PubMed:27134166 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/27134166","sourcedb":"PubMed","sourceid":"27134166","text":"Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling.\nTherapeutic targeting of tumor angiogenesis with VEGF inhibitors results in demonstrable, but transitory efficacy in certain human tumors and mouse models of cancer, limited by unconventional forms of adaptive/evasive resistance. In one such mouse model, potent angiogenesis inhibitors elicit compartmental reorganization of cancer cells around remaining blood vessels. The glucose and lactate transporters GLUT1 and MCT4 are induced in distal hypoxic cells in a HIF1α-dependent fashion, indicative of glycolysis. Tumor cells proximal to blood vessels instead express the lactate transporter MCT1, and p-S6, the latter reflecting mTOR signaling. Normoxic cancer cells import and metabolize lactate, resulting in upregulation of mTOR signaling via glutamine metabolism enhanced by lactate catabolism. Thus, metabolic symbiosis is established in the face of angiogenesis inhibition, whereby hypoxic cancer cells import glucose and export lactate, while normoxic cells import and catabolize lactate. mTOR signaling inhibition disrupts this metabolic symbiosis, associated with upregulation of the glucose transporter GLUT2.","tracks":[{"project":"TEST-DiseaseOrPhenotypicFeature","denotations":[{"id":"T1","span":{"begin":137,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":243,"end":249},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":270,"end":276},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":437,"end":443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":556,"end":563},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":626,"end":631},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":767,"end":773},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1001,"end":1008},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1009,"end":1015},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A9","pred":"#label","subj":"T9","obj":"D009369"},{"id":"A6","pred":"#label","subj":"T6","obj":"D009369"},{"id":"A2","pred":"#label","subj":"T2","obj":"D009369"},{"id":"A5","pred":"#label","subj":"T5","obj":"DISEASE"},{"id":"A4","pred":"#label","subj":"T4","obj":"D009369"},{"id":"A1","pred":"#label","subj":"T1","obj":"D009369"},{"id":"A7","pred":"#label","subj":"T7","obj":"D009369"},{"id":"A3","pred":"#label","subj":"T3","obj":"D009369"},{"id":"A8","pred":"#label","subj":"T8","obj":"DISEASE"},{"subj":"T1","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T2","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T3","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T4","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T5","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T6","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T7","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T8","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T9","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"}]},{"project":"TEST-ChemicalEntity","denotations":[{"id":"T1","span":{"begin":486,"end":493},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":498,"end":505},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":684,"end":691},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":802,"end":809},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":859,"end":868},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":892,"end":899},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":1029,"end":1036},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":1048,"end":1055},"obj":"ChemicalEntity"},{"id":"T18","span":{"begin":1100,"end":1107},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":1206,"end":1213},"obj":"ChemicalEntity"}],"attributes":[{"id":"A13","pred":"ID:","subj":"T13","obj":"D005947"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A15","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D019344"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D019344"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D005947"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A18","pred":"ID:","subj":"T18","obj":"D019344"},{"id":"A19","pred":"ID:","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D019344"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D019344"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D019344"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_28300"},{"id":"A20","pred":"ID:","subj":"T20","obj":"D005947"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"subj":"T1","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T4","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T6","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T8","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T10","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T11","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T13","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T16","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T18","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T20","pred":"source","obj":"TEST-ChemicalEntity"}]},{"project":"TEST-OrganismTaxon","denotations":[{"id":"T1","span":{"begin":237,"end":242},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":254,"end":259},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":354,"end":359},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T2","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T3","pred":"source","obj":"TEST-OrganismTaxon"}]},{"project":"Test-merged","denotations":[{"id":"T9","span":{"begin":1009,"end":1015},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1001,"end":1008},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":767,"end":773},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":626,"end":631},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":556,"end":563},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":437,"end":443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":270,"end":276},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":243,"end":249},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T1","span":{"begin":137,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T33893","span":{"begin":354,"end":359},"obj":"OrganismTaxon"},{"id":"T36277","span":{"begin":254,"end":259},"obj":"OrganismTaxon"},{"id":"T86620","span":{"begin":237,"end":242},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":1226,"end":1231},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1206,"end":1225},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1109,"end":1113},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":840,"end":844},"obj":"GeneOrGeneProduct"},{"id":"T54106","span":{"begin":742,"end":746},"obj":"GeneOrGeneProduct"},{"id":"T29817","span":{"begin":704,"end":708},"obj":"GeneOrGeneProduct"},{"id":"T62996","span":{"begin":684,"end":703},"obj":"GeneOrGeneProduct"},{"id":"T38337","span":{"begin":575,"end":579},"obj":"GeneOrGeneProduct"},{"id":"T45517","span":{"begin":529,"end":533},"obj":"GeneOrGeneProduct"},{"id":"T95670","span":{"begin":519,"end":524},"obj":"GeneOrGeneProduct"},{"id":"T96899","span":{"begin":498,"end":518},"obj":"GeneOrGeneProduct"},{"id":"T71979","span":{"begin":161,"end":165},"obj":"GeneOrGeneProduct"},{"id":"T4252","span":{"begin":96,"end":100},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1100,"end":1107},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":1048,"end":1055},"obj":"ChemicalEntity"},{"id":"T89942","span":{"begin":1029,"end":1036},"obj":"ChemicalEntity"},{"id":"T30009","span":{"begin":892,"end":899},"obj":"ChemicalEntity"},{"id":"T23716","span":{"begin":859,"end":868},"obj":"ChemicalEntity"},{"id":"T81611","span":{"begin":802,"end":809},"obj":"ChemicalEntity"},{"id":"T9159","span":{"begin":486,"end":493},"obj":"ChemicalEntity"}],"attributes":[{"id":"A74374","pred":"ID:","subj":"T9159","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A28262","pred":"ID:","subj":"T9159","obj":"D005947"},{"id":"A69813","pred":"ID:","subj":"T9159","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A6","pred":"#label","subj":"T6","obj":"D009369"},{"id":"A3","pred":"#label","subj":"T3","obj":"D009369"},{"id":"A12","pred":"ID:","subj":"T30009","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A11","pred":"ID:","subj":"T30009","obj":"D019344"},{"id":"A10","pred":"ID:","subj":"T23716","obj":"http://purl.obolibrary.org/obo/CHEBI_28300"},{"id":"A15","pred":"ID:","subj":"T89942","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A14","pred":"ID:","subj":"T89942","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A13","pred":"ID:","subj":"T89942","obj":"D005947"},{"id":"A9","pred":"#label","subj":"T9","obj":"D009369"},{"id":"A1","pred":"#label","subj":"T1","obj":"D009369"},{"id":"A7","pred":"#label","subj":"T7","obj":"D009369"},{"id":"A19","pred":"ID:","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A18","pred":"ID:","subj":"T18","obj":"D019344"},{"id":"A34443","pred":"ID:","subj":"T81611","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A95165","pred":"ID:","subj":"T81611","obj":"D019344"},{"id":"A8","pred":"#label","subj":"T8","obj":"DISEASE"},{"id":"A4","pred":"#label","subj":"T4","obj":"D009369"},{"id":"A5","pred":"#label","subj":"T5","obj":"DISEASE"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D019344"},{"id":"A2","pred":"#label","subj":"T2","obj":"D009369"},{"subj":"T9","pred":"source","obj":"Test-merged"},{"subj":"T8","pred":"source","obj":"Test-merged"},{"subj":"T7","pred":"source","obj":"Test-merged"},{"subj":"T6","pred":"source","obj":"Test-merged"},{"subj":"T5","pred":"source","obj":"Test-merged"},{"subj":"T4","pred":"source","obj":"Test-merged"},{"subj":"T3","pred":"source","obj":"Test-merged"},{"subj":"T2","pred":"source","obj":"Test-merged"},{"subj":"T1","pred":"source","obj":"Test-merged"},{"subj":"T33893","pred":"source","obj":"Test-merged"},{"subj":"T36277","pred":"source","obj":"Test-merged"},{"subj":"T86620","pred":"source","obj":"Test-merged"},{"subj":"T13","pred":"source","obj":"Test-merged"},{"subj":"T12","pred":"source","obj":"Test-merged"},{"subj":"T11","pred":"source","obj":"Test-merged"},{"subj":"T10","pred":"source","obj":"Test-merged"},{"subj":"T54106","pred":"source","obj":"Test-merged"},{"subj":"T29817","pred":"source","obj":"Test-merged"},{"subj":"T62996","pred":"source","obj":"Test-merged"},{"subj":"T38337","pred":"source","obj":"Test-merged"},{"subj":"T45517","pred":"source","obj":"Test-merged"},{"subj":"T95670","pred":"source","obj":"Test-merged"},{"subj":"T96899","pred":"source","obj":"Test-merged"},{"subj":"T71979","pred":"source","obj":"Test-merged"},{"subj":"T4252","pred":"source","obj":"Test-merged"},{"subj":"T18","pred":"source","obj":"Test-merged"},{"subj":"T16","pred":"source","obj":"Test-merged"},{"subj":"T89942","pred":"source","obj":"Test-merged"},{"subj":"T30009","pred":"source","obj":"Test-merged"},{"subj":"T23716","pred":"source","obj":"Test-merged"},{"subj":"T81611","pred":"source","obj":"Test-merged"},{"subj":"T9159","pred":"source","obj":"Test-merged"}]},{"project":"Test-GeneOrGeneProduct","denotations":[{"id":"T1","span":{"begin":96,"end":100},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":161,"end":165},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":498,"end":518},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":519,"end":524},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":529,"end":533},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":575,"end":579},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":684,"end":703},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":704,"end":708},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":742,"end":746},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":840,"end":844},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1109,"end":1113},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1206,"end":1225},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1226,"end":1231},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T2","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T3","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T4","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T5","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T6","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T7","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T8","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T9","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T10","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T11","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T12","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T13","pred":"source","obj":"Test-GeneOrGeneProduct"}]},{"project":"Test-merged-2","denotations":[{"id":"T9159","span":{"begin":486,"end":493},"obj":"ChemicalEntity"},{"id":"T27559","span":{"begin":498,"end":505},"obj":"ChemicalEntity"},{"id":"T76972","span":{"begin":684,"end":691},"obj":"ChemicalEntity"},{"id":"T81611","span":{"begin":802,"end":809},"obj":"ChemicalEntity"},{"id":"T23716","span":{"begin":859,"end":868},"obj":"ChemicalEntity"},{"id":"T30009","span":{"begin":892,"end":899},"obj":"ChemicalEntity"},{"id":"T89942","span":{"begin":1029,"end":1036},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":1048,"end":1055},"obj":"ChemicalEntity"},{"id":"T18","span":{"begin":1100,"end":1107},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":1206,"end":1213},"obj":"ChemicalEntity"},{"id":"T4252","span":{"begin":96,"end":100},"obj":"GeneOrGeneProduct"},{"id":"T71979","span":{"begin":161,"end":165},"obj":"GeneOrGeneProduct"},{"id":"T96899","span":{"begin":498,"end":518},"obj":"GeneOrGeneProduct"},{"id":"T95670","span":{"begin":519,"end":524},"obj":"GeneOrGeneProduct"},{"id":"T45517","span":{"begin":529,"end":533},"obj":"GeneOrGeneProduct"},{"id":"T38337","span":{"begin":575,"end":579},"obj":"GeneOrGeneProduct"},{"id":"T62996","span":{"begin":684,"end":703},"obj":"GeneOrGeneProduct"},{"id":"T29817","span":{"begin":704,"end":708},"obj":"GeneOrGeneProduct"},{"id":"T54106","span":{"begin":742,"end":746},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":840,"end":844},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1109,"end":1113},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1206,"end":1225},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1226,"end":1231},"obj":"GeneOrGeneProduct"},{"id":"T86620","span":{"begin":237,"end":242},"obj":"OrganismTaxon"},{"id":"T36277","span":{"begin":254,"end":259},"obj":"OrganismTaxon"},{"id":"T33893","span":{"begin":354,"end":359},"obj":"OrganismTaxon"},{"id":"T1","span":{"begin":137,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":243,"end":249},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":270,"end":276},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":437,"end":443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":556,"end":563},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":626,"end":631},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":767,"end":773},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1001,"end":1008},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1009,"end":1015},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"#label","subj":"T5","obj":"DISEASE"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D019344"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A95165","pred":"ID:","subj":"T81611","obj":"D019344"},{"id":"A34443","pred":"ID:","subj":"T81611","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A6","pred":"#label","subj":"T6","obj":"D009369"},{"id":"A40812","pred":"ID:","subj":"T76972","obj":"D019344"},{"id":"A57866","pred":"ID:","subj":"T76972","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A4","pred":"#label","subj":"T4","obj":"D009369"},{"id":"A8","pred":"#label","subj":"T8","obj":"DISEASE"},{"id":"A69813","pred":"ID:","subj":"T9159","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A28262","pred":"ID:","subj":"T9159","obj":"D005947"},{"id":"A74374","pred":"ID:","subj":"T9159","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A18","pred":"ID:","subj":"T18","obj":"D019344"},{"id":"A19","pred":"ID:","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A14445","pred":"ID:","subj":"T27559","obj":"D019344"},{"id":"A18852","pred":"ID:","subj":"T27559","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A2","pred":"#label","subj":"T2","obj":"D009369"},{"id":"A9","pred":"#label","subj":"T9","obj":"D009369"},{"id":"A1","pred":"#label","subj":"T1","obj":"D009369"},{"id":"A3","pred":"#label","subj":"T3","obj":"D009369"},{"id":"A20","pred":"ID:","subj":"T20","obj":"D005947"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A10","pred":"ID:","subj":"T23716","obj":"http://purl.obolibrary.org/obo/CHEBI_28300"},{"id":"A11","pred":"ID:","subj":"T30009","obj":"D019344"},{"id":"A12","pred":"ID:","subj":"T30009","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A13","pred":"ID:","subj":"T89942","obj":"D005947"},{"id":"A14","pred":"ID:","subj":"T89942","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A15","pred":"ID:","subj":"T89942","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A7","pred":"#label","subj":"T7","obj":"D009369"},{"subj":"T9159","pred":"source","obj":"Test-merged-2"},{"subj":"T27559","pred":"source","obj":"Test-merged-2"},{"subj":"T76972","pred":"source","obj":"Test-merged-2"},{"subj":"T81611","pred":"source","obj":"Test-merged-2"},{"subj":"T23716","pred":"source","obj":"Test-merged-2"},{"subj":"T30009","pred":"source","obj":"Test-merged-2"},{"subj":"T89942","pred":"source","obj":"Test-merged-2"},{"subj":"T16","pred":"source","obj":"Test-merged-2"},{"subj":"T18","pred":"source","obj":"Test-merged-2"},{"subj":"T20","pred":"source","obj":"Test-merged-2"},{"subj":"T4252","pred":"source","obj":"Test-merged-2"},{"subj":"T71979","pred":"source","obj":"Test-merged-2"},{"subj":"T96899","pred":"source","obj":"Test-merged-2"},{"subj":"T95670","pred":"source","obj":"Test-merged-2"},{"subj":"T45517","pred":"source","obj":"Test-merged-2"},{"subj":"T38337","pred":"source","obj":"Test-merged-2"},{"subj":"T62996","pred":"source","obj":"Test-merged-2"},{"subj":"T29817","pred":"source","obj":"Test-merged-2"},{"subj":"T54106","pred":"source","obj":"Test-merged-2"},{"subj":"T10","pred":"source","obj":"Test-merged-2"},{"subj":"T11","pred":"source","obj":"Test-merged-2"},{"subj":"T12","pred":"source","obj":"Test-merged-2"},{"subj":"T13","pred":"source","obj":"Test-merged-2"},{"subj":"T86620","pred":"source","obj":"Test-merged-2"},{"subj":"T36277","pred":"source","obj":"Test-merged-2"},{"subj":"T33893","pred":"source","obj":"Test-merged-2"},{"subj":"T1","pred":"source","obj":"Test-merged-2"},{"subj":"T2","pred":"source","obj":"Test-merged-2"},{"subj":"T3","pred":"source","obj":"Test-merged-2"},{"subj":"T4","pred":"source","obj":"Test-merged-2"},{"subj":"T5","pred":"source","obj":"Test-merged-2"},{"subj":"T6","pred":"source","obj":"Test-merged-2"},{"subj":"T7","pred":"source","obj":"Test-merged-2"},{"subj":"T8","pred":"source","obj":"Test-merged-2"},{"subj":"T9","pred":"source","obj":"Test-merged-2"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST-DiseaseOrPhenotypicFeature","color":"#ec9993","default":true},{"id":"TEST-ChemicalEntity","color":"#93a6ec"},{"id":"TEST-OrganismTaxon","color":"#c0ec93"},{"id":"Test-merged","color":"#ec93da"},{"id":"Test-GeneOrGeneProduct","color":"#93ece3"},{"id":"Test-merged-2","color":"#ecc993"}]}]}}