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PubMed:27023913 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
27023913_0 57-63 ProteinMutation denotes G2019S rs34637584
27023913_1 284-290 ProteinMutation denotes G2019S rs34637584
27023913_2 397-403 ProteinMutation denotes G2019S rs34637584
27023913_3 662-668 ProteinMutation denotes G2019S rs34637584
27023913_4 735-741 ProteinMutation denotes G2019S rs34637584
27023913_5 1016-1022 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-4 PR:000017077 denotes ULK1
T2 0-4 PR:O75385 denotes ULK1
T3 0-4 PR:O70405 denotes ULK1
T4 9-12 PR:P92208 denotes JNK
T5 9-12 GO:0004705 denotes JNK
T6 29-38 GO:0000423 denotes mitophagy
T7 29-38 GO:0000422 denotes mitophagy
T8 51-56 PR:Q5S006 denotes LRRK2
T9 51-56 PR:000003033 denotes LRRK2
T10 51-56 PR:Q5S007 denotes LRRK2
T11 92-95 PR:Q54H45 denotes RK2
T13 97-104 6308 denotes Leucine
T14 97-104 SO:0001437 denotes Leucine
T12 97-104 CHEBI:15603 denotes Leucine
T15 97-104 D007930 denotes Leucine
T16 97-104 CHEBI:25017 denotes Leucine
T17 97-104 D007930 denotes Leucine
T18 110-116 SO:0001068 denotes repeat
T23 148-167 D010300 denotes Parkinson's disease
T24 148-167 D010300 denotes Parkinson's disease
T27 271-276 PR:Q5S006 denotes LRRK2
T28 271-276 PR:000003033 denotes LRRK2
T29 271-276 PR:Q5S007 denotes LRRK2
T30 278-283 PR:Q5S006 denotes LRRK2
T31 278-283 PR:000003033 denotes LRRK2
T32 278-283 PR:Q5S007 denotes LRRK2
T33 300-321 GO:0000266 denotes mitochondrial fission
T35 341-344 UBERON:0003105 denotes DLP
T38 341-345 PR:Q33DR3 denotes DLP1
T39 341-345 PR:000012522 denotes DLP1
T40 341-345 PR:Q8LF21 denotes DLP1
T41 341-345 PR:Q86YH6 denotes DLP1
T42 341-345 PR:O00429 denotes DLP1
T43 341-345 PR:Q5U2R1 denotes DLP1
T44 341-345 PR:O35303 denotes DLP1
T45 341-345 PR:O13851 denotes DLP1
T46 341-345 P97314 denotes DLP1
T47 341-345 PR:Q63164 denotes DLP1
T48 341-345 PR:000006602 denotes DLP1
T49 341-345 P82172 denotes DLP1
T50 341-345 PR:000005959 denotes DLP1
T51 341-345 PR:P97314 denotes DLP1
T52 391-396 PR:Q5S006 denotes LRRK2
T53 391-396 PR:000003033 denotes LRRK2
T54 391-396 PR:Q5S007 denotes LRRK2
T55 415-427 GO:0005739 denotes mitochondria
T56 436-445 GO:0000423 denotes mitophagy
T57 436-445 GO:0000422 denotes mitophagy
T58 477-482 PR:Q5S006 denotes LRRK2
T59 477-482 PR:000003033 denotes LRRK2
T60 477-482 PR:Q5S007 denotes LRRK2
T61 495-503 CHEBI:36080 denotes proteins
T62 519-524 PR:Q5S006 denotes LRRK2
T63 519-524 PR:000003033 denotes LRRK2
T64 519-524 PR:Q5S007 denotes LRRK2
T65 540-544 PR:000017077 denotes ULK1
T66 540-544 PR:O75385 denotes ULK1
T67 540-544 PR:O70405 denotes ULK1
T68 578-587 GO:0016236 denotes autophagy
T69 578-587 GO:0006914 denotes autophagy
T70 609-613 PR:000017077 denotes ULK1
T71 609-613 PR:O75385 denotes ULK1
T72 609-613 PR:O70405 denotes ULK1
T74 617-620 UBERON:0003105 denotes DLP
T77 617-621 PR:Q33DR3 denotes DLP1
T78 617-621 PR:000012522 denotes DLP1
T79 617-621 PR:Q8LF21 denotes DLP1
T80 617-621 PR:Q86YH6 denotes DLP1
T81 617-621 PR:O00429 denotes DLP1
T82 617-621 PR:Q5U2R1 denotes DLP1
T83 617-621 PR:O35303 denotes DLP1
T84 617-621 PR:O13851 denotes DLP1
T85 617-621 P97314 denotes DLP1
T86 617-621 PR:Q63164 denotes DLP1
T87 617-621 PR:000006602 denotes DLP1
T88 617-621 P82172 denotes DLP1
T89 617-621 PR:000005959 denotes DLP1
T90 617-621 PR:P97314 denotes DLP1
T91 656-661 PR:Q5S006 denotes LRRK2
T92 656-661 PR:000003033 denotes LRRK2
T93 656-661 PR:Q5S007 denotes LRRK2
T94 729-734 PR:Q5S006 denotes LRRK2
T95 729-734 PR:000003033 denotes LRRK2
T96 729-734 PR:Q5S007 denotes LRRK2
T97 761-782 GO:0000266 denotes mitochondrial fission
T99 791-794 UBERON:0003105 denotes DLP
T102 791-795 PR:Q33DR3 denotes DLP1
T103 791-795 PR:000012522 denotes DLP1
T104 791-795 PR:Q8LF21 denotes DLP1
T105 791-795 PR:Q86YH6 denotes DLP1
T106 791-795 PR:O00429 denotes DLP1
T107 791-795 PR:Q5U2R1 denotes DLP1
T108 791-795 PR:O35303 denotes DLP1
T109 791-795 PR:O13851 denotes DLP1
T110 791-795 P97314 denotes DLP1
T111 791-795 PR:Q63164 denotes DLP1
T112 791-795 PR:000006602 denotes DLP1
T113 791-795 P82172 denotes DLP1
T114 791-795 PR:000005959 denotes DLP1
T115 791-795 PR:P97314 denotes DLP1
T116 808-817 GO:0000423 denotes mitophagy
T117 808-817 GO:0000422 denotes mitophagy
T118 825-829 PR:000017077 denotes ULK1
T119 825-829 PR:O75385 denotes ULK1
T120 825-829 PR:O70405 denotes ULK1
T121 840-847 CHEBI:34922 denotes pathway
T122 864-868 PR:000017077 denotes ULK1
T123 864-868 PR:O75385 denotes ULK1
T124 864-868 PR:O70405 denotes ULK1
T125 884-889 PR:Q5S006 denotes LRRK2
T126 884-889 PR:000003033 denotes LRRK2
T127 884-889 PR:Q5S007 denotes LRRK2
T129 920-924 PR:000035964 denotes MKK4
T130 920-924 PR:P45985 denotes MKK4
T131 920-924 PR:Q20347 denotes MKK4
T132 920-924 PR:P47809 denotes MKK4
T134 920-924 PR:000003283 denotes MKK4
T135 920-924 PR:O80397 denotes MKK4
T133 920-924 GO:0004708 denotes MKK4
T137 928-931 C537702 denotes JIP
T139 928-932 PR:O13555 denotes JIP3
T140 928-932 Q9ESN9 denotes JIP3
T141 928-932 PR:Q9ESN9 denotes JIP3
T142 928-932 E9PSK7 denotes JIP3
T143 928-932 PR:Q9UPT6 denotes JIP3
T144 928-932 PR:E9PSK7 denotes JIP3
T145 928-932 Q9UPT6 denotes JIP3
T146 928-932 PR:000010162 denotes JIP3
T147 980-983 PR:P92208 denotes JNK
T148 980-983 GO:0004705 denotes JNK
T149 984-993 GO:0023052 denotes signaling
T150 1010-1015 PR:Q5S006 denotes LRRK2
T151 1010-1015 PR:000003033 denotes LRRK2
T152 1010-1015 PR:Q5S007 denotes LRRK2
T153 1039-1051 GO:0005739 denotes mitochondria
T154 1090-1093 PR:P92208 denotes JNK
T155 1090-1093 GO:0004705 denotes JNK
T156 1090-1104 CHEBI:90172 denotes JNK inhibitors
T157 1090-1104 CHEBI:79091 denotes JNK inhibitors
T159 1138-1141 PR:P92208 denotes JNK
T160 1138-1141 GO:0004705 denotes JNK
T161 1142-1149 CHEBI:34922 denotes pathway
T162 1189-1194 PR:Q5S006 denotes LRRK2
T163 1189-1194 PR:000003033 denotes LRRK2
T164 1189-1194 PR:Q5S007 denotes LRRK2
T165 1258-1270 GO:0009405 denotes pathogenesis

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 76-173 DRI_Approach denotes Mutations in LR RK2 (Leucine rich repeat kinase 2) are a major cause of Parkinson's disease (PD).
T2 174-277 DRI_Approach denotes We and others reported recently that expression of the pathogenic gainof-function mutant form of LRRK2,
T3 290-346 DRI_Approach denotes , induces mitochondrial fission in neurons through DLP1.
T4 347-390 DRI_Outcome denotes Here we provide evidence that expression of
T5 404-446 DRI_Outcome denotes stimulates mitochondria loss or mitophagy.
T6 447-588 DRI_Outcome denotes We have characterized several LRRK2 interacting proteins and found that LRRK2 interacts with ULK1 which plays an essential role in autophagy.
T7 589-655 DRI_Background denotes Knockdown of either ULK1 or DLP1 expression with shRNAs suppresses
T8 688-728 DRI_Background denotes mitochondrial clearance, suggesting that
T9 742-848 DRI_Background denotes expression induces mitochondrial fission through DLP1 followed by mitophagy via an ULK1 dependent pathway.
T10 849-994 DRI_Outcome denotes In addition to ULK1, we found that LRRK2 interacts with the endogenous MKK4/7, JIP3 and coordinates with them in the activation of JNK signaling.
T11 995-1009 DRI_Background denotes Interestingly,
T12 1031-1195 DRI_Background denotes loss of mitochondria can also be suppressed by 3 different JNK inhibitors, implying the involvement of the JNK pathway in the pathogenic mechanism of mutated LRRK2.
T13 1196-1350 DRI_Outcome denotes Thus our findings may provide an insight into the complicated pathogenesis of PD as well as some clues to the development of novel therapeutic strategies.