PubMed:27090298
Annnotations
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-50 | Sentence | denotes | Circulating Fatty Acid Synthase in pregnant women: |
T2 | 51-126 | Sentence | denotes | Relationship to blood pressure, maternal metabolism and newborn parameters. |
T3 | 127-232 | Sentence | denotes | The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. |
T4 | 233-280 | Sentence | denotes | FASN is highly expressed in the human placenta. |
T5 | 281-433 | Sentence | denotes | We aimed to investigate the relationship circulating FASN has with blood pressure, maternal metabolism and newborn parameters in healthy pregnant women. |
T6 | 434-705 | Sentence | denotes | Circulating FASN was assessed in 115 asymptomatic pregnant women in the second trimester of gestation along with C-peptide, fasting glucose and insulin, post-load glucose lipids, HMW-adiponectin and blood pressure (the latter was assessed in each trimester of gestation). |
T7 | 706-752 | Sentence | denotes | At birth, newborns and placentas were weighed. |
T8 | 753-814 | Sentence | denotes | FASN expression was also able to be assessed in 80 placentas. |
T9 | 815-1095 | Sentence | denotes | Higher circulating FASN was associated with lower systolic blood pressure (SBP), with a more favourable metabolic phenotype (lower fasting glucose and insulin, post load glucose, HbAc1, HOMA-IR and C-peptide), and with lower placental and birth weight (all p < 0.05 to p < 0.001). |
T10 | 1096-1219 | Sentence | denotes | Placental FASN expression related positively to circulating FASN (p < 0.005) and negatively to placental weight (p < 0.05). |
T11 | 1220-1303 | Sentence | denotes | Our observations suggest a physiological role of placental FASN in human pregnancy. |
T12 | 1304-1533 | Sentence | denotes | Future studies will clarify whether circulating FASN of placental origin does actually regulate placental and fetal growth, and (thereby) has a favourable influence on the pregnant mother's insulin sensitivity and blood pressure. |
LitCoin-entities-OrganismTaxon-PD
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 265-270 | OrganismTaxon | denotes | human | NCBItxid:9606 |
T2 | 1040-1049 | OrganismTaxon | denotes | placental | NCBItxid:9347 |
T3 | 1096-1105 | OrganismTaxon | denotes | Placental | NCBItxid:9347 |
T4 | 1191-1200 | OrganismTaxon | denotes | placental | NCBItxid:9347 |
T5 | 1269-1278 | OrganismTaxon | denotes | placental | NCBItxid:9347 |
T6 | 1287-1292 | OrganismTaxon | denotes | human | NCBItxid:9606 |
T7 | 1360-1369 | OrganismTaxon | denotes | placental | NCBItxid:9347 |
T8 | 1400-1409 | OrganismTaxon | denotes | placental | NCBItxid:9347 |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
11214 | 12-31 | GeneOrGeneProduct | denotes | Fatty Acid Synthase | NCBIGene:2194 |
11215 | 44-49 | OrganismTaxon | denotes | women | NCBITaxon:9606 |
11216 | 138-142 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11217 | 144-163 | GeneOrGeneProduct | denotes | fatty acid synthase | NCBIGene:2194 |
11218 | 193-205 | DiseaseOrPhenotypicFeature | denotes | hypertension | MESH:D006973 |
11219 | 210-231 | DiseaseOrPhenotypicFeature | denotes | metabolic dysfunction | MESH:D008659 |
11220 | 233-237 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11221 | 265-270 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
11222 | 334-338 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11223 | 427-432 | OrganismTaxon | denotes | women | NCBITaxon:9606 |
11224 | 446-450 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11225 | 493-498 | OrganismTaxon | denotes | women | NCBITaxon:9606 |
11226 | 547-556 | ChemicalEntity | denotes | C-peptide | MESH:D002096 |
11227 | 566-573 | ChemicalEntity | denotes | glucose | MESH:D005947 |
11228 | 578-585 | GeneOrGeneProduct | denotes | insulin | NCBIGene:3630 |
11229 | 597-604 | ChemicalEntity | denotes | glucose | MESH:D005947 |
11230 | 605-611 | ChemicalEntity | denotes | lipids | MESH:D008055 |
11231 | 613-616 | GeneOrGeneProduct | denotes | HMW | NCBIGene:57587 |
11232 | 617-628 | GeneOrGeneProduct | denotes | adiponectin | NCBIGene:9370 |
11233 | 753-757 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11234 | 834-838 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11235 | 954-961 | ChemicalEntity | denotes | glucose | MESH:D005947 |
11236 | 966-973 | GeneOrGeneProduct | denotes | insulin | NCBIGene:3630 |
11237 | 985-992 | ChemicalEntity | denotes | glucose | MESH:D005947 |
11238 | 994-999 | GeneOrGeneProduct | denotes | HbAc1 | NCBIGene:3043 |
11239 | 1013-1022 | ChemicalEntity | denotes | C-peptide | MESH:D002096 |
11240 | 1106-1110 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11241 | 1156-1160 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11242 | 1279-1283 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11243 | 1287-1292 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
11244 | 1352-1356 | GeneOrGeneProduct | denotes | FASN | NCBIGene:2194 |
11245 | 1494-1501 | GeneOrGeneProduct | denotes | insulin | NCBIGene:3630 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 12-31 | GeneOrGeneProduct | denotes | Fatty Acid Synthase |
T2 | 131-137 | GeneOrGeneProduct | denotes | enzyme |
T3 | 138-142 | GeneOrGeneProduct | denotes | FASN |
T4 | 144-163 | GeneOrGeneProduct | denotes | fatty acid synthase |
T5 | 193-205 | GeneOrGeneProduct | denotes | hypertension |
T6 | 233-237 | GeneOrGeneProduct | denotes | FASN |
T7 | 241-247 | GeneOrGeneProduct | denotes | highly |
T8 | 334-338 | GeneOrGeneProduct | denotes | FASN |
T9 | 446-450 | GeneOrGeneProduct | denotes | FASN |
T10 | 547-556 | GeneOrGeneProduct | denotes | C-peptide |
T11 | 558-573 | GeneOrGeneProduct | denotes | fasting glucose |
T12 | 578-585 | GeneOrGeneProduct | denotes | insulin |
T13 | 587-591 | GeneOrGeneProduct | denotes | post |
T14 | 617-628 | GeneOrGeneProduct | denotes | adiponectin |
T15 | 753-757 | GeneOrGeneProduct | denotes | FASN |
T16 | 834-838 | GeneOrGeneProduct | denotes | FASN |
T17 | 889-902 | GeneOrGeneProduct | denotes | (SBP), with a |
T18 | 946-961 | GeneOrGeneProduct | denotes | fasting glucose |
T19 | 966-973 | GeneOrGeneProduct | denotes | insulin |
T20 | 975-979 | GeneOrGeneProduct | denotes | post |
T21 | 994-999 | GeneOrGeneProduct | denotes | HbAc1 |
T22 | 1013-1022 | GeneOrGeneProduct | denotes | C-peptide |
T23 | 1054-1066 | GeneOrGeneProduct | denotes | birth weight |
T24 | 1068-1073 | GeneOrGeneProduct | denotes | all p |
T25 | 1106-1110 | GeneOrGeneProduct | denotes | FASN |
T26 | 1156-1160 | GeneOrGeneProduct | denotes | FASN |
T27 | 1279-1283 | GeneOrGeneProduct | denotes | FASN |
T28 | 1352-1356 | GeneOrGeneProduct | denotes | FASN |
T29 | 1391-1399 | GeneOrGeneProduct | denotes | regulate |
T30 | 1420-1426 | GeneOrGeneProduct | denotes | growth |
T31 | 1442-1447 | GeneOrGeneProduct | denotes | has a |
T32 | 1494-1501 | GeneOrGeneProduct | denotes | insulin |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 12-31 | GeneOrGeneProduct | denotes | Fatty Acid Synthase |
T2 | 131-137 | GeneOrGeneProduct | denotes | enzyme |
T3 | 138-142 | GeneOrGeneProduct | denotes | FASN |
T4 | 144-163 | GeneOrGeneProduct | denotes | fatty acid synthase |
T5 | 193-205 | GeneOrGeneProduct | denotes | hypertension |
T6 | 233-237 | GeneOrGeneProduct | denotes | FASN |
T7 | 334-338 | GeneOrGeneProduct | denotes | FASN |
T8 | 446-450 | GeneOrGeneProduct | denotes | FASN |
T9 | 547-556 | GeneOrGeneProduct | denotes | C-peptide |
T10 | 558-573 | GeneOrGeneProduct | denotes | fasting glucose |
T11 | 578-585 | GeneOrGeneProduct | denotes | insulin |
T12 | 587-591 | GeneOrGeneProduct | denotes | post |
T13 | 617-628 | GeneOrGeneProduct | denotes | adiponectin |
T14 | 753-757 | GeneOrGeneProduct | denotes | FASN |
T15 | 834-838 | GeneOrGeneProduct | denotes | FASN |
T16 | 946-961 | GeneOrGeneProduct | denotes | fasting glucose |
T17 | 966-973 | GeneOrGeneProduct | denotes | insulin |
T18 | 975-979 | GeneOrGeneProduct | denotes | post |
T19 | 1013-1022 | GeneOrGeneProduct | denotes | C-peptide |
T20 | 1054-1066 | GeneOrGeneProduct | denotes | birth weight |
T21 | 1106-1110 | GeneOrGeneProduct | denotes | FASN |
T22 | 1156-1160 | GeneOrGeneProduct | denotes | FASN |
T23 | 1279-1283 | GeneOrGeneProduct | denotes | FASN |
T24 | 1352-1356 | GeneOrGeneProduct | denotes | FASN |
T25 | 1420-1426 | GeneOrGeneProduct | denotes | growth |
T26 | 1494-1501 | GeneOrGeneProduct | denotes | insulin |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 193-205 | DiseaseOrPhenotypicFeature | denotes | hypertension | D006973 |
T2 | 1054-1066 | DiseaseOrPhenotypicFeature | denotes | birth weight | D001724 |
T3 | 1494-1513 | DiseaseOrPhenotypicFeature | denotes | insulin sensitivity | D007333 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 12-31 | GeneOrGeneProduct | denotes | Fatty Acid Synthase |
T2 | 138-142 | GeneOrGeneProduct | denotes | FASN |
T3 | 144-163 | GeneOrGeneProduct | denotes | fatty acid synthase |
T4 | 233-237 | GeneOrGeneProduct | denotes | FASN |
T5 | 334-338 | GeneOrGeneProduct | denotes | FASN |
T6 | 446-450 | GeneOrGeneProduct | denotes | FASN |
T7 | 617-628 | GeneOrGeneProduct | denotes | adiponectin |
T8 | 753-757 | GeneOrGeneProduct | denotes | FASN |
T9 | 834-838 | GeneOrGeneProduct | denotes | FASN |
T10 | 1106-1110 | GeneOrGeneProduct | denotes | FASN |
T11 | 1156-1160 | GeneOrGeneProduct | denotes | FASN |
T12 | 1279-1283 | GeneOrGeneProduct | denotes | FASN |
T13 | 1352-1356 | GeneOrGeneProduct | denotes | FASN |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 193-205 | DiseaseOrPhenotypicFeature | denotes | hypertension | 0005044 |
T2 | 1502-1513 | DiseaseOrPhenotypicFeature | denotes | sensitivity | 0000605 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 193-205 | DiseaseOrPhenotypicFeature | denotes | hypertension | D006973 |
T2 | 210-231 | DiseaseOrPhenotypicFeature | denotes | metabolic dysfunction | DISEASE |
T3 | 1054-1066 | DiseaseOrPhenotypicFeature | denotes | birth weight | D001724 |
T4 | 1494-1513 | DiseaseOrPhenotypicFeature | denotes | insulin sensitivity | D007333 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 193-205 | DiseaseOrPhenotypicFeature | denotes | hypertension | D006973 |
T2 | 210-231 | DiseaseOrPhenotypicFeature | denotes | metabolic dysfunction | DISEASE |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 144-163 | ChemicalEntity | denotes | fatty acid synthase | D064429 |
T2 | 547-556 | ChemicalEntity | denotes | C-peptide | http://purl.obolibrary.org/obo/CHEBI_80332 |
T3 | 566-573 | ChemicalEntity | denotes | glucose | D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234 |
T6 | 597-604 | ChemicalEntity | denotes | glucose | D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234 |
T9 | 617-628 | ChemicalEntity | denotes | adiponectin | http://purl.obolibrary.org/obo/CHEBI_81572 |
T10 | 954-961 | ChemicalEntity | denotes | glucose | D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234 |
T13 | 985-992 | ChemicalEntity | denotes | glucose | D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234 |
T16 | 1013-1022 | ChemicalEntity | denotes | C-peptide | http://purl.obolibrary.org/obo/CHEBI_80332 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 44-49 | OrganismTaxon | denotes | women |
T2 | 265-270 | OrganismTaxon | denotes | human |
T3 | 427-432 | OrganismTaxon | denotes | women |
T4 | 493-498 | OrganismTaxon | denotes | women |
T5 | 1040-1049 | OrganismTaxon | denotes | placental |
T6 | 1096-1105 | OrganismTaxon | denotes | Placental |
T7 | 1191-1200 | OrganismTaxon | denotes | placental |
T8 | 1269-1278 | OrganismTaxon | denotes | placental |
T9 | 1287-1292 | OrganismTaxon | denotes | human |
T10 | 1360-1369 | OrganismTaxon | denotes | placental |
T11 | 1400-1409 | OrganismTaxon | denotes | placental |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T16 | 1013-1022 | ChemicalEntity | denotes | C-peptide | http://purl.obolibrary.org/obo/CHEBI_80332 | |
T13 | 985-992 | ChemicalEntity | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947 | |
T10 | 954-961 | ChemicalEntity | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947 | |
T9 | 617-628 | ChemicalEntity | denotes | adiponectin | http://purl.obolibrary.org/obo/CHEBI_81572 | |
T6 | 597-604 | ChemicalEntity | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947 | |
T3 | 566-573 | ChemicalEntity | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947 | |
T2 | 547-556 | ChemicalEntity | denotes | C-peptide | http://purl.obolibrary.org/obo/CHEBI_80332 | |
T1 | 144-163 | ChemicalEntity | denotes | fatty acid synthase | D064429 | |
T38937 | 1352-1356 | GeneOrGeneProduct | denotes | FASN | ||
T12 | 1279-1283 | GeneOrGeneProduct | denotes | FASN | ||
T11 | 1156-1160 | GeneOrGeneProduct | denotes | FASN | ||
T79592 | 1106-1110 | GeneOrGeneProduct | denotes | FASN | ||
T79701 | 834-838 | GeneOrGeneProduct | denotes | FASN | ||
T8 | 753-757 | GeneOrGeneProduct | denotes | FASN | ||
T7 | 617-628 | GeneOrGeneProduct | denotes | adiponectin | ||
T50950 | 446-450 | GeneOrGeneProduct | denotes | FASN | ||
T5 | 334-338 | GeneOrGeneProduct | denotes | FASN | ||
T4 | 233-237 | GeneOrGeneProduct | denotes | FASN | ||
T19959 | 144-163 | GeneOrGeneProduct | denotes | fatty acid synthase | ||
T99266 | 138-142 | GeneOrGeneProduct | denotes | FASN | ||
T74791 | 12-31 | GeneOrGeneProduct | denotes | Fatty Acid Synthase | ||
T28589 | 210-231 | DiseaseOrPhenotypicFeature | denotes | metabolic dysfunction | DISEASE | |
T81726 | 193-205 | DiseaseOrPhenotypicFeature | denotes | hypertension | D006973 | |
T48805 | 1400-1409 | OrganismTaxon | denotes | placental | ||
T44861 | 1360-1369 | OrganismTaxon | denotes | placental | ||
T51920 | 1287-1292 | OrganismTaxon | denotes | human | ||
T50712 | 1269-1278 | OrganismTaxon | denotes | placental | ||
T1019 | 1191-1200 | OrganismTaxon | denotes | placental | ||
T15220 | 1096-1105 | OrganismTaxon | denotes | Placental | ||
T28411 | 1040-1049 | OrganismTaxon | denotes | placental | ||
T58157 | 493-498 | OrganismTaxon | denotes | women | ||
T2460 | 427-432 | OrganismTaxon | denotes | women | ||
T78177 | 265-270 | OrganismTaxon | denotes | human | ||
T34684 | 44-49 | OrganismTaxon | denotes | women |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 193-205 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 193-205 | Phenotype | denotes | hypertension | HP:0000822 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 265-270 | OrganismTaxon | denotes | human | 9606 |
T2 | 1287-1292 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 67-72 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T2 | 271-279 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
T3 | 348-353 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T4 | 633-638 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T5 | 729-738 | Body_part | denotes | placentas | http://purl.obolibrary.org/obo/UBERON_0001987 |
T6 | 804-813 | Body_part | denotes | placentas | http://purl.obolibrary.org/obo/UBERON_0001987 |
T7 | 874-879 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T8 | 1518-1523 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 67-72 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
T3 | 271-279 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
T4 | 348-353 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
T6 | 633-638 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
T8 | 729-738 | Body_part | denotes | placentas | http://purl.obolibrary.org/obo/MAT_0000279 |
T9 | 804-813 | Body_part | denotes | placentas | http://purl.obolibrary.org/obo/MAT_0000279 |
T10 | 874-879 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
T12 | 1518-1523 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |