PubMed:26921319
Annnotations
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 92-100 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | Placenta |
| T2 | 291-299 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
| T3 | 421-429 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
| T4 | 899-904 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T5 | 899-904 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T6 | 919-924 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T7 | 919-924 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T8 | 933-942 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placentas |
| T9 | 2114-2122 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 26921319-10#72#74#gene3643 | 1931-1933 | gene3643 | denotes | IR |
| 26921319-10#55#63#diseaseC0011847 | 1914-1922 | diseaseC0011847 | denotes | diabetes |
| 26921319-10#55#63#diseaseC0011849 | 1914-1922 | diseaseC0011849 | denotes | diabetes |
| 72#74#gene364355#63#diseaseC0011847 | 26921319-10#72#74#gene3643 | 26921319-10#55#63#diseaseC0011847 | associated_with | IR,diabetes |
| 72#74#gene364355#63#diseaseC0011849 | 26921319-10#72#74#gene3643 | 26921319-10#55#63#diseaseC0011849 | associated_with | IR,diabetes |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T398 | 1931-1933 | gene:3643 | denotes | IR |
| T399 | 1914-1922 | disease:C0011847 | denotes | diabetes |
| R1 | T398 | T399 | associated_with | IR,diabetes |
| R2 | T398 | T399 | associated_with | IR,diabetes |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-101 | Sentence | denotes | Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta. |
| TextSentencer_T2 | 102-300 | Sentence | denotes | Earlier findings have identified the requirement of insulin signaling on maturation and the translocation of serotonin (5-HT) transporter, SERT to the plasma membrane of the trophoblast in placenta. |
| TextSentencer_T3 | 301-495 | Sentence | denotes | Because of the defect on insulin receptor (IR) in the trophoblast of the gestational diabetes mellitus (GDM)-associated placenta, SERT is found entrapped in the cytoplasm of the GDM-trophoblast. |
| TextSentencer_T4 | 496-568 | Sentence | denotes | SERT is encoded by the same gene expressed in trophoblast and platelets. |
| TextSentencer_T5 | 569-697 | Sentence | denotes | Additionally, alteration in plasma 5-HT levels and the 5-HT uptake rates are associated with the aggregation rates of platelets. |
| TextSentencer_T6 | 698-905 | Sentence | denotes | Therefore, here, we investigated a novel hypothesis that GDM-associated defects in platelet IR should change their 5-HT uptake rates, and this should be a leading factor for thrombosis in GDM maternal blood. |
| TextSentencer_T7 | 906-1364 | Sentence | denotes | The maternal blood and the placentas were obtained at the time of cesarean section from the GDM and non-diabetic subjects (n = 6 for each group), and the platelets and trophoblasts were isolated to determine the IR activity, surface level of SERT, and their 5-HT uptake rates.Interestingly, no significant differences were evident in IR tyrosine phosphorylation or the downstream elements, AKT and S6K in platelets and their aggregation rates in both groups. |
| TextSentencer_T8 | 1365-1478 | Sentence | denotes | Furthermore, insulin stimulation up-regulated 5-HT uptake rates of GDM-platelets as it does in the control group. |
| TextSentencer_T9 | 1479-1710 | Sentence | denotes | However, the phosphorylation of IR and the downstream elements were significantly lower in GDM-trophoblast and showed no response to the insulin stimulation while they showed 4-fold increase to insulin stimulation in control group. |
| TextSentencer_T10 | 1711-1858 | Sentence | denotes | Similarly, the 5-HT uptake rates of GDM-trophoblast and the SERT expression on their surface were severalfold lower compared with control subjects. |
| TextSentencer_T11 | 1859-1957 | Sentence | denotes | IR is expressed in all tissues, but it is not known if diabetes affects IR in all tissues equally. |
| TextSentencer_T12 | 1958-2085 | Sentence | denotes | Here, for the first time, our findings with clinical samples show that in GDM-associated defect on IR is tissue type-dependent. |
| TextSentencer_T13 | 2086-2157 | Sentence | denotes | While IR is impaired in GDM-placenta, it is unaffected in GDM-platelet. |
| T1 | 0-101 | Sentence | denotes | Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta. |
| T2 | 102-300 | Sentence | denotes | Earlier findings have identified the requirement of insulin signaling on maturation and the translocation of serotonin (5-HT) transporter, SERT to the plasma membrane of the trophoblast in placenta. |
| T3 | 301-495 | Sentence | denotes | Because of the defect on insulin receptor (IR) in the trophoblast of the gestational diabetes mellitus (GDM)-associated placenta, SERT is found entrapped in the cytoplasm of the GDM-trophoblast. |
| T4 | 496-568 | Sentence | denotes | SERT is encoded by the same gene expressed in trophoblast and platelets. |
| T5 | 569-697 | Sentence | denotes | Additionally, alteration in plasma 5-HT levels and the 5-HT uptake rates are associated with the aggregation rates of platelets. |
| T6 | 698-905 | Sentence | denotes | Therefore, here, we investigated a novel hypothesis that GDM-associated defects in platelet IR should change their 5-HT uptake rates, and this should be a leading factor for thrombosis in GDM maternal blood. |
| T7 | 906-1364 | Sentence | denotes | The maternal blood and the placentas were obtained at the time of cesarean section from the GDM and non-diabetic subjects (n = 6 for each group), and the platelets and trophoblasts were isolated to determine the IR activity, surface level of SERT, and their 5-HT uptake rates.Interestingly, no significant differences were evident in IR tyrosine phosphorylation or the downstream elements, AKT and S6K in platelets and their aggregation rates in both groups. |
| T8 | 1365-1478 | Sentence | denotes | Furthermore, insulin stimulation up-regulated 5-HT uptake rates of GDM-platelets as it does in the control group. |
| T9 | 1479-1710 | Sentence | denotes | However, the phosphorylation of IR and the downstream elements were significantly lower in GDM-trophoblast and showed no response to the insulin stimulation while they showed 4-fold increase to insulin stimulation in control group. |
| T10 | 1711-1858 | Sentence | denotes | Similarly, the 5-HT uptake rates of GDM-trophoblast and the SERT expression on their surface were severalfold lower compared with control subjects. |
| T11 | 1859-1957 | Sentence | denotes | IR is expressed in all tissues, but it is not known if diabetes affects IR in all tissues equally. |
| T12 | 1958-2085 | Sentence | denotes | Here, for the first time, our findings with clinical samples show that in GDM-associated defect on IR is tissue type-dependent. |
| T13 | 2086-2157 | Sentence | denotes | While IR is impaired in GDM-placenta, it is unaffected in GDM-platelet. |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 92-100 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | Placenta |
| PD-UBERON-AE-B_T2 | 291-299 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| PD-UBERON-AE-B_T3 | 421-429 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| PD-UBERON-AE-B_T4 | 2114-2122 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| PD-UBERON-AE-B_T5 | 276-287 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T6 | 355-366 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T7 | 483-494 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T8 | 542-553 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T9 | 1574-1585 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T10 | 1751-1762 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T11 | 899-904 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T12 | 919-924 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T13 | 1882-1889 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T14 | 1941-1948 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T15 | 2063-2069 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 1882-1889 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T2 | 1941-1948 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T3 | 2063-2069 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
| PD-UBERON-AE-B_T4 | 899-904 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T5 | 919-924 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T6 | 92-100 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | Placenta |
| PD-UBERON-AE-B_T7 | 291-299 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| PD-UBERON-AE-B_T8 | 421-429 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| PD-UBERON-AE-B_T9 | 933-942 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placentas |
| PD-UBERON-AE-B_T10 | 2114-2122 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| PD-UBERON-AE-B_T11 | 276-287 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T12 | 355-366 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T13 | 483-494 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T14 | 542-553 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T15 | 1074-1086 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblasts |
| PD-UBERON-AE-B_T16 | 1574-1585 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T17 | 1751-1762 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 42-62 | Disease | denotes | Gestational Diabetes | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T2 | 73-76 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T3 | 374-403 | Disease | denotes | gestational diabetes mellitus | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T4 | 405-408 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T5 | 479-482 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T6 | 755-758 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T7 | 872-882 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T8 | 886-889 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T9 | 998-1001 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T10 | 1432-1435 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T11 | 1570-1573 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T12 | 1747-1750 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T13 | 1914-1922 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T14 | 2032-2035 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T15 | 2110-2113 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
| T16 | 2144-2147 | Disease | denotes | GDM | http://purl.obolibrary.org/obo/MONDO_0005406 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 92-100 | Body_part | denotes | Placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
| T2 | 291-299 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
| T3 | 421-429 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
| T4 | 899-904 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T6 | 919-924 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T8 | 933-942 | Body_part | denotes | placentas | http://purl.obolibrary.org/obo/MAT_0000279 |
| T9 | 2114-2122 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 54-71 | Phenotype | denotes | Diabetes Mellitus | HP:0000819 |
| T2 | 386-403 | Phenotype | denotes | diabetes mellitus | HP:0000819 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 92-100 | Body_part | denotes | Placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T2 | 253-268 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T3 | 276-287 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T4 | 291-299 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T5 | 355-366 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T6 | 421-429 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T7 | 462-471 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T8 | 483-494 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T9 | 542-553 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T10 | 558-567 | Body_part | denotes | platelets | http://purl.obolibrary.org/obo/CL_0000233 |
| T11 | 597-603 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T12 | 687-696 | Body_part | denotes | platelets | http://purl.obolibrary.org/obo/CL_0000233 |
| T13 | 781-789 | Body_part | denotes | platelet | http://purl.obolibrary.org/obo/CL_0000233 |
| T14 | 899-904 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T15 | 919-924 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T16 | 933-942 | Body_part | denotes | placentas | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T17 | 1060-1069 | Body_part | denotes | platelets | http://purl.obolibrary.org/obo/CL_0000233 |
| T18 | 1074-1086 | Body_part | denotes | trophoblasts | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T19 | 1311-1320 | Body_part | denotes | platelets | http://purl.obolibrary.org/obo/CL_0000233 |
| T20 | 1436-1445 | Body_part | denotes | platelets | http://purl.obolibrary.org/obo/CL_0000233 |
| T21 | 1574-1585 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T22 | 1751-1762 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T23 | 2063-2069 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T24 | 2114-2122 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T25 | 2148-2156 | Body_part | denotes | platelet | http://purl.obolibrary.org/obo/CL_0000233 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 78-87 | Cell | denotes | Platelets | http://purl.obolibrary.org/obo/CL:0000233 |
| T2 | 558-567 | Cell | denotes | platelets | http://purl.obolibrary.org/obo/CL:0000233 |
| T3 | 687-696 | Cell | denotes | platelets | http://purl.obolibrary.org/obo/CL:0000233 |
| T4 | 781-789 | Cell | denotes | platelet | http://purl.obolibrary.org/obo/CL:0000233 |
| T5 | 1060-1069 | Cell | denotes | platelets | http://purl.obolibrary.org/obo/CL:0000233 |
| T6 | 1311-1320 | Cell | denotes | platelets | http://purl.obolibrary.org/obo/CL:0000233 |
| T7 | 1436-1445 | Cell | denotes | platelets | http://purl.obolibrary.org/obo/CL:0000233 |
| T8 | 2148-2156 | Cell | denotes | platelet | http://purl.obolibrary.org/obo/CL:0000233 |