PubMed:26931464 / 1791-1984
Annnotations
PubTator4TogoVar
Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
---|---|---|---|---|---|
26931464_6 | 57-63 | ProteinMutation | denotes | G2019S | rs34637584 |
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T246 | 31-41 | 6472 | denotes | lovastatin |
T244 | 31-41 | D008148 | denotes | lovastatin |
T245 | 31-41 | D008148 | denotes | lovastatin |
T247 | 31-41 | CHEBI:40303 | denotes | lovastatin |
T248 | 51-56 | PR:Q5S006 | denotes | LRRK2 |
T249 | 51-56 | PR:000003033 | denotes | LRRK2 |
T250 | 51-56 | PR:Q5S007 | denotes | LRRK2 |
T251 | 64-71 | GO:0043005 | denotes | neurite |
T252 | 99-102 | PR:000029189 | denotes | Akt |
T253 | 99-102 | PR:P54644 | denotes | Akt |
T254 | 99-102 | PR:P31750 | denotes | Akt |
T255 | 99-102 | PR:000002190 | denotes | Akt |
T256 | 99-102 | Q8INB9 | denotes | Akt |
T260 | 103-107 | PR:Q60795 | denotes | NRF2 |
T261 | 103-107 | PR:O54968 | denotes | NRF2 |
T262 | 103-107 | PR:000011170 | denotes | NRF2 |
T263 | 103-107 | Q16236 | denotes | NRF2 |
T264 | 103-107 | PR:Q16236 | denotes | NRF2 |
T265 | 108-115 | CHEBI:34922 | denotes | pathway |
T266 | 131-141 | SO:0001633 | denotes | downstream |
T268 | 142-145 | GO:0050321 | denotes | GSK |
T270 | 142-146 | P83101 | denotes | GSK3 |
T271 | 142-146 | PR:Q9U2Q9 | denotes | GSK3 |
T273 | 142-146 | PR:P51136 | denotes | GSK3 |
T274 | 142-146 | PR:P38615 | denotes | GSK3 |
T275 | 142-146 | PR:P18431 | denotes | GSK3 |
T276 | 142-146 | P51136 | denotes | GSK3 |
T277 | 142-146 | PR:Q10452 | denotes | GSK3 |
T272 | 142-146 | D038362 | denotes | GSK3 |
T278 | 174-181 | CHEBI:48108 | denotes | phospho |
T279 | 182-185 | PR:P16525 | denotes | tau |
T280 | 182-185 | PR:000024142 | denotes | tau |
T281 | 182-185 | PR:P10636 | denotes | tau |
T282 | 182-185 | PR:000010173 | denotes | tau |
T283 | 182-185 | PR:P19332 | denotes | tau |
T285 | 182-185 | PR:P10637 | denotes | tau |
T284 | 182-185 | CHEBI:36355 | denotes | tau |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T14 | 0-193 | DRI_Outcome | denotes | Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3β activity, which decreased phospho-tau levels. |