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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-143 Sentence denotes Intranasal Delivery of Recombinant AAV Containing BDNF Fused with HA2TAT: a Potential Promising Therapy Strategy for Major Depressive Disorder.
TextSentencer_T2 144-216 Sentence denotes Depression is a disturbing psychiatric disease with unsatisfied therapy.
TextSentencer_T3 217-427 Sentence denotes Not all patients are sensitive to anti-depressants currently in use, side-effects are unavoidable during therapy, and the cases with effectiveness are always accompanied with delayed onset of clinical efficacy.
TextSentencer_T4 428-521 Sentence denotes Delivering brain-derived neurotrophic factor (BDNF) to brain seems to be a promising therapy.
TextSentencer_T5 522-582 Sentence denotes However, a better approach to delivery is still rudimentary.
TextSentencer_T6 583-758 Sentence denotes The purpose of our present work is to look for a rapid-onset and long-lasting therapeutic strategy for major depressive disorder (MDD) by effectively delivering BDNF to brain.
TextSentencer_T7 759-988 Sentence denotes BDNF, fused with cell-penetrating peptides (TAT and HA2), was packaged in adenovirus associated virus (AAV) to construct the BDNF-HA2TAT/AAV for intranasally delivering BDNF to central nervous system (CNS) via nose-brain pathway.
TextSentencer_T8 989-1149 Sentence denotes Intranasal administration of BDNF-HA2TAT/AAV to normal mice displayed anti-depression effect in forced swimming test when the delivery lasted relatively longer.
TextSentencer_T9 1150-1301 Sentence denotes The AAV applied to mice subjected to chronic mild stress (CMS) through intranasal administration for 10 days also alleviated depression-like behaviors.
TextSentencer_T10 1302-1413 Sentence denotes Western-blotting analysis revealed that BDNF-HA2TAT/AAV nasal administration enhanced hippocampal BDNF content.
TextSentencer_T11 1414-1646 Sentence denotes These results indicate intranasal administration of constructed BDNF-HA2TAT/AAV exerts anti-depression effect in CMS mice by increasing hippocampal BDNF, suggesting that this strategy holds a promising therapeutic potential for MDD.
T1 0-143 Sentence denotes Intranasal Delivery of Recombinant AAV Containing BDNF Fused with HA2TAT: a Potential Promising Therapy Strategy for Major Depressive Disorder.
T2 144-216 Sentence denotes Depression is a disturbing psychiatric disease with unsatisfied therapy.
T3 217-427 Sentence denotes Not all patients are sensitive to anti-depressants currently in use, side-effects are unavoidable during therapy, and the cases with effectiveness are always accompanied with delayed onset of clinical efficacy.
T4 428-521 Sentence denotes Delivering brain-derived neurotrophic factor (BDNF) to brain seems to be a promising therapy.
T5 522-582 Sentence denotes However, a better approach to delivery is still rudimentary.
T6 583-758 Sentence denotes The purpose of our present work is to look for a rapid-onset and long-lasting therapeutic strategy for major depressive disorder (MDD) by effectively delivering BDNF to brain.
T7 759-988 Sentence denotes BDNF, fused with cell-penetrating peptides (TAT and HA2), was packaged in adenovirus associated virus (AAV) to construct the BDNF-HA2TAT/AAV for intranasally delivering BDNF to central nervous system (CNS) via nose-brain pathway.
T8 989-1149 Sentence denotes Intranasal administration of BDNF-HA2TAT/AAV to normal mice displayed anti-depression effect in forced swimming test when the delivery lasted relatively longer.
T9 1150-1301 Sentence denotes The AAV applied to mice subjected to chronic mild stress (CMS) through intranasal administration for 10 days also alleviated depression-like behaviors.
T10 1302-1413 Sentence denotes Western-blotting analysis revealed that BDNF-HA2TAT/AAV nasal administration enhanced hippocampal BDNF content.
T11 1414-1646 Sentence denotes These results indicate intranasal administration of constructed BDNF-HA2TAT/AAV exerts anti-depression effect in CMS mice by increasing hippocampal BDNF, suggesting that this strategy holds a promising therapeutic potential for MDD.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26935651-0#50#54#gene627 50-54 gene627 denotes BDNF
26935651-0#117#142#diseaseC0041696 117-142 diseaseC0041696 denotes Major Depressive Disorder
26935651-0#117#142#diseaseC1269683 117-142 diseaseC1269683 denotes Major Depressive Disorder
26935651-10#64#68#gene627 1478-1482 gene627 denotes BDNF
26935651-10#148#152#gene627 1562-1566 gene627 denotes BDNF
26935651-10#92#102#diseaseC0011570 1506-1516 diseaseC0011570 denotes depression
26935651-10#92#102#diseaseC0011581 1506-1516 diseaseC0011581 denotes depression
26935651-10#92#102#diseaseC0011570 1506-1516 diseaseC0011570 denotes depression
26935651-10#92#102#diseaseC0011581 1506-1516 diseaseC0011581 denotes depression
50#54#gene627117#142#diseaseC0041696 26935651-0#50#54#gene627 26935651-0#117#142#diseaseC0041696 associated_with BDNF,Major Depressive Disorder
50#54#gene627117#142#diseaseC1269683 26935651-0#50#54#gene627 26935651-0#117#142#diseaseC1269683 associated_with BDNF,Major Depressive Disorder
64#68#gene62792#102#diseaseC0011570 26935651-10#64#68#gene627 26935651-10#92#102#diseaseC0011570 associated_with BDNF,depression
64#68#gene62792#102#diseaseC0011581 26935651-10#64#68#gene627 26935651-10#92#102#diseaseC0011581 associated_with BDNF,depression
64#68#gene62792#102#diseaseC0011570 26935651-10#64#68#gene627 26935651-10#92#102#diseaseC0011570 associated_with BDNF,depression
64#68#gene62792#102#diseaseC0011581 26935651-10#64#68#gene627 26935651-10#92#102#diseaseC0011581 associated_with BDNF,depression
148#152#gene62792#102#diseaseC0011570 26935651-10#148#152#gene627 26935651-10#92#102#diseaseC0011570 associated_with BDNF,depression
148#152#gene62792#102#diseaseC0011581 26935651-10#148#152#gene627 26935651-10#92#102#diseaseC0011581 associated_with BDNF,depression
148#152#gene62792#102#diseaseC0011570 26935651-10#148#152#gene627 26935651-10#92#102#diseaseC0011570 associated_with BDNF,depression
148#152#gene62792#102#diseaseC0011581 26935651-10#148#152#gene627 26935651-10#92#102#diseaseC0011581 associated_with BDNF,depression

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2292 1478-1482 gene:627 denotes BDNF
T2293 1506-1516 disease:C0011570 denotes depression
T2294 1562-1566 gene:627 denotes BDNF
R1 T2292 T2293 associated_with BDNF,depression
R2 T2292 T2293 associated_with BDNF,depression
R3 T2294 T2293 associated_with BDNF,depression
R4 T2294 T2293 associated_with BDNF,depression

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 439-444 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T2 483-488 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T3 752-757 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T4 974-979 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T5 936-943 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T6 936-958 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
PD-UBERON-AE-B_T7 944-958 http://purl.obolibrary.org/obo/UBERON_0001016 denotes nervous system
PD-UBERON-AE-B_T8 969-973 http://purl.obolibrary.org/obo/UBERON_0000004 denotes nose

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 969-973 http://purl.obolibrary.org/obo/UBERON_0000004 denotes nose
PD-UBERON-AE-B_T2 439-444 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T3 483-488 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T4 752-757 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T5 974-979 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T6 936-958 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
PD-UBERON-AE-B_T7 936-943 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T8 944-958 http://purl.obolibrary.org/obo/UBERON_0001016 denotes nervous system

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 117-142 Disease denotes Major Depressive Disorder http://purl.obolibrary.org/obo/MONDO_0002009|http://purl.obolibrary.org/obo/MONDO_0005263
T3 144-154 Disease denotes Depression http://purl.obolibrary.org/obo/MONDO_0002050
T4 171-190 Disease denotes psychiatric disease http://purl.obolibrary.org/obo/MONDO_0002025
T5 713-716 Disease denotes MDD http://purl.obolibrary.org/obo/MONDO_0012048|http://purl.obolibrary.org/obo/MONDO_0016217
T7 1064-1074 Disease denotes depression http://purl.obolibrary.org/obo/MONDO_0002050
T8 1208-1211 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940
T9 1275-1285 Disease denotes depression http://purl.obolibrary.org/obo/MONDO_0002050
T10 1506-1516 Disease denotes depression http://purl.obolibrary.org/obo/MONDO_0002050
T11 1527-1530 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940
T12 1642-1645 Disease denotes MDD http://purl.obolibrary.org/obo/MONDO_0012048|http://purl.obolibrary.org/obo/MONDO_0016217

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 123-142 Phenotype denotes Depressive Disorder HP:0000716
T2 144-154 Phenotype denotes Depression HP:0000716
T3 692-711 Phenotype denotes depressive disorder HP:0000716
T4 1064-1074 Phenotype denotes depression HP:0000716
T5 1275-1285 Phenotype denotes depression HP:0000716
T6 1506-1516 Phenotype denotes depression HP:0000716

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1044-1048 OrganismTaxon denotes mice 10088
T2 1169-1173 OrganismTaxon denotes mice 10088
T3 1531-1535 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-10 Body_part denotes Intranasal http://purl.obolibrary.org/obo/UBERON_0011167
T2 439-444 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T4 483-488 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T6 752-757 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T8 904-916 Body_part denotes intranasally http://purl.obolibrary.org/obo/UBERON_0011167
T9 936-958 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T10 960-963 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T11 969-973 Body_part denotes nose http://purl.obolibrary.org/obo/UBERON_0000004|http://purl.obolibrary.org/obo/UBERON_0007827
T13 974-979 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T15 989-999 Body_part denotes Intranasal http://purl.obolibrary.org/obo/UBERON_0011167
T16 1221-1231 Body_part denotes intranasal http://purl.obolibrary.org/obo/UBERON_0011167
T17 1437-1447 Body_part denotes intranasal http://purl.obolibrary.org/obo/UBERON_0011167

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 439-444 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 483-488 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 752-757 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T4 936-958 Body_part denotes central nervous system http://purl.obolibrary.org/obo/MAT_0000457
T5 960-963 Body_part denotes CNS http://purl.obolibrary.org/obo/MAT_0000457
T6 969-973 Body_part denotes nose http://purl.obolibrary.org/obo/MAT_0000139
T7 974-979 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098