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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11101 0-15 GeneOrGeneProduct denotes Serum Amyloid A NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11102 104-119 GeneOrGeneProduct denotes Serum amyloid A NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11103 121-124 GeneOrGeneProduct denotes SAA NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11104 250-279 DiseaseOrPhenotypicFeature denotes liver injury and fibrogenesis MESH:D008107
11105 356-359 GeneOrGeneProduct denotes SAA NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11106 438-453 GeneOrGeneProduct denotes Serum amyloid A NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11107 473-483 GeneOrGeneProduct denotes IκB kinase NCBIGene:84351|NCBIGene:9641
11108 485-508 GeneOrGeneProduct denotes c-Jun N-terminal kinase NCBIGene:116554|NCBIGene:5599
11109 510-513 GeneOrGeneProduct denotes JNK NCBIGene:116554|NCBIGene:5599
11110 516-519 GeneOrGeneProduct denotes Erk NCBIGene:116590|NCBIGene:5594
11111 524-527 GeneOrGeneProduct denotes Akt NCBIGene:207|NCBIGene:24185
11112 541-546 GeneOrGeneProduct denotes NF-κB NCBIGene:4790|NCBIGene:81736
11113 588-593 OrganismTaxon denotes human NCBITaxon:9606
11114 598-601 OrganismTaxon denotes rat NCBITaxon:10116
11115 608-623 GeneOrGeneProduct denotes Serum amyloid A NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11116 653-658 GeneOrGeneProduct denotes MCP-1 NCBIGene:24770|NCBIGene:6347
11117 660-666 GeneOrGeneProduct denotes RANTES NCBIGene:6352|NCBIGene:81780
11118 671-675 GeneOrGeneProduct denotes MMP9 NCBIGene:4318|NCBIGene:81687
11119 682-687 GeneOrGeneProduct denotes NF-κB NCBIGene:4790|NCBIGene:81736
11120 693-696 GeneOrGeneProduct denotes JNK NCBIGene:116554|NCBIGene:5599
11121 727-732 GeneOrGeneProduct denotes NF-κB NCBIGene:4790|NCBIGene:81736
11122 742-751 DiseaseOrPhenotypicFeature denotes cytotoxic MESH:D064420
11123 763-766 GeneOrGeneProduct denotes SAA NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11124 815-824 GeneOrGeneProduct denotes caspase 3 NCBIGene:25402|NCBIGene:836
11125 829-833 GeneOrGeneProduct denotes PARP NCBIGene:142|NCBIGene:25591
11126 847-856 GeneOrGeneProduct denotes Annexin V NCBIGene:25673|NCBIGene:308
11127 867-882 GeneOrGeneProduct denotes Serum amyloid A NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11128 928-931 GeneOrGeneProduct denotes JNK NCBIGene:116554|NCBIGene:5599
11129 933-936 GeneOrGeneProduct denotes Erk NCBIGene:116590|NCBIGene:5594
11130 941-944 GeneOrGeneProduct denotes Akt NCBIGene:207|NCBIGene:24185
11131 979-982 GeneOrGeneProduct denotes SAA NCBIGene:20208|NCBIGene:20210|NCBIGene:6288
11132 998-1010 GeneOrGeneProduct denotes MAP kinases, NCBIGene:116554|NCBIGene:116590|NCBIGene:207|NCBIGene:24185|NCBIGene:5594|NCBIGene:5599
11133 1056-1061 GeneOrGeneProduct denotes NF-κB NCBIGene:4790|NCBIGene:81736
11134 1091-1111 DiseaseOrPhenotypicFeature denotes hepatic fibrogenesis MESH:D008107
11135 1113-1117 GeneOrGeneProduct denotes CCl4 NCBIGene:6351
11136 1175-1179 GeneOrGeneProduct denotes SAA1 NCBIGene:20208
11137 1184-1188 GeneOrGeneProduct denotes SAA3 NCBIGene:20210
11138 1229-1232 GeneOrGeneProduct denotes SAA NCBIGene:20208|NCBIGene:20210|NCBIGene:6288

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T4 312-437 Sentence denotes In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the main fibrogenic cell type of the liver.
T11 1214-1378 Sentence denotes In conclusion, SAA may modulate fibrogenic responses in the liver in a positive and negative fashion by inducing inflammation, proliferation and cell death in HSCs.
T1 0-103 Sentence denotes Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
T2 104-228 Sentence denotes Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes.
T3 229-311 Sentence denotes However, its role in liver injury and fibrogenesis has not been elucidated so far.
T5 438-607 Sentence denotes Serum amyloid A potently activated IκB kinase, c-Jun N-terminal kinase (JNK), Erk and Akt and enhanced NF-κB-dependent luciferase activity in primary human and rat HSCs.
T6 608-714 Sentence denotes Serum amyloid A induced the transcription of MCP-1, RANTES and MMP9 in an NF-κB- and JNK-dependent manner.
T7 715-866 Sentence denotes Blockade of NF-κB revealed cytotoxic effects of SAA in primary HSCs with signs of apoptosis such as caspase 3 and PARP cleavage and Annexin V staining.
T8 867-954 Sentence denotes Serum amyloid A induced HSC proliferation, which depended on JNK, Erk and Akt activity.
T9 955-1073 Sentence denotes In primary hepatocytes, SAA also activated MAP kinases, but did not induce relevant cell death after NF-κB inhibition.
T10 1074-1213 Sentence denotes In two models of hepatic fibrogenesis, CCl4 treatment and bile duct ligation, hepatic mRNA levels of SAA1 and SAA3 were strongly increased.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 588-593 OrganismTaxon denotes human NCBItxid:9606
T2 598-601 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 80-87 DiseaseOrPhenotypicFeature denotes Hepatic 0002251
T2 256-262 DiseaseOrPhenotypicFeature denotes injury 0021178
T3 363-370 DiseaseOrPhenotypicFeature denotes hepatic 0002251
T4 1091-1098 DiseaseOrPhenotypicFeature denotes hepatic 0002251
T5 1152-1159 DiseaseOrPhenotypicFeature denotes hepatic 0002251

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 6-15 GeneOrGeneProduct denotes Amyloid A
T2 16-23 GeneOrGeneProduct denotes Induces
T3 56-60 GeneOrGeneProduct denotes Cell
T4 70-79 GeneOrGeneProduct denotes Activated
T5 97-102 GeneOrGeneProduct denotes Cells
T6 110-119 GeneOrGeneProduct denotes amyloid A
T7 121-124 GeneOrGeneProduct denotes SAA
T8 145-151 GeneOrGeneProduct denotes highly
T9 152-161 GeneOrGeneProduct denotes conserved
T10 162-181 GeneOrGeneProduct denotes acute phase protein
T11 204-212 GeneOrGeneProduct denotes secreted
T12 250-255 GeneOrGeneProduct denotes liver
T13 330-344 GeneOrGeneProduct denotes determined the
T14 356-359 GeneOrGeneProduct denotes SAA
T15 380-385 GeneOrGeneProduct denotes cells
T16 398-402 GeneOrGeneProduct denotes main
T17 414-418 GeneOrGeneProduct denotes cell
T18 431-436 GeneOrGeneProduct denotes liver
T19 444-453 GeneOrGeneProduct denotes amyloid A
T20 463-472 GeneOrGeneProduct denotes activated
T21 477-483 GeneOrGeneProduct denotes kinase
T22 485-508 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T23 557-567 GeneOrGeneProduct denotes luciferase
T24 568-576 GeneOrGeneProduct denotes activity
T25 614-623 GeneOrGeneProduct denotes amyloid A
T26 624-631 GeneOrGeneProduct denotes induced
T27 636-649 GeneOrGeneProduct denotes transcription
T28 653-658 GeneOrGeneProduct denotes MCP-1
T29 660-666 GeneOrGeneProduct denotes RANTES
T30 671-675 GeneOrGeneProduct denotes MMP9
T31 763-766 GeneOrGeneProduct denotes SAA
T32 797-806 GeneOrGeneProduct denotes apoptosis
T33 815-824 GeneOrGeneProduct denotes caspase 3
T34 829-833 GeneOrGeneProduct denotes PARP
T35 847-856 GeneOrGeneProduct denotes Annexin V
T36 873-882 GeneOrGeneProduct denotes amyloid A
T37 883-890 GeneOrGeneProduct denotes induced
T38 945-953 GeneOrGeneProduct denotes activity
T39 979-982 GeneOrGeneProduct denotes SAA
T40 988-997 GeneOrGeneProduct denotes activated
T41 998-1009 GeneOrGeneProduct denotes MAP kinases
T42 1023-1029 GeneOrGeneProduct denotes induce
T43 1039-1043 GeneOrGeneProduct denotes cell
T44 1113-1117 GeneOrGeneProduct denotes CCl4
T45 1160-1164 GeneOrGeneProduct denotes mRNA
T46 1175-1179 GeneOrGeneProduct denotes SAA1
T47 1184-1188 GeneOrGeneProduct denotes SAA3
T48 1229-1232 GeneOrGeneProduct denotes SAA
T49 1274-1279 GeneOrGeneProduct denotes liver
T50 1318-1326 GeneOrGeneProduct denotes inducing
T51 1359-1363 GeneOrGeneProduct denotes cell

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 6-15 GeneOrGeneProduct denotes Amyloid A
T2 110-119 GeneOrGeneProduct denotes amyloid A
T3 121-124 GeneOrGeneProduct denotes SAA
T4 152-161 GeneOrGeneProduct denotes conserved
T5 162-181 GeneOrGeneProduct denotes acute phase protein
T6 250-255 GeneOrGeneProduct denotes liver
T7 356-359 GeneOrGeneProduct denotes SAA
T8 414-418 GeneOrGeneProduct denotes cell
T9 431-436 GeneOrGeneProduct denotes liver
T10 444-453 GeneOrGeneProduct denotes amyloid A
T11 477-483 GeneOrGeneProduct denotes kinase
T12 485-508 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T13 557-567 GeneOrGeneProduct denotes luciferase
T14 614-623 GeneOrGeneProduct denotes amyloid A
T15 636-649 GeneOrGeneProduct denotes transcription
T16 653-658 GeneOrGeneProduct denotes MCP-1
T17 660-666 GeneOrGeneProduct denotes RANTES
T18 671-675 GeneOrGeneProduct denotes MMP9
T19 763-766 GeneOrGeneProduct denotes SAA
T20 797-806 GeneOrGeneProduct denotes apoptosis
T21 815-824 GeneOrGeneProduct denotes caspase 3
T22 829-833 GeneOrGeneProduct denotes PARP
T23 847-856 GeneOrGeneProduct denotes Annexin V
T24 873-882 GeneOrGeneProduct denotes amyloid A
T25 979-982 GeneOrGeneProduct denotes SAA
T26 998-1009 GeneOrGeneProduct denotes MAP kinases
T27 1039-1043 GeneOrGeneProduct denotes cell
T28 1160-1164 GeneOrGeneProduct denotes mRNA
T29 1175-1179 GeneOrGeneProduct denotes SAA1
T30 1184-1188 GeneOrGeneProduct denotes SAA3
T31 1229-1232 GeneOrGeneProduct denotes SAA
T32 1274-1279 GeneOrGeneProduct denotes liver
T33 1359-1363 GeneOrGeneProduct denotes cell

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 24-36 DiseaseOrPhenotypicFeature denotes Inflammation D007249
T2 61-66 DiseaseOrPhenotypicFeature denotes Death D003643
T3 256-262 DiseaseOrPhenotypicFeature denotes injury D014947
T4 742-751 DiseaseOrPhenotypicFeature denotes cytotoxic DISEASE
T5 1044-1049 DiseaseOrPhenotypicFeature denotes death D003643
T6 1327-1339 DiseaseOrPhenotypicFeature denotes inflammation D007249
T7 1364-1369 DiseaseOrPhenotypicFeature denotes death D003643

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 6-15 GeneOrGeneProduct denotes Amyloid A
T2 110-119 GeneOrGeneProduct denotes amyloid A
T3 121-124 GeneOrGeneProduct denotes SAA
T4 162-181 GeneOrGeneProduct denotes acute phase protein
T5 356-359 GeneOrGeneProduct denotes SAA
T6 444-453 GeneOrGeneProduct denotes amyloid A
T7 485-508 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T8 524-527 GeneOrGeneProduct denotes Akt
T9 614-623 GeneOrGeneProduct denotes amyloid A
T10 653-658 GeneOrGeneProduct denotes MCP-1
T11 660-666 GeneOrGeneProduct denotes RANTES
T12 671-675 GeneOrGeneProduct denotes MMP9
T13 763-766 GeneOrGeneProduct denotes SAA
T14 815-824 GeneOrGeneProduct denotes caspase 3
T15 829-833 GeneOrGeneProduct denotes PARP
T16 847-856 GeneOrGeneProduct denotes Annexin V
T17 873-882 GeneOrGeneProduct denotes amyloid A
T18 941-944 GeneOrGeneProduct denotes Akt
T19 979-982 GeneOrGeneProduct denotes SAA
T20 998-1009 GeneOrGeneProduct denotes MAP kinases
T21 1175-1179 GeneOrGeneProduct denotes SAA1
T22 1184-1188 GeneOrGeneProduct denotes SAA3
T23 1229-1232 GeneOrGeneProduct denotes SAA

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 6-13 DiseaseOrPhenotypicFeature denotes Amyloid 0019065
T2 110-117 DiseaseOrPhenotypicFeature denotes amyloid 0019065
T3 256-262 DiseaseOrPhenotypicFeature denotes injury 0021178
T4 444-451 DiseaseOrPhenotypicFeature denotes amyloid 0019065
T5 614-621 DiseaseOrPhenotypicFeature denotes amyloid 0019065
T6 873-880 DiseaseOrPhenotypicFeature denotes amyloid 0019065
T7 998-1001 DiseaseOrPhenotypicFeature denotes MAP 0012041

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 24-36 DiseaseOrPhenotypicFeature denotes Inflammation DISEASE|D007249
T3 61-66 DiseaseOrPhenotypicFeature denotes Death D003643
T4 256-262 DiseaseOrPhenotypicFeature denotes injury D014947
T5 742-751 DiseaseOrPhenotypicFeature denotes cytotoxic DISEASE
T6 1044-1049 DiseaseOrPhenotypicFeature denotes death D003643
T7 1091-1111 DiseaseOrPhenotypicFeature denotes hepatic fibrogenesis DISEASE
T8 1327-1339 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T10 1364-1369 DiseaseOrPhenotypicFeature denotes death D003643

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 24-36 DiseaseOrPhenotypicFeature denotes Inflammation D007249
T2 742-751 DiseaseOrPhenotypicFeature denotes cytotoxic DISEASE
T3 1091-1111 DiseaseOrPhenotypicFeature denotes hepatic fibrogenesis DISEASE
T4 1327-1339 DiseaseOrPhenotypicFeature denotes inflammation D007249

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 588-593 OrganismTaxon denotes human
T2 598-601 OrganismTaxon denotes rat

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 653-656 ChemicalEntity denotes MCP http://purl.obolibrary.org/obo/CHEBI_50099|http://purl.obolibrary.org/obo/CHEBI_132592
T3 891-894 ChemicalEntity denotes HSC http://purl.obolibrary.org/obo/CHEBI_50443
T4 998-1001 ChemicalEntity denotes MAP http://purl.obolibrary.org/obo/CHEBI_6716
T5 1113-1117 ChemicalEntity denotes CCl4 http://purl.obolibrary.org/obo/CHEBI_27385

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T5 1113-1117 ChemicalEntity denotes CCl4 http://purl.obolibrary.org/obo/CHEBI_27385
T4 998-1001 ChemicalEntity denotes MAP http://purl.obolibrary.org/obo/CHEBI_6716
T3 891-894 ChemicalEntity denotes HSC http://purl.obolibrary.org/obo/CHEBI_50443
T1 653-656 ChemicalEntity denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T23 1229-1232 GeneOrGeneProduct denotes SAA
T22 1184-1188 GeneOrGeneProduct denotes SAA3
T21 1175-1179 GeneOrGeneProduct denotes SAA1
T20 998-1009 GeneOrGeneProduct denotes MAP kinases
T19 979-982 GeneOrGeneProduct denotes SAA
T18 941-944 GeneOrGeneProduct denotes Akt
T17 873-882 GeneOrGeneProduct denotes amyloid A
T16 847-856 GeneOrGeneProduct denotes Annexin V
T15 829-833 GeneOrGeneProduct denotes PARP
T14 815-824 GeneOrGeneProduct denotes caspase 3
T13 763-766 GeneOrGeneProduct denotes SAA
T12 671-675 GeneOrGeneProduct denotes MMP9
T11 660-666 GeneOrGeneProduct denotes RANTES
T10 653-658 GeneOrGeneProduct denotes MCP-1
T9 614-623 GeneOrGeneProduct denotes amyloid A
T8 524-527 GeneOrGeneProduct denotes Akt
T7 485-508 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T6 444-453 GeneOrGeneProduct denotes amyloid A
T48504 356-359 GeneOrGeneProduct denotes SAA
T72007 162-181 GeneOrGeneProduct denotes acute phase protein
T96727 121-124 GeneOrGeneProduct denotes SAA
T2 110-119 GeneOrGeneProduct denotes amyloid A
T5727 6-15 GeneOrGeneProduct denotes Amyloid A
T50162 1327-1339 DiseaseOrPhenotypicFeature denotes inflammation D007249
T29613 1091-1111 DiseaseOrPhenotypicFeature denotes hepatic fibrogenesis DISEASE
T57400 742-751 DiseaseOrPhenotypicFeature denotes cytotoxic DISEASE
T28271 24-36 DiseaseOrPhenotypicFeature denotes Inflammation D007249
T24930 598-601 OrganismTaxon denotes rat
T2507 588-593 OrganismTaxon denotes human

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
T2 104-228 Sentence denotes Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes.
T3 229-311 Sentence denotes However, its role in liver injury and fibrogenesis has not been elucidated so far.
T4 312-437 Sentence denotes In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the main fibrogenic cell type of the liver.
T5 438-607 Sentence denotes Serum amyloid A potently activated IκB kinase, c-Jun N-terminal kinase (JNK), Erk and Akt and enhanced NF-κB-dependent luciferase activity in primary human and rat HSCs.
T6 608-714 Sentence denotes Serum amyloid A induced the transcription of MCP-1, RANTES and MMP9 in an NF-κB- and JNK-dependent manner.
T7 715-866 Sentence denotes Blockade of NF-κB revealed cytotoxic effects of SAA in primary HSCs with signs of apoptosis such as caspase 3 and PARP cleavage and Annexin V staining.
T8 867-954 Sentence denotes Serum amyloid A induced HSC proliferation, which depended on JNK, Erk and Akt activity.
T9 955-1073 Sentence denotes In primary hepatocytes, SAA also activated MAP kinases, but did not induce relevant cell death after NF-κB inhibition.
T10 1074-1213 Sentence denotes In two models of hepatic fibrogenesis, CCl4 treatment and bile duct ligation, hepatic mRNA levels of SAA1 and SAA3 were strongly increased.
T11 1214-1378 Sentence denotes In conclusion, SAA may modulate fibrogenic responses in the liver in a positive and negative fashion by inducing inflammation, proliferation and cell death in HSCs.
T1 0-103 Sentence denotes Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
T2 104-228 Sentence denotes Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes.
T3 229-311 Sentence denotes However, its role in liver injury and fibrogenesis has not been elucidated so far.
T4 312-437 Sentence denotes In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the main fibrogenic cell type of the liver.
T5 438-607 Sentence denotes Serum amyloid A potently activated IκB kinase, c-Jun N-terminal kinase (JNK), Erk and Akt and enhanced NF-κB-dependent luciferase activity in primary human and rat HSCs.
T6 608-714 Sentence denotes Serum amyloid A induced the transcription of MCP-1, RANTES and MMP9 in an NF-κB- and JNK-dependent manner.
T7 715-866 Sentence denotes Blockade of NF-κB revealed cytotoxic effects of SAA in primary HSCs with signs of apoptosis such as caspase 3 and PARP cleavage and Annexin V staining.
T8 867-954 Sentence denotes Serum amyloid A induced HSC proliferation, which depended on JNK, Erk and Akt activity.
T9 955-1073 Sentence denotes In primary hepatocytes, SAA also activated MAP kinases, but did not induce relevant cell death after NF-κB inhibition.
T10 1074-1213 Sentence denotes In two models of hepatic fibrogenesis, CCl4 treatment and bile duct ligation, hepatic mRNA levels of SAA1 and SAA3 were strongly increased.
T11 1214-1378 Sentence denotes In conclusion, SAA may modulate fibrogenic responses in the liver in a positive and negative fashion by inducing inflammation, proliferation and cell death in HSCs.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26937641-4#103#108#gene4790 541-546 gene4790 denotes NF-κB
26937641-4#6#13#diseaseC0002726 444-451 diseaseC0002726 denotes amyloid
103#108#gene47906#13#diseaseC0002726 26937641-4#103#108#gene4790 26937641-4#6#13#diseaseC0002726 associated_with NF-κB,amyloid