PubMed:2709684 JSON TXT

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PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":122,"end":139},"obj":"HP_0000819"},{"id":"T2","span":{"begin":174,"end":184},"obj":"HP_0003076"},{"id":"T3","span":{"begin":303,"end":322},"obj":"HP_0001919"},{"id":"T4","span":{"begin":309,"end":322},"obj":"HP_0000083"},{"id":"T5","span":{"begin":528,"end":538},"obj":"HP_0003076"},{"id":"T6","span":{"begin":1044,"end":1054},"obj":"HP_0003076"}],"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.\nBecause rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)"}

bc5cdr-valid-experiment

bc5cdr-valid-deepseek-nr-ng-experiment

{"project":"bc5cdr-valid-deepseek-nr-ng-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T2","span":{"begin":18,"end":28},"obj":"Disease"},{"id":"T3","span":{"begin":46,"end":56},"obj":"Chemical"},{"id":"T4","span":{"begin":57,"end":71},"obj":"Disease"},{"id":"T5","span":{"begin":99,"end":113},"obj":"Chemical"},{"id":"T6","span":{"begin":122,"end":130},"obj":"Disease"},{"id":"T7","span":{"begin":131,"end":139},"obj":"Disease"},{"id":"T8","span":{"begin":141,"end":143},"obj":"Disease"},{"id":"T9","span":{"begin":174,"end":184},"obj":"Disease"},{"id":"T10","span":{"begin":284,"end":294},"obj":"Chemical"},{"id":"T11","span":{"begin":303,"end":314},"obj":"Disease"},{"id":"T12","span":{"begin":315,"end":322},"obj":"Disease"},{"id":"T13","span":{"begin":324,"end":327},"obj":"Disease"},{"id":"T14","span":{"begin":350,"end":360},"obj":"Chemical"},{"id":"T15","span":{"begin":361,"end":375},"obj":"Disease"},{"id":"T16","span":{"begin":495,"end":504},"obj":"Chemical"},{"id":"T17","span":{"begin":506,"end":507},"obj":"Chemical"},{"id":"T18","span":{"begin":510,"end":512},"obj":"Disease"},{"id":"T19","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"T20","span":{"begin":573,"end":574},"obj":"Chemical"},{"id":"T21","span":{"begin":722,"end":723},"obj":"Chemical"},{"id":"T22","span":{"begin":774,"end":776},"obj":"Chemical"},{"id":"T23","span":{"begin":782,"end":792},"obj":"Chemical"},{"id":"T24","span":{"begin":834,"end":836},"obj":"Disease"}],"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.\nBecause rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)"}

bc5cdr-valid-deepseek-nr-g-experiment

{"project":"bc5cdr-valid-deepseek-nr-g-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T2","span":{"begin":18,"end":28},"obj":"Disease"},{"id":"T3","span":{"begin":46,"end":56},"obj":"Chemical"},{"id":"T4","span":{"begin":57,"end":71},"obj":"Disease"},{"id":"T5","span":{"begin":122,"end":139},"obj":"Disease"},{"id":"T6","span":{"begin":141,"end":143},"obj":"Disease"},{"id":"T7","span":{"begin":174,"end":184},"obj":"Disease"},{"id":"T8","span":{"begin":284,"end":294},"obj":"Chemical"},{"id":"T9","span":{"begin":303,"end":322},"obj":"Disease"},{"id":"T10","span":{"begin":324,"end":327},"obj":"Disease"},{"id":"T11","span":{"begin":350,"end":360},"obj":"Chemical"},{"id":"T12","span":{"begin":361,"end":375},"obj":"Disease"},{"id":"T13","span":{"begin":495,"end":504},"obj":"Chemical"},{"id":"T14","span":{"begin":506,"end":507},"obj":"Chemical"},{"id":"T15","span":{"begin":510,"end":512},"obj":"Disease"},{"id":"T16","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"T17","span":{"begin":573,"end":574},"obj":"Chemical"},{"id":"T18","span":{"begin":782,"end":792},"obj":"Chemical"}],"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.\nBecause rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)"}

bc5cdr-valid-gpt-r-ng-experiment

{"project":"bc5cdr-valid-gpt-r-ng-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T2","span":{"begin":18,"end":28},"obj":"Disease"},{"id":"T3","span":{"begin":46,"end":56},"obj":"Chemical"},{"id":"T4","span":{"begin":57,"end":71},"obj":"Disease"},{"id":"T5","span":{"begin":99,"end":113},"obj":"Chemical"},{"id":"T6","span":{"begin":122,"end":144},"obj":"Disease"},{"id":"T7","span":{"begin":174,"end":184},"obj":"Disease"},{"id":"T8","span":{"begin":284,"end":294},"obj":"Chemical"},{"id":"T9","span":{"begin":303,"end":328},"obj":"Disease"},{"id":"T10","span":{"begin":350,"end":360},"obj":"Chemical"},{"id":"T11","span":{"begin":361,"end":375},"obj":"Disease"},{"id":"T12","span":{"begin":469,"end":476},"obj":"Chemical"},{"id":"T13","span":{"begin":495,"end":504},"obj":"Chemical"},{"id":"T14","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"T15","span":{"begin":782,"end":792},"obj":"Chemical"},{"id":"T16","span":{"begin":806,"end":816},"obj":"Chemical"},{"id":"T17","span":{"begin":905,"end":915},"obj":"Chemical"},{"id":"T18","span":{"begin":1044,"end":1054},"obj":"Disease"},{"id":"T19","span":{"begin":1214,"end":1230},"obj":"Disease"},{"id":"T20","span":{"begin":1299,"end":1302},"obj":"Disease"},{"id":"T21","span":{"begin":1412,"end":1428},"obj":"Disease"},{"id":"T22","span":{"begin":1598,"end":1614},"obj":"Disease"}],"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.\nBecause rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)"}

bc5cdr-valid-gpt-r-g-experiment

{"project":"bc5cdr-valid-gpt-r-g-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T2","span":{"begin":18,"end":28},"obj":"Disease"},{"id":"T3","span":{"begin":46,"end":56},"obj":"Chemical"},{"id":"T4","span":{"begin":57,"end":71},"obj":"Disease"},{"id":"T5","span":{"begin":99,"end":113},"obj":"Chemical"},{"id":"T6","span":{"begin":122,"end":139},"obj":"Disease"},{"id":"T7","span":{"begin":141,"end":143},"obj":"Disease"},{"id":"T8","span":{"begin":174,"end":184},"obj":"Disease"},{"id":"T9","span":{"begin":284,"end":294},"obj":"Chemical"},{"id":"T10","span":{"begin":303,"end":322},"obj":"Disease"},{"id":"T11","span":{"begin":324,"end":327},"obj":"Disease"},{"id":"T12","span":{"begin":350,"end":360},"obj":"Chemical"},{"id":"T13","span":{"begin":361,"end":375},"obj":"Disease"},{"id":"T14","span":{"begin":469,"end":476},"obj":"Chemical"},{"id":"T15","span":{"begin":495,"end":504},"obj":"Chemical"},{"id":"T16","span":{"begin":506,"end":507},"obj":"Chemical"},{"id":"T17","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"T18","span":{"begin":573,"end":574},"obj":"Chemical"},{"id":"T19","span":{"begin":722,"end":723},"obj":"Chemical"},{"id":"T20","span":{"begin":740,"end":741},"obj":"Chemical"},{"id":"T21","span":{"begin":782,"end":792},"obj":"Chemical"},{"id":"T22","span":{"begin":806,"end":816},"obj":"Chemical"},{"id":"T23","span":{"begin":843,"end":845},"obj":"Disease"},{"id":"T24","span":{"begin":905,"end":915},"obj":"Chemical"},{"id":"T25","span":{"begin":1012,"end":1013},"obj":"Chemical"},{"id":"T26","span":{"begin":1044,"end":1054},"obj":"Disease"},{"id":"T27","span":{"begin":1125,"end":1142},"obj":"Disease"},{"id":"T28","span":{"begin":1214,"end":1230},"obj":"Disease"},{"id":"T29","span":{"begin":1270,"end":1271},"obj":"Chemical"},{"id":"T30","span":{"begin":1288,"end":1298},"obj":"Chemical"},{"id":"T31","span":{"begin":1299,"end":1302},"obj":"Disease"},{"id":"T32","span":{"begin":1412,"end":1428},"obj":"Disease"},{"id":"T33","span":{"begin":1598,"end":1614},"obj":"Disease"}],"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.\nBecause rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)"}

bc5cdr-valid-gpt-r-m30

{"project":"bc5cdr-valid-gpt-r-m30","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T2","span":{"begin":18,"end":28},"obj":"Disease"},{"id":"T3","span":{"begin":46,"end":56},"obj":"Chemical"},{"id":"T4","span":{"begin":57,"end":71},"obj":"Disease"},{"id":"T5","span":{"begin":99,"end":113},"obj":"Chemical"},{"id":"T6","span":{"begin":122,"end":139},"obj":"Disease"},{"id":"T7","span":{"begin":141,"end":143},"obj":"Disease"},{"id":"T8","span":{"begin":174,"end":184},"obj":"Disease"},{"id":"T9","span":{"begin":284,"end":294},"obj":"Chemical"},{"id":"T10","span":{"begin":303,"end":322},"obj":"Disease"},{"id":"T11","span":{"begin":324,"end":327},"obj":"Disease"},{"id":"T12","span":{"begin":350,"end":360},"obj":"Chemical"},{"id":"T13","span":{"begin":361,"end":375},"obj":"Disease"},{"id":"T14","span":{"begin":469,"end":476},"obj":"Chemical"},{"id":"T15","span":{"begin":495,"end":504},"obj":"Chemical"},{"id":"T16","span":{"begin":506,"end":507},"obj":"Chemical"},{"id":"T17","span":{"begin":510,"end":512},"obj":"Disease"},{"id":"T18","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"T19","span":{"begin":573,"end":574},"obj":"Chemical"},{"id":"T20","span":{"begin":722,"end":723},"obj":"Chemical"},{"id":"T21","span":{"begin":740,"end":741},"obj":"Chemical"},{"id":"T22","span":{"begin":782,"end":792},"obj":"Chemical"},{"id":"T23","span":{"begin":806,"end":816},"obj":"Chemical"},{"id":"T24","span":{"begin":843,"end":845},"obj":"Disease"},{"id":"T25","span":{"begin":905,"end":915},"obj":"Chemical"},{"id":"T26","span":{"begin":1044,"end":1054},"obj":"Disease"},{"id":"T27","span":{"begin":1190,"end":1201},"obj":"Disease"},{"id":"T28","span":{"begin":1214,"end":1230},"obj":"Disease"},{"id":"T29","span":{"begin":1270,"end":1271},"obj":"Chemical"},{"id":"T30","span":{"begin":1288,"end":1298},"obj":"Chemical"},{"id":"T31","span":{"begin":1299,"end":1302},"obj":"Disease"},{"id":"T32","span":{"begin":1366,"end":1377},"obj":"Disease"},{"id":"T33","span":{"begin":1412,"end":1428},"obj":"Disease"},{"id":"T34","span":{"begin":1536,"end":1537},"obj":"Chemical"},{"id":"T35","span":{"begin":1556,"end":1567},"obj":"Disease"},{"id":"T36","span":{"begin":1598,"end":1614},"obj":"Disease"}],"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.\nBecause rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)"}

bc5cdr-valid-gpt-r-m20

{"project":"bc5cdr-valid-gpt-r-m20","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T2","span":{"begin":18,"end":28},"obj":"Disease"},{"id":"T3","span":{"begin":46,"end":56},"obj":"Chemical"},{"id":"T4","span":{"begin":57,"end":71},"obj":"Disease"},{"id":"T5","span":{"begin":99,"end":113},"obj":"Chemical"},{"id":"T6","span":{"begin":122,"end":139},"obj":"Disease"},{"id":"T7","span":{"begin":141,"end":143},"obj":"Disease"},{"id":"T8","span":{"begin":174,"end":184},"obj":"Disease"},{"id":"T9","span":{"begin":284,"end":294},"obj":"Chemical"},{"id":"T10","span":{"begin":303,"end":322},"obj":"Disease"},{"id":"T11","span":{"begin":324,"end":327},"obj":"Disease"},{"id":"T12","span":{"begin":350,"end":360},"obj":"Chemical"},{"id":"T13","span":{"begin":361,"end":375},"obj":"Disease"},{"id":"T14","span":{"begin":469,"end":476},"obj":"Chemical"},{"id":"T15","span":{"begin":495,"end":504},"obj":"Chemical"},{"id":"T16","span":{"begin":506,"end":507},"obj":"Chemical"},{"id":"T17","span":{"begin":510,"end":512},"obj":"Disease"},{"id":"T18","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"T19","span":{"begin":573,"end":574},"obj":"Chemical"},{"id":"T20","span":{"begin":722,"end":723},"obj":"Chemical"},{"id":"T21","span":{"begin":740,"end":741},"obj":"Chemical"},{"id":"T22","span":{"begin":782,"end":792},"obj":"Chemical"},{"id":"T23","span":{"begin":806,"end":816},"obj":"Chemical"},{"id":"T24","span":{"begin":843,"end":845},"obj":"Disease"},{"id":"T25","span":{"begin":905,"end":915},"obj":"Chemical"},{"id":"T26","span":{"begin":1012,"end":1013},"obj":"Chemical"},{"id":"T27","span":{"begin":1044,"end":1054},"obj":"Disease"},{"id":"T28","span":{"begin":1190,"end":1201},"obj":"Disease"},{"id":"T29","span":{"begin":1214,"end":1230},"obj":"Disease"},{"id":"T30","span":{"begin":1270,"end":1271},"obj":"Chemical"},{"id":"T31","span":{"begin":1288,"end":1298},"obj":"Chemical"},{"id":"T32","span":{"begin":1299,"end":1302},"obj":"Disease"},{"id":"T33","span":{"begin":1366,"end":1377},"obj":"Disease"},{"id":"T34","span":{"begin":1412,"end":1428},"obj":"Disease"},{"id":"T35","span":{"begin":1556,"end":1567},"obj":"Disease"},{"id":"T36","span":{"begin":1598,"end":1614},"obj":"Disease"}],"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.\nBecause rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)"}