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PubMed:26900322 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11062 0-3 GeneOrGeneProduct denotes CFI NCBIGene:3426
11063 4-13 SequenceVariant denotes rs7356506 DBSNP:rs7356506
11064 44-73 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada syndrome MESH:D014607
11065 84-103 GeneOrGeneProduct denotes Complement factor I NCBIGene:3426
11066 105-108 GeneOrGeneProduct denotes CFI NCBIGene:3426
11067 210-217 DiseaseOrPhenotypicFeature denotes uveitis MESH:D014605
11068 306-309 GeneOrGeneProduct denotes CFI NCBIGene:3426
11069 336-371 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada (VKH) syndrome MESH:D014607
11070 397-405 OrganismTaxon denotes patients NCBITaxon:9606
11071 421-433 DiseaseOrPhenotypicFeature denotes VKH syndrome MESH:D014607
11072 575-578 GeneOrGeneProduct denotes CFI NCBIGene:3426
11073 579-588 SequenceVariant denotes rs7356506 DBSNP:rs7356506
11074 709-717 OrganismTaxon denotes patients NCBITaxon:9606
11075 813-821 DiseaseOrPhenotypicFeature denotes cataract MESH:D002386
11076 834-841 ChemicalEntity denotes steroid MESH:D013256
11077 914-917 GeneOrGeneProduct denotes CFI NCBIGene:3426
11078 918-927 SequenceVariant denotes rs7356506 DBSNP:rs7356506
11079 946-958 DiseaseOrPhenotypicFeature denotes VKH syndrome MESH:D014607
11080 969-977 OrganismTaxon denotes patients NCBITaxon:9606
11081 993-1005 DiseaseOrPhenotypicFeature denotes VKH syndrome MESH:D014607
11082 1067-1070 GeneOrGeneProduct denotes CFI NCBIGene:3426
11083 1071-1080 SequenceVariant denotes rs7356506 DBSNP:rs7356506
11084 1344-1347 GeneOrGeneProduct denotes CFI NCBIGene:3426
11085 1348-1357 SequenceVariant denotes rs7356506 DBSNP:rs7356506
11086 1361-1369 OrganismTaxon denotes patients NCBITaxon:9606
11087 1375-1387 DiseaseOrPhenotypicFeature denotes VKH syndrome MESH:D014607
11088 1405-1413 DiseaseOrPhenotypicFeature denotes cataract MESH:D002386
11089 1579-1587 OrganismTaxon denotes patients NCBITaxon:9606
11090 1593-1605 DiseaseOrPhenotypicFeature denotes VKH syndrome MESH:D014607
11091 1609-1616 ChemicalEntity denotes steroid MESH:D013256
11092 1653-1656 GeneOrGeneProduct denotes CFI NCBIGene:3426
11093 1657-1666 SequenceVariant denotes rs7356506 DBSNP:rs7356506
11094 1721-1724 GeneOrGeneProduct denotes CFI NCBIGene:3426
11095 1777-1789 DiseaseOrPhenotypicFeature denotes VKH syndrome MESH:D014607
11096 1850-1853 GeneOrGeneProduct denotes CFI NCBIGene:3426
11097 1854-1861 SequenceVariant denotes 7356506 DBSNP:rs7356506
11098 1867-1879 DiseaseOrPhenotypicFeature denotes VKH syndrome MESH:D014607
11099 1937-1945 DiseaseOrPhenotypicFeature denotes cataract MESH:D002386
11100 1968-1975 ChemicalEntity denotes steroid MESH:D013256

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes CFI-rs7356506 polymorphisms associated with Vogt-Koyanagi-Harada syndrome.
T2 75-83 Sentence denotes PURPOSE:
T3 84-218 Sentence denotes Complement factor I (CFI) plays an important role in complement activation pathways and is known to affect the development of uveitis.
T4 219-372 Sentence denotes The present study was performed to investigate the existence of an association between CFI genetic polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome.
T5 373-381 Sentence denotes METHODS:
T6 382-488 Sentence denotes A total of 100 patients diagnosed with VKH syndrome and 300 healthy controls were recruited for the study.
T7 489-574 Sentence denotes Two milliliters of peripheral blood were collected in a sterile anticoagulative tube.
T8 575-654 Sentence denotes CFI-rs7356506 polymorphisms were genotyped using Sequenom MassARRAY technology.
T9 655-749 Sentence denotes Allele and genotype frequencies were compared between patients and controls using a χ(2) test.
T10 750-859 Sentence denotes The analyses were stratified for recurrent status, complicated cataract status, and steroid-sensitive status.
T11 860-868 Sentence denotes RESULTS:
T12 869-959 Sentence denotes No significant association was found between CFI-rs7356506 polymorphisms and VKH syndrome.
T13 960-1239 Sentence denotes However, patients with recurrent VKH syndrome had lower frequencies of the G allele and GG homozygosity in CFI-rs7356506 when compared to the controls (p=0.016, odds ratio [OR]=0.429, 95% confidence interval [CI]=0.212-0.871; p=0.014, OR=0.364, 95% CI=0.158-0.837, respectively).
T14 1240-1532 Sentence denotes Furthermore, there were significant decreases in the frequencies of the G allele and GG homozygosity in CFI-rs7356506 in patients with VKH syndrome with complicated cataract compared to the controls (p<0.001, OR=0.357, 95% CI=0.197-0.648; p<0.001, OR=0.273, 95% CI=0.135-0.551, respectively).
T15 1533-1681 Sentence denotes Nevertheless, no significant association with patients with VKH syndrome in steroid-sensitive statuses was detected for CFI-rs7356506 polymorphisms.
T16 1682-1694 Sentence denotes CONCLUSIONS:
T17 1695-1993 Sentence denotes Our results indicate that CFI polymorphisms are not significantly associated with VKH syndrome; nevertheless, we identified a trend for the association of CFI-7356506 with VKH syndrome that depends on the recurrent status and the complicated cataract status but not on the steroid-sensitive status.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 210-217 DiseaseOrPhenotypicFeature denotes uveitis 0020283
T2 813-821 DiseaseOrPhenotypicFeature denotes cataract 0005129
T3 1405-1413 DiseaseOrPhenotypicFeature denotes cataract 0005129
T4 1937-1945 DiseaseOrPhenotypicFeature denotes cataract 0005129

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 4-13 SequenceVariant denotes rs7356506
T2 579-588 SequenceVariant denotes rs7356506
T3 918-927 SequenceVariant denotes rs7356506
T4 1071-1080 SequenceVariant denotes rs7356506
T5 1348-1357 SequenceVariant denotes rs7356506
T6 1657-1666 SequenceVariant denotes rs7356506

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 65-73 GeneOrGeneProduct denotes syndrome
T2 84-103 GeneOrGeneProduct denotes Complement factor I
T3 148-158 GeneOrGeneProduct denotes activation
T4 363-371 GeneOrGeneProduct denotes syndrome
T5 373-380 GeneOrGeneProduct denotes METHODS
T6 384-389 GeneOrGeneProduct denotes total
T7 425-433 GeneOrGeneProduct denotes syndrome
T8 540-544 GeneOrGeneProduct denotes in a
T9 569-573 GeneOrGeneProduct denotes tube
T10 675-686 GeneOrGeneProduct denotes frequencies
T11 744-748 GeneOrGeneProduct denotes test
T12 813-821 GeneOrGeneProduct denotes cataract
T13 950-958 GeneOrGeneProduct denotes syndrome
T14 997-1005 GeneOrGeneProduct denotes syndrome
T15 1016-1027 GeneOrGeneProduct denotes frequencies
T16 1293-1304 GeneOrGeneProduct denotes frequencies
T17 1379-1387 GeneOrGeneProduct denotes syndrome
T18 1405-1413 GeneOrGeneProduct denotes cataract
T19 1597-1605 GeneOrGeneProduct denotes syndrome
T20 1781-1789 GeneOrGeneProduct denotes syndrome
T21 1871-1879 GeneOrGeneProduct denotes syndrome
T22 1937-1945 GeneOrGeneProduct denotes cataract

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 65-73 GeneOrGeneProduct denotes syndrome
T2 84-103 GeneOrGeneProduct denotes Complement factor I
T3 363-371 GeneOrGeneProduct denotes syndrome
T4 425-433 GeneOrGeneProduct denotes syndrome
T5 569-573 GeneOrGeneProduct denotes tube
T6 813-821 GeneOrGeneProduct denotes cataract
T7 950-958 GeneOrGeneProduct denotes syndrome
T8 997-1005 GeneOrGeneProduct denotes syndrome
T9 1379-1387 GeneOrGeneProduct denotes syndrome
T10 1405-1413 GeneOrGeneProduct denotes cataract
T11 1597-1605 GeneOrGeneProduct denotes syndrome
T12 1781-1789 GeneOrGeneProduct denotes syndrome
T13 1871-1879 GeneOrGeneProduct denotes syndrome
T14 1937-1945 GeneOrGeneProduct denotes cataract

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 44-73 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada syndrome D014607
T2 210-217 DiseaseOrPhenotypicFeature denotes uveitis D014605
T3 357-371 DiseaseOrPhenotypicFeature denotes (VKH) syndrome D014607
T4 421-433 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T5 783-792 DiseaseOrPhenotypicFeature denotes recurrent D012008
T6 813-821 DiseaseOrPhenotypicFeature denotes cataract D002386
T7 946-958 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T8 983-992 DiseaseOrPhenotypicFeature denotes recurrent D012008
T9 993-1005 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T10 1375-1387 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T11 1405-1413 DiseaseOrPhenotypicFeature denotes cataract D002386
T12 1593-1605 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T13 1777-1789 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T14 1867-1879 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T15 1900-1909 DiseaseOrPhenotypicFeature denotes recurrent D012008
T16 1937-1945 DiseaseOrPhenotypicFeature denotes cataract D002386

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-3 GeneOrGeneProduct denotes CFI
T2 84-103 GeneOrGeneProduct denotes Complement factor I
T3 105-108 GeneOrGeneProduct denotes CFI
T4 306-309 GeneOrGeneProduct denotes CFI
T5 575-578 GeneOrGeneProduct denotes CFI
T6 914-917 GeneOrGeneProduct denotes CFI
T7 1067-1070 GeneOrGeneProduct denotes CFI
T8 1344-1347 GeneOrGeneProduct denotes CFI
T9 1653-1656 GeneOrGeneProduct denotes CFI
T10 1721-1724 GeneOrGeneProduct denotes CFI
T11 1850-1853 GeneOrGeneProduct denotes CFI

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 44-73 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada syndrome 0018092
T2 210-217 DiseaseOrPhenotypicFeature denotes uveitis 0020283
T3 357-371 DiseaseOrPhenotypicFeature denotes (VKH) syndrome 0018092
T4 421-433 DiseaseOrPhenotypicFeature denotes VKH syndrome 0018092
T5 545-552 DiseaseOrPhenotypicFeature denotes sterile 0005047
T6 813-821 DiseaseOrPhenotypicFeature denotes cataract 0005129
T7 842-851 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T8 946-958 DiseaseOrPhenotypicFeature denotes VKH syndrome 0018092
T9 993-1005 DiseaseOrPhenotypicFeature denotes VKH syndrome 0018092
T10 1375-1387 DiseaseOrPhenotypicFeature denotes VKH syndrome 0018092
T11 1405-1413 DiseaseOrPhenotypicFeature denotes cataract 0005129
T12 1593-1605 DiseaseOrPhenotypicFeature denotes VKH syndrome 0018092
T13 1617-1626 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T14 1777-1789 DiseaseOrPhenotypicFeature denotes VKH syndrome 0018092
T15 1867-1879 DiseaseOrPhenotypicFeature denotes VKH syndrome 0018092
T16 1937-1945 DiseaseOrPhenotypicFeature denotes cataract 0005129
T17 1976-1985 DiseaseOrPhenotypicFeature denotes sensitive 0000605

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 44-73 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada syndrome D014607
T2 210-217 DiseaseOrPhenotypicFeature denotes uveitis D014605
T3 336-371 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada (VKH) syndrome DISEASE
T4 421-433 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T5 813-821 DiseaseOrPhenotypicFeature denotes cataract D002386
T6 946-958 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T7 993-1005 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T8 1375-1387 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T9 1405-1413 DiseaseOrPhenotypicFeature denotes cataract D002386
T10 1593-1605 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T11 1777-1789 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T12 1867-1879 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T13 1937-1945 DiseaseOrPhenotypicFeature denotes cataract D002386

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 44-73 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada syndrome D014607
T2 210-217 DiseaseOrPhenotypicFeature denotes uveitis D014605
T3 336-371 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada (VKH) syndrome DISEASE
T4 421-433 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T5 813-821 DiseaseOrPhenotypicFeature denotes cataract D002386
T6 946-958 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T7 993-1005 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T8 1375-1387 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T9 1405-1413 DiseaseOrPhenotypicFeature denotes cataract D002386
T10 1593-1605 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T11 1777-1789 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T12 1867-1879 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T13 1937-1945 DiseaseOrPhenotypicFeature denotes cataract D002386

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 397-405 OrganismTaxon denotes patients
T2 709-717 OrganismTaxon denotes patients
T3 969-977 OrganismTaxon denotes patients
T4 1361-1369 OrganismTaxon denotes patients
T5 1579-1587 OrganismTaxon denotes patients

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-3 ChemicalEntity denotes CFI C010073
T2 105-108 ChemicalEntity denotes CFI C010073
T3 306-309 ChemicalEntity denotes CFI C010073
T4 575-578 ChemicalEntity denotes CFI C010073
T5 834-841 ChemicalEntity denotes steroid D013256|http://purl.obolibrary.org/obo/CHEBI_35341
T7 914-917 ChemicalEntity denotes CFI C010073
T8 1067-1070 ChemicalEntity denotes CFI C010073
T9 1344-1347 ChemicalEntity denotes CFI C010073
T10 1609-1616 ChemicalEntity denotes steroid D013256|http://purl.obolibrary.org/obo/CHEBI_35341
T12 1653-1656 ChemicalEntity denotes CFI C010073
T13 1721-1724 ChemicalEntity denotes CFI C010073
T14 1850-1853 ChemicalEntity denotes CFI C010073
T15 1968-1975 ChemicalEntity denotes steroid D013256|http://purl.obolibrary.org/obo/CHEBI_35341

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T15 1968-1975 ChemicalEntity denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341|D013256
T14 1850-1853 ChemicalEntity denotes CFI C010073
T13 1721-1724 ChemicalEntity denotes CFI C010073
T12 1653-1656 ChemicalEntity denotes CFI C010073
T10 1609-1616 ChemicalEntity denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341|D013256
T9 1344-1347 ChemicalEntity denotes CFI C010073
T8 1067-1070 ChemicalEntity denotes CFI C010073
T7 914-917 ChemicalEntity denotes CFI C010073
T5 834-841 ChemicalEntity denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341|D013256
T4 575-578 ChemicalEntity denotes CFI C010073
T3 306-309 ChemicalEntity denotes CFI C010073
T2 105-108 ChemicalEntity denotes CFI C010073
T1 0-3 ChemicalEntity denotes CFI C010073
T11 1850-1853 GeneOrGeneProduct denotes CFI
T27514 1721-1724 GeneOrGeneProduct denotes CFI
T92760 1653-1656 GeneOrGeneProduct denotes CFI
T60582 1344-1347 GeneOrGeneProduct denotes CFI
T28320 1067-1070 GeneOrGeneProduct denotes CFI
T6 914-917 GeneOrGeneProduct denotes CFI
T3558 575-578 GeneOrGeneProduct denotes CFI
T84934 306-309 GeneOrGeneProduct denotes CFI
T87732 105-108 GeneOrGeneProduct denotes CFI
T96339 84-103 GeneOrGeneProduct denotes Complement factor I
T63822 0-3 GeneOrGeneProduct denotes CFI
T66997 1937-1945 DiseaseOrPhenotypicFeature denotes cataract D002386
T364 1867-1879 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T9570 1777-1789 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T64713 1593-1605 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T50868 1405-1413 DiseaseOrPhenotypicFeature denotes cataract D002386
T12807 1375-1387 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T9466 993-1005 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T37851 946-958 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T23663 813-821 DiseaseOrPhenotypicFeature denotes cataract D002386
T9663 421-433 DiseaseOrPhenotypicFeature denotes VKH syndrome D014607
T42418 336-371 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada (VKH) syndrome DISEASE
T94191 210-217 DiseaseOrPhenotypicFeature denotes uveitis D014605
T53725 44-73 DiseaseOrPhenotypicFeature denotes Vogt-Koyanagi-Harada syndrome D014607
T35283 1579-1587 OrganismTaxon denotes patients
T57425 1361-1369 OrganismTaxon denotes patients
T69637 969-977 OrganismTaxon denotes patients
T12006 709-717 OrganismTaxon denotes patients
T60602 397-405 OrganismTaxon denotes patients
T24657 1657-1666 SequenceVariant denotes rs7356506
T1460 1348-1357 SequenceVariant denotes rs7356506
T21251 1071-1080 SequenceVariant denotes rs7356506
T82589 918-927 SequenceVariant denotes rs7356506
T31025 579-588 SequenceVariant denotes rs7356506
T63964 4-13 SequenceVariant denotes rs7356506