PubMed:26931464 / 1791-1984 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
26931464_6 57-63 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T246 31-41 6472 denotes lovastatin
T244 31-41 D008148 denotes lovastatin
T245 31-41 D008148 denotes lovastatin
T247 31-41 CHEBI:40303 denotes lovastatin
T248 51-56 PR:Q5S006 denotes LRRK2
T249 51-56 PR:000003033 denotes LRRK2
T250 51-56 PR:Q5S007 denotes LRRK2
T251 64-71 GO:0043005 denotes neurite
T252 99-102 PR:000029189 denotes Akt
T253 99-102 PR:P54644 denotes Akt
T254 99-102 PR:P31750 denotes Akt
T255 99-102 PR:000002190 denotes Akt
T256 99-102 Q8INB9 denotes Akt
T260 103-107 PR:Q60795 denotes NRF2
T261 103-107 PR:O54968 denotes NRF2
T262 103-107 PR:000011170 denotes NRF2
T263 103-107 Q16236 denotes NRF2
T264 103-107 PR:Q16236 denotes NRF2
T265 108-115 CHEBI:34922 denotes pathway
T266 131-141 SO:0001633 denotes downstream
T268 142-145 GO:0050321 denotes GSK
T270 142-146 P83101 denotes GSK3
T271 142-146 PR:Q9U2Q9 denotes GSK3
T273 142-146 PR:P51136 denotes GSK3
T274 142-146 PR:P38615 denotes GSK3
T275 142-146 PR:P18431 denotes GSK3
T276 142-146 P51136 denotes GSK3
T277 142-146 PR:Q10452 denotes GSK3
T272 142-146 D038362 denotes GSK3
T278 174-181 CHEBI:48108 denotes phospho
T279 182-185 PR:P16525 denotes tau
T280 182-185 PR:000024142 denotes tau
T281 182-185 PR:P10636 denotes tau
T282 182-185 PR:000010173 denotes tau
T283 182-185 PR:P19332 denotes tau
T285 182-185 PR:P10637 denotes tau
T284 182-185 CHEBI:36355 denotes tau

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T14 0-193 DRI_Outcome denotes Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3β activity, which decreased phospho-tau levels.