| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-104 |
Sentence |
denotes |
Maternal and fetal human leukocyte antigen class Ia and II alleles in severe preeclampsia and eclampsia. |
| TextSentencer_T2 |
105-280 |
Sentence |
denotes |
A line of investigations indicate that genes in the human leukocyte antigen (HLA) complex are involved in a successful acceptance of the semiallogeneic fetus during pregnancy. |
| TextSentencer_T3 |
281-528 |
Sentence |
denotes |
In this study, associations between specific HLA class Ia (HLA-A and -B) and class II (HLA-DRB1, -DQA1, -DQB1, -DPA1 and -DPB1) alleles and the risk of developing severe preeclampsia/eclampsia were investigated in a detailed and large-scale study. |
| TextSentencer_T4 |
529-706 |
Sentence |
denotes |
In total, 259 women diagnosed with severe preeclampsia or eclampsia and 260 matched control women with no preeclampsia, together with their neonates, were included in the study. |
| TextSentencer_T5 |
707-794 |
Sentence |
denotes |
HLA genotyping for mothers and neonates was performed using next-generation sequencing. |
| TextSentencer_T6 |
795-1111 |
Sentence |
denotes |
The HLA-DPB1*04:01:01G allele was significantly more frequent (Pc=0.044) among women diagnosed with severe preeclampsia/eclampsia compared with controls, and the DQA1*01:02:01G allele frequency was significantly lower (Pc=0.042) among newborns born by women with severe preeclampsia/eclampsia compared with controls. |
| TextSentencer_T7 |
1112-1259 |
Sentence |
denotes |
In mothers with severe preeclampsia/eclampsia, homozygosity was significantly more common compared with controls at the HLA-DPB1 locus (Pc=0.0028). |
| TextSentencer_T8 |
1260-1455 |
Sentence |
denotes |
Although the current large study shows some positive results, more studies, also with a functional focus, are needed to further clarify a possible role of the classical HLA genes in preeclampsia. |
| T1 |
0-104 |
Sentence |
denotes |
Maternal and fetal human leukocyte antigen class Ia and II alleles in severe preeclampsia and eclampsia. |
| T2 |
105-280 |
Sentence |
denotes |
A line of investigations indicate that genes in the human leukocyte antigen (HLA) complex are involved in a successful acceptance of the semiallogeneic fetus during pregnancy. |
| T3 |
281-528 |
Sentence |
denotes |
In this study, associations between specific HLA class Ia (HLA-A and -B) and class II (HLA-DRB1, -DQA1, -DQB1, -DPA1 and -DPB1) alleles and the risk of developing severe preeclampsia/eclampsia were investigated in a detailed and large-scale study. |
| T4 |
529-706 |
Sentence |
denotes |
In total, 259 women diagnosed with severe preeclampsia or eclampsia and 260 matched control women with no preeclampsia, together with their neonates, were included in the study. |
| T5 |
707-794 |
Sentence |
denotes |
HLA genotyping for mothers and neonates was performed using next-generation sequencing. |
| T6 |
795-1111 |
Sentence |
denotes |
The HLA-DPB1*04:01:01G allele was significantly more frequent (Pc=0.044) among women diagnosed with severe preeclampsia/eclampsia compared with controls, and the DQA1*01:02:01G allele frequency was significantly lower (Pc=0.042) among newborns born by women with severe preeclampsia/eclampsia compared with controls. |
| T7 |
1112-1259 |
Sentence |
denotes |
In mothers with severe preeclampsia/eclampsia, homozygosity was significantly more common compared with controls at the HLA-DPB1 locus (Pc=0.0028). |
| T8 |
1260-1455 |
Sentence |
denotes |
Although the current large study shows some positive results, more studies, also with a functional focus, are needed to further clarify a possible role of the classical HLA genes in preeclampsia. |
