PubMed:27179944 JSONTXT

{"project":"Zierdiyeerkenaili_800","denotations":[{"id":"T1","span":{"begin":73,"end":96},"obj":"DP"},{"id":"T2","span":{"begin":361,"end":384},"obj":"DP"},{"id":"T3","span":{"begin":592,"end":615},"obj":"DP"},{"id":"T4","span":{"begin":731,"end":754},"obj":"DP"},{"id":"T5","span":{"begin":1016,"end":1039},"obj":"DP"},{"id":"T6","span":{"begin":1272,"end":1295},"obj":"DP"},{"id":"T7","span":{"begin":1324,"end":1347},"obj":"DP"},{"id":"T8","span":{"begin":2141,"end":2164},"obj":"DP"},{"id":"T9","span":{"begin":2321,"end":2344},"obj":"DP"}],"text":"Efficacy of transcranial direct-current stimulation (tDCS) in women with provoked vestibulodynia: study protocol for a randomized controlled trial.\nBACKGROUND: Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked vestibulodynia remain limited. For a high proportion of women, significant pain persists despite the currently available treatments. Growing evidence suggests that the central nervous system (CNS) could play a key role in provoked vestibulodynia; thus, treatment targeting the CNS, rather than localized dysfunctions, may be beneficial for women suffering from provoked vestibulodynia. In this study, we aim to build on the promising results of a previous case report and evaluate whether transcranial direct-current stimulation, a non-invasive brain stimulation technique targeting the CNS, could be an effective treatment option for women with provoked vestibulodynia.\nMETHODS/DESIGN: This single-center, triple-blind, parallel group, randomized, controlled trial aims to compare the efficacy of transcranial direct-current stimulation with sham transcranial direct-current stimulation in women with provoked vestibulodynia. Forty women diagnosed with provoked vestibulodynia by a gynecologist, following a standardized treatment protocol, are randomized to either active transcranial direct-current stimulation treatment for ten sessions of 20 minutes at an intensity of 2 mA or sham transcranial direct-current stimulation over a 2-week period. Outcome measures are collected at baseline, 2 weeks after treatment and at 3-month follow-up. The primary outcome is pain during intercourse, assessed with a numerical rating scale. Secondary measurements focus on the sexual function, vestibular pain sensitivity, psychological distress, treatment satisfaction, and the patient's global impression of change.\nDISCUSSION: To our knowledge, this study is the first randomized controlled trial to examine the efficacy of transcranial direct-current stimulation in women with provoked vestibulodynia. Findings from this trial are expected to provide significant information about a promising intervention targeting the centralization of pain in women with provoked vestibulodynia.\nTRIAL REGISTRATION: Clinicaltrials.gov, NCT02543593 . Registered on September 4, 2015."}

{"project":"maxiaofeng52_800_3","denotations":[{"id":"T1","span":{"begin":82,"end":96},"obj":"DP"},{"id":"T2","span":{"begin":169,"end":183},"obj":"DP"},{"id":"T3","span":{"begin":370,"end":384},"obj":"DP"},{"id":"T4","span":{"begin":601,"end":615},"obj":"DP"},{"id":"T5","span":{"begin":740,"end":754},"obj":"DP"},{"id":"T6","span":{"begin":1025,"end":1039},"obj":"DP"},{"id":"T7","span":{"begin":1281,"end":1295},"obj":"DP"},{"id":"T8","span":{"begin":1333,"end":1347},"obj":"DP"},{"id":"T9","span":{"begin":2150,"end":2164},"obj":"DP"},{"id":"T10","span":{"begin":2330,"end":2344},"obj":"DP"}],"text":"Efficacy of transcranial direct-current stimulation (tDCS) in women with provoked vestibulodynia: study protocol for a randomized controlled trial.\nBACKGROUND: Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked vestibulodynia remain limited. For a high proportion of women, significant pain persists despite the currently available treatments. Growing evidence suggests that the central nervous system (CNS) could play a key role in provoked vestibulodynia; thus, treatment targeting the CNS, rather than localized dysfunctions, may be beneficial for women suffering from provoked vestibulodynia. In this study, we aim to build on the promising results of a previous case report and evaluate whether transcranial direct-current stimulation, a non-invasive brain stimulation technique targeting the CNS, could be an effective treatment option for women with provoked vestibulodynia.\nMETHODS/DESIGN: This single-center, triple-blind, parallel group, randomized, controlled trial aims to compare the efficacy of transcranial direct-current stimulation with sham transcranial direct-current stimulation in women with provoked vestibulodynia. Forty women diagnosed with provoked vestibulodynia by a gynecologist, following a standardized treatment protocol, are randomized to either active transcranial direct-current stimulation treatment for ten sessions of 20 minutes at an intensity of 2 mA or sham transcranial direct-current stimulation over a 2-week period. Outcome measures are collected at baseline, 2 weeks after treatment and at 3-month follow-up. The primary outcome is pain during intercourse, assessed with a numerical rating scale. Secondary measurements focus on the sexual function, vestibular pain sensitivity, psychological distress, treatment satisfaction, and the patient's global impression of change.\nDISCUSSION: To our knowledge, this study is the first randomized controlled trial to examine the efficacy of transcranial direct-current stimulation in women with provoked vestibulodynia. Findings from this trial are expected to provide significant information about a promising intervention targeting the centralization of pain in women with provoked vestibulodynia.\nTRIAL REGISTRATION: Clinicaltrials.gov, NCT02543593 . Registered on September 4, 2015."}

{"project":"wangzhuo19_800_3","denotations":[{"id":"T1","span":{"begin":82,"end":96},"obj":"DP"},{"id":"T2","span":{"begin":169,"end":183},"obj":"DP"},{"id":"T3","span":{"begin":370,"end":384},"obj":"DP"},{"id":"T4","span":{"begin":601,"end":615},"obj":"DP"},{"id":"T5","span":{"begin":740,"end":754},"obj":"DP"},{"id":"T6","span":{"begin":1025,"end":1039},"obj":"DP"},{"id":"T7","span":{"begin":1281,"end":1295},"obj":"DP"},{"id":"T8","span":{"begin":1333,"end":1347},"obj":"DP"},{"id":"T9","span":{"begin":2150,"end":2164},"obj":"DP"},{"id":"T10","span":{"begin":2330,"end":2344},"obj":"DP"}],"text":"Efficacy of transcranial direct-current stimulation (tDCS) in women with provoked vestibulodynia: study protocol for a randomized controlled trial.\nBACKGROUND: Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked vestibulodynia remain limited. For a high proportion of women, significant pain persists despite the currently available treatments. Growing evidence suggests that the central nervous system (CNS) could play a key role in provoked vestibulodynia; thus, treatment targeting the CNS, rather than localized dysfunctions, may be beneficial for women suffering from provoked vestibulodynia. In this study, we aim to build on the promising results of a previous case report and evaluate whether transcranial direct-current stimulation, a non-invasive brain stimulation technique targeting the CNS, could be an effective treatment option for women with provoked vestibulodynia.\nMETHODS/DESIGN: This single-center, triple-blind, parallel group, randomized, controlled trial aims to compare the efficacy of transcranial direct-current stimulation with sham transcranial direct-current stimulation in women with provoked vestibulodynia. Forty women diagnosed with provoked vestibulodynia by a gynecologist, following a standardized treatment protocol, are randomized to either active transcranial direct-current stimulation treatment for ten sessions of 20 minutes at an intensity of 2 mA or sham transcranial direct-current stimulation over a 2-week period. Outcome measures are collected at baseline, 2 weeks after treatment and at 3-month follow-up. The primary outcome is pain during intercourse, assessed with a numerical rating scale. Secondary measurements focus on the sexual function, vestibular pain sensitivity, psychological distress, treatment satisfaction, and the patient's global impression of change.\nDISCUSSION: To our knowledge, this study is the first randomized controlled trial to examine the efficacy of transcranial direct-current stimulation in women with provoked vestibulodynia. Findings from this trial are expected to provide significant information about a promising intervention targeting the centralization of pain in women with provoked vestibulodynia.\nTRIAL REGISTRATION: Clinicaltrials.gov, NCT02543593 . Registered on September 4, 2015."}