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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes [Esmolol improves clinical outcome and tissue oxygen metabolism in patients with septic shock through controlling heart rate].
T2 127-137 Sentence denotes OBJECTIVE:
T3 138-290 Sentence denotes To investigate whether esmolol could improve clinical outcome and tissue oxygen metabolism by controlling heart rate (HR) in patients with septic shock.
T4 291-299 Sentence denotes METHODS:
T5 300-373 Sentence denotes A single-center double-blinded randomized controlled trial was conducted.
T6 374-787 Sentence denotes The patients suffering from septic shock received 6-hour early goal directed herapy (EGDT) with pulmonary artery wedge pressure ≥ 12 mmHg (1 mmHg = 0.133 kPa) or central venous pressure CVP) ≥ 12 mmHg requiring norepinephrine to maintain mean arterial pressure (MAP) ≥ 65 mmHg and HR ≥ 95 bpm admitted to intensive care unit (ICU) of Guangdong General Hospital from September 2013 to September 2014 were enrolled.
T7 788-894 Sentence denotes They were randomly divided into esmolol group and control group by computer-based random number generator.
T8 895-1160 Sentence denotes All patients received conventional basic treatment, while those in the esmolol group received in addition persistent esmolol infusion by micro pump with dosage of 0.05 mg · kg(-1) · min(-1) with the dosage adjusted to maintain HR lower than 100 bpm within 24 hours.
T9 1161-1232 Sentence denotes The patients in control group did not receive drug intervention for HR.
T10 1233-1312 Sentence denotes The primary end-points consisted of length of stay in ICU and 28-day mortality.
T11 1313-1627 Sentence denotes The secondary end-points included hemodynamic parameters [HR, MAP, CVP, cardiac index (CI), stroke volume index (SVI), systemic vascular resistance index (SVRI)] and tissue oxygen metabolism parameters [central venous oxygen saturation (ScvO2), lactate level (Lac)] before and 24, 48, 72 hours after the treatment.
T12 1628-1636 Sentence denotes RESULTS:
T13 1637-1893 Sentence denotes A total of 48 patients with septic shock were enrolled with 24 patients in esmolol group and 24 in control group. (1) The primary end-points: compared with control group, the length of stay in the ICU in the esmolol group was significantly shortened (days:
T14 1894-2208 Sentence denotes 13.75 ± 8.68 vs. 21.70 ± 6.06, t = 3.680, P = 0.001), and 28-day mortality was significantly lowered [25.0% (6/24) vs. 62.5% (15/24 ), χ2 = 6.857, P = 0.009]. (2) The secondary end-points: there were no significant difference in the hemodynamic and tissue metabolism parameters before treatment between two groups.
T15 2209-2321 Sentence denotes No significant difference was found between before and after treatment of all above parameters in control group.
T16 2322-2482 Sentence denotes HR and Lac in the esmolol group were obviously declined, SVI, SVRI, SCvO2 were gradually increased, but no significant difference in MAP, CVP, and CI was found.
T17 2483-2572 Sentence denotes Compared with the control group, HR in the esomolol group was significantly lowered (bpm:
T18 2573-2701 Sentence denotes 84.4 ± 3.5 vs. 111.2 ± 7.2, P < 0.01), SVRI and ScvO2 were significantly increased from 24 hours [SVRI (kPa · s · L(-1) ·m(-2)):
T19 2702-2737 Sentence denotes 137.9 ± 1.6 vs. 126.9 ± 1.3, ScvO2:
T20 2738-2826 Sentence denotes 0.652 ± 0.017 vs. 0.620 ± 0.017, both P < 0.01]; SVI was significantly increased (mL/m2:
T21 2827-2923 Sentence denotes 39.9 ± 2.2 vs. 36.8 ± 1.7, P < 0.01) and Lac level significantly declined from 48 hours (mmol/L:
T22 2924-2959 Sentence denotes 2.8 ± 0.3 vs. 3.4 ± 0.3, P < 0.01).
T23 2960-2971 Sentence denotes CONCLUSION:
T24 2972-3203 Sentence denotes The results demonstrate that HR controlled by a titrated esmolol infusion given to septic shock patients was associated with an improvement in tissue metabolism, reduction in the length of ICU stay and lowering of 28-day mortality.
T1 0-126 Sentence denotes [Esmolol improves clinical outcome and tissue oxygen metabolism in patients with septic shock through controlling heart rate].
T2 127-137 Sentence denotes OBJECTIVE:
T3 138-290 Sentence denotes To investigate whether esmolol could improve clinical outcome and tissue oxygen metabolism by controlling heart rate (HR) in patients with septic shock.
T4 291-299 Sentence denotes METHODS:
T5 300-373 Sentence denotes A single-center double-blinded randomized controlled trial was conducted.
T6 374-787 Sentence denotes The patients suffering from septic shock received 6-hour early goal directed herapy (EGDT) with pulmonary artery wedge pressure ≥ 12 mmHg (1 mmHg = 0.133 kPa) or central venous pressure CVP) ≥ 12 mmHg requiring norepinephrine to maintain mean arterial pressure (MAP) ≥ 65 mmHg and HR ≥ 95 bpm admitted to intensive care unit (ICU) of Guangdong General Hospital from September 2013 to September 2014 were enrolled.
T7 788-894 Sentence denotes They were randomly divided into esmolol group and control group by computer-based random number generator.
T8 895-1160 Sentence denotes All patients received conventional basic treatment, while those in the esmolol group received in addition persistent esmolol infusion by micro pump with dosage of 0.05 mg · kg(-1) · min(-1) with the dosage adjusted to maintain HR lower than 100 bpm within 24 hours.
T9 1161-1232 Sentence denotes The patients in control group did not receive drug intervention for HR.
T10 1233-1312 Sentence denotes The primary end-points consisted of length of stay in ICU and 28-day mortality.
T11 1313-1627 Sentence denotes The secondary end-points included hemodynamic parameters [HR, MAP, CVP, cardiac index (CI), stroke volume index (SVI), systemic vascular resistance index (SVRI)] and tissue oxygen metabolism parameters [central venous oxygen saturation (ScvO2), lactate level (Lac)] before and 24, 48, 72 hours after the treatment.
T12 1628-1636 Sentence denotes RESULTS:
T13 1637-1893 Sentence denotes A total of 48 patients with septic shock were enrolled with 24 patients in esmolol group and 24 in control group. (1) The primary end-points: compared with control group, the length of stay in the ICU in the esmolol group was significantly shortened (days:
T14 1894-2208 Sentence denotes 13.75 ± 8.68 vs. 21.70 ± 6.06, t = 3.680, P = 0.001), and 28-day mortality was significantly lowered [25.0% (6/24) vs. 62.5% (15/24 ), χ2 = 6.857, P = 0.009]. (2) The secondary end-points: there were no significant difference in the hemodynamic and tissue metabolism parameters before treatment between two groups.
T15 2209-2321 Sentence denotes No significant difference was found between before and after treatment of all above parameters in control group.
T16 2322-2482 Sentence denotes HR and Lac in the esmolol group were obviously declined, SVI, SVRI, SCvO2 were gradually increased, but no significant difference in MAP, CVP, and CI was found.
T17 2483-2572 Sentence denotes Compared with the control group, HR in the esomolol group was significantly lowered (bpm:
T18 2573-2701 Sentence denotes 84.4 ± 3.5 vs. 111.2 ± 7.2, P < 0.01), SVRI and ScvO2 were significantly increased from 24 hours [SVRI (kPa · s · L(-1) ·m(-2)):
T19 2702-2737 Sentence denotes 137.9 ± 1.6 vs. 126.9 ± 1.3, ScvO2:
T20 2738-2826 Sentence denotes 0.652 ± 0.017 vs. 0.620 ± 0.017, both P < 0.01]; SVI was significantly increased (mL/m2:
T21 2827-2923 Sentence denotes 39.9 ± 2.2 vs. 36.8 ± 1.7, P < 0.01) and Lac level significantly declined from 48 hours (mmol/L:
T22 2924-2959 Sentence denotes 2.8 ± 0.3 vs. 3.4 ± 0.3, P < 0.01).
T23 2960-2971 Sentence denotes CONCLUSION:
T24 2972-3203 Sentence denotes The results demonstrate that HR controlled by a titrated esmolol infusion given to septic shock patients was associated with an improvement in tissue metabolism, reduction in the length of ICU stay and lowering of 28-day mortality.