328 | GeneOrGeneProduct | denotes | NRF2 | |||
| T61570 | 1137-1141 | GeneOrGeneProduct | denotes | MT1G | |||
| T7 | 1078-1095 | GeneOrGeneProduct | denotes | kinase inhibitors | |||
| T71714 | 965-969 | GeneOrGeneProduct | denotes | MT1G | |||
| T5 | 900-904 | GeneOrGeneProduct | denotes | Huh7 | |||
| T14010 | 855-858 | GeneOrGeneProduct | denotes | MT1 | |||
| T3 | 836-853 | GeneOrGeneProduct | denotes | metallothionein-1 | |||
| T54816 | 142-158 | GeneOrGeneProduct | denotes | kinase inhibitor | |||
| T81538 | 0-17 | GeneOrGeneProduct | denotes | Metallothionein-1 | |||
| T98655 | 1834-1840 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 | ||
| T18 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | HCC | D006528|DISEASE | ||
| T16 | 1510-1513 | DiseaseOrPhenotypicFeature | denotes | HCC | D006528|DISEASE | ||
| T9866 | 1471-1477 | DiseaseOrPhenotypicFeature | denotes | tumour | DISEASE | ||
| T14 | 995-1001 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 | ||
| T78776 | 886-889 | DiseaseOrPhenotypicFeature | denotes | HCC | D006528|DISEASE | ||
| T55000 | 748-751 | DiseaseOrPhenotypicFeature | denotes | HCC | D006528|DISEASE | ||
| T87883 | 703-706 | DiseaseOrPhenotypicFeature | denotes | HCC | D006528|DISEASE | ||
| T93319 | 677-701 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 | ||
| T617 | 638-644 | DiseaseOrPhenotypicFeature | denotes | Tumour | DISEASE | ||
| T3023 | 611-617 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 | ||
| T50206 | 392-398 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 | ||
| T39241 | 281-287 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 | ||
| T22881 | 188-195 | DiseaseOrPhenotypicFeature | denotes | tumours | DISEASE | ||
| T28839 | 64-88 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | D006528 | ||
| T40254 | 1607-1615 | OrganismTaxon | denotes | patients | |||
| T33957 | 1345-1354 | OrganismTaxon | denotes | erythroid | |||
| T75696 | 989-994 | OrganismTaxon | denotes | human | |||
| T55587 | 752-760 | OrganismTaxon | denotes | patients |