| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-135 |
Sentence |
denotes |
Heterogeneity of serum prolactin throughout the menstrual cycle and pregnancy in hyperprolactinemic women with normal ovarian function. |
| TextSentencer_T2 |
136-282 |
Sentence |
denotes |
We have demonstrated the selective secretion of high mol wt PRL series (big big PRL) in women with hyperprolactinemia and normal ovarian function. |
| TextSentencer_T3 |
283-413 |
Sentence |
denotes |
This observation suggests that big big PRL is immunologically similar, but biologically less active, than monomeric or little PRL. |
| TextSentencer_T4 |
414-658 |
Sentence |
denotes |
In this study we determined the molecular size heterogeneity of immunoreactive PRL in the serum from two ovulatory hyperprolactinemic women (subjects A and B) who had large amounts of serum big big PRL during a menstrual cycle and/or gestation. |
| TextSentencer_T5 |
659-899 |
Sentence |
denotes |
Serum samples obtained throughout the menstrual cycle (days 6, 10, 14, 17, 23, and 28, taking as day 1 the first day of bleeding) and pregnancy (weeks 7, 9, 11, 15, 20, 25, 30, 34, and 38) were fractionated by gel filtration chromatography. |
| TextSentencer_T6 |
900-953 |
Sentence |
denotes |
PRL was identified in column eluates by specific RIA. |
| TextSentencer_T7 |
954-1097 |
Sentence |
denotes |
Two additional pregnant women, one with a bromocriptine-treated PRL-secreting adenoma (subject C), and a normal woman (subject D) were studied. |
| TextSentencer_T8 |
1098-1257 |
Sentence |
denotes |
Big big PRL was the predominant species throughout the different phases of the menstrual cycle in subject B, comprising 70-80% of the total immunoreactive PRL. |
| TextSentencer_T9 |
1258-1374 |
Sentence |
denotes |
Most of the remainder was big PRL, and little PRL was present in only small amounts (6-12%) during the luteal phase. |
| TextSentencer_T10 |
1375-1564 |
Sentence |
denotes |
During their pregnancies, the serum PRL in subjects A and B initially was mostly big big PRL, but later in gestation the PRL composition shifted from the high mol wt variants to little PRL. |
| TextSentencer_T11 |
1565-1707 |
Sentence |
denotes |
The infant's cord (subject A) and peripheral (subject B) serum at birth contained appreciable quantities of big big and big PRL, respectively. |
| TextSentencer_T12 |
1708-1867 |
Sentence |
denotes |
These results indicate that structural changes in PRL occur during pregnancy and the menstrual cycle which are probably influenced by the hormonal environment. |
| TextSentencer_T13 |
1868-2084 |
Sentence |
denotes |
In addition, the occurrence of larger mol wt PRL species in the serum of the infant of a hyperprolactinemic mother suggests that the presence of high proportions of big big PRL in the serum is genetically determined. |
| T1 |
0-135 |
Sentence |
denotes |
Heterogeneity of serum prolactin throughout the menstrual cycle and pregnancy in hyperprolactinemic women with normal ovarian function. |
| T2 |
136-282 |
Sentence |
denotes |
We have demonstrated the selective secretion of high mol wt PRL series (big big PRL) in women with hyperprolactinemia and normal ovarian function. |
| T3 |
283-413 |
Sentence |
denotes |
This observation suggests that big big PRL is immunologically similar, but biologically less active, than monomeric or little PRL. |
| T4 |
414-658 |
Sentence |
denotes |
In this study we determined the molecular size heterogeneity of immunoreactive PRL in the serum from two ovulatory hyperprolactinemic women (subjects A and B) who had large amounts of serum big big PRL during a menstrual cycle and/or gestation. |
| T5 |
659-899 |
Sentence |
denotes |
Serum samples obtained throughout the menstrual cycle (days 6, 10, 14, 17, 23, and 28, taking as day 1 the first day of bleeding) and pregnancy (weeks 7, 9, 11, 15, 20, 25, 30, 34, and 38) were fractionated by gel filtration chromatography. |
| T6 |
900-953 |
Sentence |
denotes |
PRL was identified in column eluates by specific RIA. |
| T7 |
954-1097 |
Sentence |
denotes |
Two additional pregnant women, one with a bromocriptine-treated PRL-secreting adenoma (subject C), and a normal woman (subject D) were studied. |
| T8 |
1098-1257 |
Sentence |
denotes |
Big big PRL was the predominant species throughout the different phases of the menstrual cycle in subject B, comprising 70-80% of the total immunoreactive PRL. |
| T9 |
1258-1374 |
Sentence |
denotes |
Most of the remainder was big PRL, and little PRL was present in only small amounts (6-12%) during the luteal phase. |
| T10 |
1375-1564 |
Sentence |
denotes |
During their pregnancies, the serum PRL in subjects A and B initially was mostly big big PRL, but later in gestation the PRL composition shifted from the high mol wt variants to little PRL. |
| T11 |
1565-1707 |
Sentence |
denotes |
The infant's cord (subject A) and peripheral (subject B) serum at birth contained appreciable quantities of big big and big PRL, respectively. |
| T12 |
1708-1867 |
Sentence |
denotes |
These results indicate that structural changes in PRL occur during pregnancy and the menstrual cycle which are probably influenced by the hormonal environment. |
| T13 |
1868-2084 |
Sentence |
denotes |
In addition, the occurrence of larger mol wt PRL species in the serum of the infant of a hyperprolactinemic mother suggests that the presence of high proportions of big big PRL in the serum is genetically determined. |
