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PubMed:27040849 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-84 Sentence denotes Afatinib-associated Stevens-Johnson syndrome in an EGFR-mutated lung cancer patient.
TextSentencer_T2 85-98 Sentence denotes INTRODUCTION:
TextSentencer_T3 99-288 Sentence denotes Afatinib is a tyrosine kinase inhibitor (TKI), that has been approved for treating patients with epidermal growth factor receptor (EGFR) mutated advanced non-small-cell lung cancer (NSCLC).
TextSentencer_T4 289-374 Sentence denotes Stevens-Johnson syndrome (SJS) related to EGFR directed TKIs is a rare adverse event.
TextSentencer_T5 375-393 Sentence denotes CASE PRESENTATION:
TextSentencer_T6 394-606 Sentence denotes We report a case of a 79-year-old white female with EGFR-mutated, metastatic non-small-cell lung cancer treated with afatinib as first-line palliative treatment, who developed a SJS after two months of treatment.
TextSentencer_T7 607-716 Sentence denotes Discontinuation of the TKI and systemic glucocorticoid treatment led to improvement of symptoms and recovery.
TextSentencer_T8 717-728 Sentence denotes CONCLUSION:
TextSentencer_T9 729-920 Sentence denotes Severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes during treatment with afatinib should alert clinicians to suspect SJS and react appropriately.
T1 0-84 Sentence denotes Afatinib-associated Stevens-Johnson syndrome in an EGFR-mutated lung cancer patient.
T2 85-98 Sentence denotes INTRODUCTION:
T3 99-288 Sentence denotes Afatinib is a tyrosine kinase inhibitor (TKI), that has been approved for treating patients with epidermal growth factor receptor (EGFR) mutated advanced non-small-cell lung cancer (NSCLC).
T4 289-374 Sentence denotes Stevens-Johnson syndrome (SJS) related to EGFR directed TKIs is a rare adverse event.
T5 375-393 Sentence denotes CASE PRESENTATION:
T6 394-606 Sentence denotes We report a case of a 79-year-old white female with EGFR-mutated, metastatic non-small-cell lung cancer treated with afatinib as first-line palliative treatment, who developed a SJS after two months of treatment.
T7 607-716 Sentence denotes Discontinuation of the TKI and systemic glucocorticoid treatment led to improvement of symptoms and recovery.
T8 717-728 Sentence denotes CONCLUSION:
T9 729-920 Sentence denotes Severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes during treatment with afatinib should alert clinicians to suspect SJS and react appropriately.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
27040849-0#51#55#gene1956 51-55 gene1956 denotes EGFR
27040849-0#64#75#diseaseC0242379 64-75 diseaseC0242379 denotes lung cancer
27040849-0#64#75#diseaseC0684249 64-75 diseaseC0684249 denotes lung cancer
27040849-0#64#75#diseaseC1306460 64-75 diseaseC1306460 denotes lung cancer
27040849-0#20#44#diseaseC0038325 20-44 diseaseC0038325 denotes Stevens-Johnson syndrome
27040849-1#97#129#gene1956 196-228 gene1956 denotes epidermal growth factor receptor
27040849-1#131#135#gene1956 230-234 gene1956 denotes EGFR
27040849-1#154#180#diseaseC0007131 253-279 diseaseC0007131 denotes non-small-cell lung cancer
27040849-1#182#187#diseaseC0007131 281-286 diseaseC0007131 denotes NSCLC
27040849-1#154#180#diseaseC0007131 253-279 diseaseC0007131 denotes non-small-cell lung cancer
27040849-1#182#187#diseaseC0007131 281-286 diseaseC0007131 denotes NSCLC
27040849-3#52#56#gene1956 446-450 gene1956 denotes EGFR
27040849-3#178#181#diseaseC0036391 572-575 diseaseC0036391 denotes SJS
51#55#gene195664#75#diseaseC0242379 27040849-0#51#55#gene1956 27040849-0#64#75#diseaseC0242379 associated_with EGFR,lung cancer
51#55#gene195664#75#diseaseC0684249 27040849-0#51#55#gene1956 27040849-0#64#75#diseaseC0684249 associated_with EGFR,lung cancer
51#55#gene195664#75#diseaseC1306460 27040849-0#51#55#gene1956 27040849-0#64#75#diseaseC1306460 associated_with EGFR,lung cancer
51#55#gene195620#44#diseaseC0038325 27040849-0#51#55#gene1956 27040849-0#20#44#diseaseC0038325 associated_with EGFR,Stevens-Johnson syndrome
97#129#gene1956154#180#diseaseC0007131 27040849-1#97#129#gene1956 27040849-1#154#180#diseaseC0007131 associated_with epidermal growth factor receptor,non-small-cell lung cancer
97#129#gene1956182#187#diseaseC0007131 27040849-1#97#129#gene1956 27040849-1#182#187#diseaseC0007131 associated_with epidermal growth factor receptor,NSCLC
97#129#gene1956154#180#diseaseC0007131 27040849-1#97#129#gene1956 27040849-1#154#180#diseaseC0007131 associated_with epidermal growth factor receptor,non-small-cell lung cancer
97#129#gene1956182#187#diseaseC0007131 27040849-1#97#129#gene1956 27040849-1#182#187#diseaseC0007131 associated_with epidermal growth factor receptor,NSCLC
131#135#gene1956154#180#diseaseC0007131 27040849-1#131#135#gene1956 27040849-1#154#180#diseaseC0007131 associated_with EGFR,non-small-cell lung cancer
131#135#gene1956182#187#diseaseC0007131 27040849-1#131#135#gene1956 27040849-1#182#187#diseaseC0007131 associated_with EGFR,NSCLC
131#135#gene1956154#180#diseaseC0007131 27040849-1#131#135#gene1956 27040849-1#154#180#diseaseC0007131 associated_with EGFR,non-small-cell lung cancer
131#135#gene1956182#187#diseaseC0007131 27040849-1#131#135#gene1956 27040849-1#182#187#diseaseC0007131 associated_with EGFR,NSCLC
52#56#gene1956178#181#diseaseC0036391 27040849-3#52#56#gene1956 27040849-3#178#181#diseaseC0036391 associated_with EGFR,SJS

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 64-68 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 268-272 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 486-490 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T197 51-55 gene:1956 denotes EGFR
T198 64-75 disease:C0242379 denotes lung cancer
R1 T197 T198 associated_with EGFR,lung cancer
R2 T197 T198 associated_with EGFR,lung cancer
R3 T197 T198 associated_with EGFR,lung cancer

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 257-279 ORDO:70573 denotes small-cell lung cancer
AB2 475-497 ORDO:70573 denotes small-cell lung cancer

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 64-68 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 268-272 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 486-490 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung